%PDF-1.4 5 0 obj << /S /GoTo /D (section.1) >> endobj 8 0 obj (Overview) endobj 9 0 obj << /S /GoTo /D (section.2) >> endobj 12 0 obj (Obtaining the initial graph) endobj 13 0 obj << /S /GoTo /D (section.3) >> endobj 16 0 obj (Laying out the graph) endobj 17 0 obj << /S /GoTo /D (section.4) >> endobj 20 0 obj (Working with the layout) endobj 21 0 obj << /S /GoTo /D (section.5) >> endobj 24 0 obj (Conclusions) endobj 25 0 obj << /S /GoTo /D [26 0 R /Fit ] >> endobj 29 0 obj << /Length 1546 /Filter /FlateDecode >> stream xڵWIoFWH!5+ܒfiE ݚhH-v_߷ EJvaY޼mb6g}hudtY(>bgs"~HtH**oa]#t! nG8gtuVyoP/2uJ$cYi Lo)A0IVpfp8nɯ6c'9RDځrR*;ԙ,ˊ$k=L73)*r# T ayr-ѫ 74`m=^ >@oc+/E//=O𑎍Z4 -|$^k^Tvi+B9/7{҃Tct!hƊUBC\&י)~#qrZ;O봍(m-_im$6rF\u~}%{f lm}V^w@gTiƁ10YؓOuu&9{-HIa_D2*2rV2)KF^M Εtq/d`E6H8")Swl C# n[M6֧ǿ4X7`{DՕ^'_e8y\֙Zlvvg ʪ;Pk^3|9ۖRrXcu0< -LhzQv ˬp/<"T.d[ H=^BD"]aE8?^iBE@ Y E PЙW Yt䏯$k\QzŤ( 4:^!`oPE[m_$K‚j 49[T!BǦ\Tړ" )l:$#?1T(+3u՚RڍøWVANMoj=wBB:j詤@BjLu'T\W@QZ6qQ~׏J;N<-jSw@GDV[{RgWDZiL^UTZd4Yt) D4 Q9ћni}xt5v~Q[9VX3jz|f%'m^7^pT|U ޓ-\L:? ҈Kݎ[LK֡;#3D!冈L݌PZڠj#=($R rD96!䨴fhWrP Sc#"p/;9ߦO7f7;`8Ql"ȷ(nŲXI(kQ孧1'市S MD*SgMx%Ր.Ԩ %- M(<ԩG0U놺#p@Or, d=j7$YN>ap>k\&n(·v(tniڑp4,ܢ-qԆQóuCB!6hnI2sn -͡%Imi.u#endstream endobj 26 0 obj << /Type /Page /Contents 29 0 R /Resources 28 0 R /MediaBox [0 0 612 792] /Parent 54 0 R /Annots [ 47 0 R 51 0 R 52 0 R 53 0 R ] >> endobj 27 0 obj << /Type /XObject /Subtype /Image /Width 919 /Height 496 /BitsPerComponent 4 /ColorSpace [/Indexed /DeviceRGB 4 55 0 R] /Length 8730 /Filter /FlateDecode >> stream xv*π6p{'o o;33cB!!I{IR&, Ka)MXJ҄4a), KiR҄4a)MXJR&, KiRXJ҄,,@XJ;Ʋ|G҄RX KiEXg (` 'Hf,ce=O $VR*VX@&, Z_/g 56IϙZMiQ,OT}عEڛ$"fXvr%Z5UXr؊VDk,k%W{&$HR6Y~,&c%wW_Zձ#R{"=lX^+>pf7ս=|WyS>4y-EZaBjhjei;z`brG,RY&Əv"XY#=Y\N"K2QԭLQ\>=']CL#ډe}S;Nj~P.ap.9#nQArbXnȥxcxlq{a9 $Vw*6}qN2s3qQ(3CuHOL m[L;2fCe[S`JYryӮ{gi֛zd$v%@.CaRzI, f/rsȝbbL3]yv^Bu,O䓾|%ˤO/(K2 뵰Laa8; 2z>xֽ0&!LdI..ܼ@^tMTG\yb?J`4ʥGY7޵!^ܔkǒC{Yv۠ p%p%R|sQ&`|3h^}Y 0գQKu,3+<إY.Ѕa \2*9ޠ_t%g5VR֢s_&:Ʋ#dz;r vse>]cq_ <)KXO&Ҿ)Tz2;K^ S/nR)+jSg@Xc]^xau~8=:dt2'6vl:KF^OPpƒf:Vr,W&68o=ZXTkI,mҬ SXSYKb3kqJc72WX'2n JIG18@ ˜,,7_kr("5ѪXse_ZFͻct29o[DT卋%%uk,9w [װ4\ oO{]? X1Nu9o_%߷)KauoPxʜeE:,vkO%\u\$: 5&`Y`ec5_Bžߎ~]xRP^Ŷo{\Az%Z 9Ve_P ,slʥ =ŲM*iDiƝ'4e}[ү(kf01K"r_7PTbl(Zj}. Jc5RXc9'g>ںo]nxlefA\2^>1GHxW{W,,ʟU,;ygҽ+2cGzd7rm8S7&.2s%a,qٽ,,?6){gf,EYdy/"ZA? yr\XOk]Cy }~6 fܞ%)ݯ%rj:֊sno<c%kx_ ,arb s161Ft=zd ȯ0X(|-Iy\bN-$ `j3X8Y&" $HiRU ?x9׷P,:oӠKM}F+g9vR|c(gKȐY4u\i)Ud9Zr3W%(.r;^/\`Ke _k0?os-mPrR|-wLj@,` +tng}s%ޯAeg'#utE9BkaL7TjrX;L"g4c#,t% `5,aՉ7cr,E=QUk$/fX㋷iop),/LYZcNYFm%C3aye+h}R|˧YF?ȄDvC²+߮Iքa'Fy3UyeJDYcL}>kG7=ož%$X`|rXKRnn^diN*v͂gaV+ަ(>ҫ+n+gѳeN#ԹF˒BRbXzG<",%hUzK+vNá۟Z`ԳaWX reҀFY[{>xdȲۯ|&n9-i$-sbnNb-8,x,2+wY4˅=tU,Co}„yeP:p&V L޹2˹.,UD((d0O{你+rmts lt$$?gX$XLU;h,"ra{,]vnXz/'X1}l4arq*ʲnPRqʌ$}ARXK6[L瑓eqb{T&pS`t24),ޥY^Tjd¤)5Lz J]#β\0 :oc ̢@߰c*#M],{5LK5yx/J4,D/( P]e 82nJc.?Ys46r~/2:^sHC{`o/2%; ,ҔR,d5>j:NzVy@KpoŞ`~\=ǕcLNXS%\3LE:c#A% 6zݚ ϳ?u ]uQM<ʃpt: XJLXZJ&U(R#i\ⲱDay+0ԱT2a珝X8e,IMx's45WľZ㓵a10lTDzȦ,ØXdN'i7q4y\ !je39O+r|bS1ɝu%’c&,e 3trySfic&O ؙ3zQԟcYf)9vP$s?%$/MeI\Vr<.GG:dpk 5֥o6Sg(93'=N#%X=3gK>CviG_~",!rj' GK'_IuE&J(rXf/eXZp<5$XƗr4_&R8Ve eXsyce "]& K]%EX´OY`,4X}9gmd-WDж +KF/c9zLcD͘ }xfM;Z44QX*nL,o #TS~FnMU,ǻXv$/c,ar$>Wr9cD.{$Kwڃrb=96b$5ͳS eZ?_vPaQS^±w`8B0!۶r R}KҶP紗+A ,OZsH1N{ >6f^ٵOdRCdpJp)h=g2:\6_rkTYtc,i5جA(ϳ̒)vW /6=Bcdx:XEŶgdYRǮ*Y5,-ҨAKei*q+5 ۺl6L392m6nd܍:v2^)^u),!ּ2[cvJ;Ev *FepǖtORu>5vf2-),]% Kam,iW)ˢ,W:F|ćM,KEO$X=Kl%d%mf"QM²FI+b6,Y>dvr` ),iwDak=:3o57,2²6%ro`ZO aCxwYOE7R+efRY>%ҾC,PXnY#,!3ɛ"|n+yu y;" I_6c*94eJW.]~ybي +KNX>j> Y>YXx ,V n9bK2-4O(}bK˒e^aodA@__Ćÿz?T87CMPSݚe1K;bWg?52Q.#,[;ry[r9%I]9 R˥aKݏ:v{'%v}Y7tvWop8c$vs,;ZI]5ş :KHgi5dN?t߾{e l9ck@E7Ick, 3V#ϴX> skkATezN%dY&bM*(,7gh%;mۓ,Rܔ`:dh{9" , [RpEbr\!E˕b M׊,,!E%v'a 8RPedXl%trDuO77dזİ!BHCg-7hޮwvheQX S[AKÅoj d7XbC,QXn,{yYޖ dO\*g;ȥ?xdey_CrI(wnfci{ӅIMʖPRO,?'z`R5lP)K fy5YB(,xKjyA!ˑaI7zX;)?' |&XެjQP4nְѥ Թ[eVj"ݍ,I|+Tv;68^cHozzj@βDozʬvQXWUa1V6zOy2,v5ɓ9u%sX;AKS"#_lU @ei(_$’AjB).%hM4JycI"{ul ʕm$.Iʥȥyۉ\v2`I/\*W1m{ ұ˱%h NY)XH]az2ڱX<3sBja+xd0'q5sϋ_Ȋ^"[V"G` !F7do˦R  ͎=),easo4-²rٜm'@N!" W¬&+Շ?O0²j.!3G K0C~!²fáQKd~l%1K7^l%Vטh&!nb B7> stream xݻw;::X endstream endobj 47 0 obj << /Type /Annot /Border[0 0 1]/H/I/C[0 1 1] /Rect [366.8545 482.9873 478.4757 494.8477] /Subtype/Link/A<> >> endobj 51 0 obj << /Type /Annot /Border[0 0 1]/H/I/C[0 1 1] /Rect [132.7721 471.0321 218.2913 482.8926] /Subtype/Link/A<> >> endobj 52 0 obj << /Type /Annot /Border[0 0 1]/H/I/C[0 1 1] /Rect [283.3279 459.0769 478.4757 470.9374] /Subtype/Link/A<> >> endobj 53 0 obj << /Type /Annot /Border[0 0 1]/H/I/C[0 1 1] /Rect [132.7721 447.1218 223.5117 458.9822] /Subtype/Link/A<> >> endobj 30 0 obj << /D [26 0 R /XYZ 133.7684 692.1046 null] >> endobj 31 0 obj << /D [26 0 R /XYZ 133.7684 667.198 null] >> endobj 6 0 obj << /D [26 0 R /XYZ 133.7684 535.851 null] >> endobj 10 0 obj << /D [26 0 R /XYZ 133.7684 213.2355 null] >> endobj 28 0 obj << /Font << /F35 34 0 R /F21 37 0 R /F42 40 0 R /F8 43 0 R /F49 46 0 R /F51 50 0 R >> /XObject << /Im1 27 0 R >> /ProcSet [ /PDF /Text /ImageC /ImageI ] >> endobj 58 0 obj << /Length 1207 /Filter /FlateDecode >> stream xWKoFWF$1].졀m-9J6 Q ?Zb('rpJuW6(mt; 6#j"ܴMjMPY2( PBz$J$SJmmat,Tk?5) hoqRG@ȩR5'0"I(P[oĕ&fL}fhPAL>$.J2 -LqOc: R!IvSˠ \V4,AQnb+^KgTk?\o;9UH9r,Y"ы>O$BebYaFsS#Z=cs}/K-x 1>MY),jr,j96봐DlvWE؎"D;]!vaZ 6;=]uR+/EޒK5KQ? G+},Z-,Kw|voC a (T^Cm!{ϾRQ1{6qu>nOa%.zWA|:P^{I{i$<"aΕ( gB맰F\$i;bq6\> endobj 59 0 obj << /D [57 0 R /XYZ 133.7684 692.1046 null] >> endobj 56 0 obj << /Font << /F8 43 0 R /F51 50 0 R /F49 46 0 R /F55 62 0 R /F54 63 0 R >> /ProcSet [ /PDF /Text ] >> endobj 66 0 obj << /Length 402 /Filter /FlateDecode >> stream xVJ@+]:3wl>Q H)(n7~w#mJ[ dr$>2(;#-oa`Sh 5r:ENZboN4;B?)ψX- )b"MI8& _p^ zm  .t3i.| gKTBI?.ȸiL09 b,g MSɩ{+2ڍ,NV-E^dЀb$v7BoT kGR/ $NxB&F5 h% Z ЬZ?1 `٥POJǰyie2Ku ̩su T{N4/-Ωx)Ȯ@s+X!=8g}9*;9endstream endobj 65 0 obj << /Type /Page /Contents 66 0 R /Resources 64 0 R /MediaBox [0 0 612 792] /Parent 54 0 R >> endobj 67 0 obj << /D [65 0 R /XYZ 133.7684 692.1046 null] >> endobj 64 0 obj << /Font << /F51 50 0 R /F54 63 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 70 0 obj << /Length 508 /Filter /FlateDecode >> stream xWMk@W}D;[]|ԐB:N &)n%*-5{6hV={\uuY.mendstream endobj 69 0 obj << /Type /Page /Contents 70 0 R /Resources 68 0 R /MediaBox [0 0 612 792] /Parent 54 0 R >> endobj 71 0 obj << /D [69 0 R /XYZ 133.7684 692.1046 null] >> endobj 68 0 obj << /Font << /F51 50 0 R /F54 63 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 74 0 obj << /Length 394 /Filter /FlateDecode >> stream xMK@27J B6bCK6I6o.2xqZPioڗ=)8Ȑ2o7}8kL7hˍ r]cp2LLϲ=Z5LJ -7SV0Ost6*ղ$8+Ohmm"X!Hf@hO227u3A%c-ՊpUFj\FV'AֶI٢$[<ik `꿖h0X.blle/8e9bKuC^NbԒ[~o+J8&ln6[d> endobj 75 0 obj << /D [73 0 R /XYZ 133.7684 692.1046 null] >> endobj 72 0 obj << /Font << /F51 50 0 R /F54 63 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 78 0 obj << /Length 402 /Filter /FlateDecode >> stream xXMK1W,C{h$ě-.B?ޗtm-]쮇dža6ov2 kGF&^xVdω$NR&fuWvށ3:΀hZ<hw)xup K r⛍P!9ṕ`mo &1!k / x^רn&pt^F4 6kDmL Xo P^VIR:QGmr\F[2IPJ0#u֬c2>Wnd#d?(ɫ5uwd7&A(~֩0RKu8V5.tN޽5!\TCzj4wyy6m`Ҫ+'b/5a=NSu% cendstream endobj 77 0 obj << /Type /Page /Contents 78 0 R /Resources 76 0 R /MediaBox [0 0 612 792] /Parent 54 0 R >> endobj 79 0 obj << /D [77 0 R /XYZ 133.7684 692.1046 null] >> endobj 76 0 obj << /Font << /F51 50 0 R /F54 63 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 82 0 obj << /Length 431 /Filter /FlateDecode >> stream xXJP+t.:;QbP_ =7 4)&dqHz䜞=ӹ'oKI8I8&x-||rt pv U. NX!ȗF=yp4w-n# ɢ$xm)+O8WuᎼVH?D/ x^ׄ w9*uObY4:P-)UT&Uk^-&ཡWgNkpY!來4B:4h~f$Ŗf*kT̓Vmziyh$e3sTʟ-KhA)^= P;Ӷ)$#-D(S,NZ'|X??[uj w2hpN .;URz^8LƓ4 ?+Z.}Άi<Hendstream endobj 81 0 obj << /Type /Page /Contents 82 0 R /Resources 80 0 R /MediaBox [0 0 612 792] /Parent 84 0 R >> endobj 83 0 obj << /D [81 0 R /XYZ 133.7684 692.1046 null] >> endobj 80 0 obj << /Font << /F51 50 0 R /F54 63 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 87 0 obj << /Length 403 /Filter /FlateDecode >> stream xWKK@W!9tf_liFE4 =^~]iRR!>v3ٝoɰN$K,YUR'L"*c3eEzdG@?U'P\(V$ oŠUӒ8,,p/ 8YB5Bo01`<\#+2&zk&PO`$k 7Mm^ǀldejHnLܒXuZ[8eOBYKg-& ~q} :7/Y?bm{5!OՂԦmAsj%(ۅYxlFFQыF[\ƙ 5I6 K2-i#qKh7z(8endstream endobj 86 0 obj << /Type /Page /Contents 87 0 R /Resources 85 0 R /MediaBox [0 0 612 792] /Parent 84 0 R >> endobj 88 0 obj << /D [86 0 R /XYZ 133.7684 692.1046 null] >> endobj 85 0 obj << /Font << /F51 50 0 R /F54 63 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 91 0 obj << /Length 512 /Filter /FlateDecode >> stream xXMo@WX74@JU|*Q $.x~8X*qO^vgv^̬s\WFVe[T+ji!ObiX_axܤsu}úa:3"\V4]b,8/ʒkf~Wj)I# v+,u^Z*2#t` 1d m)x:\,% _ x%6SLLC o 6$2]N!\0o>OHoD"5Äa3M2S~{&}md΀M{K.W5+SB:5F⾌o3o>ݢqE3>D晜ĺuwv+|ujֶS@J6t0{6G;C`[6L,쾗Sv2\D4aЖ֬Lb/Õom 7a  if\kendstream endobj 90 0 obj << /Type /Page /Contents 91 0 R /Resources 89 0 R /MediaBox [0 0 612 792] /Parent 84 0 R >> endobj 92 0 obj << /D [90 0 R /XYZ 133.7684 692.1046 null] >> endobj 89 0 obj << /Font << /F51 50 0 R /F54 63 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 95 0 obj << /Length 516 /Filter /FlateDecode >> stream xXYK@~}twvg< @AGsL&}s6yO2 ,ˤR`ә! He`}!%c#T|823D307\dt~.N*Y#@2-!q8?]+WI(H'Z3q˘0Fqdʼ5GjKlPJiuTed,6P[Pp϶A=8%SEzj) RB3UPZjmߕ:MtB/Iq)I =EKdG/%򣣩{~C$[ŲAuV(LK@N6a4/__;|5cQ)שA\]|]mX Bʉ,H%{0ӄA=sMQ99C Э#dQwLk(MX#,So>-}Wj 8138g}|Nƿٝ AЭendstream endobj 94 0 obj << /Type /Page /Contents 95 0 R /Resources 93 0 R /MediaBox [0 0 612 792] /Parent 84 0 R >> endobj 96 0 obj << /D [94 0 R /XYZ 133.7684 692.1046 null] >> endobj 93 0 obj << /Font << /F51 50 0 R /F54 63 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 99 0 obj << /Length 550 /Filter /FlateDecode >> stream xXKO1W*!osiQ"B"jxDR $߱3aV M6ލ=ˌ=eg` Xi@Y K%MQN=^&^HDa^Mn;-]ٵ7"< Bl%YRp^R!#;dpN. W MJP©&/S0E_Ho]P2U7ӺNH-{q!i/AA j90Buhd^SU ;OҴ` #XfSkڰ^MRB?X i.t4 ײZfwendstream endobj 98 0 obj << /Type /Page /Contents 99 0 R /Resources 97 0 R /MediaBox [0 0 612 792] /Parent 84 0 R >> endobj 100 0 obj << /D [98 0 R /XYZ 133.7684 692.1046 null] >> endobj 97 0 obj << /Font << /F51 50 0 R /F54 63 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 103 0 obj << /Length 595 /Filter /FlateDecode >> stream xWNA+F0MKn쐄! aLE8Q.Tk{pxQ^N+94Y1Ϙh+3-:5}+. 0 K˧_{ \K VhHxҠÀCH3^~Np=kQp*YB&gƈSlA/Oϡ# %O|9 bi [T4tSKHM&mJ{R p450P·tԔ!K4? mP1Ksx9|)b w;nf~.cTF4h9KW1[I܆V bUǷ"kh'3|?ŒP~ (/;m<y+=QE+GƜ]8Jէb>r[utU611l >[\G9pvƙJ> endobj 104 0 obj << /D [102 0 R /XYZ 133.7684 692.1046 null] >> endobj 101 0 obj << /Font << /F51 50 0 R /F54 63 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 107 0 obj << /Length 591 /Filter /FlateDecode >> stream xڵVMO@WXz[ C%R8DR@*g{U0Z'y3owvrp eAW>y ȋE\p| cp$B-aBX}y퍽cA&e*0%*P嗄ocqw #;ש-̞c*/n򛨼3[`M~Wݺ*/3yK_nw _nf9lYZ2o-SCҌLWȲӯvOgs\-sjk/5y f_k@*Ƽ]{]zkG#yS޺xzp%32Snݧ!T~;-`H.nbjʷկGoAU[KOi$Ma6WJIg+m%+ԇԂfYm>aڛvl+hz>H>y^/5Y᭫ny[~l!G mC3rFxan$A q&i'4Mu^3ǍwWoy*ˏ MYIV3^\?Zendstream endobj 106 0 obj << /Type /Page /Contents 107 0 R /Resources 105 0 R /MediaBox [0 0 612 792] /Parent 109 0 R >> endobj 108 0 obj << /D [106 0 R /XYZ 133.7684 692.1046 null] >> endobj 105 0 obj << /Font << /F51 50 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 112 0 obj << /Length 360 /Filter /FlateDecode >> stream x͖]K0+x]4k|xShd y#x߶)=I7y{ΊtNJ etg’ڐf9^NX$!m]"!-Qs |qG> xkP^? FS)kbѬsX>vQ5Qh;GpUbx hFKu7jy7"}> endobj 113 0 obj << /D [111 0 R /XYZ 133.7684 692.1046 null] >> endobj 110 0 obj << /Font << /F51 50 0 R /F54 63 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 116 0 obj << /Length 330 /Filter /FlateDecode >> stream xڵV=O0+,!qq*X:T:%9aDx A> endobj 117 0 obj << /D [115 0 R /XYZ 133.7684 692.1046 null] >> endobj 114 0 obj << /Font << /F51 50 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 120 0 obj << /Length 308 /Filter /FlateDecode >> stream xڵVN0L˔U9F ۪q(hjbxxy3/[m:(#ܣecl-LRJ wC3Vt~Bp$<0?#0w-*QIsz霑u5)5] /zh7fwԱZ@-\>A3m&&P辛ct4"F==.:zk%m C Lg\1Uhp7cNw6jMg7cmj%JNkٕendstream endobj 119 0 obj << /Type /Page /Contents 120 0 R /Resources 118 0 R /MediaBox [0 0 612 792] /Parent 109 0 R >> endobj 121 0 obj << /D [119 0 R /XYZ 133.7684 692.1046 null] >> endobj 118 0 obj << /Font << /F51 50 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 124 0 obj << /Length 420 /Filter /FlateDecode >> stream xVMO@+X;/o mIP$Q1 e1v^2ݝיE:kHFxJ@)aJO6/bh4sĂDX?G".w>B ɒcY'c nby)-ѺI^!.b+PW1 nCF%뚣u~F},xU3R]Q8k|7cèD9ϬN]hT#\*^r6rǬ֒Ymilg!^*9=>G!3E]> endobj 125 0 obj << /D [123 0 R /XYZ 133.7684 692.1046 null] >> endobj 122 0 obj << /Font << /F51 50 0 R /F54 63 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 128 0 obj << /Length 409 /Filter /FlateDecode >> stream xUMK1W=ldfoZ*])Ūl6]AF!;f^f29[!pґ" Zfd ̤ҨE>tЙ3>˜1ނ}(m=4HCΣ5q O$iXG>T-{'jnQw?䔯;Ɯt:oC^u]rǚM*Md3(yڮXkmA*wRiĭ9c%gEK3<./a!ݿ.8t(6nM/l*/sej2{A> endobj 129 0 obj << /D [127 0 R /XYZ 133.7684 692.1046 null] >> endobj 126 0 obj << /Font << /F51 50 0 R /F54 63 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 133 0 obj << /Length 1382 /Filter /FlateDecode >> stream xXIoFWA$`13,mQ-K[DK)Seۆ"%E0C[ffﮜYYb2(c2_;)ϴqf2[|HR9b-]:u$oDR0poQfyB.ӺTB0 Һ` G'SeLLeïƷ'(ʩ楍o&])J `>mY]Me|#59XY 'n'IvPXĮ40[י| @VWS TF嘀:+uL µ#lh aNwInUdE 6+^`*՞PX 29jH[{RgdnZ: C;܇ݣߺjywJlz@jXǶ7]R$U> YR֤A{a €,xU=?VC̛T'mW2&+{x~U1G; ;NZcc[^VPpZ4e.YW}`u'a` ccZ U8@2 ??*D'R`1p؃Q[ #Ԝ 9ڡKܮus@U20I3='8c/bKPINS4oyl8 YS~`ޮ뎧J>=A&f, b)}Z8iVkp@ޟP"JiD~3(`77XT=Ի@e:UKB(C3rP>T64\d >,3UQAg =8|潻ַ/8{߱[NIreZvAiPWW+>]{L:,ynZ1n?0wHzq#;wC=mPˋA79`&\{(՗8/B ٦oIL9v!> endobj 134 0 obj << /D [132 0 R /XYZ 133.7684 692.1046 null] >> endobj 14 0 obj << /D [132 0 R /XYZ 133.7684 462.0875 null] >> endobj 131 0 obj << /Font << /F51 50 0 R /F54 63 0 R /F42 40 0 R /F8 43 0 R /F49 46 0 R /F55 62 0 R >> /ProcSet [ /PDF /Text ] >> endobj 138 0 obj << /Length 1280 /Filter /FlateDecode >> stream xWK6WA/@f۴hzhzPemy%m e+@B+oF42#.%+r"Y &Q}XEQrkZJWiADߵ(KGiD%+sG+ .d$MDh=7I*TpgjHXx{^IfLQ=U>͛Dx:;B˒Ir|䛕KR4=r# 20Ƈu>>f!B3^ ED:~-2Mןw4v {kʹ-zOmbC7`92Vj-/h¾MR)ebAa"B ٺh8hW5ٷNp!# \=B-/K\WAv{pC-dLspÙ6+n7d#8 4O4mTT|DL(sݻPqa j?#gٰS{: ŷa@/&*mz;8BE-2w#eBUkm\x;%<X:VBÝP׼Ƚ>C{B=8+ǿ՗;ocePQC&$j4Cnܹ;LgOASva 6{D> endobj 130 0 obj << /Type /XObject /Subtype /Form /FormType 1 /PTEX.FileName (./layingOutPathways-initial.pdf) /PTEX.PageNumber 1 /PTEX.InfoDict 143 0 R /Matrix [1.00000000 0.00000000 0.00000000 1.00000000 0.00000000 0.00000000] /BBox [0.00000000 0.00000000 432.00000000 432.00000000] /Resources << /ProcSet [ /PDF /Text ] /Font << /F1 144 0 R /F2 145 0 R >> /ExtGState << >>>> /Length 146 0 R >> stream q Q q 0.72 0.72 430.56 430.56 re W n 0.000 0.000 0.000 RG 0.75 w [] 0 d 1 J 1 j 10.00 M BT /F1 1 Tf 1 Tr 21.24 0 0 21.24 15.92 219.85 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 1.00 0.00 -0.00 1.00 23.17 226.87 Tm (ITGB) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 41.48 316.75 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 48.72 323.76 Tm (ITGA) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 41.48 278.11 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 49.14 285.12 Tm (ILK) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 41.48 239.18 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 48.90 246.19 Tm (CAV) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 41.48 200.53 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 48.83 207.54 Tm (SHC) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 67.03 239.18 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 74.44 246.19 Tm (FYN) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 67.03 200.53 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 74.08 207.54 Tm (GRB2) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 92.59 218.72 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 99.94 225.73 Tm (SOS) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 118.15 238.61 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 124.74 245.63 Tm (Ha-Ras) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 143.70 268.44 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 151.33 275.46 Tm (Raf) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 220.37 283.50 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 227.69 290.52 Tm (MEK) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 245.92 334.08 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 253.31 341.09 Tm (ERK) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 348.15 363.64 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 355.19 370.65 Tm (MYLK) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 373.70 378.41 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 381.01 385.42 Tm (MYO) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 41.48 130.91 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 48.54 137.93 Tm (ACTN) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 67.03 120.69 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 74.47 127.70 Tm (VCL) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 92.59 160.47 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 100.06 167.48 Tm (TLN) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 169.26 126.08 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 176.64 133.09 Tm (PXN) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 67.03 58.17 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 74.47 65.18 Tm (ZYX) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 92.59 23.79 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 99.71 30.80 Tm (VASP) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 92.59 101.08 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 99.39 108.09 Tm (SH3D5) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 92.59 62.43 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 100.00 69.44 Tm (TNS) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 118.15 185.19 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 125.17 192.20 Tm (CAPN) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 143.70 185.19 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 150.39 192.20 Tm (CAPNS) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 169.26 185.19 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 176.61 192.20 Tm (SRC) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 194.81 155.64 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 202.29 162.65 Tm (FAK) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 220.37 155.64 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 227.11 162.65 Tm (BCAR1) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 194.81 253.67 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 202.19 260.68 Tm (CSK) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 245.92 155.64 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 253.28 162.65 Tm (CRK) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 271.48 158.48 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 278.17 165.49 Tm (DOCK1) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 271.48 119.55 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 278.56 126.56 Tm (GRF2) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 297.03 154.50 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 304.14 161.51 Tm (RAP1) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 348.15 242.87 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 355.61 249.89 Tm (JNK) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 194.81 91.99 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 202.11 99.00 Tm (GIT2) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 297.03 98.52 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 303.36 105.53 Tm (ARHGEF) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 322.59 249.97 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 330.06 256.99 Tm (PAK) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 194.81 215.02 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 202.39 222.15 Tm (p85) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 220.37 204.79 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 227.67 211.92 Tm (p110) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 245.92 256.51 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 246.08 263.63 Tm (Phosphatidylinositol signaling system) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 271.48 295.16 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 278.96 302.17 Tm (VAV) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 271.48 217.58 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 278.25 224.59 Tm (PDPK1) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 297.03 213.32 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 304.47 220.33 Tm (AKT) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 297.03 286.06 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 304.40 293.07 Tm (RAC) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 271.48 256.51 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 278.25 263.52 Tm (CDC42) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 194.81 354.54 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 202.11 361.55 Tm (RHO) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 220.37 340.05 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 227.69 347.07 Tm (PI5K) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 245.92 380.97 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 252.90 387.98 Tm (ROCK) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 322.59 393.47 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 329.28 400.48 Tm (MYO-P) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 373.70 228.38 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 378.36 235.40 Tm (cell maintenance) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 322.59 288.90 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 328.56 296.02 Tm (cell motility) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 399.26 378.41 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 406.01 385.43 Tm (F-actin) Tj /F1 1 Tf 1 Tr 21.24 0 0 21.24 271.48 334.08 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 276.41 341.19 Tm (cell proliferation) Tj ET 28.00 241.84 m 29.27 246.76 l 30.68 252.13 l 32.20 257.88 l 33.81 263.92 l 35.48 270.17 l 37.17 276.55 l 38.88 282.99 l 40.57 289.40 l S 28.00 241.84 m 26.89 237.45 l S 25.56 242.15 m 26.89 237.45 l 30.29 240.95 l S 40.57 289.40 m 42.22 295.70 l S 42.73 297.52 m 43.24 299.37 l 43.75 301.24 l 44.25 303.13 l 44.74 305.01 l 45.23 306.88 l 45.70 308.71 l 46.17 310.50 l 46.62 312.23 l S 42.73 297.52 m 42.22 295.70 l S 46.62 312.23 m 47.05 313.89 l S 48.34 309.18 m 47.05 313.89 l 43.62 310.42 l S 30.11 240.31 m 31.75 244.04 l 33.49 248.01 l 35.28 252.14 l 37.11 256.35 l 38.94 260.56 l 40.73 264.68 l 42.47 268.66 l 44.11 272.39 l S 30.11 240.31 m 28.59 236.89 l S 28.08 241.74 m 28.59 236.89 l 32.54 239.76 l S 44.11 272.39 m 45.63 275.81 l S 46.14 270.96 m 45.63 275.81 l 41.68 272.94 l S 33.63 234.16 m 34.45 234.84 l 35.28 235.52 l 36.14 236.20 l 37.00 236.89 l 37.88 237.57 l 38.76 238.25 l 39.64 238.93 l 40.51 239.61 l S 33.63 234.16 m 32.85 233.48 l S 34.44 238.09 m 32.85 233.48 l 37.64 234.41 l S 40.51 239.61 m 41.37 240.30 l S 39.58 235.76 m 41.37 240.30 l 36.54 239.58 l S 33.63 220.29 m 34.45 219.61 l 35.28 218.93 l 36.14 218.24 l 37.00 217.56 l 37.88 216.88 l 38.76 216.20 l 39.64 215.52 l 40.51 214.83 l S 33.63 220.29 m 32.85 220.97 l S 37.64 220.04 m 32.85 220.97 l 34.44 216.36 l S 40.51 214.83 m 41.37 214.15 l S 36.54 214.87 m 41.37 214.15 l 39.58 218.69 l S 28.97 211.39 m 30.75 204.96 l 32.72 197.91 l 34.83 190.43 l 37.00 182.75 l 39.19 175.07 l 41.32 167.60 l 43.34 160.55 l 45.17 154.11 l S 28.97 211.39 m 27.46 216.99 l S 30.92 213.55 m 27.46 216.99 l 26.20 212.28 l S 45.17 154.11 m 46.77 148.51 l S 43.26 151.91 m 46.77 148.51 l 47.96 153.25 l S 29.37 215.63 m 30.49 213.61 l 31.69 211.53 l 32.96 209.42 l 34.31 207.30 l 35.73 205.21 l 37.23 203.17 l 38.81 201.21 l 40.48 199.37 l S 29.37 215.63 m 28.31 217.56 l S 32.48 215.03 m 28.31 217.56 l 28.20 212.68 l S 40.48 199.37 m 42.22 197.67 l S 46.76 193.80 m 51.63 190.20 l 56.74 186.87 l 61.97 183.81 l 67.25 181.01 l 72.46 178.48 l 77.52 176.21 l 82.32 174.20 l 86.77 172.45 l S 46.76 193.80 m 42.22 197.67 l S 86.77 172.45 m 90.78 170.96 l S 85.96 170.15 m 90.78 170.96 l 87.67 174.72 l S 57.09 218.65 m 58.41 220.70 l 59.80 222.82 l 61.22 224.99 l 62.67 227.19 l 64.11 229.37 l 65.54 231.52 l 66.92 233.60 l 68.24 235.59 l S 57.09 218.65 m 55.85 216.71 l S 56.07 221.59 m 55.85 216.71 l 60.19 218.96 l S 68.24 235.59 m 69.48 237.45 l S 69.17 232.58 m 69.48 237.45 l 65.11 235.29 l S 60.83 207.90 m 61.28 207.90 l 61.73 207.90 l 62.20 207.90 l 62.67 207.90 l 63.13 207.90 l 63.60 207.90 l 64.06 207.90 l 64.50 207.90 l S 60.83 207.90 m 60.40 207.90 l S 64.62 210.34 m 60.40 207.90 l 64.62 205.46 l S 64.50 207.90 m 64.94 207.90 l S 60.71 205.46 m 64.94 207.90 l 60.71 210.34 l S 82.65 213.15 m 83.66 213.87 l 84.70 214.62 l 85.78 215.38 l 86.87 216.14 l 87.99 216.91 l 89.11 217.67 l 90.24 218.41 l 91.37 219.14 l S 82.65 213.15 m 81.69 212.45 l S 91.37 219.14 m 92.48 219.84 l S 90.19 215.52 m 92.48 219.84 l 87.60 219.66 l S 107.93 231.70 m 108.96 232.51 l 110.03 233.35 l 111.15 234.21 l 112.29 235.07 l 113.44 235.95 l 114.61 236.83 l 115.77 237.71 l 116.91 238.58 l S 107.93 231.70 m 106.96 230.92 l S 116.91 238.58 m 118.04 239.44 l S 116.17 234.93 m 118.04 239.44 l 113.20 238.81 l S 132.90 253.29 m 134.20 254.74 l 135.55 256.29 l 136.94 257.90 l 138.34 259.55 l 139.74 261.21 l 141.13 262.87 l 142.48 264.50 l 143.78 266.08 l S 132.90 253.29 m 131.67 251.95 l S 143.78 266.08 m 145.01 267.57 l S 144.21 262.76 m 145.01 267.57 l 140.44 265.86 l S 164.38 278.17 m 169.73 279.24 l 175.65 280.41 l 181.96 281.66 l 188.49 282.95 l 195.06 284.25 l 201.50 285.53 l 207.64 286.75 l 213.28 287.88 l S 164.38 278.17 m 159.78 277.23 l S 213.28 287.88 m 218.27 288.89 l S 214.61 285.66 m 218.27 288.89 l 213.64 290.44 l S 233.64 300.53 m 235.27 303.70 l 237.02 307.13 l 238.85 310.74 l 240.74 314.46 l 242.63 318.21 l 244.49 321.93 l 246.29 325.53 l 247.97 328.93 l S 233.64 300.53 m 232.19 297.69 l S 247.97 328.93 m 249.51 332.08 l S 249.84 327.21 m 249.51 332.08 l 245.46 329.35 l S 261.83 346.32 m 262.86 346.94 l 263.94 347.56 l 265.07 348.18 l 266.22 348.81 l 267.41 349.42 l 268.61 350.02 l 269.81 350.60 l 271.02 351.16 l S 261.83 346.32 m 260.86 345.72 l S 271.02 351.16 m 272.22 351.68 l S 280.06 354.54 m 288.16 357.15 l 296.38 359.51 l 304.59 361.63 l 312.65 363.51 l 320.43 365.17 l 327.80 366.60 l 334.61 367.80 l 340.74 368.80 l S 280.06 354.54 m 272.22 351.68 l S 340.74 368.80 m 346.05 369.58 l S 342.22 366.55 m 346.05 369.58 l 341.51 371.38 l S 262.69 341.45 m 263.39 341.45 l 264.11 341.45 l 264.84 341.45 l 265.58 341.45 l 266.33 341.45 l 267.09 341.45 l 267.85 341.45 l 268.62 341.45 l S 262.69 341.45 m 262.00 341.45 l S 268.62 341.45 m 269.38 341.45 l S 265.16 339.01 m 269.38 341.45 l 265.16 343.89 l S 364.24 375.43 m 365.14 375.93 l 366.06 376.45 l 367.00 377.01 l 367.95 377.58 l 368.91 378.15 l 369.88 378.73 l 370.84 379.30 l 371.80 379.86 l S 364.24 375.43 m 363.37 374.98 l S 371.80 379.86 m 372.74 380.38 l S 370.24 376.19 m 372.74 380.38 l 367.86 380.45 l S 393.05 385.78 m 393.50 385.78 l 393.96 385.78 l 394.42 385.78 l 394.89 385.78 l 395.36 385.78 l 395.82 385.78 l 396.28 385.78 l 396.73 385.78 l S 393.05 385.78 m 392.62 385.78 l S 396.84 388.22 m 392.62 385.78 l 396.84 383.34 l S 396.73 385.78 m 397.16 385.78 l S 392.93 383.34 m 397.16 385.78 l 392.93 388.22 l S 60.42 134.06 m 61.02 133.82 l 61.62 133.60 l 62.21 133.38 l 62.81 133.17 l 63.40 132.96 l 64.00 132.74 l 64.60 132.51 l 65.19 132.28 l S 60.42 134.06 m 59.83 134.31 l S 64.67 134.94 m 59.83 134.31 l 62.79 130.43 l S 65.19 132.28 m 65.79 132.03 l S 60.95 131.40 m 65.79 132.03 l 62.82 135.91 l S 62.13 145.38 m 65.24 147.22 l 68.54 149.15 l 71.96 151.14 l 75.44 153.17 l 78.93 155.18 l 82.35 157.15 l 85.65 159.04 l 88.76 160.81 l S 62.13 145.38 m 59.26 143.68 l S 61.65 147.94 m 59.26 143.68 l 64.14 143.74 l S 88.76 160.81 m 91.63 162.44 l S 89.15 158.23 m 91.63 162.44 l 86.75 162.48 l S 54.93 123.85 m 56.74 118.83 l 58.69 113.42 l 60.71 107.75 l 62.77 101.95 l 64.83 96.16 l 66.83 90.51 l 68.73 85.14 l 70.48 80.18 l S 54.93 123.85 m 53.30 128.34 l S 57.04 125.20 m 53.30 128.34 l 52.45 123.53 l S 70.48 80.18 m 72.04 75.77 l S 68.33 78.94 m 72.04 75.77 l 72.93 80.57 l S 82.44 139.17 m 83.83 141.30 l 85.26 143.51 l 86.73 145.77 l 88.22 148.05 l 89.71 150.32 l 91.18 152.56 l 92.62 154.72 l 94.00 156.80 l S 82.44 139.17 m 81.12 137.15 l S 81.38 142.02 m 81.12 137.15 l 85.47 139.36 l S 94.00 156.80 m 95.32 158.74 l S 94.97 153.87 m 95.32 158.74 l 90.93 156.61 l S 92.46 128.99 m 100.04 129.39 l 108.43 129.83 l 117.36 130.29 l 126.56 130.75 l 135.75 131.22 l 144.68 131.68 l 153.07 132.11 l 160.65 132.52 l S 92.46 128.99 m 85.95 128.62 l S 90.03 131.30 m 85.95 128.62 l 90.31 126.42 l S 160.65 132.52 m 167.16 132.89 l S 163.08 130.21 m 167.16 132.89 l 162.80 135.09 l S 84.75 120.84 m 85.56 120.16 l 86.39 119.48 l 87.25 118.81 l 88.12 118.14 l 88.99 117.49 l 89.87 116.84 l 90.75 116.21 l 91.62 115.59 l S 84.75 120.84 m 83.96 121.52 l S 88.75 120.58 m 83.96 121.52 l 85.55 116.90 l S 91.62 115.59 m 92.48 114.98 l S 87.62 115.42 m 92.48 114.98 l 90.43 119.41 l S 81.22 114.97 m 82.87 111.24 l 84.60 107.26 l 86.40 103.14 l 88.22 98.93 l 90.05 94.72 l 91.84 90.59 l 93.58 86.62 l 95.22 82.89 l S 81.22 114.97 m 79.70 118.39 l S 83.65 115.52 m 79.70 118.39 l 79.19 113.54 l S 95.22 82.89 m 96.74 79.46 l S 92.79 82.34 m 96.74 79.46 l 97.26 84.32 l S 109.63 176.17 m 110.63 177.13 l 111.67 178.11 l 112.73 179.09 l 113.81 180.09 l 114.90 181.10 l 115.99 182.11 l 117.07 183.13 l 118.13 184.15 l S 109.63 176.17 m 108.67 175.22 l S 109.97 179.93 m 108.67 175.22 l 113.39 176.45 l S 118.13 184.15 m 119.17 185.17 l S 117.87 180.46 m 119.17 185.17 l 114.45 183.94 l S 118.01 167.20 m 125.59 166.81 l 133.98 166.41 l 142.91 165.99 l 152.11 165.56 l 161.31 165.14 l 170.24 164.72 l 178.63 164.31 l 186.21 163.93 l S 118.01 167.20 m 111.51 167.55 l S 115.86 169.76 m 111.51 167.55 l 115.59 164.88 l S 186.21 163.93 m 192.72 163.57 l S 188.36 161.37 m 192.72 163.57 l 188.63 166.24 l S 185.89 142.92 m 187.04 144.20 l 188.21 145.53 l 189.39 146.89 l 190.59 148.27 l 191.78 149.65 l 192.96 151.04 l 194.13 152.41 l 195.28 153.75 l S 185.89 142.92 m 184.77 141.69 l S 185.82 146.46 m 184.77 141.69 l 189.42 143.16 l S 195.28 153.75 m 196.41 155.05 l S 195.49 150.25 m 196.41 155.05 l 191.80 153.44 l S 187.33 139.09 m 190.54 140.95 l 194.03 142.97 l 197.72 145.11 l 201.52 147.31 l 205.36 149.52 l 209.14 151.71 l 212.80 153.82 l 216.25 155.80 l S 187.33 139.09 m 184.48 137.43 l S 216.25 155.80 m 219.41 157.61 l S 216.95 153.39 m 219.41 157.61 l 214.53 157.62 l S 183.46 125.51 m 184.81 123.69 l 186.24 121.78 l 187.73 119.79 l 189.27 117.75 l 190.84 115.70 l 192.41 113.66 l 193.97 111.66 l 195.50 109.73 l S 183.46 125.51 m 182.21 127.20 l S 195.50 109.73 m 196.98 107.88 l S 192.43 109.65 m 196.98 107.88 l 196.24 112.70 l S 82.92 55.36 m 84.19 53.63 l 85.51 51.86 l 86.86 50.06 l 88.22 48.24 l 89.58 46.44 l 90.93 44.66 l 92.25 42.93 l 93.53 41.27 l S 82.92 55.36 m 81.69 57.02 l S 86.16 55.06 m 81.69 57.02 l 82.24 52.17 l S 93.53 41.27 m 94.75 39.68 l S 90.24 41.53 m 94.75 39.68 l 94.10 44.52 l S 137.50 192.56 m 137.94 192.56 l 138.40 192.56 l 138.87 192.56 l 139.33 192.56 l 139.80 192.56 l 140.27 192.56 l 140.72 192.56 l 141.17 192.56 l S 137.50 192.56 m 137.06 192.56 l S 141.29 195.00 m 137.06 192.56 l 141.29 190.12 l S 141.17 192.56 m 141.60 192.56 l S 137.38 190.12 m 141.60 192.56 l 137.38 195.00 l S 160.47 192.56 m 161.17 192.56 l 161.89 192.56 l 162.62 192.56 l 163.36 192.56 l 164.11 192.56 l 164.87 192.56 l 165.63 192.56 l 166.39 192.56 l S 160.47 192.56 m 159.78 192.56 l S 166.39 192.56 m 167.16 192.56 l S 162.93 190.12 m 167.16 192.56 l 162.93 195.00 l S 184.01 185.19 m 185.31 183.71 l 186.67 182.18 l 188.07 180.60 l 189.49 178.99 l 190.91 177.36 l 192.34 175.73 l 193.74 174.11 l 195.10 172.52 l S 184.01 185.19 m 182.78 186.59 l S 195.10 172.52 m 196.41 170.96 l S 191.82 172.63 m 196.41 170.96 l 195.56 175.77 l S 189.91 185.46 m 193.02 183.63 l 196.32 181.69 l 199.74 179.70 l 203.22 177.67 l 206.70 175.66 l 210.13 173.69 l 213.42 171.80 l 216.54 170.03 l S 189.91 185.46 m 187.04 187.16 l S 191.92 187.10 m 187.04 187.16 l 189.43 182.90 l S 216.54 170.03 m 219.41 168.40 l S 214.53 168.36 m 219.41 168.40 l 216.93 172.61 l S 182.98 206.62 m 184.75 211.21 l 186.63 216.17 l 188.57 221.37 l 190.55 226.69 l 192.52 232.03 l 194.44 237.25 l 196.28 242.25 l 197.99 246.90 l S 182.98 206.62 m 181.36 202.50 l S 180.64 207.33 m 181.36 202.50 l 185.18 205.54 l S 197.99 246.90 m 199.53 251.09 l S 200.36 246.28 m 199.53 251.09 l 195.78 247.97 l S 206.23 178.40 m 208.20 188.11 l 210.46 199.35 l 212.93 211.62 l 215.50 224.45 l 218.09 237.37 l 220.61 249.90 l 222.96 261.56 l 225.05 271.87 l S 206.23 178.40 m 204.64 170.68 l S 225.05 271.87 m 226.79 280.36 l S 228.33 275.73 m 226.79 280.36 l 223.55 276.71 l S 211.58 163.01 m 212.28 163.01 l 213.00 163.01 l 213.73 163.01 l 214.47 163.01 l 215.22 163.01 l 215.98 163.01 l 216.74 163.01 l 217.51 163.01 l S 211.58 163.01 m 210.89 163.01 l S 217.51 163.01 m 218.27 163.01 l S 214.04 160.57 m 218.27 163.01 l 214.04 165.45 l S 208.36 172.56 m 209.94 175.60 l 211.62 178.88 l 213.38 182.33 l 215.18 185.88 l 216.99 189.47 l 218.78 193.02 l 220.51 196.47 l 222.15 199.75 l S 208.36 172.56 m 206.91 169.83 l S 222.15 199.75 m 223.67 202.79 l S 223.96 197.91 m 223.67 202.79 l 219.59 200.10 l S 237.13 163.01 m 237.84 163.01 l 238.56 163.01 l 239.29 163.01 l 240.03 163.01 l 240.78 163.01 l 241.53 163.01 l 242.30 163.01 l 243.06 163.01 l S 237.13 163.01 m 236.44 163.01 l S 243.06 163.01 m 243.83 163.01 l S 239.60 160.57 m 243.83 163.01 l 239.60 165.45 l S 265.27 164.22 m 265.72 164.28 l 266.18 164.34 l 266.64 164.38 l 267.11 164.43 l 267.58 164.47 l 268.04 164.52 l 268.50 164.57 l 268.95 164.63 l S 265.27 164.22 m 264.84 164.14 l S 268.57 167.29 m 264.84 164.14 l 269.43 162.48 l S 268.95 164.63 m 269.38 164.71 l S 265.65 161.57 m 269.38 164.71 l 264.79 166.37 l S 260.13 154.88 m 261.50 152.87 l 262.96 150.75 l 264.48 148.56 l 266.05 146.31 l 267.63 144.05 l 269.20 141.80 l 270.74 139.60 l 272.23 137.47 l S 260.13 154.88 m 258.88 156.75 l S 272.23 137.47 m 273.64 135.44 l S 269.22 137.52 m 273.64 135.44 l 273.23 140.31 l S 285.69 134.88 m 287.06 136.74 l 288.52 138.73 l 290.04 140.80 l 291.60 142.94 l 293.18 145.10 l 294.76 147.25 l 296.30 149.36 l 297.79 151.41 l S 285.69 134.88 m 284.43 133.17 l S 297.79 151.41 m 299.20 153.34 l S 298.68 148.49 m 299.20 153.34 l 294.74 151.36 l S 312.45 173.76 m 316.16 180.25 l 320.39 187.62 l 324.97 195.59 l 329.76 203.89 l 334.59 212.25 l 339.30 220.40 l 343.74 228.06 l 347.75 234.98 l S 312.45 173.76 m 309.42 168.40 l S 347.75 234.98 m 351.16 240.86 l S 351.15 235.98 m 351.16 240.86 l 346.93 238.43 l S 364.24 246.03 m 365.14 245.49 l 366.06 244.94 l 367.00 244.38 l 367.95 243.81 l 368.91 243.23 l 369.88 242.65 l 370.84 242.05 l 371.80 241.46 l S 364.24 246.03 m 363.37 246.55 l S 371.80 241.46 m 372.74 240.86 l S 367.86 241.06 m 372.74 240.86 l 370.47 245.18 l S 217.10 100.31 m 224.62 100.78 l 233.14 101.31 l 242.36 101.89 l 251.96 102.48 l 261.63 103.07 l 271.08 103.65 l 279.98 104.18 l 288.04 104.65 l S 217.10 100.31 m 210.89 99.92 l S 288.04 104.65 m 294.94 105.04 l S 290.86 102.36 m 294.94 105.04 l 290.58 107.24 l S 308.96 126.01 m 310.90 137.91 l 313.17 151.52 l 315.64 166.28 l 318.22 181.62 l 320.80 196.95 l 323.28 211.71 l 325.54 225.33 l 327.49 237.23 l S 308.96 126.01 m 307.43 116.40 l S 305.68 120.96 m 307.43 116.40 l 310.50 120.20 l S 327.49 237.23 m 329.01 246.83 l S 330.76 242.27 m 329.01 246.83 l 325.94 243.04 l S 333.79 266.51 m 334.32 268.42 l 334.87 270.45 l 335.42 272.56 l 335.97 274.75 l 336.52 276.99 l 337.07 279.26 l 337.61 281.54 l 338.15 283.81 l S 333.79 266.51 m 333.27 264.73 l S 338.15 283.81 m 338.67 286.04 l S 340.61 294.19 m 342.53 302.52 l 344.39 310.90 l 346.19 319.21 l 347.90 327.32 l 349.50 335.10 l 350.99 342.44 l 352.34 349.20 l 353.54 355.26 l S 340.61 294.19 m 338.67 286.04 l S 353.54 355.26 m 354.57 360.49 l S 356.15 355.87 m 354.57 360.49 l 351.36 356.81 l S 339.16 255.10 m 339.95 254.85 l 340.74 254.60 l 341.55 254.35 l 342.36 254.11 l 343.17 253.88 l 343.97 253.66 l 344.77 253.45 l 345.56 253.26 l S 339.16 255.10 m 338.38 255.36 l S 345.56 253.26 m 346.33 253.08 l S 341.67 251.65 m 346.33 253.08 l 342.76 256.41 l S 213.76 218.17 m 214.35 217.93 l 214.95 217.71 l 215.55 217.49 l 216.14 217.28 l 216.74 217.07 l 217.33 216.85 l 217.93 216.62 l 218.53 216.39 l S 213.76 218.17 m 213.16 218.42 l S 218.00 219.05 m 213.16 218.42 l 216.13 214.54 l S 218.53 216.39 m 219.12 216.14 l S 214.28 215.51 m 219.12 216.14 l 216.16 220.02 l S 233.71 222.12 m 235.38 225.33 l 237.15 228.83 l 239.00 232.53 l 240.88 236.35 l 242.78 240.22 l 244.65 244.05 l 246.46 247.76 l 248.19 251.27 l S 233.71 222.12 m 232.19 219.27 l S 248.19 251.27 m 249.79 254.50 l S 250.10 249.63 m 249.79 254.50 l 245.73 251.80 l S 240.15 211.73 m 244.40 211.63 l 249.11 211.60 l 254.19 211.65 l 259.55 211.81 l 265.11 212.08 l 270.77 212.50 l 276.46 213.06 l 282.08 213.80 l S 240.15 211.73 m 236.44 211.88 l S 282.08 213.80 m 287.56 214.72 l S 288.41 214.82 m 289.26 214.96 l 290.10 215.12 l 290.94 215.30 l 291.78 215.50 l 292.61 215.72 l 293.42 215.96 l 294.22 216.20 l 295.02 216.46 l S 288.41 214.82 m 287.56 214.72 l S 295.02 216.46 m 295.79 216.71 l S 292.54 213.07 m 295.79 216.71 l 291.01 217.71 l S 259.93 272.39 m 261.39 274.56 l 262.92 276.86 l 264.52 279.27 l 266.15 281.75 l 267.79 284.25 l 269.42 286.73 l 271.00 289.16 l 272.51 291.51 l S 259.93 272.39 m 258.59 270.42 l S 272.51 291.51 m 273.93 293.72 l S 273.70 288.84 m 273.93 293.72 l 269.59 291.48 l S 259.86 255.36 m 261.25 253.17 l 262.75 250.84 l 264.32 248.39 l 265.94 245.87 l 267.59 243.33 l 269.24 240.81 l 270.86 238.34 l 272.43 235.98 l S 259.86 255.36 m 258.59 257.34 l S 272.43 235.98 m 273.93 233.76 l S 269.54 235.90 m 273.93 233.76 l 273.59 238.63 l S 288.05 299.63 m 288.83 299.31 l 289.63 299.01 l 290.44 298.70 l 291.25 298.40 l 292.06 298.11 l 292.86 297.80 l 293.66 297.49 l 294.45 297.17 l S 288.05 299.63 m 287.27 299.97 l S 294.45 297.17 m 295.22 296.84 l S 290.38 296.27 m 295.22 296.84 l 292.30 300.75 l S 288.32 223.44 m 289.09 223.33 l 289.85 223.21 l 290.60 223.09 l 291.35 222.96 l 292.09 222.83 l 292.82 222.71 l 293.54 222.59 l 294.25 222.49 l S 288.32 223.44 m 287.56 223.53 l S 294.25 222.49 m 294.94 222.39 l S 290.42 220.54 m 294.94 222.39 l 291.08 225.38 l S 317.72 223.04 m 323.07 224.11 l 328.98 225.29 l 335.30 226.54 l 341.83 227.83 l 348.40 229.13 l 354.84 230.40 l 360.97 231.62 l 366.62 232.75 l S 317.72 223.04 m 313.11 222.11 l S 366.62 232.75 m 371.60 233.76 l S 367.95 230.53 m 371.60 233.76 l 366.98 235.31 l S 311.24 285.31 m 312.61 283.30 l 314.07 281.18 l 315.59 278.98 l 317.16 276.74 l 318.74 274.48 l 320.31 272.23 l 321.85 270.02 l 323.34 267.89 l S 311.24 285.31 m 309.99 287.18 l S 323.34 267.89 m 324.75 265.87 l S 320.33 267.94 m 324.75 265.87 l 324.34 270.73 l S 313.80 294.37 m 314.51 294.45 l 315.22 294.54 l 315.96 294.63 l 316.70 294.71 l 317.45 294.80 l 318.20 294.88 l 318.96 294.97 l 319.73 295.05 l S 313.80 294.37 m 313.11 294.28 l S 319.73 295.05 m 320.49 295.14 l S 316.56 292.24 m 320.49 295.14 l 316.02 297.09 l S 290.35 262.59 m 293.41 262.15 l 296.67 261.69 l 300.09 261.22 l 303.60 260.75 l 307.14 260.29 l 310.66 259.82 l 314.10 259.36 l 317.39 258.92 l S 290.35 262.59 m 287.56 263.03 l S 317.39 258.92 m 320.49 258.48 l S 315.97 256.65 m 320.49 258.48 l 316.65 261.48 l S 286.23 271.25 m 287.54 272.73 l 288.89 274.26 l 290.29 275.84 l 291.71 277.45 l 293.14 279.07 l 294.56 280.70 l 295.96 282.32 l 297.32 283.92 l S 286.23 271.25 m 285.00 269.85 l S 297.32 283.92 m 298.63 285.48 l S 297.78 280.67 m 298.63 285.48 l 294.04 283.81 l S 210.91 357.70 m 211.80 357.16 l 212.72 356.62 l 213.66 356.05 l 214.62 355.48 l 215.58 354.90 l 216.54 354.32 l 217.51 353.73 l 218.46 353.13 l S 210.91 357.70 m 210.04 358.22 l S 218.46 353.13 m 219.41 352.54 l S 214.53 352.73 m 219.41 352.54 l 217.14 356.86 l S 212.88 367.14 m 216.07 368.83 l 219.53 370.64 l 223.19 372.52 l 226.97 374.45 l 230.79 376.39 l 234.57 378.30 l 238.25 380.15 l 241.74 381.89 l S 212.88 367.14 m 210.04 365.61 l S 241.74 381.89 m 244.96 383.51 l S 242.28 379.43 m 244.96 383.51 l 240.09 383.80 l S 232.58 334.99 m 234.40 329.03 l 236.44 322.37 l 238.64 315.23 l 240.92 307.82 l 243.21 300.34 l 245.46 293.02 l 247.59 286.07 l 249.53 279.69 l S 232.58 334.99 m 231.05 340.03 l S 249.53 279.69 m 251.21 274.11 l S 247.65 277.45 m 251.21 274.11 l 252.33 278.86 l S 266.60 390.23 m 271.95 391.11 l 277.87 392.08 l 284.18 393.12 l 290.71 394.20 l 297.29 395.29 l 303.73 396.35 l 309.86 397.37 l 315.51 398.31 l S 266.60 390.23 m 262.00 389.48 l S 315.51 398.31 m 320.49 399.14 l S 316.73 396.04 m 320.49 399.14 l 315.92 400.85 l S 341.19 397.75 m 344.29 396.85 l 347.62 395.89 l 351.12 394.88 l 354.71 393.84 l 358.34 392.80 l 361.93 391.76 l 365.43 390.76 l 368.77 389.80 l S 341.19 397.75 m 338.38 398.57 l S 368.77 389.80 m 371.89 388.91 l S 367.15 387.72 m 371.89 388.91 l 368.50 392.42 l S Q endstream endobj 143 0 obj << /CreationDate (D:20061226132449) /ModDate (D:20061226132449) /Title (R Graphics Output) /Producer (R 2.4.1) /Creator (R) >> endobj 144 0 obj << /Type /Font /Subtype /Type1 /Name /F1 /BaseFont /ZapfDingbats >> endobj 145 0 obj << /Type /Font /Subtype /Type1 /Name /F2 /BaseFont /Helvetica /Encoding 147 0 R >> endobj 146 0 obj 25327 endobj 147 0 obj << /Type /Encoding /BaseEncoding /WinAnsiEncoding /Differences [ 45/minus 96/quoteleft 144/dotlessi/grave/acute/circumflex/tilde/macron/breve/dotaccent/dieresis/.notdef/ring/cedilla/.notdef/hungarumlaut/ogonek/caron/space] >> endobj 139 0 obj << /D [137 0 R /XYZ 133.7684 692.1046 null] >> endobj 136 0 obj << /Font << /F8 43 0 R /F49 46 0 R /F50 142 0 R /F51 50 0 R /F55 62 0 R >> /XObject << /Im2 130 0 R >> /ProcSet [ /PDF /Text ] >> endobj 151 0 obj << /Length 1536 /Filter /FlateDecode >> stream xio6{~P ĪH:l@M]] C#l+߻xQn_5.Qy2?y̨IR|<ɯo`EKX>puv|g2zb,w߆g?>Dkv.:K~"J#3X{=8Fm%{eO]3qMd\=\9 з'O'* cB:TQ'I!2/MAT<ɷͼY, a׀yMV))-(%E{l/bVE# Ccds |L{xʡao7@IԍǛXҬXk:G ~'}?H-GBt|r~oXV47oiߠr[p `˚l88.$R_Tl6Z+L0ܶK{ʁ?r'KpkoQ;԰;*?zᒹm>8 5_6"+&ۖ1:B17KYip ?|r^!`:F=tEsé24X&Ik|)i soh!Jx.P޷RL[K!Ũ|FќѕqCTt}QʧE>'U ;F1Q}ʔV)[GwjAn9yį~UvqOȥBͰ| l 46aH*GM;޶7kJ̚tL82Y k㝈-"V#qHAKi|'jHn#J. xd*gb٢VDq'Uru>-XbabKk6" I&߅;&zF1'SzΡ!ӀY|/È1ܞ"7=Yô/=_ iΆv%ԃMh$l,]u ^'p$ HۍP\nY LŎ4{:6^=0ad8VWEZMWOBGr6"Ť<kFCtixmYB zc#hjx5Ls6Q"p}/k s ƻ'ܺpP EB.cloB]9j;SY'69Iomw*endstream endobj 150 0 obj << /Type /Page /Contents 151 0 R /Resources 149 0 R /MediaBox [0 0 612 792] /Parent 135 0 R >> endobj 148 0 obj << /Type /XObject /Subtype /Form /FormType 1 /PTEX.FileName (./layingOutPathways-plotWNodeAttrs.pdf) /PTEX.PageNumber 1 /PTEX.InfoDict 153 0 R /Matrix [1.00000000 0.00000000 0.00000000 1.00000000 0.00000000 0.00000000] /BBox [0.00000000 0.00000000 432.00000000 432.00000000] /Resources << /ProcSet [ /PDF /Text ] /Font << /F1 154 0 R /F2 155 0 R >> /ExtGState << >>>> /Length 156 0 R >> stream q Q q 0.72 0.72 430.56 430.56 re W n 1.000 1.000 1.000 rg 0.000 0.000 0.000 RG 0.75 w [] 0 d 1 J 1 j 10.00 M BT /F1 1 Tf 2 Tr 20.45 0 0 20.45 15.95 219.99 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 21.72 226.36 Tm (ITGB) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 40.56 317.12 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 46.32 323.50 Tm (ITGA) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 40.56 278.27 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 47.16 284.65 Tm (ILK) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 40.56 239.41 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 46.67 245.79 Tm (CAV) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 40.56 200.56 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 46.55 206.94 Tm (SHC) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 65.17 239.41 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 71.27 245.79 Tm (FYN) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 65.17 200.56 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 70.54 206.94 Tm (GRB2) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 89.78 218.89 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 95.76 225.27 Tm (SOS) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 114.39 238.87 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 118.85 245.26 Tm (Ha-Ras) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 139.00 268.69 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 145.54 275.07 Tm (Raf) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 212.82 283.74 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 218.75 290.12 Tm (MEK) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 244.82 334.36 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 250.86 340.74 Tm (ERK) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 350.63 363.91 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 356.01 370.29 Tm (MYLK) Tj 1.000 1.000 1.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 375.24 378.41 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 381.15 384.79 Tm (MYO) Tj 1.000 1.000 1.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 40.56 131.06 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 45.97 137.44 Tm (ACTN) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 65.17 120.93 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 71.32 127.31 Tm (VCL) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 89.78 160.61 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 95.99 166.99 Tm (TLN) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 163.61 126.13 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 169.65 132.51 Tm (PXN) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 65.17 58.27 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 71.32 64.65 Tm (ZYX) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 89.78 24.07 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 95.29 30.45 Tm (VASP) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 89.78 101.51 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 94.65 107.89 Tm (SH3D5) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 89.78 62.65 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 95.88 69.03 Tm (TNS) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 114.39 185.51 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 119.71 191.89 Tm (CAPN) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 139.00 185.51 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 143.65 191.89 Tm (CAPNS) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 163.61 185.51 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 169.59 191.89 Tm (SRC) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 188.21 155.96 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 194.45 162.34 Tm (FAK) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 212.82 155.96 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 217.59 162.34 Tm (BCAR1) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 188.21 253.91 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 194.26 260.29 Tm (CSK) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 244.82 155.96 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 250.80 162.34 Tm (CRK) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 276.81 158.69 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 281.46 165.07 Tm (DOCK1) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 276.81 119.84 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 282.24 126.22 Tm (GRF2) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 301.42 154.86 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 306.90 161.24 Tm (RAP1) Tj 1.000 1.000 1.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 350.63 243.24 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 356.84 249.64 Tm (JNK) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 188.21 92.20 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 194.09 98.58 Tm (GIT2) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 301.42 98.77 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 305.35 105.15 Tm (ARHGEF) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 326.02 250.36 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 332.24 256.74 Tm (PAK) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 188.21 215.06 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 194.64 221.66 Tm (p85) Tj 1.000 1.000 1.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 212.82 204.94 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 218.70 211.54 Tm (p110) Tj ET 1.000 1.000 1.000 rg 238.15 263.75 m 238.45 265.22 l 238.74 265.83 l 239.04 266.28 l 239.34 266.66 l 239.64 266.98 l 239.94 267.27 l 240.24 267.53 l 240.53 267.77 l 240.83 267.99 l 241.13 268.20 l 241.43 268.39 l 241.73 268.57 l 242.03 268.74 l 242.32 268.90 l 242.62 269.04 l 242.92 269.19 l 243.22 269.32 l 243.52 269.45 l 243.82 269.57 l 244.11 269.68 l 244.41 269.79 l 244.71 269.89 l 245.01 269.99 l 245.31 270.08 l 245.61 270.17 l 245.90 270.25 l 246.20 270.33 l 246.50 270.40 l 246.80 270.47 l 247.10 270.54 l 247.40 270.60 l 247.69 270.66 l 247.99 270.71 l 248.29 270.76 l 248.59 270.81 l 248.89 270.85 l 249.18 270.90 l 249.48 270.93 l 249.78 270.97 l 250.08 271.00 l 250.38 271.03 l 250.68 271.05 l 250.97 271.07 l 251.27 271.09 l 251.57 271.10 l 251.87 271.12 l 252.17 271.13 l 252.47 271.13 l 252.76 271.13 l 253.06 271.13 l 253.36 271.13 l 253.66 271.13 l 253.96 271.12 l 254.26 271.10 l 254.55 271.09 l 254.85 271.07 l 255.15 271.05 l 255.45 271.03 l 255.75 271.00 l 256.05 270.97 l 256.34 270.93 l 256.64 270.90 l 256.94 270.85 l 257.24 270.81 l 257.54 270.76 l 257.84 270.71 l 258.13 270.66 l 258.43 270.60 l 258.73 270.54 l 259.03 270.47 l 259.33 270.40 l 259.63 270.33 l 259.92 270.25 l 260.22 270.17 l 260.52 270.08 l 260.82 269.99 l 261.12 269.89 l 261.41 269.79 l 261.71 269.68 l 262.01 269.57 l 262.31 269.45 l 262.61 269.32 l 262.91 269.19 l 263.20 269.04 l 263.50 268.90 l 263.80 268.74 l 264.10 268.57 l 264.40 268.39 l 264.70 268.20 l 264.99 267.99 l 265.29 267.77 l 265.59 267.53 l 265.89 267.27 l 266.19 266.98 l 266.49 266.66 l 266.78 266.28 l 267.08 265.83 l 267.38 265.22 l 267.68 263.75 l 267.68 263.75 l 267.38 262.27 l 267.08 261.67 l 266.78 261.21 l 266.49 260.84 l 266.19 260.51 l 265.89 260.22 l 265.59 259.96 l 265.29 259.72 l 264.99 259.50 l 264.70 259.29 l 264.40 259.10 l 264.10 258.92 l 263.80 258.76 l 263.50 258.60 l 263.20 258.45 l 262.91 258.31 l 262.61 258.17 l 262.31 258.05 l 262.01 257.93 l 261.71 257.81 l 261.41 257.71 l 261.12 257.60 l 260.82 257.51 l 260.52 257.41 l 260.22 257.33 l 259.92 257.24 l 259.63 257.17 l 259.33 257.09 l 259.03 257.02 l 258.73 256.96 l 258.43 256.89 l 258.13 256.84 l 257.84 256.78 l 257.54 256.73 l 257.24 256.68 l 256.94 256.64 l 256.64 256.60 l 256.34 256.56 l 256.05 256.53 l 255.75 256.50 l 255.45 256.47 l 255.15 256.44 l 254.85 256.42 l 254.55 256.40 l 254.26 256.39 l 253.96 256.38 l 253.66 256.37 l 253.36 256.36 l 253.06 256.36 l 252.76 256.36 l 252.47 256.36 l 252.17 256.37 l 251.87 256.38 l 251.57 256.39 l 251.27 256.40 l 250.97 256.42 l 250.68 256.44 l 250.38 256.47 l 250.08 256.50 l 249.78 256.53 l 249.48 256.56 l 249.18 256.60 l 248.89 256.64 l 248.59 256.68 l 248.29 256.73 l 247.99 256.78 l 247.69 256.84 l 247.40 256.89 l 247.10 256.96 l 246.80 257.02 l 246.50 257.09 l 246.20 257.17 l 245.90 257.24 l 245.61 257.33 l 245.31 257.41 l 245.01 257.51 l 244.71 257.60 l 244.41 257.71 l 244.11 257.81 l 243.82 257.93 l 243.52 258.05 l 243.22 258.17 l 242.92 258.31 l 242.62 258.45 l 242.32 258.60 l 242.03 258.76 l 241.73 258.92 l 241.43 259.10 l 241.13 259.29 l 240.83 259.50 l 240.53 259.72 l 240.24 259.96 l 239.94 260.22 l 239.64 260.51 l 239.34 260.84 l 239.04 261.21 l 238.74 261.67 l 238.45 262.27 l 238.15 263.75 l h f 238.15 263.75 m 238.45 265.22 l 238.74 265.83 l 239.04 266.28 l 239.34 266.66 l 239.64 266.98 l 239.94 267.27 l 240.24 267.53 l 240.53 267.77 l 240.83 267.99 l 241.13 268.20 l 241.43 268.39 l 241.73 268.57 l 242.03 268.74 l 242.32 268.90 l 242.62 269.04 l 242.92 269.19 l 243.22 269.32 l 243.52 269.45 l 243.82 269.57 l 244.11 269.68 l 244.41 269.79 l 244.71 269.89 l 245.01 269.99 l 245.31 270.08 l 245.61 270.17 l 245.90 270.25 l 246.20 270.33 l 246.50 270.40 l 246.80 270.47 l 247.10 270.54 l 247.40 270.60 l 247.69 270.66 l 247.99 270.71 l 248.29 270.76 l 248.59 270.81 l 248.89 270.85 l 249.18 270.90 l 249.48 270.93 l 249.78 270.97 l 250.08 271.00 l 250.38 271.03 l 250.68 271.05 l 250.97 271.07 l 251.27 271.09 l 251.57 271.10 l 251.87 271.12 l 252.17 271.13 l 252.47 271.13 l 252.76 271.13 l 253.06 271.13 l 253.36 271.13 l 253.66 271.13 l 253.96 271.12 l 254.26 271.10 l 254.55 271.09 l 254.85 271.07 l 255.15 271.05 l 255.45 271.03 l 255.75 271.00 l 256.05 270.97 l 256.34 270.93 l 256.64 270.90 l 256.94 270.85 l 257.24 270.81 l 257.54 270.76 l 257.84 270.71 l 258.13 270.66 l 258.43 270.60 l 258.73 270.54 l 259.03 270.47 l 259.33 270.40 l 259.63 270.33 l 259.92 270.25 l 260.22 270.17 l 260.52 270.08 l 260.82 269.99 l 261.12 269.89 l 261.41 269.79 l 261.71 269.68 l 262.01 269.57 l 262.31 269.45 l 262.61 269.32 l 262.91 269.19 l 263.20 269.04 l 263.50 268.90 l 263.80 268.74 l 264.10 268.57 l 264.40 268.39 l 264.70 268.20 l 264.99 267.99 l 265.29 267.77 l 265.59 267.53 l 265.89 267.27 l 266.19 266.98 l 266.49 266.66 l 266.78 266.28 l 267.08 265.83 l 267.38 265.22 l 267.68 263.75 l 267.68 263.75 l 267.38 262.27 l 267.08 261.67 l 266.78 261.21 l 266.49 260.84 l 266.19 260.51 l 265.89 260.22 l 265.59 259.96 l 265.29 259.72 l 264.99 259.50 l 264.70 259.29 l 264.40 259.10 l 264.10 258.92 l 263.80 258.76 l 263.50 258.60 l 263.20 258.45 l 262.91 258.31 l 262.61 258.17 l 262.31 258.05 l 262.01 257.93 l 261.71 257.81 l 261.41 257.71 l 261.12 257.60 l 260.82 257.51 l 260.52 257.41 l 260.22 257.33 l 259.92 257.24 l 259.63 257.17 l 259.33 257.09 l 259.03 257.02 l 258.73 256.96 l 258.43 256.89 l 258.13 256.84 l 257.84 256.78 l 257.54 256.73 l 257.24 256.68 l 256.94 256.64 l 256.64 256.60 l 256.34 256.56 l 256.05 256.53 l 255.75 256.50 l 255.45 256.47 l 255.15 256.44 l 254.85 256.42 l 254.55 256.40 l 254.26 256.39 l 253.96 256.38 l 253.66 256.37 l 253.36 256.36 l 253.06 256.36 l 252.76 256.36 l 252.47 256.36 l 252.17 256.37 l 251.87 256.38 l 251.57 256.39 l 251.27 256.40 l 250.97 256.42 l 250.68 256.44 l 250.38 256.47 l 250.08 256.50 l 249.78 256.53 l 249.48 256.56 l 249.18 256.60 l 248.89 256.64 l 248.59 256.68 l 248.29 256.73 l 247.99 256.78 l 247.69 256.84 l 247.40 256.89 l 247.10 256.96 l 246.80 257.02 l 246.50 257.09 l 246.20 257.17 l 245.90 257.24 l 245.61 257.33 l 245.31 257.41 l 245.01 257.51 l 244.71 257.60 l 244.41 257.71 l 244.11 257.81 l 243.82 257.93 l 243.52 258.05 l 243.22 258.17 l 242.92 258.31 l 242.62 258.45 l 242.32 258.60 l 242.03 258.76 l 241.73 258.92 l 241.43 259.10 l 241.13 259.29 l 240.83 259.50 l 240.53 259.72 l 240.24 259.96 l 239.94 260.22 l 239.64 260.51 l 239.34 260.84 l 239.04 261.21 l 238.74 261.67 l 238.45 262.27 l 238.15 263.75 l 238.15 263.75 l S BT 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 236.41 263.25 Tm (Phosphatidylinositol signaling system) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 276.81 295.50 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 283.05 301.88 Tm (VAV) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 276.81 217.80 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 281.63 224.17 Tm (PDPK1) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 301.42 213.69 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 307.57 220.07 Tm (AKT) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 301.42 286.48 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 307.43 292.85 Tm (RAC) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 276.81 256.65 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 281.63 263.03 Tm (CDC42) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 188.21 354.88 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 194.09 361.26 Tm (RHO) Tj 1.000 1.000 1.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 212.82 340.38 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 218.75 346.78 Tm (PI5K) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 244.82 381.15 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 250.04 387.53 Tm (ROCK) Tj 1.000 1.000 1.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 326.02 393.73 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 330.68 400.11 Tm (MYO-P) Tj 1.000 1.000 1.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 375.24 228.74 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 375.84 235.13 Tm (cell maintenance) Tj 1.000 1.000 1.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 326.02 288.94 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 329.23 295.53 Tm (cell motility) Tj 1.000 1.000 1.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 399.85 378.41 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 404.64 384.81 Tm (F-actin) Tj 1.000 1.000 1.000 rg /F1 1 Tf 2 Tr 20.45 0 0 20.45 276.81 334.36 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 277.94 340.93 Tm (cell proliferation) Tj ET 27.57 241.26 m 28.78 246.15 l 30.11 251.50 l 31.55 257.25 l 33.07 263.30 l 34.66 269.58 l 36.29 275.99 l 37.96 282.45 l 39.62 288.89 l S 27.57 241.26 m 26.51 236.93 l S 25.20 241.45 m 26.51 236.93 l 29.76 240.32 l S 39.62 288.89 m 41.28 295.21 l S 41.78 297.12 m 42.29 299.07 l 42.80 301.04 l 43.32 303.02 l 43.84 305.00 l 44.35 306.96 l 44.84 308.89 l 45.32 310.77 l 45.77 312.60 l S 41.78 297.12 m 41.28 295.21 l S 45.77 312.60 m 46.20 314.37 l S 47.53 309.86 m 46.20 314.37 l 42.96 310.96 l S 29.61 239.86 m 31.20 243.66 l 32.87 247.71 l 34.60 251.93 l 36.35 256.22 l 38.11 260.52 l 39.84 264.73 l 41.51 268.78 l 43.09 272.58 l S 29.61 239.86 m 28.15 236.38 l S 27.56 241.05 m 28.15 236.38 l 31.90 239.22 l S 43.09 272.58 m 44.56 276.06 l S 45.14 271.40 m 44.56 276.06 l 40.81 273.22 l S 32.81 234.04 m 33.65 234.71 l 34.50 235.40 l 35.36 236.08 l 36.22 236.76 l 37.08 237.43 l 37.94 238.09 l 38.79 238.73 l 39.63 239.35 l S 32.81 234.04 m 31.98 233.37 l S 33.68 237.75 m 31.98 233.37 l 36.62 234.09 l S 39.63 239.35 m 40.46 239.94 l S 38.51 235.67 m 40.46 239.94 l 35.78 239.49 l S 32.81 220.12 m 33.65 219.45 l 34.50 218.77 l 35.36 218.08 l 36.22 217.40 l 37.08 216.73 l 37.94 216.07 l 38.79 215.43 l 39.63 214.81 l S 32.81 220.12 m 31.98 220.79 l S 36.62 220.07 m 31.98 220.79 l 33.68 216.41 l S 39.63 214.81 m 40.46 214.22 l S 35.78 214.67 m 40.46 214.22 l 38.51 218.50 l S 28.32 211.56 m 30.11 205.04 l 32.09 197.88 l 34.19 190.30 l 36.35 182.52 l 38.52 174.74 l 40.62 167.18 l 42.59 160.06 l 44.38 153.60 l S 28.32 211.56 m 26.78 217.23 l S 30.12 213.92 m 26.78 217.23 l 25.58 212.69 l S 44.38 153.60 m 45.92 148.01 l S 42.58 151.31 m 45.92 148.01 l 47.11 152.55 l S 28.83 215.84 m 29.87 213.81 l 31.01 211.72 l 32.24 209.60 l 33.55 207.48 l 34.95 205.39 l 36.42 203.34 l 37.97 201.38 l 39.59 199.52 l S 28.83 215.84 m 27.88 217.78 l S 31.78 215.16 m 27.88 217.78 l 27.56 213.09 l S 39.59 199.52 m 41.28 197.80 l S 45.65 193.91 m 50.34 190.29 l 55.26 186.92 l 60.31 183.82 l 65.41 180.98 l 70.45 178.40 l 75.36 176.08 l 80.03 174.03 l 84.38 172.24 l S 45.65 193.91 m 41.28 197.80 l S 84.38 172.24 m 88.31 170.72 l S 83.66 170.00 m 88.31 170.72 l 85.36 174.38 l S 55.13 218.17 m 56.49 220.30 l 57.90 222.51 l 59.35 224.77 l 60.83 227.05 l 62.30 229.32 l 63.75 231.55 l 65.17 233.72 l 66.52 235.80 l S 55.13 218.17 m 53.85 216.14 l S 54.03 220.83 m 53.85 216.14 l 58.01 218.33 l S 66.52 235.80 m 67.80 237.75 l S 67.54 233.06 m 67.80 237.75 l 63.61 235.63 l S 59.19 207.65 m 59.62 207.65 l 60.07 207.65 l 60.51 207.65 l 60.96 207.65 l 61.41 207.65 l 61.86 207.65 l 62.30 207.65 l 62.73 207.65 l S 59.19 207.65 m 58.78 207.65 l S 62.85 210.00 m 58.78 207.65 l 62.85 205.30 l S 62.73 207.65 m 63.15 207.65 l S 59.08 205.30 m 63.15 207.65 l 59.08 210.00 l S 80.21 212.78 m 81.18 213.54 l 82.18 214.32 l 83.22 215.10 l 84.27 215.90 l 85.35 216.70 l 86.43 217.51 l 87.52 218.33 l 88.60 219.15 l S 80.21 212.78 m 79.28 212.03 l S 88.60 219.15 m 89.67 219.97 l S 87.87 215.63 m 89.67 219.97 l 85.01 219.36 l S 104.63 231.48 m 105.67 232.34 l 106.76 233.23 l 107.86 234.13 l 108.98 235.05 l 110.12 235.98 l 111.25 236.91 l 112.37 237.84 l 113.47 238.76 l S 104.63 231.48 m 103.62 230.64 l S 113.47 238.76 m 114.56 239.67 l S 112.96 235.25 m 114.56 239.67 l 109.93 238.84 l S 128.33 253.16 m 129.60 254.70 l 130.94 256.32 l 132.32 257.98 l 133.73 259.68 l 135.15 261.38 l 136.55 263.07 l 137.93 264.73 l 139.26 266.33 l S 128.33 253.16 m 127.13 251.71 l S 139.26 266.33 m 140.53 267.85 l S 139.73 263.22 m 140.53 267.85 l 136.12 266.23 l S 158.91 278.06 m 164.06 279.11 l 169.76 280.27 l 175.84 281.51 l 182.13 282.80 l 188.46 284.09 l 194.66 285.35 l 200.56 286.56 l 206.00 287.67 l S 158.91 278.06 m 154.48 277.15 l S 206.00 287.67 m 210.80 288.65 l S 207.29 285.53 m 210.80 288.65 l 206.35 290.14 l S 226.80 300.05 m 228.82 303.35 l 231.03 306.93 l 233.37 310.71 l 235.79 314.61 l 238.23 318.52 l 240.65 322.38 l 242.98 326.08 l 245.17 329.55 l S 226.80 300.05 m 225.02 297.13 l S 245.17 329.55 m 247.17 332.70 l S 246.97 328.00 m 247.17 332.70 l 243.00 330.53 l S 261.28 345.06 m 262.91 345.70 l 264.62 346.37 l 266.40 347.07 l 268.23 347.78 l 270.09 348.50 l 271.96 349.22 l 273.84 349.94 l 275.70 350.63 l S 261.28 345.06 m 259.75 344.47 l S 275.70 350.63 m 277.52 351.31 l S 285.21 353.64 m 293.11 355.89 l 301.08 358.03 l 309.00 360.05 l 316.76 361.94 l 324.22 363.70 l 331.26 365.30 l 337.76 366.74 l 343.58 368.01 l S 285.21 353.64 m 277.52 351.31 l S 343.58 368.01 m 348.62 369.09 l S 345.13 365.94 m 348.62 369.09 l 344.14 370.53 l S 261.64 341.46 m 263.04 341.46 l 264.48 341.46 l 265.95 341.46 l 267.44 341.46 l 268.94 341.46 l 270.43 341.46 l 271.92 341.46 l 273.37 341.46 l S 261.64 341.46 m 260.30 341.46 l S 273.37 341.46 m 274.79 341.46 l S 270.72 339.11 m 274.79 341.46 l 270.72 343.81 l S 366.13 375.35 m 366.99 375.88 l 367.88 376.43 l 368.79 377.00 l 369.70 377.57 l 370.63 378.15 l 371.56 378.71 l 372.49 379.27 l 373.41 379.80 l S 366.13 375.35 m 365.29 374.84 l S 373.41 379.80 m 374.32 380.31 l S 371.91 376.27 m 374.32 380.31 l 369.62 380.38 l S 393.88 385.51 m 394.31 385.51 l 394.75 385.51 l 395.20 385.51 l 395.65 385.51 l 396.10 385.51 l 396.54 385.51 l 396.98 385.51 l 397.42 385.51 l S 393.88 385.51 m 393.46 385.51 l S 397.53 387.86 m 393.46 385.51 l 397.53 383.16 l S 397.42 385.51 m 397.83 385.51 l S 393.76 383.16 m 397.83 385.51 l 393.76 387.86 l S 58.80 134.09 m 59.38 133.86 l 59.95 133.64 l 60.53 133.44 l 61.10 133.23 l 61.67 133.02 l 62.25 132.81 l 62.82 132.60 l 63.40 132.37 l S 58.80 134.09 m 58.23 134.32 l S 62.89 134.93 m 58.23 134.32 l 61.09 130.59 l S 63.40 132.37 m 63.97 132.13 l S 59.31 131.53 m 63.97 132.13 l 61.11 135.87 l S 60.25 145.07 m 63.31 146.92 l 66.53 148.87 l 69.87 150.88 l 73.27 152.93 l 76.66 154.98 l 80.00 156.99 l 83.23 158.94 l 86.29 160.79 l S 60.25 145.07 m 57.41 143.35 l S 59.67 147.47 m 57.41 143.35 l 62.11 143.45 l S 86.29 160.79 m 89.13 162.51 l S 86.86 158.39 m 89.13 162.51 l 84.43 162.41 l S 53.45 123.80 m 55.16 118.74 l 57.01 113.27 l 58.96 107.53 l 60.96 101.66 l 62.96 95.80 l 64.92 90.08 l 66.77 84.66 l 68.48 79.66 l S 53.45 123.80 m 51.94 128.30 l S 55.46 125.19 m 51.94 128.30 l 51.00 123.70 l S 68.48 79.66 m 69.99 75.22 l S 66.45 78.32 m 69.99 75.22 l 70.90 79.83 l S 79.81 138.83 m 81.23 140.98 l 82.69 143.23 l 84.18 145.53 l 85.67 147.87 l 87.16 150.20 l 88.63 152.51 l 90.05 154.75 l 91.40 156.91 l S 79.81 138.83 m 78.46 136.79 l S 78.75 141.48 m 78.46 136.79 l 82.67 138.88 l S 91.40 156.91 m 92.68 158.95 l S 92.51 154.25 m 92.68 158.95 l 88.53 156.75 l S 89.65 128.93 m 96.95 129.32 l 105.03 129.74 l 113.63 130.18 l 122.49 130.63 l 131.34 131.08 l 139.94 131.52 l 148.02 131.94 l 155.32 132.33 l S 89.65 128.93 m 83.38 128.58 l S 87.32 131.15 m 83.38 128.58 l 87.58 126.46 l S 155.32 132.33 m 161.59 132.68 l S 157.65 130.11 m 161.59 132.68 l 157.39 134.80 l S 82.03 121.07 m 82.87 120.40 l 83.72 119.72 l 84.57 119.03 l 85.44 118.35 l 86.30 117.68 l 87.15 117.02 l 88.00 116.38 l 88.85 115.76 l S 82.03 121.07 m 81.20 121.74 l S 85.84 121.02 m 81.20 121.74 l 82.90 117.36 l S 88.85 115.76 m 89.67 115.17 l S 85.00 115.62 m 89.67 115.17 l 87.72 119.45 l S 78.83 115.25 m 80.41 111.45 l 82.08 107.40 l 83.81 103.19 l 85.57 98.89 l 87.33 94.59 l 89.06 90.38 l 90.73 86.33 l 92.31 82.53 l S 78.83 115.25 m 77.37 118.73 l S 81.11 115.89 m 77.37 118.73 l 76.78 114.06 l S 92.31 82.53 m 93.78 79.05 l S 90.03 81.89 m 93.78 79.05 l 94.36 83.72 l S 105.99 175.82 m 107.01 176.85 l 108.06 177.90 l 109.12 178.97 l 110.18 180.05 l 111.25 181.14 l 112.31 182.24 l 113.35 183.33 l 114.38 184.42 l S 105.99 175.82 m 104.99 174.82 l S 106.20 179.36 m 104.99 174.82 l 109.53 176.04 l S 114.38 184.42 m 115.38 185.49 l S 114.32 180.91 m 115.38 185.49 l 110.88 184.11 l S 114.26 167.09 m 121.56 166.72 l 129.64 166.33 l 138.24 165.93 l 147.09 165.52 l 155.95 165.11 l 164.55 164.70 l 172.63 164.32 l 179.93 163.95 l S 114.26 167.09 m 107.99 167.43 l S 112.19 169.56 m 107.99 167.43 l 111.93 164.86 l S 179.93 163.95 m 186.20 163.60 l S 182.00 161.48 m 186.20 163.60 l 182.26 166.17 l S 179.16 142.50 m 180.34 143.88 l 181.55 145.28 l 182.76 146.71 l 183.97 148.14 l 185.18 149.58 l 186.37 151.00 l 187.53 152.41 l 188.66 153.78 l S 179.16 142.50 m 177.99 141.16 l S 178.89 145.78 m 177.99 141.16 l 182.44 142.69 l S 188.66 153.78 m 189.75 155.12 l S 189.00 150.48 m 189.75 155.12 l 185.36 153.45 l S 180.81 138.74 m 183.96 140.64 l 187.37 142.71 l 190.97 144.89 l 194.67 147.15 l 198.41 149.43 l 202.10 151.69 l 205.68 153.88 l 209.06 155.95 l S 180.81 138.74 m 177.99 137.06 l S 209.06 155.95 m 212.17 157.86 l S 209.93 153.73 m 212.17 157.86 l 207.47 157.74 l S 177.29 125.50 m 178.61 123.66 l 180.01 121.73 l 181.48 119.72 l 182.98 117.67 l 184.50 115.59 l 186.02 113.51 l 187.51 111.45 l 188.94 109.44 l S 177.29 125.50 m 176.08 127.21 l S 188.94 109.44 m 190.30 107.51 l S 186.03 109.49 m 190.30 107.51 l 189.88 112.19 l S 80.46 55.48 m 81.69 53.74 l 82.96 51.94 l 84.26 50.11 l 85.57 48.27 l 86.88 46.43 l 88.18 44.60 l 89.45 42.80 l 90.68 41.06 l S 80.46 55.48 m 79.28 57.16 l S 83.54 55.18 m 79.28 57.16 l 79.70 52.48 l S 90.68 41.06 m 91.86 39.38 l S 87.60 41.36 m 91.86 39.38 l 91.45 44.06 l S 133.02 192.61 m 133.45 192.61 l 133.89 192.61 l 134.34 192.61 l 134.79 192.61 l 135.24 192.61 l 135.69 192.61 l 136.13 192.61 l 136.56 192.61 l S 133.02 192.61 m 132.60 192.61 l S 136.67 194.96 m 132.60 192.61 l 136.67 190.26 l S 136.56 192.61 m 136.98 192.61 l S 132.91 190.26 m 136.98 192.61 l 132.91 194.96 l S 155.14 192.61 m 155.82 192.61 l 156.51 192.61 l 157.22 192.61 l 157.93 192.61 l 158.65 192.61 l 159.38 192.61 l 160.11 192.61 l 160.85 192.61 l S 155.14 192.61 m 154.48 192.61 l S 160.85 192.61 m 161.59 192.61 l S 157.52 190.26 m 161.59 192.61 l 157.52 194.96 l S 177.55 185.48 m 178.82 184.00 l 180.16 182.43 l 181.54 180.80 l 182.95 179.13 l 184.36 177.44 l 185.77 175.76 l 187.15 174.11 l 188.48 172.51 l S 177.55 185.48 m 176.35 186.86 l S 188.48 172.51 m 189.75 170.99 l S 185.34 172.61 m 189.75 170.99 l 188.95 175.62 l S 183.29 185.69 m 186.35 183.84 l 189.58 181.89 l 192.92 179.88 l 196.31 177.83 l 199.71 175.78 l 203.05 173.77 l 206.27 171.82 l 209.33 169.97 l S 183.29 185.69 m 180.45 187.41 l S 185.15 187.31 m 180.45 187.41 l 182.72 183.29 l S 209.33 169.97 m 212.17 168.25 l S 207.47 168.35 m 212.17 168.25 l 209.91 172.37 l S 176.55 206.67 m 178.28 211.36 l 180.12 216.40 l 182.03 221.67 l 183.97 227.05 l 185.91 232.42 l 187.80 237.67 l 189.60 242.66 l 191.26 247.29 l S 176.55 206.67 m 174.98 202.46 l S 174.20 207.09 m 174.98 202.46 l 178.61 205.45 l S 191.26 247.29 m 192.76 251.43 l S 193.59 246.81 m 192.76 251.43 l 189.17 248.40 l S 199.14 178.11 m 201.00 187.82 l 203.17 199.09 l 205.54 211.42 l 208.04 224.35 l 210.56 237.37 l 213.01 250.00 l 215.29 261.76 l 217.33 272.16 l S 199.14 178.11 m 197.68 170.44 l S 217.33 272.16 m 219.01 280.71 l S 220.53 276.26 m 219.01 280.71 l 215.92 277.17 l S 204.36 163.05 m 205.04 163.05 l 205.73 163.05 l 206.43 163.05 l 207.15 163.05 l 207.87 163.05 l 208.60 163.05 l 209.33 163.05 l 210.07 163.05 l S 204.36 163.05 m 203.70 163.05 l S 210.07 163.05 m 210.80 163.05 l S 206.73 160.70 m 210.80 163.05 l 206.73 165.40 l S 201.00 172.35 m 202.56 175.40 l 204.25 178.71 l 206.03 182.20 l 207.87 185.80 l 209.71 189.44 l 211.54 193.05 l 213.31 196.56 l 214.99 199.90 l S 201.00 172.35 m 199.59 169.62 l S 214.99 199.90 m 216.55 203.00 l S 216.82 198.31 m 216.55 203.00 l 212.62 200.42 l S 229.65 163.05 m 231.05 163.05 l 232.49 163.05 l 233.96 163.05 l 235.45 163.05 l 236.95 163.05 l 238.44 163.05 l 239.92 163.05 l 241.38 163.05 l S 229.65 163.05 m 228.30 163.05 l S 241.38 163.05 m 242.80 163.05 l S 238.73 160.70 m 242.80 163.05 l 238.73 165.40 l S 264.19 164.03 m 265.36 164.17 l 266.53 164.30 l 267.72 164.42 l 268.91 164.52 l 270.10 164.62 l 271.28 164.72 l 272.46 164.80 l 273.63 164.89 l S 264.19 164.03 m 263.03 163.88 l S 266.75 166.75 m 263.03 163.88 l 267.38 162.09 l S 273.63 164.89 m 274.79 164.97 l S 270.90 162.34 m 274.79 164.97 l 270.56 167.02 l S 259.57 155.60 m 261.46 153.46 l 263.48 151.19 l 265.59 148.84 l 267.75 146.43 l 269.92 144.01 l 272.08 141.60 l 274.18 139.26 l 276.19 137.00 l S 259.57 155.60 m 257.84 157.58 l S 276.19 137.00 m 278.07 134.87 l S 273.61 136.37 m 278.07 134.87 l 277.14 139.48 l S 290.49 134.76 m 291.81 136.72 l 293.21 138.79 l 294.68 140.95 l 296.18 143.15 l 297.71 145.37 l 299.22 147.57 l 300.71 149.72 l 302.14 151.79 l S 290.49 134.76 m 289.28 132.96 l S 302.14 151.79 m 303.50 153.75 l S 303.11 149.07 m 303.50 153.75 l 299.25 151.75 l S 316.06 173.81 m 319.69 180.27 l 323.82 187.64 l 328.28 195.64 l 332.93 203.99 l 337.62 212.42 l 342.20 220.64 l 346.53 228.38 l 350.45 235.36 l S 316.06 173.81 m 313.07 168.53 l S 350.45 235.36 m 353.81 241.31 l S 353.85 236.61 m 353.81 241.31 l 349.76 238.92 l S 366.13 246.00 m 366.99 245.47 l 367.88 244.91 l 368.79 244.35 l 369.70 243.77 l 370.63 243.20 l 371.56 242.63 l 372.49 242.08 l 373.41 241.54 l S 366.13 246.00 m 365.29 246.51 l S 373.41 241.54 m 374.32 241.04 l S 369.62 240.97 m 374.32 241.04 l 371.91 245.07 l S 210.55 100.23 m 219.06 100.70 l 228.81 101.25 l 239.43 101.84 l 250.52 102.45 l 261.69 103.06 l 272.56 103.65 l 282.72 104.19 l 291.80 104.66 l S 210.55 100.23 m 203.70 99.85 l S 291.80 104.66 m 299.40 105.05 l S 295.45 102.50 m 299.40 105.05 l 295.21 107.19 l S 312.63 125.57 m 314.53 137.50 l 316.74 151.20 l 319.17 166.08 l 321.72 181.56 l 324.27 197.04 l 326.72 211.94 l 328.98 225.69 l 330.93 237.68 l S 312.63 125.57 m 311.16 115.99 l S 309.45 120.37 m 311.16 115.99 l 314.10 119.66 l S 330.93 237.68 m 332.48 247.33 l S 334.16 242.94 m 332.48 247.33 l 329.52 243.68 l S 336.54 266.37 m 337.08 268.31 l 337.63 270.37 l 338.20 272.53 l 338.77 274.76 l 339.34 277.04 l 339.91 279.34 l 340.46 281.65 l 341.00 283.94 l S 336.54 266.37 m 336.04 264.57 l S 341.00 283.94 m 341.51 286.18 l S 343.38 294.36 m 345.22 302.73 l 347.02 311.14 l 348.75 319.49 l 350.39 327.64 l 351.94 335.46 l 353.37 342.82 l 354.67 349.59 l 355.83 355.66 l S 343.38 294.36 m 341.51 286.18 l S 355.83 355.66 m 356.82 360.88 l S 358.37 356.45 m 356.82 360.88 l 353.75 357.32 l S 341.98 255.09 m 342.74 254.91 l 343.51 254.71 l 344.28 254.51 l 345.06 254.31 l 345.84 254.10 l 346.62 253.90 l 347.38 253.71 l 348.14 253.52 l S 341.98 255.09 m 341.23 255.26 l S 348.14 253.52 m 348.89 253.35 l S 344.39 251.97 m 348.89 253.35 l 345.45 256.55 l S 206.46 218.09 m 207.03 217.86 l 207.61 217.65 l 208.18 217.44 l 208.75 217.23 l 209.33 217.03 l 209.90 216.82 l 210.48 216.60 l 211.05 216.38 l S 206.46 218.09 m 205.88 218.33 l S 210.54 218.93 m 205.88 218.33 l 208.74 214.59 l S 211.05 216.38 m 211.63 216.14 l S 206.96 215.53 m 211.63 216.14 l 208.77 219.87 l S 226.53 221.24 m 228.55 224.52 l 230.76 228.09 l 233.11 231.85 l 235.55 235.73 l 238.02 239.66 l 240.47 243.55 l 242.84 247.32 l 245.10 250.88 l S 226.53 221.24 m 224.75 218.33 l S 245.10 250.88 m 247.17 254.17 l S 246.99 249.47 m 247.17 254.17 l 243.01 251.98 l S 232.67 211.60 m 237.79 211.47 l 243.57 211.40 l 249.88 211.42 l 256.60 211.55 l 263.62 211.84 l 270.82 212.30 l 278.07 212.97 l 285.27 213.87 l S 232.67 211.60 m 228.30 211.76 l S 285.27 213.87 m 292.29 215.04 l S 293.11 215.14 m 293.93 215.27 l 294.74 215.42 l 295.55 215.60 l 296.36 215.79 l 297.15 216.01 l 297.94 216.23 l 298.71 216.47 l 299.47 216.71 l S 293.11 215.14 m 292.29 215.04 l S 299.47 216.71 m 300.22 216.96 l S 297.09 213.45 m 300.22 216.96 l 295.62 217.92 l S 260.38 272.67 m 262.25 274.93 l 264.23 277.34 l 266.29 279.85 l 268.40 282.42 l 270.51 285.01 l 272.59 287.57 l 274.62 290.06 l 276.54 292.44 l S 260.38 272.67 m 258.66 270.59 l S 276.54 292.44 m 278.34 294.67 l S 277.61 290.02 m 278.34 294.67 l 273.96 292.98 l S 260.38 254.83 m 262.25 252.56 l 264.23 250.15 l 266.29 247.64 l 268.40 245.07 l 270.51 242.49 l 272.59 239.92 l 274.62 237.43 l 276.54 235.05 l S 260.38 254.83 m 258.66 256.91 l S 276.54 235.05 m 278.34 232.83 l S 273.96 234.52 m 278.34 232.83 l 277.61 237.47 l S 292.76 299.82 m 293.52 299.51 l 294.29 299.21 l 295.06 298.92 l 295.84 298.63 l 296.62 298.35 l 297.40 298.05 l 298.17 297.76 l 298.92 297.45 l S 292.76 299.82 m 292.01 300.14 l S 298.92 297.45 m 299.67 297.13 l S 295.00 296.58 m 299.67 297.13 l 296.86 300.90 l S 293.03 223.43 m 293.76 223.33 l 294.50 223.22 l 295.22 223.10 l 295.95 222.98 l 296.66 222.85 l 297.36 222.74 l 298.05 222.62 l 298.73 222.52 l S 293.03 223.43 m 292.29 223.52 l S 298.73 222.52 m 299.40 222.43 l S 295.05 220.65 m 299.40 222.43 l 295.68 225.30 l S 321.33 223.06 m 326.48 224.11 l 332.18 225.28 l 338.26 226.52 l 344.55 227.80 l 350.88 229.09 l 357.08 230.36 l 362.98 231.56 l 368.42 232.67 l S 321.33 223.06 m 316.90 222.16 l S 368.42 232.67 m 373.22 233.65 l S 369.71 230.53 m 373.22 233.65 l 368.77 235.14 l S 314.90 285.73 m 316.28 283.73 l 317.74 281.59 l 319.25 279.35 l 320.79 277.05 l 322.36 274.73 l 323.92 272.42 l 325.45 270.15 l 326.95 267.98 l S 314.90 285.73 m 313.62 287.55 l S 326.95 267.98 m 328.38 265.94 l S 324.12 267.92 m 328.38 265.94 l 327.97 270.62 l S 317.56 294.47 m 318.24 294.53 l 318.93 294.58 l 319.64 294.62 l 320.35 294.67 l 321.07 294.71 l 321.80 294.75 l 322.53 294.80 l 323.27 294.87 l S 317.56 294.47 m 316.90 294.39 l S 323.27 294.87 m 324.01 294.94 l S 320.19 292.19 m 324.01 294.94 l 319.72 296.87 l S 294.98 262.51 m 297.92 262.08 l 301.07 261.64 l 304.36 261.19 l 307.74 260.74 l 311.15 260.29 l 314.54 259.84 l 317.85 259.40 l 321.02 258.97 l S 294.98 262.51 m 292.29 262.93 l S 321.02 258.97 m 324.01 258.55 l S 319.65 256.79 m 324.01 258.55 l 320.30 261.44 l S 290.75 270.94 m 292.02 272.49 l 293.36 274.10 l 294.74 275.77 l 296.15 277.46 l 297.57 279.17 l 298.97 280.86 l 300.35 282.51 l 301.68 284.11 l S 290.75 270.94 m 289.55 269.49 l S 301.68 284.11 m 302.95 285.64 l S 302.15 281.01 m 302.95 285.64 l 298.54 284.01 l S 203.71 357.64 m 204.57 357.10 l 205.46 356.55 l 206.37 355.98 l 207.28 355.41 l 208.21 354.84 l 209.14 354.27 l 210.07 353.72 l 210.99 353.18 l S 203.71 357.64 m 202.88 358.15 l S 210.99 353.18 m 211.90 352.67 l S 207.20 352.61 m 211.90 352.67 l 209.49 356.71 l S 206.37 366.57 m 210.06 368.34 l 214.11 370.26 l 218.42 372.28 l 222.87 374.36 l 227.36 376.45 l 231.79 378.52 l 236.05 380.52 l 240.03 382.41 l S 206.37 366.57 m 203.15 364.99 l S 240.03 382.41 m 243.62 384.14 l S 240.97 380.26 m 243.62 384.14 l 238.93 384.49 l S 225.59 335.57 m 227.90 329.54 l 230.49 322.78 l 233.28 315.50 l 236.17 307.94 l 239.07 300.31 l 241.90 292.84 l 244.58 285.74 l 247.00 279.26 l S 225.59 335.57 m 223.66 340.63 l S 247.00 279.26 m 249.09 273.60 l S 245.47 276.60 m 249.09 273.60 l 249.88 278.23 l S 265.15 390.08 m 270.89 390.97 l 277.30 391.97 l 284.18 393.04 l 291.33 394.16 l 298.55 395.29 l 305.63 396.39 l 312.37 397.43 l 318.56 398.37 l S 265.15 390.08 m 260.30 389.34 l S 318.56 398.37 m 324.01 399.19 l S 320.33 396.26 m 324.01 399.19 l 319.63 400.91 l S 343.94 397.78 m 346.92 396.83 l 350.13 395.82 l 353.50 394.76 l 356.96 393.68 l 360.45 392.59 l 363.91 391.52 l 367.28 390.46 l 370.50 389.46 l S 343.94 397.78 m 341.23 398.64 l S 370.50 389.46 m 373.50 388.52 l S 368.91 387.49 m 373.50 388.52 l 370.32 391.98 l S Q endstream endobj 153 0 obj << /CreationDate (D:20061226132450) /ModDate (D:20061226132450) /Title (R Graphics Output) /Producer (R 2.4.1) /Creator (R) >> endobj 154 0 obj << /Type /Font /Subtype /Type1 /Name /F1 /BaseFont /ZapfDingbats >> endobj 155 0 obj << /Type /Font /Subtype /Type1 /Name /F2 /BaseFont /Helvetica /Encoding 157 0 R >> endobj 156 0 obj 34256 endobj 157 0 obj << /Type /Encoding /BaseEncoding /WinAnsiEncoding /Differences [ 45/minus 96/quoteleft 144/dotlessi/grave/acute/circumflex/tilde/macron/breve/dotaccent/dieresis/.notdef/ring/cedilla/.notdef/hungarumlaut/ogonek/caron/space] >> endobj 152 0 obj << /D [150 0 R /XYZ 133.7684 692.1046 null] >> endobj 149 0 obj << /Font << /F51 50 0 R /F55 62 0 R /F8 43 0 R /F49 46 0 R >> /XObject << /Im3 148 0 R >> /ProcSet [ /PDF /Text ] >> endobj 160 0 obj << /Length 2022 /Filter /FlateDecode >> stream xڵX[o6~ϯ0>h[ERNѤi-݇4|iƖ1H%RݬA3Hwυ/ϟ=厚Hiו3GR[}tyݬTv*]~uZFYwթQ*^㷒tEr{YNq&p?eYw['qppQ;vȮp]KGy?GJ卵 @P08w@(elHy#l3U7gi aq;>_V0P ǽ,o;\d31`@K@CqQ}y8ukwIl#PJ$X k%i.7-$veG4S_{䝡s+W7)t1_'[80 zWh#A(\ Haq7;F;:?J0E71oW:s˼ЍUmY Fp;i{( [UO.;!/3`'0mGV_1e*bfb'邕܋1xLߗyWQpUvڮR\]fD#ϴDwF 7yH!>c$ b` &k j j+rUu/8Í8V$pY"ђ~׻QBj>)*!dDHHtaDM2 'LT6Y[kndO>_y-o?j>X!=zG0y %\l&m7ٓAضjn2UdvjkE-8*eLx}$vY+m$ uilyotRLlޕR\7kBWsXV4ee@M4exa Cȝ-L x⠾SՄ~$4Lxiiv4t6Ha U,I{+K&6 u_٩S,捊l~yjl@9='a/)n96F'@Bt2 0u402&xɅy3WMb?x<"M{A>ނݹmTɹy⑍\<]R2L Kn*\SO6^T?aAlT]#%o<7F\Ukڇ6{WSJ=D5 e[k7r"#QH͝[vH6f.Ug+G{/«&T_Y&AQti+}x8mtnk^LN 746Jq{t6Ir^&Ng ԩ9jͧO]p-.ۊrr|g;qJw-@wLXqm-9NO\N?gU@rRN4Oi-94Γo=ɫяPL7O-ك}r xem*kJ—]mJ;s0 ER=endstream endobj 159 0 obj << /Type /Page /Contents 160 0 R /Resources 158 0 R /MediaBox [0 0 612 792] /Parent 135 0 R >> endobj 161 0 obj << /D [159 0 R /XYZ 133.7684 692.1046 null] >> endobj 158 0 obj << /Font << /F8 43 0 R /F49 46 0 R /F51 50 0 R /F55 62 0 R /F50 142 0 R >> /ProcSet [ /PDF /Text ] >> endobj 164 0 obj << /Length 436 /Filter /FlateDecode >> stream xڭUn0V!0& *^UZ.Uc{ Yޛ7 JFB*H4'LUA(٥\HAȿo0 XMɅ 0,u \x45i&c4EcN> ႆ]9}żSr=?!B@IY>q͵tBZaE>eYw]u>zW5sЩUA-)Leh2 00W3*H{y-5-꘼IP\GGNi> endobj 165 0 obj << /D [163 0 R /XYZ 133.7684 692.1046 null] >> endobj 162 0 obj << /Font << /F51 50 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 168 0 obj << /Length 595 /Filter /FlateDecode >> stream xڭVMO@WX`ǺI 6Qb*$ &J8x?JFț7tgAq! 4HEP]C 0JO3aI8dxS_ b,.R"q8IUA9q3q.B*T9Sh99p4|.ad0w27+'235+fs{vjk _}afJx^^\}<-M3V>Z=KfJx|-=2fIrs2t{|L] )3#^Z==C)jq0W=%Sv,rcfD}$c[~qq#[+|-?T6~>u5ʞoT - ye˖ew~w_/6-/lk".}iǿz:,epQRcTiendstream endobj 167 0 obj << /Type /Page /Contents 168 0 R /Resources 166 0 R /MediaBox [0 0 612 792] /Parent 135 0 R >> endobj 169 0 obj << /D [167 0 R /XYZ 133.7684 692.1046 null] >> endobj 166 0 obj << /Font << /F51 50 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 172 0 obj << /Length 361 /Filter /FlateDecode >> stream xVQK0~߯CЬwKNQоT|P{m3::@>._]ՓAy-ZU:,WI 2 U@{y :mYvC&x|v~G$X ? ;UCkpaI{(Mʨk녜@3`&Zļj ':u(u#±ԫv>iC' *ӏj/UFxZ.;aoHve!8 BP[hB^[L,O+(%g#ZZCdi1_7Nrmm8wm_}ծ2(5s>m֓ozendstream endobj 171 0 obj << /Type /Page /Contents 172 0 R /Resources 170 0 R /MediaBox [0 0 612 792] /Parent 174 0 R >> endobj 173 0 obj << /D [171 0 R /XYZ 133.7684 692.1046 null] >> endobj 170 0 obj << /Font << /F51 50 0 R /F54 63 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 177 0 obj << /Length 326 /Filter /FlateDecode >> stream xڵUMK0WL>zwU ~AXW6fkɛoWlnhYf̭̚\2U; ˘=, 5y%>RaPZ>V'^6pAx 3u9BkZR1;%E袽k6a~.$}P1UMC;%]1DQ4hJ_qV`PQ}8I>:j4N7_xg x 4bPGU!1gҭ:w5w 5w`6w?JkdBtZ5h7IY%_(Lendstream endobj 176 0 obj << /Type /Page /Contents 177 0 R /Resources 175 0 R /MediaBox [0 0 612 792] /Parent 174 0 R >> endobj 178 0 obj << /D [176 0 R /XYZ 133.7684 692.1046 null] >> endobj 175 0 obj << /Font << /F51 50 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 181 0 obj << /Length 332 /Filter /FlateDecode >> stream xڽVj0+D>X˽u jttB-;R'6$Ãfi`|fT+xQ3@k#V9G˧L $|~T(|!, o!1@ϿGy N5X Ez\O =8b&W,1!b V6sZMBj ^@&VUƱʥ]ႠD͉ ɳe s/bĦorm`7︜z\hWe¼mXMg0j斾f_Sd>ߧa,zE"Y㓩57DJFv]endstream endobj 180 0 obj << /Type /Page /Contents 181 0 R /Resources 179 0 R /MediaBox [0 0 612 792] /Parent 174 0 R >> endobj 182 0 obj << /D [180 0 R /XYZ 133.7684 692.1046 null] >> endobj 179 0 obj << /Font << /F51 50 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 185 0 obj << /Length 355 /Filter /FlateDecode >> stream xڽV=o0VmwK2J[%UJ=&PbhhOwgXɬl$~F1H ) ՛trAYz`x޿\`_ܑt=ַ@9!ǾeML f Li=IUjyCek)))92ӭm _W#uPO/1@aC 3qC"NHz/|}+?0 .OA؏:KLU(=AA<" mP qhYRb8z2.vmM|!Uendstream endobj 184 0 obj << /Type /Page /Contents 185 0 R /Resources 183 0 R /MediaBox [0 0 612 792] /Parent 174 0 R >> endobj 186 0 obj << /D [184 0 R /XYZ 133.7684 692.1046 null] >> endobj 183 0 obj << /Font << /F51 50 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 189 0 obj << /Length 322 /Filter /FlateDecode >> stream xڽMO0 5NnV`L %!qAV[!ᑢ:vuCLJqA3ȄhFAd~yd"}%ވ,G-% z~@%qD"<_{,;$=;Nhɝ(FQlK(jFW;$['5Qվ(ujc ]] [:#YUW}@a*[V ͩ5Ѷ*p yMѾGp>aOY}ų@l_Zsk[kjv&3| endstream endobj 188 0 obj << /Type /Page /Contents 189 0 R /Resources 187 0 R /MediaBox [0 0 612 792] /Parent 174 0 R >> endobj 190 0 obj << /D [188 0 R /XYZ 133.7684 692.1046 null] >> endobj 187 0 obj << /Font << /F51 50 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 193 0 obj << /Length 449 /Filter /FlateDecode >> stream xVMO0 WTC{hՄH8 !4`C$zkڲri8ytp280A,1VFi&,A:~#s2_cĄ7S1 qD\ پhֿ͔.*A  jo&5Zw!~K䯫dcIG6Q \%}氷{}Uƥo{,.[Ő+dr]%COMw'}`sw]7Ctqٻ"h7-JO*=Idj䳠OQ~-e=Y秔͟$eYJ~soQIᶢ(KJ&!pֲ%X$Tok8ѭ0|(|:WAZ[ݖ-"9OŖ`FK]? 7Nsdendstream endobj 192 0 obj << /Type /Page /Contents 193 0 R /Resources 191 0 R /MediaBox [0 0 612 792] /Parent 174 0 R >> endobj 194 0 obj << /D [192 0 R /XYZ 133.7684 692.1046 null] >> endobj 191 0 obj << /Font << /F51 50 0 R /F54 63 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 197 0 obj << /Length 339 /Filter /FlateDecode >> stream xڽV=O0+,Đqo* 0,|IH FQ0<ɝ^].9|)2H*}D1H ) ]y=#+ 1elkSد>p=E5F@,1u=E].@6f9}pمR`Jk׋8Kmbk)_^z )Rbz&2x,O*N$"ҝ&Zel쫐#]̭zWAHDOëܑhB#7 '#3Tn'Cw=~i]+Hj}f<\dv1Gfs[̗X+NA?VƟs5)mh1endstream endobj 196 0 obj << /Type /Page /Contents 197 0 R /Resources 195 0 R /MediaBox [0 0 612 792] /Parent 199 0 R >> endobj 198 0 obj << /D [196 0 R /XYZ 133.7684 692.1046 null] >> endobj 195 0 obj << /Font << /F51 50 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 202 0 obj << /Length 466 /Filter /FlateDecode >> stream xVN0+"ġ=d#Rp@eTglO$M""TOu"ww1}Fl"}oB{tߋ3S/K13Y!B& zFZPbV+8n8W߳0&P]9ٶ+fnP5eRvTf-Rb$.dMTZdu tfEP ے,%#XfE 1ʍ'(sE>T%fqX"[`Z(5"LqǴPo Z-u 3zh4 72dJR&ynaMh#5\TK//ޮ';%Ûgp*^cDgmz4z=4=<)R_CŅ55cTָro3%endstream endobj 201 0 obj << /Type /Page /Contents 202 0 R /Resources 200 0 R /MediaBox [0 0 612 792] /Parent 199 0 R >> endobj 203 0 obj << /D [201 0 R /XYZ 133.7684 692.1046 null] >> endobj 200 0 obj << /Font << /F51 50 0 R /F54 63 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 206 0 obj << /Length 584 /Filter /FlateDecode >> stream xVKo@WXV![ϾVPs@QTJC8ݝƎ$5ogw:M)K5Av,FZ% %l~ ZƊh_wbS.Ok] n3X7#q"M61K(ߪ:N4'2nr\ n-~C.K/+ao3(CNK9G8U.|SY%fw rGb<]8-DCGFVF&,6`vyTJ1S iެnS\cY.X ?H͊:aFKldh)A2gz]I\Giz-kml> rz )xAɋJ$ʕ(|K6I!fR5וչ[B!Vʎ$Z'|ZO"I}3hzȈC@KL=#eqk_I6z [b>!Y{H^;kv2O[^3P vdGukOƝ;v61Z3H> endobj 207 0 obj << /D [205 0 R /XYZ 133.7684 692.1046 null] >> endobj 204 0 obj << /Font << /F51 50 0 R /F54 63 0 R /F8 43 0 R >> /ProcSet [ /PDF /Text ] >> endobj 211 0 obj << /Length 764 /Filter /FlateDecode >> stream xڭV[OP ~WDhF9$'HM6iJjVM[ڴI;:؟/n? O*OM nmR4ɔ zEAVy&ELl|$drd2g}ؖ ?#7 'XْBguvYFܵ-Xjvףo ?vܣWLx+v^ALH;\B\.}=-dPG'9%ʝ͡BgB 'Q$i8,Ƽ7\bq(0悁+fQ\ H{ L>EƇ%_K&ܨJa)dZRQ+CII6sjD;xfU7'/쟝Ɛ[%t>A=,_(>+:LXg@(1Pm88Ů )fJJD`T B՚dxEnJ(Ht$:{J+_P5tlE tc'Ac 4}TP=v3ixU=>Z ^[xcF/|tHe{XAW!kGP/k(Q1s>8?#%te,Wİ|r*YB;F yYw;귬yfN+`[ɠnƍyO{>鎟4U>sPf0,)i`jaendstream endobj 210 0 obj << /Type /Page /Contents 211 0 R /Resources 209 0 R /MediaBox [0 0 612 792] /Parent 199 0 R >> endobj 212 0 obj << /D [210 0 R /XYZ 133.7684 692.1046 null] >> endobj 209 0 obj << /Font << /F51 50 0 R /F8 43 0 R /F49 46 0 R /F55 62 0 R >> /ProcSet [ /PDF /Text ] >> endobj 215 0 obj << /Length 1642 /Filter /FlateDecode >> stream xڅXYoF~>HhD@mZE}H@KdεCtrwvf9>F3mm$F{;[ߟ;T;a뙖2qgf2j^UY_")RV3$l*=[m>YxK7i{;xyúű */L>RDqک:V<̾Wzg{DRרub1ӼZ|YpN Aaw8k~Rt憝7EK[3xk\G\ʖC5ag3(+uN(Yy/'L@0I,Ӑ0\SUs Bp]MKcs<6r. 4ƣ}Ч@Q1cPiѭ!*JPRRjgV6 ]3L(07rLn(>BÒ7 ˡetoDZ%; *:GM3yCK ]x; <Hb `P(%%8J&:; B!a`EK2ny 6 w(+e#y~x^HɯC)FT: Q:Ņ%RGXIr!p+뙅CӍs\xnH\5~Ac ߤirF@`NvEvwhjPt*pE&Noű=9m[G'^N-';CH]!0S.&dſ Q犔a{WŁu}9ɨX59b .\\n0ѽc*m0 3ГbLjQ }֎W;52@D%""&􅁒G+WHS'zH^f\`|=R|2J/=MH{>w0v9F[u f)o$P=$4K_H!UiRz۫$wDg_ƝN hʉ _b5M'aUjrOwݩMAOx~0%$Z=+]rBεR}4?kAB$GcG5:OüpD'2Y 3?ː->ҵz';E:?CChj_eM]]qle(mG>|I/ 4M 5 yVQ?fendstream endobj 214 0 obj << /Type /Page /Contents 215 0 R /Resources 213 0 R /MediaBox [0 0 612 792] /Parent 199 0 R >> endobj 208 0 obj << /Type /XObject /Subtype /Form /FormType 1 /PTEX.FileName (./layingOutPathways-plotSubgraph.pdf) /PTEX.PageNumber 1 /PTEX.InfoDict 217 0 R /Matrix [1.00000000 0.00000000 0.00000000 1.00000000 0.00000000 0.00000000] /BBox [0.00000000 0.00000000 432.00000000 432.00000000] /Resources << /ProcSet [ /PDF /Text ] /Font << /F1 218 0 R /F2 219 0 R >> /ExtGState << >>>> /Length 220 0 R >> stream q Q q 0.72 0.72 430.56 430.56 re W n 1.000 1.000 1.000 rg 0.000 0.000 0.000 RG 0.75 w [] 0 d 1 J 1 j 10.00 M BT /F1 1 Tf 2 Tr 19.98 0 0 19.98 25.05 130.13 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 30.63 136.34 Tm (ITGB) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 25.05 58.71 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 30.63 64.93 Tm (ITGA) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 25.05 94.55 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 31.47 100.77 Tm (ILK) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 25.05 23.14 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 30.98 29.36 Tm (CAV) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 97.20 278.43 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 103.00 284.65 Tm (SHC) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 121.25 278.43 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 127.16 284.65 Tm (FYN) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 121.25 319.20 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 126.44 325.41 Tm (GRB2) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 145.29 319.75 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 151.10 325.96 Tm (SOS) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 169.34 320.57 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 173.62 326.80 Tm (Ha-Ras) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 193.39 321.66 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 199.75 327.88 Tm (Raf) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 217.44 321.66 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 223.19 327.88 Tm (MEK) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 248.70 372.28 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 254.56 378.50 Tm (ERK) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 352.11 364.35 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 357.30 370.56 Tm (MYLK) Tj 1.000 1.000 1.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 376.16 352.85 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 381.88 359.07 Tm (MYO) Tj 1.000 1.000 1.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 49.10 130.13 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 54.32 136.34 Tm (ACTN) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 73.15 130.13 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 79.12 136.34 Tm (VCL) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 97.20 130.13 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 103.22 136.34 Tm (TLN) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 97.20 94.55 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 103.05 100.77 Tm (PXN) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 97.20 240.39 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 103.17 246.61 Tm (ZYX) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 121.25 240.39 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 126.57 246.61 Tm (VASP) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 97.20 204.55 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 101.89 210.77 Tm (SH3D5) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 97.20 168.98 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 103.11 175.20 Tm (TNS) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 121.25 203.46 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 126.38 209.67 Tm (CAPN) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 145.29 210.02 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 149.76 216.24 Tm (CAPNS) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 169.34 216.04 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 175.14 222.26 Tm (SRC) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 193.39 204.55 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 199.44 210.77 Tm (FAK) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 217.44 208.11 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 222.02 214.32 Tm (BCAR1) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 193.39 286.09 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 199.25 292.31 Tm (CSK) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 248.70 300.87 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 254.50 307.08 Tm (CRK) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 279.96 331.51 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 284.43 337.73 Tm (DOCK1) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 304.01 308.80 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 309.26 315.02 Tm (GRF2) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 328.06 298.40 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 333.36 304.62 Tm (RAP1) Tj 1.000 1.000 1.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 352.11 258.73 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 358.13 264.96 Tm (JNK) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 279.96 286.09 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 285.65 292.31 Tm (GIT2) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 304.01 272.96 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 307.76 279.17 Tm (ARHGEF) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 328.06 258.73 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 334.09 264.94 Tm (PAK) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 193.39 168.98 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 199.64 175.42 Tm (p85) Tj 1.000 1.000 1.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 217.44 169.80 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 223.13 176.24 Tm (p110) Tj ET 1.000 1.000 1.000 rg 242.19 203.55 m 242.48 205.03 l 242.77 205.63 l 243.06 206.08 l 243.35 206.46 l 243.64 206.79 l 243.93 207.08 l 244.23 207.34 l 244.52 207.58 l 244.81 207.80 l 245.10 208.00 l 245.39 208.19 l 245.68 208.37 l 245.98 208.54 l 246.27 208.70 l 246.56 208.85 l 246.85 208.99 l 247.14 209.12 l 247.43 209.25 l 247.72 209.37 l 248.02 209.48 l 248.31 209.59 l 248.60 209.69 l 248.89 209.79 l 249.18 209.88 l 249.47 209.97 l 249.76 210.05 l 250.06 210.13 l 250.35 210.20 l 250.64 210.27 l 250.93 210.34 l 251.22 210.40 l 251.51 210.46 l 251.81 210.52 l 252.10 210.57 l 252.39 210.61 l 252.68 210.66 l 252.97 210.70 l 253.26 210.74 l 253.55 210.77 l 253.85 210.80 l 254.14 210.83 l 254.43 210.85 l 254.72 210.87 l 255.01 210.89 l 255.30 210.91 l 255.59 210.92 l 255.89 210.93 l 256.18 210.93 l 256.47 210.94 l 256.76 210.94 l 257.05 210.93 l 257.34 210.93 l 257.64 210.92 l 257.93 210.91 l 258.22 210.89 l 258.51 210.87 l 258.80 210.85 l 259.09 210.83 l 259.38 210.80 l 259.68 210.77 l 259.97 210.74 l 260.26 210.70 l 260.55 210.66 l 260.84 210.61 l 261.13 210.57 l 261.42 210.52 l 261.72 210.46 l 262.01 210.40 l 262.30 210.34 l 262.59 210.27 l 262.88 210.20 l 263.17 210.13 l 263.46 210.05 l 263.76 209.97 l 264.05 209.88 l 264.34 209.79 l 264.63 209.69 l 264.92 209.59 l 265.21 209.48 l 265.51 209.37 l 265.80 209.25 l 266.09 209.12 l 266.38 208.99 l 266.67 208.85 l 266.96 208.70 l 267.25 208.54 l 267.55 208.37 l 267.84 208.19 l 268.13 208.00 l 268.42 207.80 l 268.71 207.58 l 269.00 207.34 l 269.29 207.08 l 269.59 206.79 l 269.88 206.46 l 270.17 206.08 l 270.46 205.63 l 270.75 205.03 l 271.04 203.55 l 271.04 203.55 l 270.75 202.07 l 270.46 201.47 l 270.17 201.02 l 269.88 200.64 l 269.59 200.31 l 269.29 200.02 l 269.00 199.76 l 268.71 199.52 l 268.42 199.30 l 268.13 199.10 l 267.84 198.91 l 267.55 198.73 l 267.25 198.56 l 266.96 198.40 l 266.67 198.25 l 266.38 198.11 l 266.09 197.98 l 265.80 197.85 l 265.51 197.73 l 265.21 197.62 l 264.92 197.51 l 264.63 197.41 l 264.34 197.31 l 264.05 197.22 l 263.76 197.13 l 263.46 197.05 l 263.17 196.97 l 262.88 196.90 l 262.59 196.83 l 262.30 196.76 l 262.01 196.70 l 261.72 196.64 l 261.42 196.58 l 261.13 196.53 l 260.84 196.49 l 260.55 196.44 l 260.26 196.40 l 259.97 196.36 l 259.68 196.33 l 259.38 196.30 l 259.09 196.27 l 258.80 196.25 l 258.51 196.23 l 258.22 196.21 l 257.93 196.19 l 257.64 196.18 l 257.34 196.17 l 257.05 196.17 l 256.76 196.16 l 256.47 196.16 l 256.18 196.17 l 255.89 196.17 l 255.59 196.18 l 255.30 196.19 l 255.01 196.21 l 254.72 196.23 l 254.43 196.25 l 254.14 196.27 l 253.85 196.30 l 253.55 196.33 l 253.26 196.36 l 252.97 196.40 l 252.68 196.44 l 252.39 196.49 l 252.10 196.53 l 251.81 196.58 l 251.51 196.64 l 251.22 196.70 l 250.93 196.76 l 250.64 196.83 l 250.35 196.90 l 250.06 196.97 l 249.76 197.05 l 249.47 197.13 l 249.18 197.22 l 248.89 197.31 l 248.60 197.41 l 248.31 197.51 l 248.02 197.62 l 247.72 197.73 l 247.43 197.85 l 247.14 197.98 l 246.85 198.11 l 246.56 198.25 l 246.27 198.40 l 245.98 198.56 l 245.68 198.73 l 245.39 198.91 l 245.10 199.10 l 244.81 199.30 l 244.52 199.52 l 244.23 199.76 l 243.93 200.02 l 243.64 200.31 l 243.35 200.64 l 243.06 201.02 l 242.77 201.47 l 242.48 202.07 l 242.19 203.55 l h f 242.19 203.55 m 242.48 205.03 l 242.77 205.63 l 243.06 206.08 l 243.35 206.46 l 243.64 206.79 l 243.93 207.08 l 244.23 207.34 l 244.52 207.58 l 244.81 207.80 l 245.10 208.00 l 245.39 208.19 l 245.68 208.37 l 245.98 208.54 l 246.27 208.70 l 246.56 208.85 l 246.85 208.99 l 247.14 209.12 l 247.43 209.25 l 247.72 209.37 l 248.02 209.48 l 248.31 209.59 l 248.60 209.69 l 248.89 209.79 l 249.18 209.88 l 249.47 209.97 l 249.76 210.05 l 250.06 210.13 l 250.35 210.20 l 250.64 210.27 l 250.93 210.34 l 251.22 210.40 l 251.51 210.46 l 251.81 210.52 l 252.10 210.57 l 252.39 210.61 l 252.68 210.66 l 252.97 210.70 l 253.26 210.74 l 253.55 210.77 l 253.85 210.80 l 254.14 210.83 l 254.43 210.85 l 254.72 210.87 l 255.01 210.89 l 255.30 210.91 l 255.59 210.92 l 255.89 210.93 l 256.18 210.93 l 256.47 210.94 l 256.76 210.94 l 257.05 210.93 l 257.34 210.93 l 257.64 210.92 l 257.93 210.91 l 258.22 210.89 l 258.51 210.87 l 258.80 210.85 l 259.09 210.83 l 259.38 210.80 l 259.68 210.77 l 259.97 210.74 l 260.26 210.70 l 260.55 210.66 l 260.84 210.61 l 261.13 210.57 l 261.42 210.52 l 261.72 210.46 l 262.01 210.40 l 262.30 210.34 l 262.59 210.27 l 262.88 210.20 l 263.17 210.13 l 263.46 210.05 l 263.76 209.97 l 264.05 209.88 l 264.34 209.79 l 264.63 209.69 l 264.92 209.59 l 265.21 209.48 l 265.51 209.37 l 265.80 209.25 l 266.09 209.12 l 266.38 208.99 l 266.67 208.85 l 266.96 208.70 l 267.25 208.54 l 267.55 208.37 l 267.84 208.19 l 268.13 208.00 l 268.42 207.80 l 268.71 207.58 l 269.00 207.34 l 269.29 207.08 l 269.59 206.79 l 269.88 206.46 l 270.17 206.08 l 270.46 205.63 l 270.75 205.03 l 271.04 203.55 l 271.04 203.55 l 270.75 202.07 l 270.46 201.47 l 270.17 201.02 l 269.88 200.64 l 269.59 200.31 l 269.29 200.02 l 269.00 199.76 l 268.71 199.52 l 268.42 199.30 l 268.13 199.10 l 267.84 198.91 l 267.55 198.73 l 267.25 198.56 l 266.96 198.40 l 266.67 198.25 l 266.38 198.11 l 266.09 197.98 l 265.80 197.85 l 265.51 197.73 l 265.21 197.62 l 264.92 197.51 l 264.63 197.41 l 264.34 197.31 l 264.05 197.22 l 263.76 197.13 l 263.46 197.05 l 263.17 196.97 l 262.88 196.90 l 262.59 196.83 l 262.30 196.76 l 262.01 196.70 l 261.72 196.64 l 261.42 196.58 l 261.13 196.53 l 260.84 196.49 l 260.55 196.44 l 260.26 196.40 l 259.97 196.36 l 259.68 196.33 l 259.38 196.30 l 259.09 196.27 l 258.80 196.25 l 258.51 196.23 l 258.22 196.21 l 257.93 196.19 l 257.64 196.18 l 257.34 196.17 l 257.05 196.17 l 256.76 196.16 l 256.47 196.16 l 256.18 196.17 l 255.89 196.17 l 255.59 196.18 l 255.30 196.19 l 255.01 196.21 l 254.72 196.23 l 254.43 196.25 l 254.14 196.27 l 253.85 196.30 l 253.55 196.33 l 253.26 196.36 l 252.97 196.40 l 252.68 196.44 l 252.39 196.49 l 252.10 196.53 l 251.81 196.58 l 251.51 196.64 l 251.22 196.70 l 250.93 196.76 l 250.64 196.83 l 250.35 196.90 l 250.06 196.97 l 249.76 197.05 l 249.47 197.13 l 249.18 197.22 l 248.89 197.31 l 248.60 197.41 l 248.31 197.51 l 248.02 197.62 l 247.72 197.73 l 247.43 197.85 l 247.14 197.98 l 246.85 198.11 l 246.56 198.25 l 246.27 198.40 l 245.98 198.56 l 245.68 198.73 l 245.39 198.91 l 245.10 199.10 l 244.81 199.30 l 244.52 199.52 l 244.23 199.76 l 243.93 200.02 l 243.64 200.31 l 243.35 200.64 l 243.06 201.02 l 242.77 201.47 l 242.48 202.07 l 242.19 203.55 l 242.19 203.55 l S BT 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 240.11 203.05 Tm (Phosphatidylinositol signaling system) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 279.96 214.40 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 286.03 220.62 Tm (VAV) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 279.96 178.83 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 284.60 185.05 Tm (PDPK1) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 304.01 178.83 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 309.98 185.05 Tm (AKT) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 304.01 227.53 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 309.84 233.75 Tm (RAC) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 279.96 250.25 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 284.60 256.46 Tm (CDC42) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 193.39 250.25 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 199.08 256.46 Tm (RHO) Tj 1.000 1.000 1.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 217.44 248.88 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 223.18 255.11 Tm (PI5K) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 248.70 336.44 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 253.75 342.65 Tm (ROCK) Tj 1.000 1.000 1.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 328.06 341.63 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 332.53 347.85 Tm (MYO-P) Tj 1.000 1.000 1.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 400.20 186.77 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 400.62 193.00 Tm (cell maintenance) Tj 1.000 1.000 1.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 400.20 227.53 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 403.23 233.97 Tm (cell motility) Tj 1.000 1.000 1.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 400.20 352.85 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 404.81 359.09 Tm (F-actin) Tj 1.000 1.000 1.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 279.96 387.06 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 280.92 393.47 Tm (cell proliferation) Tj ET 27.34 126.34 m 26.51 124.57 l 25.67 122.72 l 24.85 120.82 l 24.05 118.86 l 23.29 116.88 l 22.58 114.88 l 21.95 112.87 l 21.40 110.86 l S 27.34 126.34 m 28.16 128.03 l S 28.50 123.45 m 28.16 128.03 l 24.36 125.45 l S 21.40 110.86 m 20.94 108.88 l S 20.65 107.04 m 20.43 105.42 l 20.27 103.98 l 20.17 102.65 l 20.14 101.39 l 20.17 100.13 l 20.27 98.83 l 20.43 97.42 l 20.65 95.87 l S 20.65 107.04 m 20.94 108.88 l S 20.65 95.87 m 20.94 94.10 l S 21.40 92.04 m 21.95 89.98 l 22.58 87.92 l 23.29 85.88 l 24.05 83.87 l 24.85 81.91 l 25.67 79.99 l 26.51 78.14 l 27.34 76.36 l S 21.40 92.04 m 20.94 94.10 l S 27.34 76.36 m 28.16 74.67 l S 24.36 77.26 m 28.16 74.67 l 28.50 79.25 l S 32.97 125.38 m 32.97 123.85 l 32.97 122.32 l 32.97 120.79 l 32.97 119.27 l 32.97 117.76 l 32.97 116.23 l 32.97 114.70 l 32.97 113.17 l S 32.97 125.38 m 32.97 126.94 l S 35.26 122.96 m 32.97 126.94 l 30.67 122.96 l S 32.97 113.17 m 32.97 111.61 l S 30.67 115.59 m 32.97 111.61 l 35.26 115.59 l S 27.34 126.34 m 26.51 124.57 l 25.67 122.72 l 24.85 120.82 l 24.05 118.86 l 23.29 116.88 l 22.58 114.88 l 21.95 112.87 l 21.40 110.86 l S 27.34 126.34 m 28.16 128.03 l S 28.50 123.45 m 28.16 128.03 l 24.36 125.45 l S 21.40 110.86 m 20.94 108.88 l S 19.79 102.67 m 18.89 97.20 l 18.25 92.31 l 17.86 87.79 l 17.74 83.46 l 17.86 79.15 l 18.25 74.66 l 18.89 69.80 l 19.79 64.40 l S 19.79 102.67 m 20.94 108.88 l S 19.79 64.40 m 20.94 58.26 l S 21.40 56.27 m 21.95 54.27 l 22.58 52.26 l 23.29 50.25 l 24.05 48.27 l 24.85 46.32 l 25.67 44.41 l 26.51 42.57 l 27.34 40.79 l S 21.40 56.27 m 20.94 58.26 l S 27.34 40.79 m 28.16 39.10 l S 24.36 41.69 m 28.16 39.10 l 28.50 43.68 l S 42.04 155.47 m 47.76 167.28 l 54.36 180.91 l 61.55 195.76 l 69.04 211.21 l 76.52 226.67 l 83.72 241.51 l 90.32 255.14 l 96.03 266.95 l S 42.04 155.47 m 37.51 146.09 l S 37.17 150.67 m 37.51 146.09 l 41.31 148.67 l S 96.03 266.95 m 100.57 276.33 l S 100.90 271.75 m 100.57 276.33 l 96.77 273.75 l S 43.26 137.06 m 43.68 137.06 l 44.11 137.06 l 44.55 137.06 l 44.99 137.06 l 45.43 137.06 l 45.87 137.06 l 46.30 137.06 l 46.72 137.06 l S 43.26 137.06 m 42.85 137.06 l S 46.83 139.36 m 42.85 137.06 l 46.83 134.76 l S 46.72 137.06 m 47.13 137.06 l S 43.15 134.76 m 47.13 137.06 l 43.15 139.36 l S 41.36 130.36 m 42.03 129.95 l 42.70 129.55 l 43.39 129.16 l 44.09 128.78 l 44.79 128.42 l 45.51 128.08 l 46.22 127.76 l 46.94 127.47 l S 41.36 130.36 m 40.71 130.77 l S 45.30 130.58 m 40.71 130.77 l 42.85 126.70 l S 46.94 127.47 m 47.66 127.21 l S 52.49 125.45 m 56.81 123.96 l 60.74 122.76 l 64.42 121.87 l 67.97 121.33 l 71.52 121.14 l 75.19 121.34 l 79.13 121.95 l 83.45 122.98 l S 52.49 125.45 m 47.66 127.21 l S 83.45 122.98 m 88.28 124.47 l S 89.31 124.83 m 90.33 125.25 l 91.33 125.72 l 92.32 126.24 l 93.29 126.80 l 94.24 127.39 l 95.18 128.01 l 96.10 128.64 l 97.01 129.29 l S 89.31 124.83 m 88.28 124.47 l S 97.01 129.29 m 97.90 129.95 l S 96.06 125.74 m 97.90 129.95 l 93.33 129.44 l S 115.41 285.36 m 115.83 285.36 l 116.26 285.36 l 116.69 285.36 l 117.13 285.36 l 117.58 285.36 l 118.01 285.36 l 118.44 285.36 l 118.86 285.36 l S 115.41 285.36 m 115.00 285.36 l S 118.97 287.66 m 115.00 285.36 l 118.97 283.07 l S 118.86 285.36 m 119.27 285.36 l S 115.30 283.07 m 119.27 285.36 l 115.30 287.66 l S 111.44 296.25 m 112.79 298.51 l 114.20 300.87 l 115.66 303.29 l 117.13 305.75 l 118.61 308.21 l 120.07 310.63 l 121.48 312.99 l 122.83 315.25 l S 111.44 296.25 m 110.19 294.12 l S 110.23 298.71 m 110.19 294.12 l 114.19 296.38 l S 122.83 315.25 m 124.08 317.38 l S 124.04 312.78 m 124.08 317.38 l 120.08 315.12 l S 137.02 326.41 m 137.69 326.41 l 138.36 326.41 l 139.05 326.41 l 139.75 326.41 l 140.45 326.41 l 141.16 326.41 l 141.88 326.41 l 142.60 326.41 l S 137.02 326.41 m 136.37 326.41 l S 142.60 326.41 m 143.32 326.41 l S 139.34 324.11 m 143.32 326.41 l 139.34 328.70 l S 161.07 326.96 m 161.73 326.98 l 162.41 327.01 l 163.10 327.05 l 163.80 327.09 l 164.50 327.13 l 165.21 327.17 l 165.93 327.20 l 166.65 327.22 l S 161.07 326.96 m 160.42 326.95 l S 166.65 327.22 m 167.37 327.23 l S 163.42 324.89 m 167.37 327.23 l 163.37 329.48 l S 185.12 327.78 m 185.78 327.80 l 186.46 327.83 l 187.15 327.87 l 187.84 327.91 l 188.55 327.95 l 189.26 327.99 l 189.98 328.02 l 190.70 328.04 l S 185.12 327.78 m 184.47 327.77 l S 190.70 328.04 m 191.42 328.05 l S 187.46 325.71 m 191.42 328.05 l 187.42 330.30 l S 209.17 328.60 m 209.83 328.60 l 210.51 328.60 l 211.19 328.60 l 211.89 328.60 l 212.60 328.60 l 213.31 328.60 l 214.02 328.60 l 214.74 328.60 l S 209.17 328.60 m 208.52 328.60 l S 214.74 328.60 m 215.47 328.60 l S 211.49 326.30 m 215.47 328.60 l 211.49 330.89 l S 231.10 337.81 m 233.07 341.11 l 235.23 344.69 l 237.52 348.47 l 239.88 352.37 l 242.27 356.28 l 244.63 360.14 l 246.91 363.84 l 249.05 367.31 l S 231.10 337.81 m 229.36 334.89 l S 249.05 367.31 m 251.00 370.46 l S 250.85 365.87 m 251.00 370.46 l 246.95 368.29 l S 270.10 378.12 m 277.78 377.49 l 286.55 376.78 l 296.06 376.04 l 305.98 375.28 l 315.99 374.53 l 325.74 373.81 l 334.90 373.15 l 343.15 372.57 l S 270.10 378.12 m 263.83 378.67 l S 343.15 372.57 m 350.14 372.10 l S 346.01 370.08 m 350.14 372.10 l 346.32 374.66 l S 264.70 382.90 m 266.16 383.60 l 267.69 384.32 l 269.25 385.06 l 270.84 385.82 l 272.45 386.58 l 274.06 387.34 l 275.67 388.11 l 277.25 388.87 l S 264.70 382.90 m 263.29 382.23 l S 277.25 388.87 m 278.79 389.61 l S 276.21 385.82 m 278.79 389.61 l 274.21 389.95 l S 367.45 367.86 m 368.23 367.45 l 369.05 367.03 l 369.89 366.61 l 370.74 366.18 l 371.61 365.75 l 372.47 365.30 l 373.33 364.85 l 374.17 364.38 l S 367.45 367.86 m 366.70 368.27 l S 374.17 364.38 m 374.99 363.89 l S 370.39 363.95 m 374.99 363.89 l 372.74 367.90 l S 394.37 359.79 m 394.79 359.79 l 395.22 359.79 l 395.65 359.79 l 396.09 359.79 l 396.54 359.79 l 396.97 359.79 l 397.40 359.79 l 397.82 359.79 l S 394.37 359.79 m 393.96 359.79 l S 397.93 362.08 m 393.96 359.79 l 397.93 357.49 l S 397.82 359.79 m 398.23 359.79 l S 394.25 357.49 m 398.23 359.79 l 394.25 362.08 l S 67.31 137.06 m 67.73 137.06 l 68.16 137.06 l 68.60 137.06 l 69.04 137.06 l 69.48 137.06 l 69.92 137.06 l 70.35 137.06 l 70.77 137.06 l S 67.31 137.06 m 66.90 137.06 l S 70.88 139.36 m 66.90 137.06 l 70.88 134.76 l S 70.77 137.06 m 71.18 137.06 l S 67.20 134.76 m 71.18 137.06 l 67.20 139.36 l S 65.85 130.56 m 66.69 130.09 l 67.56 129.64 l 68.44 129.22 l 69.34 128.82 l 70.24 128.44 l 71.15 128.09 l 72.06 127.77 l 72.96 127.47 l S 65.85 130.56 m 65.03 131.04 l S 69.62 130.99 m 65.03 131.04 l 67.28 127.04 l S 72.96 127.47 m 73.85 127.21 l S 75.64 126.69 m 77.22 126.29 l 78.63 126.00 l 79.93 125.83 l 81.16 125.77 l 82.39 125.83 l 83.66 126.00 l 85.03 126.29 l 86.55 126.69 l S 75.64 126.69 m 73.85 127.21 l S 86.55 126.69 m 88.28 127.21 l S 89.17 127.47 m 90.06 127.77 l 90.97 128.09 l 91.86 128.44 l 92.75 128.82 l 93.63 129.22 l 94.48 129.64 l 95.30 130.09 l 96.08 130.56 l S 89.17 127.47 m 88.28 127.21 l S 96.08 130.56 m 96.83 131.04 l S 94.74 126.95 m 96.83 131.04 l 92.24 130.80 l S 63.77 144.80 m 63.83 144.89 l 63.88 144.97 l 63.92 145.05 l 63.96 145.13 l 64.00 145.21 l 64.05 145.30 l 64.10 145.38 l 64.16 145.46 l S 63.77 144.80 m 63.69 144.72 l S 64.61 149.22 m 63.69 144.72 l 68.05 146.18 l S 64.16 145.46 m 64.23 145.54 l S 67.92 151.06 m 71.06 155.93 l 73.75 160.33 l 76.08 164.45 l 78.16 168.46 l 80.08 172.55 l 81.95 176.91 l 83.88 181.72 l 85.95 187.17 l S 67.92 151.06 m 64.23 145.54 l S 85.95 187.17 m 88.28 193.43 l S 89.55 196.73 m 90.54 199.66 l 91.31 202.32 l 91.91 204.79 l 92.42 207.18 l 92.89 209.58 l 93.40 212.10 l 94.01 214.83 l 94.77 217.88 l S 89.55 196.73 m 88.28 193.43 l S 94.77 217.88 m 95.76 221.34 l S 96.33 222.93 m 96.91 224.57 l 97.50 226.24 l 98.10 227.94 l 98.70 229.65 l 99.30 231.34 l 99.90 233.02 l 100.49 234.65 l 101.07 236.24 l S 96.33 222.93 m 95.76 221.34 l S 101.07 236.24 m 101.64 237.75 l S 102.39 233.22 m 101.64 237.75 l 98.09 234.84 l S 91.36 137.06 m 91.78 137.06 l 92.21 137.06 l 92.65 137.06 l 93.09 137.06 l 93.53 137.06 l 93.96 137.06 l 94.39 137.06 l 94.82 137.06 l S 91.36 137.06 m 90.95 137.06 l S 94.93 139.36 m 90.95 137.06 l 94.93 134.76 l S 94.82 137.06 m 95.22 137.06 l S 91.25 134.76 m 95.22 137.06 l 91.25 139.36 l S 87.91 127.07 m 89.19 125.20 l 90.50 123.27 l 91.83 121.28 l 93.15 119.27 l 94.47 117.27 l 95.75 115.28 l 96.98 113.34 l 98.14 111.48 l S 87.91 127.07 m 86.67 128.85 l S 90.83 126.89 m 86.67 128.85 l 87.05 124.27 l S 98.14 111.48 m 99.23 109.70 l S 95.20 111.89 m 99.23 109.70 l 99.12 114.29 l S 84.86 150.03 m 85.84 153.45 l 86.91 157.11 l 88.06 160.98 l 89.28 165.00 l 90.54 169.13 l 91.84 173.32 l 93.15 177.52 l 94.46 181.68 l S 84.86 150.03 m 84.00 146.91 l S 82.85 151.36 m 84.00 146.91 l 87.28 150.13 l S 94.46 181.68 m 95.76 185.76 l S 96.33 187.35 m 96.91 189.00 l 97.50 190.67 l 98.10 192.37 l 98.70 194.08 l 99.30 195.77 l 99.90 197.45 l 100.49 199.08 l 101.07 200.67 l S 96.33 187.35 m 95.76 185.76 l S 101.07 200.67 m 101.64 202.18 l S 102.39 197.65 m 101.64 202.18 l 98.09 199.26 l S 87.39 147.57 m 88.71 149.71 l 90.09 151.92 l 91.51 154.18 l 92.95 156.45 l 94.39 158.72 l 95.81 160.96 l 97.20 163.12 l 98.52 165.20 l S 87.39 147.57 m 86.14 145.54 l S 86.26 150.13 m 86.14 145.54 l 90.18 147.73 l S 98.52 165.20 m 99.77 167.16 l S 99.57 162.57 m 99.77 167.16 l 95.69 165.04 l S 110.21 147.16 m 110.74 148.25 l 111.26 149.36 l 111.77 150.47 l 112.26 151.60 l 112.73 152.73 l 113.19 153.87 l 113.63 155.01 l 114.05 156.16 l S 110.21 147.16 m 109.65 146.09 l S 109.43 150.68 m 109.65 146.09 l 113.51 148.58 l S 114.05 156.16 m 114.46 157.31 l S 116.04 161.75 m 117.56 166.32 l 119.03 170.97 l 120.42 175.62 l 121.74 180.22 l 122.99 184.71 l 124.14 189.02 l 125.20 193.09 l 126.16 196.86 l S 116.04 161.75 m 114.46 157.31 l S 126.16 196.86 m 127.02 200.27 l S 128.28 195.85 m 127.02 200.27 l 123.82 196.97 l S 119.23 147.90 m 126.59 153.67 l 134.90 160.14 l 143.84 167.09 l 153.11 174.27 l 162.38 181.46 l 171.34 188.40 l 179.69 194.88 l 187.11 200.65 l S 119.23 147.90 m 113.13 143.08 l S 114.83 147.35 m 113.13 143.08 l 117.67 143.74 l S 187.11 200.65 m 193.29 205.47 l S 191.56 201.21 m 193.29 205.47 l 188.74 204.83 l S 111.18 111.76 m 112.23 113.34 l 113.33 114.98 l 114.48 116.65 l 115.67 118.35 l 116.88 120.06 l 118.13 121.75 l 119.39 123.43 l 120.66 125.07 l S 111.18 111.76 m 110.19 110.25 l S 110.45 114.83 m 110.19 110.25 l 114.29 112.31 l S 120.66 125.07 m 121.94 126.66 l S 129.07 134.65 m 135.63 141.27 l 141.76 146.87 l 147.61 151.80 l 153.31 156.38 l 159.00 160.98 l 164.82 165.93 l 170.91 171.57 l 177.42 178.25 l S 129.07 134.65 m 121.94 126.66 l S 177.42 178.25 m 184.47 186.31 l S 185.75 187.90 m 187.03 189.54 l 188.29 191.22 l 189.53 192.92 l 190.75 194.62 l 191.93 196.32 l 193.08 197.99 l 194.18 199.63 l 195.23 201.21 l S 185.75 187.90 m 184.47 186.31 l S 195.23 201.21 m 196.23 202.73 l S 195.97 198.14 m 196.23 202.73 l 192.13 200.66 l S 113.81 107.87 m 117.10 110.05 l 120.80 112.31 l 124.85 114.56 l 129.19 116.71 l 133.77 118.67 l 138.52 120.36 l 143.38 121.67 l 148.30 122.53 l S 113.81 107.87 m 110.99 105.87 l S 148.30 122.53 m 153.21 122.83 l S 153.23 122.83 m 153.40 122.83 l 153.86 122.83 l 154.75 122.83 l 156.21 122.83 l 158.40 122.83 l 161.46 122.83 l 165.52 122.83 l 170.74 122.83 l S 153.23 122.83 m 153.21 122.83 l S 170.74 122.83 m 177.26 122.83 l S 182.74 124.50 m 188.24 129.14 l 193.66 136.17 l 198.92 145.05 l 203.94 155.19 l 208.63 166.04 l 212.91 177.02 l 216.69 187.59 l 219.89 197.17 l S 182.74 124.50 m 177.26 122.83 l S 219.89 197.17 m 222.41 205.19 l S 223.41 200.71 m 222.41 205.19 l 219.03 202.09 l S 115.35 101.84 m 118.78 101.92 l 122.55 102.00 l 126.60 102.07 l 130.86 102.14 l 135.28 102.20 l 139.78 102.24 l 144.31 102.28 l 148.81 102.30 l S 115.35 101.84 m 112.33 101.76 l S 148.81 102.30 m 153.21 102.31 l S 153.28 102.31 m 153.78 102.31 l 155.16 102.31 l 157.82 102.31 l 162.23 102.31 l 168.79 102.31 l 177.95 102.31 l 190.15 102.31 l 205.80 102.31 l S 153.28 102.31 m 153.21 102.31 l S 205.80 102.31 m 225.35 102.31 l S 244.86 104.88 m 258.68 112.16 l 267.77 123.56 l 273.10 138.46 l 275.65 156.25 l 276.39 176.31 l 276.29 198.03 l 276.32 220.79 l 277.46 244.00 l S 244.86 104.88 m 225.35 102.31 l S 277.46 244.00 m 280.66 267.03 l S 281.01 268.61 m 281.39 270.23 l 281.81 271.88 l 282.24 273.54 l 282.70 275.20 l 283.16 276.86 l 283.63 278.50 l 284.08 280.10 l 284.52 281.67 l S 281.01 268.61 m 280.66 267.03 l S 284.52 281.67 m 284.94 283.17 l S 286.10 278.73 m 284.94 283.17 l 281.67 279.95 l S 115.41 247.33 m 115.83 247.33 l 116.26 247.33 l 116.69 247.33 l 117.13 247.33 l 117.58 247.33 l 118.01 247.33 l 118.44 247.33 l 118.86 247.33 l S 115.41 247.33 m 115.00 247.33 l S 118.97 249.63 m 115.00 247.33 l 118.97 245.03 l S 118.86 247.33 m 119.27 247.33 l S 115.30 245.03 m 119.27 247.33 l 115.30 249.63 l S 139.53 213.22 m 140.01 213.32 l 140.48 213.44 l 140.95 213.57 l 141.42 213.71 l 141.87 213.86 l 142.32 214.01 l 142.76 214.17 l 143.18 214.33 l S 139.53 213.22 m 139.05 213.13 l S 142.53 216.12 m 139.05 213.13 l 143.38 211.60 l S 143.18 214.33 m 143.59 214.50 l S 140.75 210.88 m 143.59 214.50 l 139.04 215.15 l S 161.08 218.77 m 161.76 218.96 l 162.47 219.15 l 163.19 219.35 l 163.93 219.56 l 164.67 219.76 l 165.42 219.96 l 166.17 220.16 l 166.91 220.34 l S 161.08 218.77 m 160.42 218.60 l S 166.91 220.34 m 167.64 220.51 l S 164.29 217.37 m 167.64 220.51 l 163.24 221.84 l S 184.68 219.56 m 185.46 219.14 l 186.28 218.73 l 187.12 218.31 l 187.98 217.88 l 188.84 217.45 l 189.71 217.00 l 190.56 216.54 l 191.40 216.07 l S 184.68 219.56 m 183.94 219.97 l S 191.40 216.07 m 192.22 215.59 l S 187.63 215.65 m 192.22 215.59 l 189.97 219.59 l S 189.05 223.23 m 191.06 223.18 l 193.16 223.10 l 195.32 222.97 l 197.53 222.81 l 199.76 222.60 l 202.00 222.35 l 204.22 222.06 l 206.40 221.72 l S 189.05 223.23 m 187.14 223.25 l S 191.14 225.51 m 187.14 223.25 l 191.10 220.92 l S 206.40 221.72 m 208.52 221.34 l S 209.32 221.16 m 210.12 220.98 l 210.92 220.78 l 211.71 220.57 l 212.49 220.34 l 213.27 220.11 l 214.04 219.88 l 214.79 219.64 l 215.54 219.39 l S 209.32 221.16 m 208.52 221.34 l S 215.54 219.39 m 216.27 219.15 l S 211.76 218.24 m 216.27 219.15 l 213.23 222.59 l S 182.00 236.87 m 183.71 241.71 l 185.53 246.92 l 187.44 252.38 l 189.38 257.97 l 191.31 263.54 l 193.19 268.98 l 194.98 274.15 l 196.63 278.93 l S 182.00 236.87 m 180.46 232.55 l S 179.63 237.07 m 180.46 232.55 l 183.96 235.53 l S 196.63 278.93 m 198.10 283.17 l S 198.97 278.66 m 198.10 283.17 l 194.63 280.16 l S 204.32 225.70 m 206.10 234.55 l 208.15 244.76 l 210.40 255.88 l 212.76 267.51 l 215.14 279.22 l 217.46 290.59 l 219.64 301.20 l 221.59 310.64 l S 204.32 225.70 m 202.91 218.60 l S 221.59 310.64 m 223.21 318.47 l S 224.65 314.11 m 223.21 318.47 l 220.16 315.04 l S 209.24 212.67 m 209.96 212.77 l 210.68 212.89 l 211.39 213.00 l 212.09 213.13 l 212.79 213.25 l 213.48 213.37 l 214.15 213.48 l 214.82 213.58 l S 209.24 212.67 m 208.52 212.58 l S 214.82 213.58 m 215.47 213.67 l S 211.84 210.85 m 215.47 213.67 l 211.21 215.40 l S 206.76 203.66 m 208.05 201.73 l 209.42 199.69 l 210.85 197.57 l 212.33 195.41 l 213.81 193.23 l 215.29 191.07 l 216.75 188.94 l 218.15 186.89 l S 206.76 203.66 m 205.58 205.47 l S 218.15 186.89 m 219.47 184.94 l S 215.34 186.94 m 219.47 184.94 l 219.13 189.52 l S 229.67 227.77 m 231.96 234.56 l 234.56 242.26 l 237.36 250.59 l 240.28 259.27 l 243.22 268.02 l 246.10 276.57 l 248.82 284.64 l 251.28 291.95 l S 229.67 227.77 m 227.76 222.16 l S 251.28 291.95 m 253.41 298.22 l S 254.31 293.72 m 253.41 298.22 l 249.96 295.19 l S 265.33 316.44 m 266.94 318.04 l 268.62 319.70 l 270.35 321.40 l 272.11 323.12 l 273.87 324.84 l 275.61 326.54 l 277.29 328.21 l 278.89 329.81 l S 265.33 316.44 m 263.83 314.91 l S 264.99 319.36 m 263.83 314.91 l 268.26 316.13 l S 278.89 329.81 m 280.40 331.33 l S 279.24 326.89 m 280.40 331.33 l 275.97 330.11 l S 267.01 309.40 m 270.55 309.94 l 274.37 310.49 l 278.40 311.06 l 282.53 311.63 l 286.70 312.20 l 290.82 312.77 l 294.81 313.33 l 298.57 313.86 l S 267.01 309.40 m 263.83 308.89 l S 298.57 313.86 m 302.04 314.37 l S 298.44 311.52 m 302.04 314.37 l 297.77 316.06 l S 319.41 312.40 m 320.21 312.07 l 321.01 311.74 l 321.81 311.41 l 322.61 311.08 l 323.42 310.76 l 324.22 310.43 l 325.02 310.10 l 325.82 309.77 l S 319.41 312.40 m 318.61 312.73 l S 325.82 309.77 m 326.62 309.44 l S 322.07 308.82 m 326.62 309.44 l 323.81 313.07 l S 340.99 296.96 m 342.38 294.67 l 343.86 292.23 l 345.42 289.67 l 347.03 287.04 l 348.66 284.39 l 350.29 281.75 l 351.90 279.19 l 353.46 276.73 l S 340.99 296.96 m 339.71 299.04 l S 353.46 276.73 m 354.95 274.42 l S 350.86 276.52 m 354.95 274.42 l 354.72 279.01 l S 365.07 259.87 m 365.31 259.56 l 365.55 259.26 l 365.79 258.97 l 366.03 258.68 l 366.27 258.40 l 366.52 258.11 l 366.76 257.81 l 367.00 257.50 l S 365.07 259.87 m 364.83 260.19 l S 367.00 257.50 m 367.24 257.18 l S 371.41 251.39 m 375.58 245.42 l 379.68 239.36 l 383.69 233.31 l 387.54 227.36 l 391.21 221.60 l 394.63 216.14 l 397.78 211.06 l 400.60 206.47 l S 371.41 251.39 m 367.24 257.18 l S 400.60 206.47 m 403.04 202.46 l S 399.01 204.66 m 403.04 202.46 l 402.93 207.05 l S 295.11 289.04 m 295.95 288.59 l 296.82 288.12 l 297.70 287.63 l 298.60 287.14 l 299.50 286.65 l 300.41 286.17 l 301.32 285.69 l 302.22 285.24 l S 295.11 289.04 m 294.29 289.47 l S 302.22 285.24 m 303.11 284.82 l S 298.53 284.46 m 303.11 284.82 l 300.51 288.61 l S 321.38 274.35 m 322.03 273.98 l 322.67 273.59 l 323.31 273.19 l 323.95 272.78 l 324.59 272.37 l 325.23 271.96 l 325.87 271.57 l 326.52 271.20 l S 321.38 274.35 m 320.74 274.69 l S 325.33 274.84 m 320.74 274.69 l 323.16 270.79 l S 326.52 271.20 m 327.16 270.86 l S 322.57 270.72 m 327.16 270.86 l 324.74 274.76 l S 338.34 274.66 m 338.86 276.69 l 339.40 278.84 l 339.96 281.09 l 340.52 283.41 l 341.08 285.80 l 341.63 288.22 l 342.17 290.66 l 342.69 293.09 l S 338.34 274.66 m 337.84 272.78 l S 342.69 293.09 m 343.19 295.49 l S 344.88 302.59 m 346.59 309.86 l 348.28 317.19 l 349.94 324.47 l 351.54 331.61 l 353.06 338.47 l 354.47 344.97 l 355.77 350.99 l 356.91 356.42 l S 344.88 302.59 m 343.19 295.49 l S 356.91 356.42 m 357.88 361.16 l S 359.33 356.80 m 357.88 361.16 l 354.83 357.72 l S 343.84 265.66 m 344.50 265.66 l 345.18 265.66 l 345.86 265.66 l 346.56 265.66 l 347.27 265.66 l 347.98 265.66 l 348.70 265.66 l 349.41 265.66 l S 343.84 265.66 m 343.19 265.66 l S 349.41 265.66 m 350.14 265.66 l S 346.16 263.37 m 350.14 265.66 l 346.16 267.96 l S 211.60 176.19 m 212.02 176.19 l 212.45 176.20 l 212.89 176.21 l 213.33 176.22 l 213.77 176.25 l 214.21 176.28 l 214.64 176.33 l 215.06 176.39 l S 211.60 176.19 m 211.19 176.19 l S 215.17 178.49 m 211.19 176.19 l 215.17 173.89 l S 215.06 176.39 m 215.47 176.46 l S 211.96 173.49 m 215.47 176.46 l 211.14 178.01 l S 232.38 182.86 m 233.89 184.13 l 235.47 185.48 l 237.11 186.87 l 238.78 188.30 l 240.47 189.74 l 242.15 191.18 l 243.81 192.61 l 245.44 194.00 l S 232.38 182.86 m 230.96 181.66 l S 245.44 194.00 m 247.00 195.34 l S 245.48 191.01 m 247.00 195.34 l 242.48 194.49 l S 236.84 174.69 m 241.87 174.01 l 247.54 173.38 l 253.73 172.88 l 260.32 172.56 l 267.20 172.49 l 274.23 172.73 l 281.30 173.34 l 288.30 174.38 l S 236.84 174.69 m 232.57 175.37 l S 288.30 174.38 m 295.09 175.91 l S 295.98 176.18 m 296.88 176.47 l 297.78 176.79 l 298.68 177.14 l 299.57 177.52 l 300.44 177.92 l 301.29 178.35 l 302.11 178.80 l 302.90 179.26 l S 295.98 176.18 m 295.09 175.91 l S 302.90 179.26 m 303.64 179.75 l S 301.56 175.65 m 303.64 179.75 l 299.06 179.50 l S 267.53 209.70 m 268.85 210.42 l 270.18 211.17 l 271.52 211.94 l 272.85 212.72 l 274.16 213.49 l 275.45 214.26 l 276.70 215.01 l 277.91 215.73 l S 267.53 209.70 m 266.23 209.02 l S 277.91 215.73 m 279.06 216.41 l S 276.80 212.41 m 279.06 216.41 l 274.47 216.37 l S 267.53 197.40 m 268.85 196.68 l 270.18 195.93 l 271.52 195.16 l 272.85 194.38 l 274.16 193.61 l 275.45 192.84 l 276.70 192.09 l 277.91 191.37 l S 267.53 197.40 m 266.23 198.08 l S 277.91 191.37 m 279.06 190.69 l S 274.47 190.73 m 279.06 190.69 l 276.80 194.69 l S 295.11 225.32 m 295.95 225.77 l 296.82 226.24 l 297.70 226.73 l 298.60 227.22 l 299.50 227.71 l 300.41 228.19 l 301.32 228.67 l 302.22 229.12 l S 295.11 225.32 m 294.29 224.89 l S 302.22 229.12 m 303.11 229.54 l S 300.51 225.76 m 303.11 229.54 l 298.53 229.90 l S 295.74 185.76 m 296.40 185.76 l 297.08 185.76 l 297.77 185.76 l 298.47 185.76 l 299.17 185.76 l 299.88 185.76 l 300.60 185.76 l 301.32 185.76 l S 295.74 185.76 m 295.09 185.76 l S 301.32 185.76 m 302.04 185.76 l S 298.06 183.47 m 302.04 185.76 l 298.06 188.06 l S 324.98 186.85 m 332.06 187.47 l 340.08 188.14 l 348.75 188.86 l 357.78 189.60 l 366.89 190.33 l 375.78 191.05 l 384.16 191.72 l 391.74 192.34 l S 324.98 186.85 m 319.14 186.31 l S 391.74 192.34 m 398.23 192.88 l S 394.46 190.26 m 398.23 192.88 l 394.08 194.84 l S 317.28 241.94 m 318.43 243.49 l 319.64 245.11 l 320.89 246.80 l 322.18 248.53 l 323.49 250.28 l 324.82 252.04 l 326.15 253.79 l 327.46 255.51 l S 317.28 241.94 m 316.20 240.49 l S 327.46 255.51 m 328.76 257.18 l S 328.83 257.26 m 328.89 257.34 l 328.94 257.42 l 328.99 257.49 l 329.03 257.56 l 329.07 257.61 l 329.11 257.66 l 329.16 257.70 l 329.22 257.72 l S 328.83 257.26 m 328.76 257.18 l S 329.22 257.72 m 329.29 257.73 l S 325.59 255.01 m 329.29 257.73 l 325.09 259.58 l S 324.98 234.47 m 332.06 234.47 l 340.08 234.47 l 348.75 234.47 l 357.78 234.47 l 366.89 234.47 l 375.78 234.47 l 384.16 234.47 l 391.74 234.47 l S 324.98 234.47 m 319.14 234.47 l S 391.74 234.47 m 398.23 234.47 l S 394.25 232.17 m 398.23 234.47 l 394.25 236.77 l S 297.72 258.98 m 300.60 259.46 l 303.67 259.96 l 306.89 260.50 l 310.19 261.04 l 313.52 261.60 l 316.83 262.16 l 320.07 262.71 l 323.17 263.24 l S 297.72 258.98 m 295.09 258.55 l S 323.17 263.24 m 326.09 263.75 l S 322.56 260.80 m 326.09 263.75 l 321.78 265.33 l S 294.29 251.25 m 295.39 250.20 l 296.53 249.12 l 297.69 248.01 l 298.87 246.89 l 300.05 245.75 l 301.24 244.62 l 302.41 243.50 l 303.57 242.39 l S 294.29 251.25 m 293.22 252.25 l S 303.57 242.39 m 304.71 241.31 l S 300.25 242.39 m 304.71 241.31 l 303.41 245.72 l S 209.17 256.63 m 209.83 256.60 l 210.51 256.57 l 211.19 256.54 l 211.89 256.50 l 212.60 256.46 l 213.31 256.42 l 214.02 256.39 l 214.74 256.37 l S 209.17 256.63 m 208.52 256.63 l S 214.74 256.37 m 215.47 256.36 l S 211.46 254.11 m 215.47 256.36 l 211.51 258.70 l S 208.63 268.66 m 212.71 275.00 l 217.36 282.23 l 222.41 290.07 l 227.69 298.26 l 233.02 306.52 l 238.21 314.58 l 243.11 322.18 l 247.52 329.04 l S 208.63 268.66 m 205.31 263.47 l S 247.52 329.04 m 251.27 334.89 l S 251.05 330.30 m 251.27 334.89 l 247.19 332.78 l S 230.83 246.59 m 232.81 243.26 l 234.97 239.64 l 237.27 235.80 l 239.65 231.84 l 242.06 227.83 l 244.45 223.87 l 246.78 220.04 l 248.98 216.43 l S 230.83 246.59 m 229.09 249.52 l S 248.98 216.43 m 251.00 213.13 l S 246.97 215.31 m 251.00 213.13 l 250.88 217.72 l S 265.06 345.35 m 266.65 345.70 l 268.32 346.05 l 270.04 346.40 l 271.81 346.76 l 273.60 347.10 l 275.40 347.43 l 277.19 347.74 l 278.95 348.03 l S 265.06 345.35 m 263.56 345.01 l S 278.95 348.03 m 280.66 348.30 l S 285.53 348.73 m 290.47 349.04 l 295.42 349.24 l 300.35 349.36 l 305.18 349.39 l 309.87 349.36 l 314.36 349.28 l 318.59 349.15 l 322.52 349.01 l S 285.53 348.73 m 280.66 348.30 l S 322.52 349.01 m 326.09 348.84 l S 322.01 346.73 m 326.09 348.84 l 322.22 351.32 l S 345.82 350.75 m 348.70 351.37 l 351.77 352.07 l 354.98 352.81 l 358.29 353.60 l 361.62 354.41 l 364.93 355.23 l 368.16 356.04 l 371.27 356.84 l S 345.82 350.75 m 343.19 350.21 l S 371.27 356.84 m 374.18 357.60 l S 370.92 354.37 m 374.18 357.60 l 369.76 358.82 l S Q endstream endobj 217 0 obj << /CreationDate (D:20061226132452) /ModDate (D:20061226132452) /Title (R Graphics Output) /Producer (R 2.4.1) /Creator (R) >> endobj 218 0 obj << /Type /Font /Subtype /Type1 /Name /F1 /BaseFont /ZapfDingbats >> endobj 219 0 obj << /Type /Font /Subtype /Type1 /Name /F2 /BaseFont /Helvetica /Encoding 221 0 R >> endobj 220 0 obj 38703 endobj 221 0 obj << /Type /Encoding /BaseEncoding /WinAnsiEncoding /Differences [ 45/minus 96/quoteleft 144/dotlessi/grave/acute/circumflex/tilde/macron/breve/dotaccent/dieresis/.notdef/ring/cedilla/.notdef/hungarumlaut/ogonek/caron/space] >> endobj 216 0 obj << /D [214 0 R /XYZ 133.7684 692.1046 null] >> endobj 18 0 obj << /D [214 0 R /XYZ 133.7684 291.9937 null] >> endobj 213 0 obj << /Font << /F8 43 0 R /F42 40 0 R /F49 46 0 R /F51 50 0 R /F50 142 0 R /F55 62 0 R >> /XObject << /Im4 208 0 R >> /ProcSet [ /PDF /Text ] >> endobj 225 0 obj << /Length 1015 /Filter /FlateDecode >> stream xڭWO0~_=$ ɴM&m61BP>'N[Ji:)17c`2fQxVͮ,Vu"ganc0s mI;'9n3;;w M)1ڋ͞DS 4^BJevҥ`]^[hc|mm,\C40z 6]l`yYa`\\m3/UKN(EFɲmZyq+yA$I#a% KCE8endstream endobj 224 0 obj << /Type /Page /Contents 225 0 R /Resources 223 0 R /MediaBox [0 0 612 792] /Parent 199 0 R >> endobj 222 0 obj << /Type /XObject /Subtype /Form /FormType 1 /PTEX.FileName (./layingOutPathways-expressionGraph.pdf) /PTEX.PageNumber 1 /PTEX.InfoDict 227 0 R /Matrix [1.00000000 0.00000000 0.00000000 1.00000000 0.00000000 0.00000000] /BBox [0.00000000 0.00000000 432.00000000 432.00000000] /Resources << /ProcSet [ /PDF /Text ] /Font << /F1 228 0 R /F2 229 0 R >> /ExtGState << >>>> /Length 230 0 R >> stream q Q q 0.72 0.72 430.56 430.56 re W n 1.000 0.000 0.000 rg 0.000 0.000 0.000 RG 0.75 w [] 0 d 1 J 1 j 10.00 M BT /F1 1 Tf 2 Tr 19.98 0 0 19.98 25.05 130.13 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 30.63 136.34 Tm (ITGB) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 25.05 58.71 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 30.63 64.93 Tm (ITGA) Tj 0.000 0.000 1.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 25.05 94.55 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 31.47 100.77 Tm (ILK) Tj 1.000 0.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 25.05 23.14 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 30.98 29.36 Tm (CAV) Tj 0.000 0.000 1.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 97.20 278.43 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 103.00 284.65 Tm (SHC) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 121.25 278.43 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 127.16 284.65 Tm (FYN) Tj 1.000 0.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 121.25 319.20 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 126.44 325.41 Tm (GRB2) Tj 1.000 0.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 145.29 319.75 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 151.10 325.96 Tm (SOS) Tj 1.000 0.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 169.34 320.57 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 173.62 326.80 Tm (Ha-Ras) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 193.39 321.66 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 199.75 327.88 Tm (Raf) Tj 1.000 0.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 217.44 321.66 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 223.19 327.88 Tm (MEK) Tj 1.000 0.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 248.70 372.28 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 254.56 378.50 Tm (ERK) Tj /F1 1 Tf 1 Tr 19.98 0 0 19.98 352.11 364.35 Tm (l) Tj 0 Tr /F2 1 Tf 2.00 0.00 -0.00 2.00 357.30 370.56 Tm (MYLK) Tj /F1 1 Tf 1 Tr 19.98 0 0 19.98 376.16 352.85 Tm (l) Tj 0 Tr /F2 1 Tf 2.00 0.00 -0.00 2.00 381.88 359.07 Tm (MYO) Tj 1.000 0.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 49.10 130.13 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 54.32 136.34 Tm (ACTN) Tj 1.000 0.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 73.15 130.13 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 79.12 136.34 Tm (VCL) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 97.20 130.13 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 103.22 136.34 Tm (TLN) Tj 0.000 0.000 1.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 97.20 94.55 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 103.05 100.77 Tm (PXN) Tj 1.000 0.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 97.20 240.39 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 103.17 246.61 Tm (ZYX) Tj 1.000 0.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 121.25 240.39 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 126.57 246.61 Tm (VASP) Tj /F1 1 Tf 1 Tr 19.98 0 0 19.98 97.20 204.55 Tm (l) Tj 0 Tr /F2 1 Tf 2.00 0.00 -0.00 2.00 101.89 210.77 Tm (SH3D5) Tj /F1 1 Tf 1 Tr 19.98 0 0 19.98 97.20 168.98 Tm (l) Tj 0 Tr /F2 1 Tf 2.00 0.00 -0.00 2.00 103.11 175.20 Tm (TNS) Tj 0.000 0.000 1.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 121.25 203.46 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 126.38 209.67 Tm (CAPN) Tj 0.000 0.000 1.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 145.29 210.02 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 149.76 216.24 Tm (CAPNS) Tj 0.000 0.000 1.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 169.34 216.04 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 175.14 222.26 Tm (SRC) Tj 0.000 0.000 1.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 193.39 204.55 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 199.44 210.77 Tm (FAK) Tj /F1 1 Tf 1 Tr 19.98 0 0 19.98 217.44 208.11 Tm (l) Tj 0 Tr /F2 1 Tf 2.00 0.00 -0.00 2.00 222.02 214.32 Tm (BCAR1) Tj 1.000 0.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 193.39 286.09 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 199.25 292.31 Tm (CSK) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 248.70 300.87 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 254.50 307.08 Tm (CRK) Tj 1.000 0.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 279.96 331.51 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 284.43 337.73 Tm (DOCK1) Tj 1.000 0.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 304.01 308.80 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 309.26 315.02 Tm (GRF2) Tj 1.000 0.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 328.06 298.40 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 333.36 304.62 Tm (RAP1) Tj 0.000 0.000 1.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 352.11 258.73 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 358.13 264.96 Tm (JNK) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 279.96 286.09 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 285.65 292.31 Tm (GIT2) Tj 0.000 0.000 1.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 304.01 272.96 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 307.76 279.17 Tm (ARHGEF) Tj 0.000 0.000 1.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 328.06 258.73 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 334.09 264.94 Tm (PAK) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 193.39 168.98 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 199.64 175.42 Tm (p85) Tj 1.000 0.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 217.44 169.80 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 223.13 176.24 Tm (p110) Tj ET 242.19 203.55 m 242.48 205.03 l 242.77 205.63 l 243.06 206.08 l 243.35 206.46 l 243.64 206.79 l 243.93 207.08 l 244.23 207.34 l 244.52 207.58 l 244.81 207.80 l 245.10 208.00 l 245.39 208.19 l 245.68 208.37 l 245.98 208.54 l 246.27 208.70 l 246.56 208.85 l 246.85 208.99 l 247.14 209.12 l 247.43 209.25 l 247.72 209.37 l 248.02 209.48 l 248.31 209.59 l 248.60 209.69 l 248.89 209.79 l 249.18 209.88 l 249.47 209.97 l 249.76 210.05 l 250.06 210.13 l 250.35 210.20 l 250.64 210.27 l 250.93 210.34 l 251.22 210.40 l 251.51 210.46 l 251.81 210.52 l 252.10 210.57 l 252.39 210.61 l 252.68 210.66 l 252.97 210.70 l 253.26 210.74 l 253.55 210.77 l 253.85 210.80 l 254.14 210.83 l 254.43 210.85 l 254.72 210.87 l 255.01 210.89 l 255.30 210.91 l 255.59 210.92 l 255.89 210.93 l 256.18 210.93 l 256.47 210.94 l 256.76 210.94 l 257.05 210.93 l 257.34 210.93 l 257.64 210.92 l 257.93 210.91 l 258.22 210.89 l 258.51 210.87 l 258.80 210.85 l 259.09 210.83 l 259.38 210.80 l 259.68 210.77 l 259.97 210.74 l 260.26 210.70 l 260.55 210.66 l 260.84 210.61 l 261.13 210.57 l 261.42 210.52 l 261.72 210.46 l 262.01 210.40 l 262.30 210.34 l 262.59 210.27 l 262.88 210.20 l 263.17 210.13 l 263.46 210.05 l 263.76 209.97 l 264.05 209.88 l 264.34 209.79 l 264.63 209.69 l 264.92 209.59 l 265.21 209.48 l 265.51 209.37 l 265.80 209.25 l 266.09 209.12 l 266.38 208.99 l 266.67 208.85 l 266.96 208.70 l 267.25 208.54 l 267.55 208.37 l 267.84 208.19 l 268.13 208.00 l 268.42 207.80 l 268.71 207.58 l 269.00 207.34 l 269.29 207.08 l 269.59 206.79 l 269.88 206.46 l 270.17 206.08 l 270.46 205.63 l 270.75 205.03 l 271.04 203.55 l 271.04 203.55 l 270.75 202.07 l 270.46 201.47 l 270.17 201.02 l 269.88 200.64 l 269.59 200.31 l 269.29 200.02 l 269.00 199.76 l 268.71 199.52 l 268.42 199.30 l 268.13 199.10 l 267.84 198.91 l 267.55 198.73 l 267.25 198.56 l 266.96 198.40 l 266.67 198.25 l 266.38 198.11 l 266.09 197.98 l 265.80 197.85 l 265.51 197.73 l 265.21 197.62 l 264.92 197.51 l 264.63 197.41 l 264.34 197.31 l 264.05 197.22 l 263.76 197.13 l 263.46 197.05 l 263.17 196.97 l 262.88 196.90 l 262.59 196.83 l 262.30 196.76 l 262.01 196.70 l 261.72 196.64 l 261.42 196.58 l 261.13 196.53 l 260.84 196.49 l 260.55 196.44 l 260.26 196.40 l 259.97 196.36 l 259.68 196.33 l 259.38 196.30 l 259.09 196.27 l 258.80 196.25 l 258.51 196.23 l 258.22 196.21 l 257.93 196.19 l 257.64 196.18 l 257.34 196.17 l 257.05 196.17 l 256.76 196.16 l 256.47 196.16 l 256.18 196.17 l 255.89 196.17 l 255.59 196.18 l 255.30 196.19 l 255.01 196.21 l 254.72 196.23 l 254.43 196.25 l 254.14 196.27 l 253.85 196.30 l 253.55 196.33 l 253.26 196.36 l 252.97 196.40 l 252.68 196.44 l 252.39 196.49 l 252.10 196.53 l 251.81 196.58 l 251.51 196.64 l 251.22 196.70 l 250.93 196.76 l 250.64 196.83 l 250.35 196.90 l 250.06 196.97 l 249.76 197.05 l 249.47 197.13 l 249.18 197.22 l 248.89 197.31 l 248.60 197.41 l 248.31 197.51 l 248.02 197.62 l 247.72 197.73 l 247.43 197.85 l 247.14 197.98 l 246.85 198.11 l 246.56 198.25 l 246.27 198.40 l 245.98 198.56 l 245.68 198.73 l 245.39 198.91 l 245.10 199.10 l 244.81 199.30 l 244.52 199.52 l 244.23 199.76 l 243.93 200.02 l 243.64 200.31 l 243.35 200.64 l 243.06 201.02 l 242.77 201.47 l 242.48 202.07 l 242.19 203.55 l 242.19 203.55 l S BT /F2 1 Tf 2.00 0.00 -0.00 2.00 240.11 203.05 Tm (Phosphatidylinositol signaling system) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 279.96 214.40 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 286.03 220.62 Tm (VAV) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 279.96 178.83 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 284.60 185.05 Tm (PDPK1) Tj 1.000 0.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 304.01 178.83 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 309.98 185.05 Tm (AKT) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 304.01 227.53 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 309.84 233.75 Tm (RAC) Tj 1.000 0.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 279.96 250.25 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 284.60 256.46 Tm (CDC42) Tj 1.000 0.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 193.39 250.25 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 199.08 256.46 Tm (RHO) Tj /F1 1 Tf 1 Tr 19.98 0 0 19.98 217.44 248.88 Tm (l) Tj 0 Tr /F2 1 Tf 2.00 0.00 -0.00 2.00 223.18 255.11 Tm (PI5K) Tj 0.000 1.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 248.70 336.44 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 253.75 342.65 Tm (ROCK) Tj 1.000 0.000 0.000 rg /F1 1 Tf 2 Tr 19.98 0 0 19.98 328.06 341.63 Tm (l) Tj 0 Tr 0.000 0.000 0.000 rg /F2 1 Tf 2.00 0.00 -0.00 2.00 332.53 347.85 Tm (MYO-P) Tj /F1 1 Tf 1 Tr 19.98 0 0 19.98 400.20 186.77 Tm (l) Tj 0 Tr /F2 1 Tf 2.00 0.00 -0.00 2.00 400.62 193.00 Tm (cell maintenance) Tj /F1 1 Tf 1 Tr 19.98 0 0 19.98 400.20 227.53 Tm (l) Tj 0 Tr /F2 1 Tf 2.00 0.00 -0.00 2.00 403.23 233.97 Tm (cell motility) Tj /F1 1 Tf 1 Tr 19.98 0 0 19.98 400.20 352.85 Tm (l) Tj 0 Tr /F2 1 Tf 2.00 0.00 -0.00 2.00 404.81 359.09 Tm (F-actin) Tj /F1 1 Tf 1 Tr 19.98 0 0 19.98 279.96 387.06 Tm (l) Tj 0 Tr /F2 1 Tf 2.00 0.00 -0.00 2.00 280.92 393.47 Tm (cell proliferation) Tj ET 27.34 126.34 m 26.51 124.57 l 25.67 122.72 l 24.85 120.82 l 24.05 118.86 l 23.29 116.88 l 22.58 114.88 l 21.95 112.87 l 21.40 110.86 l S 27.34 126.34 m 28.16 128.03 l S 28.50 123.45 m 28.16 128.03 l 24.36 125.45 l S 21.40 110.86 m 20.94 108.88 l S 20.65 107.04 m 20.43 105.42 l 20.27 103.98 l 20.17 102.65 l 20.14 101.39 l 20.17 100.13 l 20.27 98.83 l 20.43 97.42 l 20.65 95.87 l S 20.65 107.04 m 20.94 108.88 l S 20.65 95.87 m 20.94 94.10 l S 21.40 92.04 m 21.95 89.98 l 22.58 87.92 l 23.29 85.88 l 24.05 83.87 l 24.85 81.91 l 25.67 79.99 l 26.51 78.14 l 27.34 76.36 l S 21.40 92.04 m 20.94 94.10 l S 27.34 76.36 m 28.16 74.67 l S 24.36 77.26 m 28.16 74.67 l 28.50 79.25 l S 32.97 125.38 m 32.97 123.85 l 32.97 122.32 l 32.97 120.79 l 32.97 119.27 l 32.97 117.76 l 32.97 116.23 l 32.97 114.70 l 32.97 113.17 l S 32.97 125.38 m 32.97 126.94 l S 35.26 122.96 m 32.97 126.94 l 30.67 122.96 l S 32.97 113.17 m 32.97 111.61 l S 30.67 115.59 m 32.97 111.61 l 35.26 115.59 l S 27.34 126.34 m 26.51 124.57 l 25.67 122.72 l 24.85 120.82 l 24.05 118.86 l 23.29 116.88 l 22.58 114.88 l 21.95 112.87 l 21.40 110.86 l S 27.34 126.34 m 28.16 128.03 l S 28.50 123.45 m 28.16 128.03 l 24.36 125.45 l S 21.40 110.86 m 20.94 108.88 l S 19.79 102.67 m 18.89 97.20 l 18.25 92.31 l 17.86 87.79 l 17.74 83.46 l 17.86 79.15 l 18.25 74.66 l 18.89 69.80 l 19.79 64.40 l S 19.79 102.67 m 20.94 108.88 l S 19.79 64.40 m 20.94 58.26 l S 21.40 56.27 m 21.95 54.27 l 22.58 52.26 l 23.29 50.25 l 24.05 48.27 l 24.85 46.32 l 25.67 44.41 l 26.51 42.57 l 27.34 40.79 l S 21.40 56.27 m 20.94 58.26 l S 27.34 40.79 m 28.16 39.10 l S 24.36 41.69 m 28.16 39.10 l 28.50 43.68 l S 42.04 155.47 m 47.76 167.28 l 54.36 180.91 l 61.55 195.76 l 69.04 211.21 l 76.52 226.67 l 83.72 241.51 l 90.32 255.14 l 96.03 266.95 l S 42.04 155.47 m 37.51 146.09 l S 37.17 150.67 m 37.51 146.09 l 41.31 148.67 l S 96.03 266.95 m 100.57 276.33 l S 100.90 271.75 m 100.57 276.33 l 96.77 273.75 l S 43.26 137.06 m 43.68 137.06 l 44.11 137.06 l 44.55 137.06 l 44.99 137.06 l 45.43 137.06 l 45.87 137.06 l 46.30 137.06 l 46.72 137.06 l S 43.26 137.06 m 42.85 137.06 l S 46.83 139.36 m 42.85 137.06 l 46.83 134.76 l S 46.72 137.06 m 47.13 137.06 l S 43.15 134.76 m 47.13 137.06 l 43.15 139.36 l S 41.36 130.36 m 42.03 129.95 l 42.70 129.55 l 43.39 129.16 l 44.09 128.78 l 44.79 128.42 l 45.51 128.08 l 46.22 127.76 l 46.94 127.47 l S 41.36 130.36 m 40.71 130.77 l S 45.30 130.58 m 40.71 130.77 l 42.85 126.70 l S 46.94 127.47 m 47.66 127.21 l S 52.49 125.45 m 56.81 123.96 l 60.74 122.76 l 64.42 121.87 l 67.97 121.33 l 71.52 121.14 l 75.19 121.34 l 79.13 121.95 l 83.45 122.98 l S 52.49 125.45 m 47.66 127.21 l S 83.45 122.98 m 88.28 124.47 l S 89.31 124.83 m 90.33 125.25 l 91.33 125.72 l 92.32 126.24 l 93.29 126.80 l 94.24 127.39 l 95.18 128.01 l 96.10 128.64 l 97.01 129.29 l S 89.31 124.83 m 88.28 124.47 l S 97.01 129.29 m 97.90 129.95 l S 96.06 125.74 m 97.90 129.95 l 93.33 129.44 l S 115.41 285.36 m 115.83 285.36 l 116.26 285.36 l 116.69 285.36 l 117.13 285.36 l 117.58 285.36 l 118.01 285.36 l 118.44 285.36 l 118.86 285.36 l S 115.41 285.36 m 115.00 285.36 l S 118.97 287.66 m 115.00 285.36 l 118.97 283.07 l S 118.86 285.36 m 119.27 285.36 l S 115.30 283.07 m 119.27 285.36 l 115.30 287.66 l S 111.44 296.25 m 112.79 298.51 l 114.20 300.87 l 115.66 303.29 l 117.13 305.75 l 118.61 308.21 l 120.07 310.63 l 121.48 312.99 l 122.83 315.25 l S 111.44 296.25 m 110.19 294.12 l S 110.23 298.71 m 110.19 294.12 l 114.19 296.38 l S 122.83 315.25 m 124.08 317.38 l S 124.04 312.78 m 124.08 317.38 l 120.08 315.12 l S 137.02 326.41 m 137.69 326.41 l 138.36 326.41 l 139.05 326.41 l 139.75 326.41 l 140.45 326.41 l 141.16 326.41 l 141.88 326.41 l 142.60 326.41 l S 137.02 326.41 m 136.37 326.41 l S 142.60 326.41 m 143.32 326.41 l S 139.34 324.11 m 143.32 326.41 l 139.34 328.70 l S 161.07 326.96 m 161.73 326.98 l 162.41 327.01 l 163.10 327.05 l 163.80 327.09 l 164.50 327.13 l 165.21 327.17 l 165.93 327.20 l 166.65 327.22 l S 161.07 326.96 m 160.42 326.95 l S 166.65 327.22 m 167.37 327.23 l S 163.42 324.89 m 167.37 327.23 l 163.37 329.48 l S 185.12 327.78 m 185.78 327.80 l 186.46 327.83 l 187.15 327.87 l 187.84 327.91 l 188.55 327.95 l 189.26 327.99 l 189.98 328.02 l 190.70 328.04 l S 185.12 327.78 m 184.47 327.77 l S 190.70 328.04 m 191.42 328.05 l S 187.46 325.71 m 191.42 328.05 l 187.42 330.30 l S 209.17 328.60 m 209.83 328.60 l 210.51 328.60 l 211.19 328.60 l 211.89 328.60 l 212.60 328.60 l 213.31 328.60 l 214.02 328.60 l 214.74 328.60 l S 209.17 328.60 m 208.52 328.60 l S 214.74 328.60 m 215.47 328.60 l S 211.49 326.30 m 215.47 328.60 l 211.49 330.89 l S 231.10 337.81 m 233.07 341.11 l 235.23 344.69 l 237.52 348.47 l 239.88 352.37 l 242.27 356.28 l 244.63 360.14 l 246.91 363.84 l 249.05 367.31 l S 231.10 337.81 m 229.36 334.89 l S 249.05 367.31 m 251.00 370.46 l S 250.85 365.87 m 251.00 370.46 l 246.95 368.29 l S 270.10 378.12 m 277.78 377.49 l 286.55 376.78 l 296.06 376.04 l 305.98 375.28 l 315.99 374.53 l 325.74 373.81 l 334.90 373.15 l 343.15 372.57 l S 270.10 378.12 m 263.83 378.67 l S 343.15 372.57 m 350.14 372.10 l S 346.01 370.08 m 350.14 372.10 l 346.32 374.66 l S 264.70 382.90 m 266.16 383.60 l 267.69 384.32 l 269.25 385.06 l 270.84 385.82 l 272.45 386.58 l 274.06 387.34 l 275.67 388.11 l 277.25 388.87 l S 264.70 382.90 m 263.29 382.23 l S 277.25 388.87 m 278.79 389.61 l S 276.21 385.82 m 278.79 389.61 l 274.21 389.95 l S 367.45 367.86 m 368.23 367.45 l 369.05 367.03 l 369.89 366.61 l 370.74 366.18 l 371.61 365.75 l 372.47 365.30 l 373.33 364.85 l 374.17 364.38 l S 367.45 367.86 m 366.70 368.27 l S 374.17 364.38 m 374.99 363.89 l S 370.39 363.95 m 374.99 363.89 l 372.74 367.90 l S 394.37 359.79 m 394.79 359.79 l 395.22 359.79 l 395.65 359.79 l 396.09 359.79 l 396.54 359.79 l 396.97 359.79 l 397.40 359.79 l 397.82 359.79 l S 394.37 359.79 m 393.96 359.79 l S 397.93 362.08 m 393.96 359.79 l 397.93 357.49 l S 397.82 359.79 m 398.23 359.79 l S 394.25 357.49 m 398.23 359.79 l 394.25 362.08 l S 67.31 137.06 m 67.73 137.06 l 68.16 137.06 l 68.60 137.06 l 69.04 137.06 l 69.48 137.06 l 69.92 137.06 l 70.35 137.06 l 70.77 137.06 l S 67.31 137.06 m 66.90 137.06 l S 70.88 139.36 m 66.90 137.06 l 70.88 134.76 l S 70.77 137.06 m 71.18 137.06 l S 67.20 134.76 m 71.18 137.06 l 67.20 139.36 l S 65.85 130.56 m 66.69 130.09 l 67.56 129.64 l 68.44 129.22 l 69.34 128.82 l 70.24 128.44 l 71.15 128.09 l 72.06 127.77 l 72.96 127.47 l S 65.85 130.56 m 65.03 131.04 l S 69.62 130.99 m 65.03 131.04 l 67.28 127.04 l S 72.96 127.47 m 73.85 127.21 l S 75.64 126.69 m 77.22 126.29 l 78.63 126.00 l 79.93 125.83 l 81.16 125.77 l 82.39 125.83 l 83.66 126.00 l 85.03 126.29 l 86.55 126.69 l S 75.64 126.69 m 73.85 127.21 l S 86.55 126.69 m 88.28 127.21 l S 89.17 127.47 m 90.06 127.77 l 90.97 128.09 l 91.86 128.44 l 92.75 128.82 l 93.63 129.22 l 94.48 129.64 l 95.30 130.09 l 96.08 130.56 l S 89.17 127.47 m 88.28 127.21 l S 96.08 130.56 m 96.83 131.04 l S 94.74 126.95 m 96.83 131.04 l 92.24 130.80 l S 63.77 144.80 m 63.83 144.89 l 63.88 144.97 l 63.92 145.05 l 63.96 145.13 l 64.00 145.21 l 64.05 145.30 l 64.10 145.38 l 64.16 145.46 l S 63.77 144.80 m 63.69 144.72 l S 64.61 149.22 m 63.69 144.72 l 68.05 146.18 l S 64.16 145.46 m 64.23 145.54 l S 67.92 151.06 m 71.06 155.93 l 73.75 160.33 l 76.08 164.45 l 78.16 168.46 l 80.08 172.55 l 81.95 176.91 l 83.88 181.72 l 85.95 187.17 l S 67.92 151.06 m 64.23 145.54 l S 85.95 187.17 m 88.28 193.43 l S 89.55 196.73 m 90.54 199.66 l 91.31 202.32 l 91.91 204.79 l 92.42 207.18 l 92.89 209.58 l 93.40 212.10 l 94.01 214.83 l 94.77 217.88 l S 89.55 196.73 m 88.28 193.43 l S 94.77 217.88 m 95.76 221.34 l S 96.33 222.93 m 96.91 224.57 l 97.50 226.24 l 98.10 227.94 l 98.70 229.65 l 99.30 231.34 l 99.90 233.02 l 100.49 234.65 l 101.07 236.24 l S 96.33 222.93 m 95.76 221.34 l S 101.07 236.24 m 101.64 237.75 l S 102.39 233.22 m 101.64 237.75 l 98.09 234.84 l S 91.36 137.06 m 91.78 137.06 l 92.21 137.06 l 92.65 137.06 l 93.09 137.06 l 93.53 137.06 l 93.96 137.06 l 94.39 137.06 l 94.82 137.06 l S 91.36 137.06 m 90.95 137.06 l S 94.93 139.36 m 90.95 137.06 l 94.93 134.76 l S 94.82 137.06 m 95.22 137.06 l S 91.25 134.76 m 95.22 137.06 l 91.25 139.36 l S 87.91 127.07 m 89.19 125.20 l 90.50 123.27 l 91.83 121.28 l 93.15 119.27 l 94.47 117.27 l 95.75 115.28 l 96.98 113.34 l 98.14 111.48 l S 87.91 127.07 m 86.67 128.85 l S 90.83 126.89 m 86.67 128.85 l 87.05 124.27 l S 98.14 111.48 m 99.23 109.70 l S 95.20 111.89 m 99.23 109.70 l 99.12 114.29 l S 84.86 150.03 m 85.84 153.45 l 86.91 157.11 l 88.06 160.98 l 89.28 165.00 l 90.54 169.13 l 91.84 173.32 l 93.15 177.52 l 94.46 181.68 l S 84.86 150.03 m 84.00 146.91 l S 82.85 151.36 m 84.00 146.91 l 87.28 150.13 l S 94.46 181.68 m 95.76 185.76 l S 96.33 187.35 m 96.91 189.00 l 97.50 190.67 l 98.10 192.37 l 98.70 194.08 l 99.30 195.77 l 99.90 197.45 l 100.49 199.08 l 101.07 200.67 l S 96.33 187.35 m 95.76 185.76 l S 101.07 200.67 m 101.64 202.18 l S 102.39 197.65 m 101.64 202.18 l 98.09 199.26 l S 87.39 147.57 m 88.71 149.71 l 90.09 151.92 l 91.51 154.18 l 92.95 156.45 l 94.39 158.72 l 95.81 160.96 l 97.20 163.12 l 98.52 165.20 l S 87.39 147.57 m 86.14 145.54 l S 86.26 150.13 m 86.14 145.54 l 90.18 147.73 l S 98.52 165.20 m 99.77 167.16 l S 99.57 162.57 m 99.77 167.16 l 95.69 165.04 l S 110.21 147.16 m 110.74 148.25 l 111.26 149.36 l 111.77 150.47 l 112.26 151.60 l 112.73 152.73 l 113.19 153.87 l 113.63 155.01 l 114.05 156.16 l S 110.21 147.16 m 109.65 146.09 l S 109.43 150.68 m 109.65 146.09 l 113.51 148.58 l S 114.05 156.16 m 114.46 157.31 l S 116.04 161.75 m 117.56 166.32 l 119.03 170.97 l 120.42 175.62 l 121.74 180.22 l 122.99 184.71 l 124.14 189.02 l 125.20 193.09 l 126.16 196.86 l S 116.04 161.75 m 114.46 157.31 l S 126.16 196.86 m 127.02 200.27 l S 128.28 195.85 m 127.02 200.27 l 123.82 196.97 l S 119.23 147.90 m 126.59 153.67 l 134.90 160.14 l 143.84 167.09 l 153.11 174.27 l 162.38 181.46 l 171.34 188.40 l 179.69 194.88 l 187.11 200.65 l S 119.23 147.90 m 113.13 143.08 l S 114.83 147.35 m 113.13 143.08 l 117.67 143.74 l S 187.11 200.65 m 193.29 205.47 l S 191.56 201.21 m 193.29 205.47 l 188.74 204.83 l S 111.18 111.76 m 112.23 113.34 l 113.33 114.98 l 114.48 116.65 l 115.67 118.35 l 116.88 120.06 l 118.13 121.75 l 119.39 123.43 l 120.66 125.07 l S 111.18 111.76 m 110.19 110.25 l S 110.45 114.83 m 110.19 110.25 l 114.29 112.31 l S 120.66 125.07 m 121.94 126.66 l S 129.07 134.65 m 135.63 141.27 l 141.76 146.87 l 147.61 151.80 l 153.31 156.38 l 159.00 160.98 l 164.82 165.93 l 170.91 171.57 l 177.42 178.25 l S 129.07 134.65 m 121.94 126.66 l S 177.42 178.25 m 184.47 186.31 l S 185.75 187.90 m 187.03 189.54 l 188.29 191.22 l 189.53 192.92 l 190.75 194.62 l 191.93 196.32 l 193.08 197.99 l 194.18 199.63 l 195.23 201.21 l S 185.75 187.90 m 184.47 186.31 l S 195.23 201.21 m 196.23 202.73 l S 195.97 198.14 m 196.23 202.73 l 192.13 200.66 l S 113.81 107.87 m 117.10 110.05 l 120.80 112.31 l 124.85 114.56 l 129.19 116.71 l 133.77 118.67 l 138.52 120.36 l 143.38 121.67 l 148.30 122.53 l S 113.81 107.87 m 110.99 105.87 l S 148.30 122.53 m 153.21 122.83 l S 153.23 122.83 m 153.40 122.83 l 153.86 122.83 l 154.75 122.83 l 156.21 122.83 l 158.40 122.83 l 161.46 122.83 l 165.52 122.83 l 170.74 122.83 l S 153.23 122.83 m 153.21 122.83 l S 170.74 122.83 m 177.26 122.83 l S 182.74 124.50 m 188.24 129.14 l 193.66 136.17 l 198.92 145.05 l 203.94 155.19 l 208.63 166.04 l 212.91 177.02 l 216.69 187.59 l 219.89 197.17 l S 182.74 124.50 m 177.26 122.83 l S 219.89 197.17 m 222.41 205.19 l S 223.41 200.71 m 222.41 205.19 l 219.03 202.09 l S 115.35 101.84 m 118.78 101.92 l 122.55 102.00 l 126.60 102.07 l 130.86 102.14 l 135.28 102.20 l 139.78 102.24 l 144.31 102.28 l 148.81 102.30 l S 115.35 101.84 m 112.33 101.76 l S 148.81 102.30 m 153.21 102.31 l S 153.28 102.31 m 153.78 102.31 l 155.16 102.31 l 157.82 102.31 l 162.23 102.31 l 168.79 102.31 l 177.95 102.31 l 190.15 102.31 l 205.80 102.31 l S 153.28 102.31 m 153.21 102.31 l S 205.80 102.31 m 225.35 102.31 l S 244.86 104.88 m 258.68 112.16 l 267.77 123.56 l 273.10 138.46 l 275.65 156.25 l 276.39 176.31 l 276.29 198.03 l 276.32 220.79 l 277.46 244.00 l S 244.86 104.88 m 225.35 102.31 l S 277.46 244.00 m 280.66 267.03 l S 281.01 268.61 m 281.39 270.23 l 281.81 271.88 l 282.24 273.54 l 282.70 275.20 l 283.16 276.86 l 283.63 278.50 l 284.08 280.10 l 284.52 281.67 l S 281.01 268.61 m 280.66 267.03 l S 284.52 281.67 m 284.94 283.17 l S 286.10 278.73 m 284.94 283.17 l 281.67 279.95 l S 115.41 247.33 m 115.83 247.33 l 116.26 247.33 l 116.69 247.33 l 117.13 247.33 l 117.58 247.33 l 118.01 247.33 l 118.44 247.33 l 118.86 247.33 l S 115.41 247.33 m 115.00 247.33 l S 118.97 249.63 m 115.00 247.33 l 118.97 245.03 l S 118.86 247.33 m 119.27 247.33 l S 115.30 245.03 m 119.27 247.33 l 115.30 249.63 l S 139.53 213.22 m 140.01 213.32 l 140.48 213.44 l 140.95 213.57 l 141.42 213.71 l 141.87 213.86 l 142.32 214.01 l 142.76 214.17 l 143.18 214.33 l S 139.53 213.22 m 139.05 213.13 l S 142.53 216.12 m 139.05 213.13 l 143.38 211.60 l S 143.18 214.33 m 143.59 214.50 l S 140.75 210.88 m 143.59 214.50 l 139.04 215.15 l S 161.08 218.77 m 161.76 218.96 l 162.47 219.15 l 163.19 219.35 l 163.93 219.56 l 164.67 219.76 l 165.42 219.96 l 166.17 220.16 l 166.91 220.34 l S 161.08 218.77 m 160.42 218.60 l S 166.91 220.34 m 167.64 220.51 l S 164.29 217.37 m 167.64 220.51 l 163.24 221.84 l S 184.68 219.56 m 185.46 219.14 l 186.28 218.73 l 187.12 218.31 l 187.98 217.88 l 188.84 217.45 l 189.71 217.00 l 190.56 216.54 l 191.40 216.07 l S 184.68 219.56 m 183.94 219.97 l S 191.40 216.07 m 192.22 215.59 l S 187.63 215.65 m 192.22 215.59 l 189.97 219.59 l S 189.05 223.23 m 191.06 223.18 l 193.16 223.10 l 195.32 222.97 l 197.53 222.81 l 199.76 222.60 l 202.00 222.35 l 204.22 222.06 l 206.40 221.72 l S 189.05 223.23 m 187.14 223.25 l S 191.14 225.51 m 187.14 223.25 l 191.10 220.92 l S 206.40 221.72 m 208.52 221.34 l S 209.32 221.16 m 210.12 220.98 l 210.92 220.78 l 211.71 220.57 l 212.49 220.34 l 213.27 220.11 l 214.04 219.88 l 214.79 219.64 l 215.54 219.39 l S 209.32 221.16 m 208.52 221.34 l S 215.54 219.39 m 216.27 219.15 l S 211.76 218.24 m 216.27 219.15 l 213.23 222.59 l S 182.00 236.87 m 183.71 241.71 l 185.53 246.92 l 187.44 252.38 l 189.38 257.97 l 191.31 263.54 l 193.19 268.98 l 194.98 274.15 l 196.63 278.93 l S 182.00 236.87 m 180.46 232.55 l S 179.63 237.07 m 180.46 232.55 l 183.96 235.53 l S 196.63 278.93 m 198.10 283.17 l S 198.97 278.66 m 198.10 283.17 l 194.63 280.16 l S 204.32 225.70 m 206.10 234.55 l 208.15 244.76 l 210.40 255.88 l 212.76 267.51 l 215.14 279.22 l 217.46 290.59 l 219.64 301.20 l 221.59 310.64 l S 204.32 225.70 m 202.91 218.60 l S 221.59 310.64 m 223.21 318.47 l S 224.65 314.11 m 223.21 318.47 l 220.16 315.04 l S 209.24 212.67 m 209.96 212.77 l 210.68 212.89 l 211.39 213.00 l 212.09 213.13 l 212.79 213.25 l 213.48 213.37 l 214.15 213.48 l 214.82 213.58 l S 209.24 212.67 m 208.52 212.58 l S 214.82 213.58 m 215.47 213.67 l S 211.84 210.85 m 215.47 213.67 l 211.21 215.40 l S 206.76 203.66 m 208.05 201.73 l 209.42 199.69 l 210.85 197.57 l 212.33 195.41 l 213.81 193.23 l 215.29 191.07 l 216.75 188.94 l 218.15 186.89 l S 206.76 203.66 m 205.58 205.47 l S 218.15 186.89 m 219.47 184.94 l S 215.34 186.94 m 219.47 184.94 l 219.13 189.52 l S 229.67 227.77 m 231.96 234.56 l 234.56 242.26 l 237.36 250.59 l 240.28 259.27 l 243.22 268.02 l 246.10 276.57 l 248.82 284.64 l 251.28 291.95 l S 229.67 227.77 m 227.76 222.16 l S 251.28 291.95 m 253.41 298.22 l S 254.31 293.72 m 253.41 298.22 l 249.96 295.19 l S 265.33 316.44 m 266.94 318.04 l 268.62 319.70 l 270.35 321.40 l 272.11 323.12 l 273.87 324.84 l 275.61 326.54 l 277.29 328.21 l 278.89 329.81 l S 265.33 316.44 m 263.83 314.91 l S 264.99 319.36 m 263.83 314.91 l 268.26 316.13 l S 278.89 329.81 m 280.40 331.33 l S 279.24 326.89 m 280.40 331.33 l 275.97 330.11 l S 267.01 309.40 m 270.55 309.94 l 274.37 310.49 l 278.40 311.06 l 282.53 311.63 l 286.70 312.20 l 290.82 312.77 l 294.81 313.33 l 298.57 313.86 l S 267.01 309.40 m 263.83 308.89 l S 298.57 313.86 m 302.04 314.37 l S 298.44 311.52 m 302.04 314.37 l 297.77 316.06 l S 319.41 312.40 m 320.21 312.07 l 321.01 311.74 l 321.81 311.41 l 322.61 311.08 l 323.42 310.76 l 324.22 310.43 l 325.02 310.10 l 325.82 309.77 l S 319.41 312.40 m 318.61 312.73 l S 325.82 309.77 m 326.62 309.44 l S 322.07 308.82 m 326.62 309.44 l 323.81 313.07 l S 340.99 296.96 m 342.38 294.67 l 343.86 292.23 l 345.42 289.67 l 347.03 287.04 l 348.66 284.39 l 350.29 281.75 l 351.90 279.19 l 353.46 276.73 l S 340.99 296.96 m 339.71 299.04 l S 353.46 276.73 m 354.95 274.42 l S 350.86 276.52 m 354.95 274.42 l 354.72 279.01 l S 365.07 259.87 m 365.31 259.56 l 365.55 259.26 l 365.79 258.97 l 366.03 258.68 l 366.27 258.40 l 366.52 258.11 l 366.76 257.81 l 367.00 257.50 l S 365.07 259.87 m 364.83 260.19 l S 367.00 257.50 m 367.24 257.18 l S 371.41 251.39 m 375.58 245.42 l 379.68 239.36 l 383.69 233.31 l 387.54 227.36 l 391.21 221.60 l 394.63 216.14 l 397.78 211.06 l 400.60 206.47 l S 371.41 251.39 m 367.24 257.18 l S 400.60 206.47 m 403.04 202.46 l S 399.01 204.66 m 403.04 202.46 l 402.93 207.05 l S 295.11 289.04 m 295.95 288.59 l 296.82 288.12 l 297.70 287.63 l 298.60 287.14 l 299.50 286.65 l 300.41 286.17 l 301.32 285.69 l 302.22 285.24 l S 295.11 289.04 m 294.29 289.47 l S 302.22 285.24 m 303.11 284.82 l S 298.53 284.46 m 303.11 284.82 l 300.51 288.61 l S 321.38 274.35 m 322.03 273.98 l 322.67 273.59 l 323.31 273.19 l 323.95 272.78 l 324.59 272.37 l 325.23 271.96 l 325.87 271.57 l 326.52 271.20 l S 321.38 274.35 m 320.74 274.69 l S 325.33 274.84 m 320.74 274.69 l 323.16 270.79 l S 326.52 271.20 m 327.16 270.86 l S 322.57 270.72 m 327.16 270.86 l 324.74 274.76 l S 338.34 274.66 m 338.86 276.69 l 339.40 278.84 l 339.96 281.09 l 340.52 283.41 l 341.08 285.80 l 341.63 288.22 l 342.17 290.66 l 342.69 293.09 l S 338.34 274.66 m 337.84 272.78 l S 342.69 293.09 m 343.19 295.49 l S 344.88 302.59 m 346.59 309.86 l 348.28 317.19 l 349.94 324.47 l 351.54 331.61 l 353.06 338.47 l 354.47 344.97 l 355.77 350.99 l 356.91 356.42 l S 344.88 302.59 m 343.19 295.49 l S 356.91 356.42 m 357.88 361.16 l S 359.33 356.80 m 357.88 361.16 l 354.83 357.72 l S 343.84 265.66 m 344.50 265.66 l 345.18 265.66 l 345.86 265.66 l 346.56 265.66 l 347.27 265.66 l 347.98 265.66 l 348.70 265.66 l 349.41 265.66 l S 343.84 265.66 m 343.19 265.66 l S 349.41 265.66 m 350.14 265.66 l S 346.16 263.37 m 350.14 265.66 l 346.16 267.96 l S 211.60 176.19 m 212.02 176.19 l 212.45 176.20 l 212.89 176.21 l 213.33 176.22 l 213.77 176.25 l 214.21 176.28 l 214.64 176.33 l 215.06 176.39 l S 211.60 176.19 m 211.19 176.19 l S 215.17 178.49 m 211.19 176.19 l 215.17 173.89 l S 215.06 176.39 m 215.47 176.46 l S 211.96 173.49 m 215.47 176.46 l 211.14 178.01 l S 232.38 182.86 m 233.89 184.13 l 235.47 185.48 l 237.11 186.87 l 238.78 188.30 l 240.47 189.74 l 242.15 191.18 l 243.81 192.61 l 245.44 194.00 l S 232.38 182.86 m 230.96 181.66 l S 245.44 194.00 m 247.00 195.34 l S 245.48 191.01 m 247.00 195.34 l 242.48 194.49 l S 236.84 174.69 m 241.87 174.01 l 247.54 173.38 l 253.73 172.88 l 260.32 172.56 l 267.20 172.49 l 274.23 172.73 l 281.30 173.34 l 288.30 174.38 l S 236.84 174.69 m 232.57 175.37 l S 288.30 174.38 m 295.09 175.91 l S 295.98 176.18 m 296.88 176.47 l 297.78 176.79 l 298.68 177.14 l 299.57 177.52 l 300.44 177.92 l 301.29 178.35 l 302.11 178.80 l 302.90 179.26 l S 295.98 176.18 m 295.09 175.91 l S 302.90 179.26 m 303.64 179.75 l S 301.56 175.65 m 303.64 179.75 l 299.06 179.50 l S 267.53 209.70 m 268.85 210.42 l 270.18 211.17 l 271.52 211.94 l 272.85 212.72 l 274.16 213.49 l 275.45 214.26 l 276.70 215.01 l 277.91 215.73 l S 267.53 209.70 m 266.23 209.02 l S 277.91 215.73 m 279.06 216.41 l S 276.80 212.41 m 279.06 216.41 l 274.47 216.37 l S 267.53 197.40 m 268.85 196.68 l 270.18 195.93 l 271.52 195.16 l 272.85 194.38 l 274.16 193.61 l 275.45 192.84 l 276.70 192.09 l 277.91 191.37 l S 267.53 197.40 m 266.23 198.08 l S 277.91 191.37 m 279.06 190.69 l S 274.47 190.73 m 279.06 190.69 l 276.80 194.69 l S 295.11 225.32 m 295.95 225.77 l 296.82 226.24 l 297.70 226.73 l 298.60 227.22 l 299.50 227.71 l 300.41 228.19 l 301.32 228.67 l 302.22 229.12 l S 295.11 225.32 m 294.29 224.89 l S 302.22 229.12 m 303.11 229.54 l S 300.51 225.76 m 303.11 229.54 l 298.53 229.90 l S 295.74 185.76 m 296.40 185.76 l 297.08 185.76 l 297.77 185.76 l 298.47 185.76 l 299.17 185.76 l 299.88 185.76 l 300.60 185.76 l 301.32 185.76 l S 295.74 185.76 m 295.09 185.76 l S 301.32 185.76 m 302.04 185.76 l S 298.06 183.47 m 302.04 185.76 l 298.06 188.06 l S 324.98 186.85 m 332.06 187.47 l 340.08 188.14 l 348.75 188.86 l 357.78 189.60 l 366.89 190.33 l 375.78 191.05 l 384.16 191.72 l 391.74 192.34 l S 324.98 186.85 m 319.14 186.31 l S 391.74 192.34 m 398.23 192.88 l S 394.46 190.26 m 398.23 192.88 l 394.08 194.84 l S 317.28 241.94 m 318.43 243.49 l 319.64 245.11 l 320.89 246.80 l 322.18 248.53 l 323.49 250.28 l 324.82 252.04 l 326.15 253.79 l 327.46 255.51 l S 317.28 241.94 m 316.20 240.49 l S 327.46 255.51 m 328.76 257.18 l S 328.83 257.26 m 328.89 257.34 l 328.94 257.42 l 328.99 257.49 l 329.03 257.56 l 329.07 257.61 l 329.11 257.66 l 329.16 257.70 l 329.22 257.72 l S 328.83 257.26 m 328.76 257.18 l S 329.22 257.72 m 329.29 257.73 l S 325.59 255.01 m 329.29 257.73 l 325.09 259.58 l S 324.98 234.47 m 332.06 234.47 l 340.08 234.47 l 348.75 234.47 l 357.78 234.47 l 366.89 234.47 l 375.78 234.47 l 384.16 234.47 l 391.74 234.47 l S 324.98 234.47 m 319.14 234.47 l S 391.74 234.47 m 398.23 234.47 l S 394.25 232.17 m 398.23 234.47 l 394.25 236.77 l S 297.72 258.98 m 300.60 259.46 l 303.67 259.96 l 306.89 260.50 l 310.19 261.04 l 313.52 261.60 l 316.83 262.16 l 320.07 262.71 l 323.17 263.24 l S 297.72 258.98 m 295.09 258.55 l S 323.17 263.24 m 326.09 263.75 l S 322.56 260.80 m 326.09 263.75 l 321.78 265.33 l S 294.29 251.25 m 295.39 250.20 l 296.53 249.12 l 297.69 248.01 l 298.87 246.89 l 300.05 245.75 l 301.24 244.62 l 302.41 243.50 l 303.57 242.39 l S 294.29 251.25 m 293.22 252.25 l S 303.57 242.39 m 304.71 241.31 l S 300.25 242.39 m 304.71 241.31 l 303.41 245.72 l S 209.17 256.63 m 209.83 256.60 l 210.51 256.57 l 211.19 256.54 l 211.89 256.50 l 212.60 256.46 l 213.31 256.42 l 214.02 256.39 l 214.74 256.37 l S 209.17 256.63 m 208.52 256.63 l S 214.74 256.37 m 215.47 256.36 l S 211.46 254.11 m 215.47 256.36 l 211.51 258.70 l S 208.63 268.66 m 212.71 275.00 l 217.36 282.23 l 222.41 290.07 l 227.69 298.26 l 233.02 306.52 l 238.21 314.58 l 243.11 322.18 l 247.52 329.04 l S 208.63 268.66 m 205.31 263.47 l S 247.52 329.04 m 251.27 334.89 l S 251.05 330.30 m 251.27 334.89 l 247.19 332.78 l S 230.83 246.59 m 232.81 243.26 l 234.97 239.64 l 237.27 235.80 l 239.65 231.84 l 242.06 227.83 l 244.45 223.87 l 246.78 220.04 l 248.98 216.43 l S 230.83 246.59 m 229.09 249.52 l S 248.98 216.43 m 251.00 213.13 l S 246.97 215.31 m 251.00 213.13 l 250.88 217.72 l S 265.06 345.35 m 266.65 345.70 l 268.32 346.05 l 270.04 346.40 l 271.81 346.76 l 273.60 347.10 l 275.40 347.43 l 277.19 347.74 l 278.95 348.03 l S 265.06 345.35 m 263.56 345.01 l S 278.95 348.03 m 280.66 348.30 l S 285.53 348.73 m 290.47 349.04 l 295.42 349.24 l 300.35 349.36 l 305.18 349.39 l 309.87 349.36 l 314.36 349.28 l 318.59 349.15 l 322.52 349.01 l S 285.53 348.73 m 280.66 348.30 l S 322.52 349.01 m 326.09 348.84 l S 322.01 346.73 m 326.09 348.84 l 322.22 351.32 l S 345.82 350.75 m 348.70 351.37 l 351.77 352.07 l 354.98 352.81 l 358.29 353.60 l 361.62 354.41 l 364.93 355.23 l 368.16 356.04 l 371.27 356.84 l S 345.82 350.75 m 343.19 350.21 l S 371.27 356.84 m 374.18 357.60 l S 370.92 354.37 m 374.18 357.60 l 369.76 358.82 l S Q endstream endobj 227 0 obj << /CreationDate (D:20061226132457) /ModDate (D:20061226132457) /Title (R Graphics Output) /Producer (R 2.4.1) /Creator (R) >> endobj 228 0 obj << /Type /Font /Subtype /Type1 /Name /F1 /BaseFont /ZapfDingbats >> endobj 229 0 obj << /Type /Font /Subtype /Type1 /Name /F2 /BaseFont /Helvetica /Encoding 231 0 R >> endobj 230 0 obj 34637 endobj 231 0 obj << /Type /Encoding /BaseEncoding /WinAnsiEncoding /Differences [ 45/minus 96/quoteleft 144/dotlessi/grave/acute/circumflex/tilde/macron/breve/dotaccent/dieresis/.notdef/ring/cedilla/.notdef/hungarumlaut/ogonek/caron/space] >> endobj 226 0 obj << /D [224 0 R /XYZ 133.7684 692.1046 null] >> endobj 223 0 obj << /Font << /F55 62 0 R /F51 50 0 R /F8 43 0 R >> /XObject << /Im5 222 0 R >> /ProcSet [ /PDF /Text ] >> endobj 235 0 obj << /Length 919 /Filter /FlateDecode >> stream x}VI@Wp tCZ徝*K= dRC21zьN|or9ykLHVhrVEdM*mt\}'st|q s53upj8&ɷ(y.Crp~=3 hL~x0aތPh<@Nx?{BSF4d$Wv5Y3R)H*,;gvGykR(/R]XuQTe2Lon@oVAI*OJHT %)u@RDǝìeV :gtT(q:V#5*>hTSw|A=Ue$Ḿÿ+b[&zЋ-a]iKj  aP|;K:':y˨8|. kЃT\>貊7Z q` @FqzaW;]h\'t s3(:ȄX5zg`2'챻,H;mGH6,oV)w4|`W_ 1%?1pC;Z~2}eu olCt$P=q\[k8k%ȋi}({^JɅڴ*`|\ѥ\W'Jendstream endobj 234 0 obj << /Type /Page /Contents 235 0 R /Resources 233 0 R /MediaBox [0 0 612 792] /Parent 237 0 R >> endobj 232 0 obj << /Type /XObject /Subtype /Form /FormType 1 /PTEX.FileName (./layingOutPathways-VJCfig.pdf) /PTEX.PageNumber 1 /PTEX.InfoDict 238 0 R /Matrix [1.00000000 0.00000000 0.00000000 1.00000000 0.00000000 0.00000000] /BBox [0.00000000 0.00000000 432.00000000 432.00000000] /Resources << /ProcSet [ /PDF /Text ] /Font << /F1 239 0 R /F2 240 0 R >> /ExtGState << >>>> /Length 241 0 R >> stream q Q q 0.72 0.72 430.56 430.56 re W n 1.000 1.000 1.000 RG 0.75 w [] 0 d 1 J 1 j 10.00 M BT /F1 1 Tf 1 Tr 7.22 0 0 7.22 125.40 408.99 Tm (l) Tj 0 Tr 1.000 1.000 1.000 rg /F2 1 Tf 1.00 0.00 -0.00 1.00 127.09 411.14 Tm (ITGB) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 28.96 385.39 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 30.65 387.53 Tm (ITGA) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 69.51 385.39 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 71.61 387.53 Tm (ILK) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 110.14 385.39 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 112.01 387.53 Tm (CAV) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 150.78 385.39 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 152.59 387.53 Tm (SHC) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 110.14 361.79 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 112.00 363.93 Tm (FYN) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 150.78 361.79 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 152.28 363.93 Tm (GRB2) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 144.03 338.18 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 145.83 340.33 Tm (SOS) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 134.95 314.58 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 135.99 316.74 Tm (Ha-Ras) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 123.66 278.19 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 125.74 280.33 Tm (Raf) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 108.50 212.78 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 110.28 214.93 Tm (MEK) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 108.50 174.40 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 110.33 176.54 Tm (ERK) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 178.39 65.20 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 179.89 67.35 Tm (MYLK) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 176.17 41.60 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 177.93 43.75 Tm (MYO) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 224.05 385.39 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 225.56 387.53 Tm (ACTN) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 246.06 361.79 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 247.94 363.93 Tm (VCL) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 203.20 338.18 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 205.11 340.33 Tm (TLN) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 316.04 259.99 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 317.87 262.13 Tm (PXN) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 327.82 361.79 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 329.70 363.93 Tm (ZYX) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 347.61 338.18 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 349.17 340.33 Tm (VASP) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 306.97 338.18 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 308.22 340.33 Tm (SH3D5) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 244.90 338.18 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 246.76 340.33 Tm (TNS) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 239.30 314.58 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 240.77 316.73 Tm (CAPN) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 242.10 290.98 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 243.24 293.13 Tm (CAPNS) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 249.44 259.99 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 251.24 262.13 Tm (SRC) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 197.60 236.39 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 199.53 238.53 Tm (FAK) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 319.90 212.78 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 321.09 214.93 Tm (BCAR1) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 278.78 236.39 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 280.61 238.53 Tm (CSK) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 340.85 174.40 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 342.65 176.54 Tm (CRK) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 340.85 143.40 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 341.99 145.55 Tm (DOCK1) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 381.39 143.40 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 382.92 145.55 Tm (GRF2) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 388.73 107.00 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 390.28 109.15 Tm (RAP1) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 269.22 65.20 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 271.14 67.36 Tm (JNK) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 369.04 236.39 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 370.78 238.53 Tm (GIT2) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 380.81 187.19 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 381.59 189.34 Tm (ARHGEF) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 269.22 88.80 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 271.14 90.95 Tm (PAK) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 238.14 236.39 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 240.17 238.64 Tm (p85) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 217.87 212.78 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 219.62 215.04 Tm (p110) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 219.03 174.40 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 219.58 176.65 Tm (phosphati.) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 300.21 143.40 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 302.14 145.55 Tm (VAV) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 219.03 143.40 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 220.25 145.55 Tm (PDPK1) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 219.03 119.80 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 220.92 121.95 Tm (AKT) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 297.99 119.80 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 299.81 121.95 Tm (RAC) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 259.57 143.40 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 260.79 145.55 Tm (CDC42) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 149.05 236.39 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 150.79 238.53 Tm (RHO) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 176.65 212.78 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 178.43 214.94 Tm (PI5K) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 145.09 199.99 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 146.51 202.13 Tm (ROCK) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 156.96 161.60 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 158.10 163.75 Tm (MYO-P) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 221.25 41.60 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 220.36 43.76 Tm (cell maintenance) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 336.31 88.80 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 336.73 91.06 Tm (cell motility) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 176.17 18.00 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 177.38 20.15 Tm (F-actin) Tj /F1 1 Tf 1 Tr 7.22 0 0 7.22 94.89 143.40 Tm (l) Tj 0 Tr /F2 1 Tf 1.00 0.00 -0.00 1.00 94.27 145.65 Tm (cell proliferation) Tj ET 0.000 0.000 0.000 RG 116.91 408.74 m 109.18 406.84 l 100.18 404.63 l 90.32 402.21 l 80.04 399.69 l 69.76 397.17 l 59.90 394.76 l 50.89 392.55 l 43.16 390.65 l S 116.91 408.74 m 122.95 410.21 l S 119.59 407.00 m 122.95 410.21 l 118.48 411.51 l S 43.16 390.65 m 37.13 389.17 l S 40.48 392.39 m 37.13 389.17 l 41.59 387.88 l S 119.57 407.84 m 115.34 406.04 l 110.62 404.04 l 105.57 401.91 l 100.35 399.71 l 95.12 397.52 l 90.06 395.40 l 85.32 393.42 l 81.08 391.65 l S 119.57 407.84 m 123.14 409.36 l S 120.35 405.65 m 123.14 409.36 l 118.53 409.92 l S 81.08 391.65 m 77.48 390.17 l S 80.31 393.85 m 77.48 390.17 l 82.09 389.56 l S 123.75 404.67 m 122.98 403.47 l 122.19 402.23 l 121.39 400.97 l 120.58 399.69 l 119.77 398.42 l 118.97 397.15 l 118.18 395.92 l 117.41 394.72 l S 123.75 404.67 m 124.49 405.81 l S 124.25 401.17 m 124.49 405.81 l 120.35 403.70 l S 117.41 394.72 m 116.67 393.58 l S 116.91 398.22 m 116.67 393.58 l 120.81 395.69 l S 134.25 406.02 m 135.82 404.56 l 137.48 403.01 l 139.20 401.40 l 140.95 399.76 l 142.70 398.13 l 144.41 396.52 l 146.07 394.97 l 147.65 393.51 l S 134.25 406.02 m 132.79 407.37 l S 137.32 406.35 m 132.79 407.37 l 134.17 402.93 l S 147.65 393.51 m 149.11 392.16 l S 144.57 393.18 m 149.11 392.16 l 147.73 396.60 l S 137.00 410.58 m 141.10 410.14 l 145.77 409.59 l 150.90 408.94 l 156.41 408.17 l 162.18 407.29 l 168.12 406.29 l 174.13 405.17 l 180.12 403.92 l S 137.00 410.58 m 133.56 410.93 l S 137.80 412.83 m 133.56 410.93 l 137.33 408.21 l S 180.12 403.92 m 185.98 402.54 l S 189.94 401.44 m 193.97 400.23 l 198.00 398.92 l 201.99 397.56 l 205.88 396.17 l 209.60 394.80 l 213.11 393.46 l 216.35 392.20 l 219.26 391.04 l S 189.94 401.44 m 185.98 402.54 l S 219.26 391.04 m 221.79 390.03 l S 217.19 389.37 m 221.79 390.03 l 218.93 393.68 l S 138.42 410.36 m 144.29 409.60 l 150.81 408.65 l 157.63 407.52 l 164.38 406.20 l 170.71 404.70 l 176.26 403.03 l 180.67 401.18 l 183.58 399.17 l S 138.42 410.36 m 133.56 410.93 l S 137.83 412.77 m 133.56 410.93 l 137.29 408.15 l S 183.58 399.17 m 184.63 396.99 l S 184.63 396.95 m 184.63 396.66 l 184.63 395.86 l 184.63 394.32 l 184.63 391.77 l 184.63 387.96 l 184.63 382.65 l 184.63 375.59 l 184.63 366.52 l S 184.63 396.95 m 184.63 396.99 l S 184.63 366.52 m 184.63 355.19 l S 184.91 353.63 m 185.71 352.10 l 186.95 350.62 l 188.54 349.20 l 190.40 347.85 l 192.45 346.58 l 194.61 345.41 l 196.80 344.33 l 198.94 343.37 l S 184.91 353.63 m 184.63 355.19 l S 198.94 343.37 m 200.94 342.54 l S 196.33 341.94 m 200.94 342.54 l 198.12 346.23 l S 146.17 383.53 m 143.27 381.82 l 140.12 379.97 l 136.78 378.03 l 133.36 376.04 l 129.93 374.06 l 126.59 372.12 l 123.42 370.29 l 120.50 368.62 l S 146.17 383.53 m 148.72 385.05 l S 146.45 380.99 m 148.72 385.05 l 144.07 384.99 l S 120.50 368.62 m 117.93 367.14 l S 120.26 371.15 m 117.93 367.14 l 122.57 367.13 l S 153.64 379.30 m 153.64 378.51 l 153.64 377.71 l 153.64 376.90 l 153.64 376.09 l 153.64 375.28 l 153.64 374.48 l 153.64 373.68 l 153.64 372.89 l S 153.64 379.30 m 153.64 380.07 l S 155.96 376.05 m 153.64 380.07 l 151.32 376.05 l S 153.64 372.89 m 153.64 372.11 l S 151.32 376.13 m 153.64 372.11 l 155.96 376.13 l S 152.28 359.66 m 151.95 358.51 l 151.60 357.27 l 151.24 355.99 l 150.87 354.66 l 150.49 353.31 l 150.11 351.94 l 149.73 350.58 l 149.36 349.24 l S 152.28 359.66 m 152.58 360.74 l S 149.36 349.24 m 149.01 347.94 l S 147.83 352.43 m 149.01 347.94 l 152.31 351.21 l S 145.21 336.16 m 144.75 334.95 l 144.26 333.66 l 143.75 332.32 l 143.22 330.93 l 142.68 329.53 l 142.13 328.12 l 141.58 326.73 l 141.04 325.37 l S 145.21 336.16 m 145.63 337.28 l S 141.04 325.37 m 140.51 324.06 l S 139.87 328.66 m 140.51 324.06 l 144.17 326.92 l S 136.12 311.57 m 135.41 309.32 l 134.62 306.82 l 133.79 304.16 l 132.92 301.38 l 132.04 298.55 l 131.17 295.73 l 130.31 292.98 l 129.50 290.36 l S 136.12 311.57 m 136.75 313.53 l S 129.50 290.36 m 128.74 287.94 l S 127.72 292.48 m 128.74 287.94 l 132.16 291.09 l S 122.04 279.79 m 119.86 279.11 l 117.50 278.20 l 115.07 277.02 l 112.69 275.54 l 110.48 273.72 l 108.55 271.54 l 107.03 268.97 l 106.03 265.96 l S 122.04 279.79 m 123.91 280.26 l S 106.03 265.96 m 105.67 262.49 l S 105.67 262.46 m 105.67 262.23 l 105.67 261.61 l 105.67 260.40 l 105.67 258.40 l 105.67 255.43 l 105.67 251.28 l 105.67 245.75 l 105.67 238.65 l S 105.67 262.46 m 105.67 262.49 l S 105.67 238.65 m 105.67 229.79 l S 105.70 228.85 m 105.78 227.92 l 105.91 227.00 l 106.08 226.08 l 106.29 225.19 l 106.54 224.31 l 106.82 223.47 l 107.12 222.65 l 107.45 221.86 l S 105.70 228.85 m 105.67 229.79 l S 107.45 221.86 m 107.79 221.12 l S 104.00 223.81 m 107.79 221.12 l 108.23 225.74 l S 111.36 209.40 m 111.36 207.06 l 111.36 204.48 l 111.36 201.71 l 111.36 198.83 l 111.36 195.89 l 111.36 192.95 l 111.36 190.07 l 111.36 187.30 l S 111.36 209.40 m 111.36 211.45 l S 111.36 187.30 m 111.36 184.72 l S 109.04 188.74 m 111.36 184.72 l 113.68 188.74 l S 115.46 174.83 m 117.28 173.66 l 119.23 172.24 l 121.22 170.57 l 123.16 168.64 l 124.96 166.45 l 126.51 163.99 l 127.74 161.27 l 128.55 158.28 l S 115.46 174.83 m 113.87 175.76 l S 128.55 158.28 m 128.83 155.01 l S 128.83 154.95 m 128.83 154.57 l 128.83 153.53 l 128.83 151.51 l 128.83 148.18 l 128.83 143.21 l 128.83 136.28 l 128.83 127.05 l 128.83 115.21 l S 128.83 154.95 m 128.83 155.01 l S 128.83 115.21 m 128.83 100.41 l S 129.80 95.99 m 132.46 91.78 l 136.51 87.82 l 141.61 84.13 l 147.43 80.74 l 153.65 77.67 l 159.93 74.97 l 165.96 72.65 l 171.41 70.74 l S 129.80 95.99 m 128.83 100.41 l S 171.41 70.74 m 175.94 69.27 l S 171.40 68.30 m 175.94 69.27 l 172.83 72.72 l S 109.19 172.01 m 108.38 170.15 l 107.48 168.10 l 106.53 165.92 l 105.53 163.64 l 104.52 161.33 l 103.51 159.01 l 102.51 156.76 l 101.55 154.60 l S 109.19 172.01 m 109.91 173.63 l S 101.55 154.60 m 100.65 152.59 l S 100.18 157.21 m 100.65 152.59 l 104.42 155.31 l S 180.77 62.85 m 180.68 61.75 l 180.58 60.60 l 180.48 59.40 l 180.37 58.16 l 180.26 56.91 l 180.15 55.64 l 180.03 54.38 l 179.92 53.14 l S 180.77 62.85 m 180.86 63.87 l S 179.92 53.14 m 179.80 51.93 l S 177.87 56.15 m 179.80 51.93 l 182.50 55.71 l S 179.03 35.51 m 179.03 34.72 l 179.03 33.92 l 179.03 33.12 l 179.03 32.31 l 179.03 31.50 l 179.03 30.69 l 179.03 29.89 l 179.03 29.10 l S 179.03 35.51 m 179.03 36.29 l S 181.35 32.26 m 179.03 36.29 l 176.71 32.26 l S 179.03 29.10 m 179.03 28.33 l S 176.71 32.35 m 179.03 28.33 l 181.35 32.35 l S 232.46 382.05 m 233.75 380.66 l 235.10 379.20 l 236.50 377.69 l 237.91 376.16 l 239.33 374.63 l 240.72 373.12 l 242.08 371.66 l 243.37 370.28 l S 232.46 382.05 m 231.25 383.34 l S 235.70 381.99 m 231.25 383.34 l 232.30 378.82 l S 243.37 370.28 m 244.57 368.98 l S 240.13 370.34 m 244.57 368.98 l 243.52 373.51 l S 219.83 385.03 m 217.75 384.04 l 215.63 382.95 l 213.54 381.76 l 211.57 380.50 l 209.79 379.17 l 208.27 377.78 l 207.09 376.34 l 206.33 374.88 l S 219.83 385.03 m 221.79 385.90 l S 219.06 382.15 m 221.79 385.90 l 217.17 386.39 l S 206.33 374.88 m 206.06 373.39 l S 206.06 373.37 m 206.06 373.25 l 206.06 372.90 l 206.06 372.23 l 206.06 371.12 l 206.06 369.46 l 206.06 367.15 l 206.06 364.07 l 206.06 360.12 l S 206.06 373.37 m 206.06 373.39 l S 206.06 360.12 m 206.06 355.19 l S 206.06 354.54 m 206.06 353.88 l 206.06 353.21 l 206.06 352.53 l 206.06 351.85 l 206.06 351.17 l 206.06 350.49 l 206.06 349.82 l 206.06 349.16 l S 206.06 354.54 m 206.06 355.19 l S 206.06 349.16 m 206.06 348.51 l S 203.73 352.53 m 206.06 348.51 l 208.38 352.53 l S 238.66 385.30 m 247.02 383.40 l 256.81 381.17 l 267.56 378.72 l 278.79 376.15 l 290.02 373.57 l 300.77 371.10 l 310.56 368.85 l 318.92 366.92 l S 238.66 385.30 m 232.22 386.76 l S 236.65 388.14 m 232.22 386.76 l 235.63 383.60 l S 318.92 366.92 m 325.37 365.43 l S 320.92 364.07 m 325.37 365.43 l 321.97 368.60 l S 241.28 359.99 m 238.17 358.31 l 234.77 356.46 l 231.18 354.50 l 227.49 352.47 l 223.80 350.44 l 220.20 348.46 l 216.80 346.59 l 213.70 344.88 l S 241.28 359.99 m 243.99 361.45 l S 241.54 357.50 m 243.99 361.45 l 239.35 361.60 l S 213.70 344.88 m 210.98 343.39 l S 213.39 347.36 m 210.98 343.39 l 215.63 343.29 l S 257.00 362.71 m 260.08 361.96 l 263.33 361.05 l 266.60 359.97 l 269.75 358.73 l 272.65 357.31 l 275.15 355.71 l 277.11 353.92 l 278.38 351.95 l S 257.00 362.71 m 254.23 363.30 l S 258.64 364.73 m 254.23 363.30 l 257.68 360.19 l S 278.38 351.95 m 278.84 349.79 l S 278.84 349.72 m 278.84 349.24 l 278.84 347.92 l 278.84 345.37 l 278.84 341.15 l 278.84 334.86 l 278.84 326.09 l 278.84 314.41 l 278.84 299.42 l S 278.84 349.72 m 278.84 349.79 l S 278.84 299.42 m 278.84 280.69 l S 279.52 277.66 m 281.41 274.94 l 284.29 272.53 l 287.93 270.42 l 292.13 268.59 l 296.65 267.02 l 301.27 265.72 l 305.79 264.65 l 309.97 263.82 l S 279.52 277.66 m 278.84 280.69 l S 309.97 263.82 m 313.59 263.20 l S 309.24 261.59 m 313.59 263.20 l 310.01 266.17 l S 256.21 362.54 m 258.44 362.00 l 260.86 361.37 l 263.45 360.68 l 266.16 359.92 l 268.95 359.10 l 271.79 358.23 l 274.64 357.31 l 277.45 356.34 l S 256.21 362.54 m 254.23 363.01 l S 258.67 364.35 m 254.23 363.01 l 257.61 359.83 l S 277.45 356.34 m 280.19 355.33 l S 282.86 354.26 m 285.56 353.10 l 288.27 351.87 l 290.96 350.61 l 293.59 349.33 l 296.13 348.06 l 298.55 346.82 l 300.83 345.63 l 302.92 344.53 l S 282.86 354.26 m 280.19 355.33 l S 302.92 344.53 m 304.81 343.53 l S 300.16 343.37 m 304.81 343.53 l 302.34 347.47 l S 248.50 355.70 m 248.46 354.91 l 248.42 354.11 l 248.38 353.30 l 248.34 352.49 l 248.29 351.68 l 248.25 350.87 l 248.21 350.07 l 248.18 349.29 l S 248.50 355.70 m 248.53 356.47 l S 250.69 352.36 m 248.53 356.47 l 246.05 352.55 l S 248.18 349.29 m 248.14 348.51 l S 245.99 352.62 m 248.14 348.51 l 250.63 352.44 l S 213.19 335.96 m 215.68 334.32 l 218.36 332.56 l 221.18 330.72 l 224.07 328.84 l 226.97 326.96 l 229.80 325.13 l 232.49 323.39 l 235.00 321.78 l S 213.19 335.96 m 210.98 337.42 l S 215.62 337.14 m 210.98 337.42 l 213.05 333.26 l S 235.00 321.78 m 237.24 320.36 l S 232.60 320.56 m 237.24 320.36 l 235.09 324.48 l S 204.74 332.22 m 204.69 331.56 l 204.63 330.89 l 204.58 330.21 l 204.54 329.53 l 204.50 328.85 l 204.46 328.17 l 204.44 327.50 l 204.42 326.84 l S 204.74 332.22 m 204.80 332.87 l S 206.76 328.66 m 204.80 332.87 l 202.13 329.07 l S 204.42 326.84 m 204.42 326.19 l S 204.42 326.12 m 204.42 325.61 l 204.42 324.22 l 204.42 321.53 l 204.42 317.09 l 204.42 310.46 l 204.42 301.22 l 204.42 288.92 l 204.42 273.12 l S 204.42 326.12 m 204.42 326.19 l S 204.42 273.12 m 204.42 253.39 l S 204.40 252.58 m 204.35 251.78 l 204.27 250.97 l 204.17 250.18 l 204.04 249.39 l 203.90 248.62 l 203.73 247.87 l 203.55 247.13 l 203.36 246.41 l S 204.40 252.58 m 204.42 253.39 l S 203.36 246.41 m 203.16 245.72 l S 202.04 250.22 m 203.16 245.72 l 206.50 248.94 l S 306.34 259.89 m 296.74 257.98 l 285.38 255.72 l 272.84 253.23 l 259.72 250.64 l 246.59 248.05 l 234.04 245.58 l 222.66 243.34 l 213.04 241.45 l S 306.34 259.89 m 313.59 261.35 l S 310.11 258.28 m 313.59 261.35 l 309.19 262.84 l S 213.04 241.45 m 205.77 240.03 l S 209.27 243.08 m 205.77 240.03 l 210.16 238.52 l S 322.89 261.32 m 324.44 260.69 l 326.09 259.88 l 327.76 258.87 l 329.37 257.66 l 330.86 256.22 l 332.15 254.55 l 333.16 252.63 l 333.82 250.45 l S 322.89 261.32 m 321.51 261.78 l S 333.82 250.45 m 334.06 247.99 l S 334.06 247.97 m 334.06 247.84 l 334.06 247.50 l 334.06 246.83 l 334.06 245.72 l 334.06 244.06 l 334.06 241.75 l 334.06 238.67 l 334.06 234.72 l S 334.06 247.97 m 334.06 247.99 l S 334.06 234.72 m 334.06 229.79 l S 333.96 228.26 m 333.69 226.81 l 333.27 225.44 l 332.71 224.16 l 332.04 222.97 l 331.28 221.86 l 330.46 220.83 l 329.58 219.90 l 328.68 219.04 l S 333.96 228.26 m 334.06 229.79 l S 328.68 219.04 m 327.78 218.27 l S 329.34 222.65 m 327.78 218.27 l 332.35 219.11 l S 324.37 260.03 m 328.21 258.31 l 332.73 256.30 l 337.73 254.08 l 343.01 251.74 l 348.38 249.36 l 353.63 247.02 l 358.59 244.82 l 363.03 242.84 l S 324.37 260.03 m 321.41 261.35 l S 363.03 242.84 m 366.78 241.17 l S 362.16 240.69 m 366.78 241.17 l 364.05 244.93 l S 335.88 358.07 m 337.00 356.75 l 338.16 355.36 l 339.36 353.94 l 340.57 352.49 l 341.78 351.04 l 342.98 349.62 l 344.15 348.23 l 345.26 346.91 l S 335.88 358.07 m 334.83 359.32 l S 339.20 357.75 m 334.83 359.32 l 335.65 354.74 l S 345.26 346.91 m 346.31 345.67 l S 341.94 347.24 m 346.31 345.67 l 345.49 350.24 l S 243.21 308.49 m 243.30 307.70 l 243.39 306.90 l 243.47 306.10 l 243.56 305.29 l 243.65 304.48 l 243.73 303.67 l 243.82 302.87 l 243.91 302.08 l S 243.21 308.49 m 243.12 309.27 l S 245.88 305.53 m 243.12 309.27 l 241.26 305.01 l S 243.91 302.08 m 243.99 301.31 l S 241.24 305.05 m 243.99 301.31 l 245.85 305.56 l S 246.20 288.23 m 246.62 286.48 l 247.07 284.57 l 247.55 282.55 l 248.05 280.44 l 248.56 278.29 l 249.07 276.14 l 249.58 274.02 l 250.08 271.97 l S 246.20 288.23 m 245.83 289.79 l S 250.08 271.97 m 250.56 270.03 l S 247.34 273.38 m 250.56 270.03 l 251.86 274.49 l S 246.90 260.03 m 243.16 258.31 l 238.76 256.30 l 233.90 254.08 l 228.77 251.74 l 223.54 249.36 l 218.42 247.02 l 213.59 244.82 l 209.25 242.84 l S 246.90 260.03 m 249.79 261.35 l S 209.25 242.84 m 205.57 241.17 l S 208.27 244.95 m 205.57 241.17 l 210.20 240.72 l S 262.73 261.44 m 269.00 260.76 l 276.00 259.88 l 283.35 258.80 l 290.65 257.52 l 297.51 256.03 l 303.53 254.33 l 308.32 252.43 l 311.48 250.31 l S 262.73 261.44 m 257.60 261.92 l S 261.83 263.86 m 257.60 261.92 l 261.39 259.23 l S 311.48 250.31 m 312.63 247.99 l S 312.63 247.97 m 312.63 247.84 l 312.63 247.50 l 312.63 246.83 l 312.63 245.72 l 312.63 244.06 l 312.63 241.75 l 312.63 238.67 l 312.63 234.72 l S 312.63 247.97 m 312.63 247.99 l S 312.63 234.72 m 312.63 229.79 l S 312.70 228.38 m 312.93 227.03 l 313.28 225.75 l 313.74 224.55 l 314.30 223.41 l 314.94 222.35 l 315.64 221.36 l 316.38 220.45 l 317.15 219.61 l S 312.70 228.38 m 312.63 229.79 l S 317.15 219.61 m 317.94 218.84 l S 313.43 219.99 m 317.94 218.84 l 316.68 223.32 l S 258.77 257.39 m 260.69 255.86 l 262.72 254.21 l 264.84 252.51 l 267.00 250.76 l 269.16 249.02 l 271.27 247.31 l 273.29 245.67 l 275.19 244.13 l S 258.77 257.39 m 257.03 258.80 l S 261.62 258.09 m 257.03 258.80 l 258.71 254.47 l S 275.19 244.13 m 276.91 242.73 l S 272.32 243.47 m 276.91 242.73 l 275.26 247.07 l S 193.08 236.90 m 186.35 235.11 l 178.13 232.93 l 168.86 230.48 l 159.00 227.87 l 149.00 225.23 l 139.31 222.67 l 130.40 220.32 l 122.70 218.29 l S 193.08 236.90 m 197.85 238.18 l S 122.70 218.29 m 116.67 216.71 l S 119.97 219.98 m 116.67 216.71 l 121.15 215.49 l S 209.43 237.09 m 218.83 235.28 l 230.56 233.03 l 243.90 230.47 l 258.12 227.75 l 272.52 224.99 l 286.37 222.35 l 298.95 219.95 l 309.55 217.93 l S 209.43 237.09 m 203.07 238.32 l S 309.55 217.93 m 317.45 216.43 l S 313.07 214.89 m 317.45 216.43 l 313.93 219.46 l S 203.58 235.22 m 204.83 233.78 l 206.20 232.19 l 207.66 230.49 l 209.17 228.72 l 210.71 226.92 l 212.26 225.12 l 213.77 223.37 l 215.22 221.69 l S 203.58 235.22 m 202.49 236.47 l S 215.22 221.69 m 216.58 220.12 l S 212.19 221.64 m 216.58 220.12 l 215.69 224.68 l S 325.55 210.16 m 326.92 207.61 l 328.48 204.74 l 330.16 201.65 l 331.93 198.41 l 333.74 195.11 l 335.53 191.83 l 337.26 188.67 l 338.87 185.70 l S 325.55 210.16 m 324.40 212.30 l S 338.87 185.70 m 340.33 183.01 l S 336.37 185.44 m 340.33 183.01 l 340.45 187.66 l S 343.71 167.64 m 343.71 166.13 l 343.71 164.58 l 343.71 163.00 l 343.71 161.40 l 343.71 159.81 l 343.71 158.23 l 343.71 156.67 l 343.71 155.17 l S 343.71 167.64 m 343.71 169.08 l S 346.03 165.06 m 343.71 169.08 l 341.39 165.06 l S 343.71 155.17 m 343.71 153.73 l S 341.39 157.75 m 343.71 153.73 l 346.03 157.75 l S 348.30 173.34 m 351.16 171.18 l 354.47 168.66 l 358.11 165.88 l 361.94 162.95 l 365.84 159.96 l 369.68 157.02 l 373.32 154.22 l 376.65 151.67 l S 348.30 173.34 m 346.03 175.05 l S 376.65 151.67 m 379.52 149.46 l S 374.92 150.07 m 379.52 149.46 l 377.75 153.75 l S 385.40 140.30 m 385.84 138.09 l 386.33 135.65 l 386.85 133.04 l 387.39 130.32 l 387.94 127.54 l 388.50 124.76 l 389.04 122.05 l 389.56 119.46 l S 385.40 140.30 m 385.02 142.21 l S 389.56 119.46 m 390.04 117.04 l S 386.97 120.53 m 390.04 117.04 l 391.53 121.45 l S 388.28 106.68 m 387.21 105.54 l 386.09 104.24 l 384.98 102.79 l 383.91 101.19 l 382.94 99.46 l 382.10 97.60 l 381.45 95.62 l 381.02 93.52 l S 388.28 106.68 m 389.27 107.66 l S 381.02 93.52 m 380.87 91.31 l S 380.87 91.30 m 380.87 91.24 l 380.87 91.06 l 380.87 90.73 l 380.87 90.17 l 380.87 89.34 l 380.87 88.19 l 380.87 86.65 l 380.87 84.68 l S 380.87 91.30 m 380.87 91.31 l S 380.87 84.68 m 380.87 82.21 l S 378.56 79.98 m 372.20 77.91 l 362.64 76.00 l 350.73 74.26 l 337.31 72.70 l 323.24 71.34 l 309.37 70.18 l 296.53 69.23 l 285.59 68.49 l S 378.56 79.98 m 380.87 82.21 l S 285.59 68.49 m 277.39 67.99 l S 281.27 70.56 m 277.39 67.99 l 281.55 65.92 l S 266.89 65.11 m 263.47 63.43 l 259.47 61.47 l 255.07 59.31 l 250.41 57.03 l 245.68 54.71 l 241.03 52.43 l 236.63 50.28 l 232.64 48.33 l S 266.89 65.11 m 269.57 66.43 l S 232.64 48.33 m 229.22 46.67 l S 231.82 50.52 m 229.22 46.67 l 233.86 46.34 l S 372.72 234.16 m 372.86 233.19 l 372.99 232.17 l 373.12 231.09 l 373.23 229.99 l 373.34 228.86 l 373.42 227.72 l 373.48 226.59 l 373.52 225.47 l S 372.72 234.16 m 372.57 235.05 l S 373.52 225.47 m 373.54 224.39 l S 373.54 224.38 m 373.54 224.32 l 373.54 224.14 l 373.54 223.81 l 373.54 223.25 l 373.54 222.42 l 373.54 221.27 l 373.54 219.73 l 373.54 217.76 l S 373.54 224.38 m 373.54 224.39 l S 373.54 217.76 m 373.54 215.29 l S 373.64 212.99 m 373.92 210.72 l 374.36 208.49 l 374.94 206.31 l 375.64 204.20 l 376.41 202.18 l 377.25 200.25 l 378.13 198.45 l 379.02 196.77 l S 373.64 212.99 m 373.54 215.29 l S 379.02 196.77 m 379.91 195.24 l S 375.88 197.57 m 379.91 195.24 l 379.91 199.89 l S 391.92 188.31 m 395.21 187.37 l 398.67 186.10 l 402.18 184.47 l 405.56 182.41 l 408.67 179.89 l 411.36 176.84 l 413.46 173.23 l 414.84 169.00 l S 391.92 188.31 m 388.98 188.99 l S 393.42 190.35 m 388.98 188.99 l 392.38 185.82 l S 414.84 169.00 m 415.33 164.11 l S 415.33 164.10 m 415.33 164.03 l 415.33 163.86 l 415.33 163.52 l 415.33 162.97 l 415.33 162.14 l 415.33 160.98 l 415.33 159.45 l 415.33 157.47 l S 415.33 164.10 m 415.33 164.11 l S 415.33 157.47 m 415.33 155.01 l S 412.17 142.79 m 403.48 132.10 l 390.45 122.86 l 374.26 114.99 l 356.10 108.41 l 337.17 103.02 l 318.64 98.76 l 301.71 95.54 l 287.56 93.27 l S 412.17 142.79 m 415.33 155.01 l S 287.56 93.27 m 277.39 91.88 l S 281.06 94.73 m 277.39 91.88 l 281.69 90.12 l S 264.61 89.32 m 257.75 87.53 l 249.35 85.35 l 239.87 82.90 l 229.79 80.29 l 219.57 77.65 l 209.67 75.09 l 200.56 72.74 l 192.70 70.71 l S 264.61 89.32 m 269.48 90.60 l S 192.70 70.71 m 186.56 69.13 l S 189.87 72.38 m 186.56 69.13 l 191.03 67.89 l S 272.08 86.45 m 272.08 85.36 l 272.08 84.20 l 272.08 83.00 l 272.08 81.77 l 272.08 80.51 l 272.08 79.25 l 272.08 77.99 l 272.08 76.74 l S 272.08 86.45 m 272.08 87.47 l S 272.08 76.74 m 272.08 75.53 l S 269.76 79.55 m 272.08 75.53 l 274.41 79.55 l S 235.74 232.78 m 234.58 231.42 l 233.36 230.01 l 232.12 228.56 l 230.87 227.09 l 229.61 225.62 l 228.37 224.17 l 227.15 222.76 l 225.99 221.40 l S 235.74 232.78 m 236.85 234.06 l S 235.98 229.49 m 236.85 234.06 l 232.46 232.53 l S 225.99 221.40 m 224.88 220.12 l S 225.75 224.69 m 224.88 220.12 l 229.27 221.65 l S 220.89 209.40 m 220.96 207.06 l 221.04 204.48 l 221.13 201.71 l 221.21 198.83 l 221.30 195.89 l 221.38 192.95 l 221.46 190.07 l 221.54 187.30 l S 220.89 209.40 m 220.83 211.45 l S 221.54 187.30 m 221.60 184.72 l S 219.18 188.69 m 221.60 184.72 l 223.82 188.80 l S 215.93 211.35 m 212.84 208.51 l 209.34 204.98 l 205.65 200.78 l 201.97 195.97 l 198.49 190.58 l 195.44 184.66 l 193.00 178.24 l 191.39 171.38 l S 215.93 211.35 m 218.41 213.44 l S 191.39 171.38 m 190.81 164.11 l S 190.81 164.08 m 190.81 163.89 l 190.81 163.37 l 190.81 162.36 l 190.81 160.69 l 190.81 158.21 l 190.81 154.74 l 190.81 150.13 l 190.81 144.20 l S 190.81 164.08 m 190.81 164.11 l S 190.81 144.20 m 190.81 136.81 l S 191.29 134.53 m 192.63 132.48 l 194.69 130.64 l 197.32 129.01 l 200.36 127.58 l 203.67 126.34 l 207.10 125.29 l 210.49 124.41 l 213.70 123.71 l S 191.29 134.53 m 190.81 136.81 l S 213.70 123.71 m 216.58 123.16 l S 212.19 121.63 m 216.58 123.16 l 213.06 126.19 l S 228.89 174.21 m 235.00 171.87 l 242.41 169.04 l 250.74 165.86 l 259.58 162.49 l 268.56 159.07 l 277.27 155.75 l 285.32 152.68 l 292.31 150.01 l S 228.89 174.21 m 224.49 175.91 l S 292.31 150.01 m 297.86 147.90 l S 293.27 147.16 m 297.86 147.90 l 294.93 151.50 l S 221.89 171.52 m 221.89 169.80 l 221.89 167.94 l 221.89 165.97 l 221.89 163.93 l 221.89 161.84 l 221.89 159.75 l 221.89 157.68 l 221.89 155.66 l S 221.89 171.52 m 221.89 173.06 l S 221.89 155.66 m 221.89 153.73 l S 219.57 157.75 m 221.89 153.73 l 224.21 157.75 l S 302.59 141.05 m 302.50 139.95 l 302.40 138.80 l 302.30 137.60 l 302.19 136.36 l 302.08 135.11 l 301.97 133.84 l 301.85 132.58 l 301.74 131.34 l S 302.59 141.05 m 302.68 142.07 l S 301.74 131.34 m 301.62 130.12 l S 299.69 134.35 m 301.62 130.12 l 304.32 133.91 l S 221.89 141.05 m 221.89 139.95 l 221.89 138.80 l 221.89 137.60 l 221.89 136.36 l 221.89 135.11 l 221.89 133.84 l 221.89 132.58 l 221.89 131.34 l S 221.89 141.05 m 221.89 142.07 l S 221.89 131.34 m 221.89 130.12 l S 219.57 134.15 m 221.89 130.12 l 224.21 134.15 l S 221.89 117.06 m 221.89 115.50 l 221.89 113.80 l 221.89 112.01 l 221.89 110.13 l 221.89 108.20 l 221.89 106.24 l 221.89 104.27 l 221.89 102.32 l S 221.89 117.06 m 221.89 118.47 l S 221.89 102.32 m 221.89 100.41 l S 221.89 100.37 m 221.89 100.08 l 221.89 99.28 l 221.89 97.73 l 221.89 95.18 l 221.89 91.38 l 221.89 86.07 l 221.89 79.01 l 221.89 69.94 l S 221.89 100.37 m 221.89 100.41 l S 221.89 69.94 m 221.89 58.61 l S 221.90 57.88 m 221.92 57.16 l 221.96 56.44 l 222.01 55.72 l 222.07 55.00 l 222.14 54.29 l 222.21 53.58 l 222.30 52.88 l 222.38 52.19 l S 221.90 57.88 m 221.89 58.61 l S 222.38 52.19 m 222.47 51.50 l S 219.66 55.20 m 222.47 51.50 l 224.27 55.78 l S 297.12 118.33 m 295.19 116.28 l 293.01 113.94 l 290.64 111.39 l 288.16 108.71 l 285.62 105.97 l 283.12 103.26 l 280.70 100.64 l 278.45 98.20 l S 297.12 118.33 m 298.73 120.03 l S 278.45 98.20 m 276.43 96.00 l S 277.44 100.54 m 276.43 96.00 l 280.86 97.39 l S 305.32 118.72 m 308.00 116.56 l 311.10 114.06 l 314.48 111.32 l 318.04 108.44 l 321.67 105.51 l 325.24 102.62 l 328.63 99.87 l 331.74 97.35 l S 305.32 118.72 m 303.17 120.46 l S 331.74 97.35 m 334.44 95.15 l S 329.85 95.89 m 334.44 95.15 l 332.79 99.49 l S 261.93 141.14 m 261.83 140.15 l 261.73 139.12 l 261.64 138.05 l 261.56 136.95 l 261.50 135.83 l 261.44 134.71 l 261.40 133.59 l 261.38 132.49 l S 261.93 141.14 m 262.04 142.07 l S 261.38 132.49 m 261.37 131.40 l S 261.37 131.38 m 261.37 131.23 l 261.37 130.81 l 261.37 130.00 l 261.37 128.67 l 261.37 126.67 l 261.37 123.89 l 261.37 120.19 l 261.37 115.44 l S 261.37 131.38 m 261.37 131.40 l S 261.37 115.44 m 261.37 109.51 l S 261.46 107.79 m 261.73 106.12 l 262.16 104.52 l 262.71 102.98 l 263.37 101.51 l 264.12 100.12 l 264.94 98.81 l 265.79 97.59 l 266.67 96.46 l S 261.46 107.79 m 261.37 109.51 l S 266.67 96.46 m 267.55 95.43 l S 263.17 96.99 m 267.55 95.43 l 266.71 100.00 l S 267.01 143.05 m 269.69 141.43 l 272.76 139.56 l 276.10 137.51 l 279.62 135.35 l 283.21 133.14 l 286.74 130.96 l 290.11 128.88 l 293.21 126.97 l S 267.01 143.05 m 264.84 144.34 l S 293.21 126.97 m 295.93 125.29 l S 291.28 125.43 m 295.93 125.29 l 293.72 129.38 l S 155.65 235.61 m 157.45 234.08 l 159.48 232.37 l 161.67 230.51 l 163.96 228.56 l 166.29 226.58 l 168.61 224.61 l 170.86 222.70 l 172.97 220.90 l S 155.65 235.61 m 154.12 236.90 l S 172.97 220.90 m 174.88 219.27 l S 170.31 220.12 m 174.88 219.27 l 173.33 223.65 l S 151.30 233.15 m 151.05 230.96 l 150.78 228.56 l 150.50 226.00 l 150.20 223.32 l 149.91 220.60 l 149.61 217.88 l 149.33 215.22 l 149.06 212.68 l S 151.30 233.15 m 151.52 235.05 l S 149.06 212.68 m 148.82 210.31 l S 146.92 214.55 m 148.82 210.31 l 151.54 214.08 l S 184.10 211.13 m 187.12 208.39 l 190.65 205.19 l 194.53 201.67 l 198.64 197.96 l 202.81 194.19 l 206.91 190.48 l 210.80 186.96 l 214.33 183.77 l S 184.10 211.13 m 181.73 213.30 l S 214.33 183.77 m 217.35 181.02 l S 212.81 182.01 m 217.35 181.02 l 215.93 185.45 l S 149.67 196.83 m 150.43 194.39 l 151.27 191.69 l 152.16 188.79 l 153.09 185.77 l 154.03 182.69 l 154.98 179.63 l 155.90 176.65 l 156.78 173.82 l S 149.67 196.83 m 149.01 198.94 l S 156.78 173.82 m 157.60 171.21 l S 154.18 174.36 m 157.60 171.21 l 158.61 175.75 l S 156.78 160.95 m 155.81 159.77 l 154.81 158.44 l 153.83 156.97 l 152.89 155.38 l 152.05 153.67 l 151.32 151.86 l 150.76 149.95 l 150.39 147.96 l S 156.78 160.95 m 157.70 161.97 l S 150.39 147.96 m 150.26 145.91 l S 150.26 145.82 m 150.26 145.21 l 150.26 143.55 l 150.26 140.32 l 150.26 134.99 l 150.26 127.05 l 150.26 115.96 l 150.26 101.21 l 150.26 82.27 l S 150.26 145.82 m 150.26 145.91 l S 150.26 82.27 m 150.26 58.61 l S 150.70 56.52 m 151.91 54.60 l 153.76 52.84 l 156.13 51.25 l 158.88 49.83 l 161.88 48.57 l 164.99 47.46 l 168.09 46.52 l 171.05 45.73 l S 150.70 56.52 m 150.26 58.61 l S 171.05 45.73 m 173.72 45.10 l S 169.27 43.77 m 173.72 45.10 l 170.34 48.29 l S BT 0.000 0.000 0.000 rg /F2 1 Tf 10.00 0.00 -0.00 10.00 116.58 407.90 Tm (ITGB) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 20.15 384.30 Tm (ITGA) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 64.86 384.30 Tm (ILK) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 103.07 384.30 Tm (CAV) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 143.09 384.30 Tm (SHC) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 103.00 360.70 Tm (FYN) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 140.03 360.70 Tm (GRB2) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 136.32 337.10 Tm (SOS) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 119.61 313.57 Tm (Ha-Ras) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 118.74 277.13 Tm (Raf) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 100.53 211.70 Tm (MEK) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 101.08 173.31 Tm (ERK) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 167.63 64.12 Tm (MYLK) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 168.06 40.52 Tm (MYO) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 213.45 384.30 Tm (ACTN) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 239.19 360.70 Tm (VCL) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 196.61 337.10 Tm (TLN) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 308.62 258.90 Tm (PXN) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 320.95 360.70 Tm (ZYX) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 337.53 337.10 Tm (VASP) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 293.71 337.10 Tm (SH3D5) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 237.76 337.10 Tm (TNS) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 228.27 313.50 Tm (CAPN) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 227.73 289.90 Tm (CAPNS) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 241.74 258.90 Tm (SRC) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 191.13 235.30 Tm (FAK) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 306.09 211.70 Tm (BCAR1) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 271.36 235.30 Tm (CSK) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 333.15 173.31 Tm (CRK) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 326.48 142.32 Tm (DOCK1) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 370.92 142.32 Tm (GRF2) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 378.53 105.92 Tm (RAP1) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 262.64 64.21 Tm (JNK) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 360.78 235.30 Tm (GIT2) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 362.84 186.11 Tm (ARHGEF) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 262.68 87.72 Tm (PAK) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 232.66 236.41 Tm (p85) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 209.61 212.81 Tm (p110) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 198.82 179.07 Tm (phosphati.) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 201.12 167.55 Tm (sign. sys.) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 293.81 142.32 Tm (VAV) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 205.49 142.32 Tm (PDPK1) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 212.16 118.71 Tm (AKT) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 290.44 118.71 Tm (RAC) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 246.04 142.32 Tm (CDC42) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 140.79 235.30 Tm (RHO) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 168.67 211.79 Tm (PI5K) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 133.60 198.90 Tm (ROCK) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 142.60 160.52 Tm (MYO-P) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 186.59 40.59 Tm (cell maintenance) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 314.73 88.79 Tm (cell motility) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 162.49 16.99 Tm (F-actin) Tj /F2 1 Tf 10.00 0.00 -0.00 10.00 62.94 143.30 Tm (cell proliferation) Tj ET Q endstream endobj 238 0 obj << /CreationDate (D:20061226132459) /ModDate (D:20061226132459) /Title (R Graphics Output) /Producer (R 2.4.1) /Creator (R) >> endobj 239 0 obj << /Type /Font /Subtype /Type1 /Name /F1 /BaseFont /ZapfDingbats >> endobj 240 0 obj << /Type /Font /Subtype /Type1 /Name /F2 /BaseFont /Helvetica /Encoding 242 0 R >> endobj 241 0 obj 34340 endobj 242 0 obj << /Type /Encoding /BaseEncoding /WinAnsiEncoding /Differences [ 45/minus 96/quoteleft 144/dotlessi/grave/acute/circumflex/tilde/macron/breve/dotaccent/dieresis/.notdef/ring/cedilla/.notdef/hungarumlaut/ogonek/caron/space] >> endobj 236 0 obj << /D [234 0 R /XYZ 133.7684 692.1046 null] >> endobj 22 0 obj << /D [234 0 R /XYZ 133.7684 342.1334 null] >> endobj 233 0 obj << /Font << /F55 62 0 R /F42 40 0 R /F8 43 0 R >> /XObject << /Im6 232 0 R >> /ProcSet [ /PDF /Text ] >> endobj 141 0 obj << /Length1 748 /Length2 1163 /Length3 532 /Length 1719 /Filter /FlateDecode >> stream xRkTBŒHUE(y!HxiCfF&8HTઠ}\E|" GA%( "6ET kU_w3}ٳϷycǑQvT,ui7H42y70*I!wFXqB ]]N8 F% FK[o` 'DCR`!p"b!Ld"0_ DABXL,8)MdlqvnDň!wA$'Z_L/8O#H'0&^JBo̱!-EwJyg8]\ߴC`)?XhFmP|X{:`Kw)$@X0XST* 'ݾ%(񱠻< )|$SbT`Tň P@AxBBN99 :U'"? tqR8E̔U(H=p];LӤY>7N5 (uU,:CI3Vٝᬜ""4-MEgMhF%S63Cis&Ӗu:!&ڌ&˽}/n=j/jF̘k5 v f粗}N.n'c ;eWci`ڞ;|2 Fnt]{+_z?NXacQOQ ۠YBUi..J|Kht]G*VyEs&m[3vhTl[j~ܻY^3zg"q("!jէXn}o>酾#ˑ!{߄{fǴ+ϴ[$ ݣu)/~m4_I[iggjn,cSI229CrUclޗˉ8Zf;7)SsbkW9qϲsT4Ӕ/B$vRHHbb D\rMcM_3Be0f;VOTUw#ċf_{@PsIjD3.d%ܵ~Л07i6,oŖ+6ZSW韼7v1BU9w MtOm:i ru?^f_6x(!hյlt-hJm%٧b/ţC4AuQ)m,IZsEu=vFN 0edv@f:d۬ùB5cP۬ h#cɗk H0?>ʵrSM%=ң+ήO32Ovg"Q&\pпԂ.^'+Ou˚3B~l?㆕fqN. sF"q߭w{5TNIذSoLj5u-so[m_݅\̓=`&L;aKQC*;\*<Ko<=ΓN$=a}y6'RLfHZ3ivP}FukneoW;[#"C Tendstream endobj 142 0 obj << /Type /Font /Subtype /Type1 /Encoding 243 0 R /FirstChar 36 /LastChar 36 /Widths 244 0 R /BaseFont /XDAYZE+CMSL10 /FontDescriptor 140 0 R >> endobj 140 0 obj << /Ascent 694 /CapHeight 683 /Descent -194 /FontName /XDAYZE+CMSL10 /ItalicAngle -9.46 /StemV 79 /XHeight 431 /FontBBox [-62 -250 1123 750] /Flags 4 /CharSet (/dollar) /FontFile 141 0 R >> endobj 244 0 obj [500 ] endobj 243 0 obj << /Type /Encoding /Differences [ 0 /.notdef 36/dollar 37/.notdef] >> endobj 245 0 obj << /Length 122 /Filter /FlateDecode >> stream x-ɱA($ \vNVb BT(Dgk$(ʢThКga+kJЮ*ig{Nxo<Ͻ_g̀>H ~endstream endobj 63 0 obj << /Type /Font /Subtype /Type3 /Name /F54 /FontMatrix [0.01205 0 0 0.01205 0 0] /FontBBox [ 10 40 28 51 ] /Resources << /ProcSet [ /PDF /ImageB ] >> /FirstChar 96 /LastChar 96 /Widths 246 0 R /Encoding 247 0 R /CharProcs 248 0 R >> endobj 246 0 obj [43.56 ] endobj 247 0 obj << /Type /Encoding /Differences [96/a96] >> endobj 248 0 obj << /a96 245 0 R >> endobj 61 0 obj << /Length1 1753 /Length2 10121 /Length3 532 /Length 11129 /Filter /FlateDecode >> stream xUX\Ͷqww:w`A5n 5h' ɟ/Ϲ:1jTͧߨj09A,oJޱYؐ% +{Ic- bbʼnD ppp$ LJ K8-@ `zt:XfV /Orf.r:9M&`f39N.bkllW0W Pr0:w6fV.v=*22Yx)[9K[T@ 2}W.XUՕ5UU [كy8lLNV=666vp _UN<c''c$p7`ˬ, #WN.G<V3[[c%.6hK~-se[ojh -:`:9l {ld#j{&`sVD?7/2|um\{<.ƿW\S ]?Ω>58og nm-Ggˀ/ .hM&v6қ-~ -@4@ ?۰jm8` ?lp \@+?7 ؕvw3yfNNp;[?L]g7[oJ h`*lZ+U8[KW{)T?~y}Y lV7|hfو|'}~4se<ȈJ74Ȧloɞڇ1@ueS9aRQgbS 7r֊I&jTp|pd9+lSjAjqZ:ȇ1# OHQmCi)pxeHg=>6XfiOn ʹ(D1AmEnAgIBuoSjQV[$.hgdk|\KM='-(+sa@bQa"5voUļ7V7##XtruIluŸCǧ -[mPSHeT'H/O#TZK%KfGq;Ëe%vT^|VgE'g:ƥm g_!XUVۙPc7 qxy,5jd Ws P."%Y"ڛ~FlxLέN )+a 0 'C^Cmn}[ ?|x[՜@qԞJ)4PH!j*Fѣa30ٿ`_ߨ:߃xꩪ:xXyy²d((P¢fYcSdsK'gi3gs硷0kHX])W8؛E!AG #C$(tȚ;Z:9ދxح՝Ӱ/dsT/m% ];&fψ3ᎾXy.8QZ/P][8:w& 7xSҭ*kBi!3qKFzd?o Ss AqgSۉb|8ɣl)RE[CAy?qnEߢ%Y6 ^FA(bJ5VaOǪ\,OG) $N)G$n" ||X ͵t5 ^uIvE6wAI͹+Bo Wc:阢ӈ!C]_߭lk{i47mEȃsm(bHoLia>!uƨ9T](g@>Pgzஒ'Qsd25?A׈rVk^M|E$'/C\LXߌM5۽Vhs焴/2Jg7;0P!utE(cHfNCƻ|H?MXU}:xOW\ݘ֟x]d8aREkP*`{6Lkr3܌¨;#dҍ]$ԛɐ/DZޅ]ldzi+ҫ_Gg`VC\cEMDrN]LX$|~*," $ƎH˭ ;;=czJ=˃ET!`)3{~Pxl/N^3 䂵OÂeOmҰI9𱢆̗esPoY=mvLu`!~$,okQGGNq^t|Jc,eXw&}#xb6<2v6KX,&Ug+$) )(s]|[^!K8n'b?hDžt7YiJw7}ef&C`85]%La-#rZw}JI!EEfSL׾IOTL䝻vHib+~e,,ss 8[]oWՈ`" b=VwZ[*S$ !S%YyGpؑanwucW 41~{cn}Snaވg'9)k2oMsF䚩䪧o'2݇|A)(ޚ2Ÿ̰ɐ[[zbσnZZ״ٺ-7/̀ʖʀμ֛r|`̔pEB%2tKyp_n-uXmtb3An˴bGM?`HQUqNfPK[e2rNvsÛSh!!Dظ?l_@`kIO]Z5ΛXT31uF+mw=PnO-B8(a+],z<{lk)JSm-@dnbhmWNíɯˍQPTOklTjHGe ኗ;ol~vhfMT%_jåpll=Bߊy|B U\swI*E*b|OV}S%өּ.V)n 0T|fo@(0oQ dmj)yP|k' P|?!z^dCGxkuڱafoFX QD \+8igDt,r!{$u4@7}M[)yO<[ʏp&P,mtH%v=6-XTl h]r\6<>`eo37AWp}Ħ`}u] `Lo qs1`*8.>\1ef8|p=-zE?E6jQr;u.aeVn\/@yO5N]{wW2?.\|n孊XaLf" ֥Qph EQf?EXN, owme2ČUQgl )enb<_ʸ$w:Kf4I F;!}TD=wD 1N)y(琉{[a:x6ϟԺ(SdXF'<}B16ޣXu{eNk͕~ HD^"ʣ` _q+RlBKR¼U "o@0?MMwُR gm$ VD5:DA'}*%j p:06.ǻj}c!pbh3d#ܜ>V: gu=Σ~0PL"s]RFE``C>;cTxT# .m/aLaBC3\̂#tE]acaM 4\c4$w^},OU2t{_WpM#s1%Ð*UriHuLSyG؁^0{^ŁK `=d3U\AD;O1lۍ!P,& 4!!4]Z(Kї +,܃Loo'bHӧ7`rkٮWuc޹ѩ@F]SVP2wCr$.,1nEDZJF:fO?g_l9DoL2,Xs$Zxezdfּq=qpziϠw%E?:V\kHzymi juJlz[-ǮśK!836=Q> )p:*?CpRZu/Ԡg h+1{z%$0j9s.iVp#:$GӪWt&U.ѯ {X5ݻ( m<2 p^w)[㿥.QR.N{1bL! ◡,Nop;Фn̚5,Dguu@#1C{@H"z?C,0*sVȖOcN%ڿcv- MtHcB /H%4*'@;/X%T ^?(2Bczw|j:>@yIg!ykb%B#Wb1Gk<:cc\iJZǙ~K|c|$Gw΃dz%gD$C|7sUR۞eֶPnaq'3z`knyIJE~spC || @J',+ipAՙ^'\~c>v2c,ebOov)`8|bDA)1Pqyh^ `9td':1*?` uݡ% : i5zѹwaGM}O+5mdZddORˬ|r(vԜXt?Wo)Ao lpCjpT-!hLb$ ^nQao :H&To_F٫gh%l8N  ~kǘ.h?GAeD4lU"R>ORaγ$Y>foxdQHMw{aU_+.|8M tYg)]V}mawo({R-UZx WK\JYv/6AHbA]䔷Ĕ=!Cˀ;Tufĕpi566(a?Lh(G.. ūZxO+{Vφ E9Դ8Iw{CÐzCc?w`5Aֲ14^YoP;~OK^Qaܳo?i;.Ԃ<fiQ&D/*M"ٷ'I̚ ];F.UΔGp!J(ϵkӯ[ ; y=:dgRL}kGX& 2)R +B3dJT7R>͵& +uq!SϏ/w#=3|6]۱q )ei9m$.~111ynzl$46B$%V,Җ ޠ9Y_$Dss+$BQ:F_> wz?`ffyE.+]$U{'~x w60!(|]p-4:~@'Ȑ1(w:g#yv1j+?"qzݐ9,FMī-XM@m5AҞ vamZ[L M۔'|cAwNĄ .a<ķco|m<quzCQH@JLC<O:d*|/Q&Qdp4tiI2޽Z 1/,ٖŏ> 99U?zϱ -=S]pQ|j%WsS+Mlmݐ0=2zXa\>H0 r[$4'OЏ Ҳw>&Nŕe`uR2NR6+ff3oL_5GYUʩecp{CѦ|~zn0zH-HS Մǝsb2inYL}{[\zܵw<ΚĨ}zb#w pۼ]4Gk'J3A,/{}k]Yga-N^JtѲʛ=#/Z,k,8H(C*EC瞟 @.ђwMLkw0CbjzL|3i_C(_ԑ)(PFM~yYC|hresbA?o7/ !ܿWƝl!Ne[ 4X,.A7ewvF@ j|)Oin\:3jџ@ A?#z5n<B(^o1^B.3^9֤cBqWe?P7aSY7%\5(#bԋ^p2~1xh^g\bTwlj&lS_s܎dC(S,X\(4(6N_4{_\lBeLQ9sK o4}$,[ }pd-?\kt5|9?]?L3"c7+! 4"5;^qe~ N.,HUQjJߟf~Sm:J /\HxҦ~\-ArB!]fiĨ [J}5+wl-UԂ2hUPy$\a@HlBP79DeN|b`4 p&H}0uסFFރZ;x%I3IOsovB;Tkl^R?<ؕ79f`j@?G3~Azϓd̥M+ 4c8zϼoϔDSYOT[p2z4r Akt"pY7(ekш2'\ |D)$x e=ԎjX_H?vL6A<=(#ez6O( ݌2XAi觴8+- ԥa$n(oS>zJ,,V3K]OM# ="Jj{o8 {Sg!t#Y*8e:Q+:ki [N81" .NF0wTia|nsIQ{No0qbRٍ0=*wz ӯrh*PQpJBWx& _1VgX!F󚥹 ;q]jծ+ g3wG{_#xԕZCwXMd"9F=1R'D)~#I΃gG?s'yd)uy=~e n5s9WT4<%xL˖@WU[$W˲,Y8 p{薯'bJQg0Y|bI7*"$sc\tp."h.]nIQ<*@(6R5/ݏzne]t說 r\,MgfoRIJ=hWR Hit*L^9&54W TKpD7y S:="*!=;" ycK0ǂW`mTG]K&&=,_@7xbcHT"-Ey-7CuԺaS]Jv AUtl2ˋ̷m>۰Ÿ}a,Dp(6a q0tl@c' ~886endstream endobj 62 0 obj << /Type /Font /Subtype /Type1 /Encoding 249 0 R /FirstChar 34 /LastChar 122 /Widths 250 0 R /BaseFont /PRNUPO+CMSLTT10 /FontDescriptor 60 0 R >> endobj 60 0 obj << /Ascent 611 /CapHeight 611 /Descent -222 /FontName /PRNUPO+CMSLTT10 /ItalicAngle -9.46 /StemV 69 /XHeight 431 /FontBBox [-20 -233 617 696] /Flags 4 /CharSet (/quotedbl/dollar/parenleft/parenright/plus/comma/hyphen/period/zero/one/two/three/four/five/eight/nine/colon/less/equal/greater/A/C/D/E/G/I/L/M/N/O/R/S/U/X/Y/bracketleft/backslash/bracketright/a/b/c/d/e/f/g/h/i/k/l/m/n/o/p/q/r/s/t/u/v/w/x/y/z) /FontFile 61 0 R >> endobj 250 0 obj [525 0 525 0 0 0 525 525 0 525 525 525 525 0 525 525 525 525 525 525 0 0 525 525 525 0 525 525 525 0 0 525 0 525 525 525 0 525 0 525 0 0 525 525 525 525 0 0 525 525 0 525 0 0 525 525 0 525 525 525 0 0 0 525 525 525 525 525 525 525 525 525 0 525 525 525 525 525 525 525 525 525 525 525 525 525 525 525 525 ] endobj 249 0 obj << /Type /Encoding /Differences [ 0 /.notdef 34/quotedbl 35/.notdef 36/dollar 37/.notdef 40/parenleft/parenright 42/.notdef 43/plus/comma/hyphen/period 47/.notdef 48/zero/one/two/three/four/five 54/.notdef 56/eight/nine/colon 59/.notdef 60/less/equal/greater 63/.notdef 65/A 66/.notdef 67/C/D/E 70/.notdef 71/G 72/.notdef 73/I 74/.notdef 76/L/M/N/O 80/.notdef 82/R/S 84/.notdef 85/U 86/.notdef 88/X/Y 90/.notdef 91/bracketleft/backslash/bracketright 94/.notdef 97/a/b/c/d/e/f/g/h/i 106/.notdef 107/k/l/m/n/o/p/q/r/s/t/u/v/w/x/y/z 123/.notdef] >> endobj 49 0 obj << /Length1 1843 /Length2 11933 /Length3 532 /Length 12962 /Filter /FlateDecode >> stream xUXͶp8w޸wwKwn]BK/Ϲ:.z̪sz~"SVc1w2trtcdeb)XXXDĀ&n6N&n|V^^63`e`!PĜ6VnZ1M8XmL &nf&5'3 7o&=@_+\@ s&VV_N2Nݝ{ [4wr[X"0+:Y\%M;8{ 'gw7 @jYGNʸۘ8Z[Xq0Wq3-p4$=*8{;_ͬ=@/ hYAAp4s2qqrL@o'`hn 339:@{ `De0;Yk?A.  hhoa'_<œfkogk ?!PJgw20ڛZ},Nf'GdgTh 6qNvP]Ad]-TFrDlx&CmLFү8uc4 f[ibk@k,a2ͮˬYhw\xZQk[x݅704"O ;u[- u'Rf Y"V.q*taA[AS 7TIZsnLMp%`\`fC"VOEOv"ST }io ,s;3}N_$8vDNmB7hJ!NvFyg?dzPVJ1y[w#Wɲ:b~m䎁`{N^pHbIJ?_)I+ vQ9$3fvP <B' 4ڼיe?*uZ|ƥOIZ\SU15T!62]QW6Y{aߢM3V9]e|Ldf^l(?Y*y;{wH _q!)%G HKߝb{&h$z2%愔Z"T/ w= ï^=n Gu=U#Q6 ZG3jE .0d,Ӵ+mُVSey\CͣeoqgpT]mXK `VO1Uw<G׀W3=Diw8ms <4ScȽk} 3vj:<~Hʤ{e`bbg&m G>cQhϩ o|NؐTTOΐ yn;/*愧ljg]QMvJggho16~nlx>oT=Id[D|>'$ҒЦn2ÖI밢,pYjq}Spw忶"RsE9/БLjIn ՍZvrOy'xjўč= 3k""Зc9-3zEC)|BQvDuztꄏqOԘT;t~TO'KB,ޫξEzͽbWy,ݸ+H{b^kJ*uB>:hZv acw?h'"[Eؠs}b Gb`qEhnr\SCsne_srk2ӋHF*éM]ʓfY~Eav'vH9q'࡯R(åW IpuMC&W|8Ϟe6Y@!y<ƛT]E>cTtl!zSOZAwZh9Yz"V0[]N,ʬi}y2EХVh_?ЌHݖUx8miR;VïP.8WqUAF]6ͥN]#\V vx(|hŸŸZ|Od"dY#M]0(hEf<&4CaFF_\ODYv}5&:g5) ?@]'^1`#]"f(nz<T'F 9"!oImah࿷0QQү@y΅.acuN-S=F1>GX8L6gL&9CFߤ bOrd{{^>%DM/  fnlYόsİdpD+3kzyvw"y r`r짎&QkUd N(gߢF$u'A.-3OV(cpڗr{nUk WS6BybGIv7Q6p{޿9T[V_缡hYp=nsng7ݓOǢU8x 7Dhs$iMq/L&df?RSCzCUXYl:-Dz"dU;-X+GʍjS*3F-Xr#JlzL^vY ճb$C/X InY勇 ieTBf !7ZBA*߇:؇0J{M}$@+.Эj3QVS6YwxDWZ\4:E]  Mh^48׳{ӪJ&(Zr8bHmgIT:T?:~-TNӪ&Cph\7`"FC·ޢup+QLU~ξHk2^Kk7(_u tKF]7`w5?\bonKfo\-YX1#Mg]+d}h];5H# •z˥ZTL TBO=]91?{ "#~edD`$A Fy\o"WA ŕL-3Q# ) ?2vQ 2ó[}Ϋ숚,7sRf#9kU!8*l]i^ڻpe]oJ)00nn?Q3 X!0va~):8]Lil!~/רqH;}[ aL` %wm S׍8jIh5LYO{0Lo(DTl/{]#\|h eR UvmqvvS_(?FtoO;.EjE K&YX#&{ .$S" I%nlj!|ヌݖKi>D5H9 /.pDaR꘥>No y yYʕe_XFk‡vqRJwHӘ,cWE䉎ٖ N:w~%|v[tG;6iyO<ЋH~H Ψq*WQ.[fXַj_Rt%i %|bI*w4QYNQ2XǵvAj^(){@mv -eR W|j QW;=.g zlה`Y0o%]0H77:4֚ֆ拿f>?Phm&$0V\}!ۣA:QY^PNgڗ;-=2|k(x֪?*Ou@WRNΕ=)7ip9HKDaRCG_]1_C*_\wq 1hYT(hx8@\A,G.8.%lɂAJz<oA1."ܐc<擄"r)+Bs;n1 S^Mm9VrM/9F uҺe"j OZMaOAY-BqN?K3Br$Fol/clbɏ+e+"IDQ@N0e*>Q,k Y't=cĥ%CKj "Cυ=۶NWb s_%@c*>hpJ)[ubdf鏝m/sb+}m7Lܜ3Wۖ>{1vQ U<Ti+N;ډS~7(mì :jz N,_>h8LD~8&| #;&)sCHQ~r!qA6)M+A(7'ǂb8MoWx*]i3Ar̓~=ЯgBXy B|iS P9O` 5-\NƩGx+xƲ:LAOb\˃P>f*/1fw>x+x_{/!JQJ,;!x52TeܗYOǣLG= ^ҙ(!D~)epp%jiׅO#⻖1I!YӰ½L?a1 + CFzOvZ1n 1Xk$Hnl58Z)(B]+;LjG)FD gcw<+M7v<}0(?HX?-Uj-܏ c"3hs20napm>k3v-ŕ$磀t*52T1c!`Q9nOqw&8I!Q/9~_ a3$y&0)g> :y 7%z Yw2Zy1-|c/qϚ,`>yu_þܐ{7q?໧O0OŃzX0(=)U ZϴU%e(HfA%T1GHjP`a6ܳiM?y5}P i;z F=9ScTߔ/PukVpTI4׺Z"bt<=gB%ˍԩ`{>"1@@u?d8A Q2 Vtn3nw7 '9ZnII%)r6ЋK98xm$yk9Ak`PG5H7y72_ߖ"GtQdgCïVBXbD:* 4I5RϼCıO@n_7Imx[X=s{[ sW~eGłlrci(},h,jP" '"msƐ)k>6%1Wi}S u8r+.m`8}uU:H߉AI`Yq_{iX\_e,?p+;.)V2ji& ap&'Gkr2}oƣzU;七MRx=)ibbMijcGcشdŷ2Bt75\bCWH/8IJ1x:BnWmqv]77C;2i\Ć`9X>=J)Hc\ ny&A15Ch]sh;d}R2`Kx!uoG#6ӣw}%[۪Ujh֑DV*L"ĦV+V !r@ R25a14K4HBNM #F󒠔LM)0WO 1L*]t9绾HR-J`kRaaId&ɑE8ƫ+Ɔ[^khM)|ţbx;{Ɯ :sȓ?<*&{~RX ҙaU}S`A@MA|&Sbruڡ;.3t;m ::dfw\cD0)Zf`/ďN~s{#u,`$R,R<Sw]:o#C/̿D?!s-Fv3)GLI&f(P`SڽȆ I>)x &=9{^r&e^v\2#uyB_D5E{"ćm) zhd0CApAO-krhf )qole+vYL-Tq[)ӳ#?j^9;ұpqYޞɃC'@- t[| MrsS<ьIYasɽs˜B@w^Ju +ݕޚC~L4j'!=ɟr5_3D|;`Lb|y@KkSoR:-X[ KM-iBˋ-9مֆIϔ".НRuoX };?~ "fO^v5tvU'!n3'ɶ `!|ŵ F%׸EԜ"H"(Bĵz㋾9*WX04W]W@gPkjwr<;BAbo{5i%#QX:Pzoҙ(AUUJm1<*B:!HV9eup\JL^FeA`c;kj_/tN|"J0Yx3gGeFXefT;^ܼ]>:6Dk+[iFlSyEzOxש-V+Z ,Y*Z쯇b/=i![zb !;eՈ?d;589λVNjl^.?H_EitsIi+O<^ XD,7t"3~h>i.wrl}2DEE"D!k\Z=QpdvpCnl%D"F='Xת\lHѮ 򳻛eU&?^{!Bc'4)~Ka4:B/pZ|aVI[sE .Ľ\9"WvRb37b/ /JC;z)wMV!F1dç`#<4|: { $n-3 嶶q7YWqHK2F<9*G}d5R=c{ s'?-W!{$]ޫFFZ弙^2*)C `>f1 p&}mJ˻$MOCֿ}msbvZ+ۂw)Dq%q3 údj_cUc읹2ߧ9#yAЦ-V-!Wgw H^~vh6Z`#Q%#n`>MPkAyN\dZX%> ^[R8֎1D/j?7t hf p<'ӯaԿјN|K<,.e_2u0oki̐AǛerP.xw2M&r0 J͖`Eߊ;tsLOD>K,`KD*~g'D3{  endstream endobj 50 0 obj << /Type /Font /Subtype /Type1 /Encoding 251 0 R /FirstChar 34 /LastChar 124 /Widths 252 0 R /BaseFont /MIINUF+CMTT10 /FontDescriptor 48 0 R >> endobj 48 0 obj << /Ascent 611 /CapHeight 611 /Descent -222 /FontName /MIINUF+CMTT10 /ItalicAngle 0 /StemV 69 /XHeight 431 /FontBBox [-4 -235 731 800] /Flags 4 /CharSet (/quotedbl/dollar/parenleft/parenright/hyphen/period/slash/zero/one/two/three/four/five/six/seven/eight/nine/colon/A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/R/S/T/U/V/W/X/Y/Z/bracketleft/bracketright/a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/r/s/t/u/v/w/x/y/z/bar) /FontFile 49 0 R >> endobj 252 0 obj [525 0 525 0 0 0 525 525 0 0 0 525 525 525 525 525 525 525 525 525 525 525 525 525 525 0 0 0 0 0 0 525 525 525 525 525 525 525 525 525 525 525 525 525 525 525 525 0 525 525 525 525 525 525 525 525 525 525 0 525 0 0 0 525 525 525 525 525 525 525 525 525 525 525 525 525 525 525 525 0 525 525 525 525 525 525 525 525 525 0 525 ] endobj 251 0 obj << /Type /Encoding /Differences [ 0 /.notdef 34/quotedbl 35/.notdef 36/dollar 37/.notdef 40/parenleft/parenright 42/.notdef 45/hyphen/period/slash/zero/one/two/three/four/five/six/seven/eight/nine/colon 59/.notdef 65/A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 81/.notdef 82/R/S/T/U/V/W/X/Y/Z/bracketleft 92/.notdef 93/bracketright 94/.notdef 97/a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p 113/.notdef 114/r/s/t/u/v/w/x/y/z 123/.notdef 124/bar 125/.notdef] >> endobj 45 0 obj << /Length1 1287 /Length2 8830 /Length3 532 /Length 9629 /Filter /FlateDecode >> stream xeX[Cp))  .ݭxBq(.E{-Z.ksv㽟s|1o3Oiյ8$-@P8'PJE[(!Pis8H#, {x RPGdzW PX;U v@-J5: 9` KNbYA\yRpC [8ws~2d IKpB@O^o.vv{R#on @-A0,˜ bYBW, qYC@38?! 'rA@f~n OP؟˿ @.?COr2&'1?CO: Hi詧ʿIɢz:ozL.?'/&'3'7_s>X\ @O&lO.p9t']$||uO=o@ݽ8x^9x6IV(, UZ` ?!O3\@ ,B4&S_‰rKG;BE9VE aM s|H^ʑR%W<6ы -cS\숝-&E5=Hs~c i)VdZPkYMUTn'ÊMw`*n>K䂕Fܯ ֲ:4󌟅0kbǪ_ʔyR>gF=&yBldSU0s@REԤQ[|Q{sӈs,?#v=jvce .JWqw*qNE~ 5਍ӫQ7z4`zzD̬sU6)5[:dc$_ {! q 7=Dʿ>TEp6QJD4E!:╄/VȥjPσ cތj6zyXbS[,ʑe$hO }_j%qǔ>-%9m(s8RS)䮨-biHY-GOqq3۾3XǶM 5&CRJ3Ƣ~FD,Ry-CĨV 4}8w/._ԄAEPkgXDd h,AaR\/Q˥ꋇ1x7Rh:vT;>Kkj3 ρqt_i6~K|.XY#UkcX?`PlXܳr]([\Hd8\T),5VaC19*G\3F!ʮ#Vǡd~ w>(Nb[*P|&O^eO$KOڝmK5zZω]^][m}.72Q*Q|~-.Qjy}7nx|h[Soc>MÜ]vPBy\[6i"(kp&[14/`V͋-;fC^I{5Bɰ md0PNͭ5n܌O\D[+ xC ɟiU}9m ӴMR=e;}1 CYeM:g"i~n$b$ | j>2Fh$a]dUwn[fz.O/b D{Y*̕Idg%2B?͊{*Dj FBq.V猢Ѣ9j/qQvceM"4ZNCl> E)=^h92yDW;g2:SRer:|/^c&WÕ=NUE.ꗑݐ`$mTNՆȆvY<)'SaRĦib(_, KՎ'~w\nM5Y^ݳDZY'’$}U~IԝF0%rpܚ"~a; +1ݮ]llv[SĈ ȨryWV.y:_69 o晛(zbMk {GdLooIُC&+(|&Z>QU*Eߢ-teM(|6e-I#IǸC+ŕtoZN4' ]۟J ie<,92+$w Q}*x H4xٸl%a9l{Fx W,%>|gF٢s V×2+*"PgƒL:=rW1-̾ɪ*sV#>(;7GX+aF?ӂ!eB.Z{b8.BBRn}dEbLJ5xb:=rZ~h";!N~Hcmp8n*#+sM}I' +RlvA{Er-0ގ^Y89yݒ5ٚhIK\v)*_[N^Wa eqTPTD:v?x?볾 ?tհm_gx}E~wÇi:עFJ,XB˖dy}6LpB!% bڞNzFi _@[qE9FAH걨G4'&7y]($@Dt,Қ#o~R%%WJ9OhަoF4M%Dy )9Ho!RLf U2{F(4߻cf]kԬ[,XDאw ,y Ę"#rTX}J5{CQ$jQSqOJ |*xkI>}}/@a"*6335+ Y7)e(1փƕe"BqWUuj)9%$ى {zGUuK,]_Z+x{뱊=c5w?2nv݊[wch[~ἽAhs"蚓ȃ6/L&c&g4]1"Z KpWZ{TԈZ2;9:nL2 -HO`p‚9px4a~OȤ8 [Wj<|"cPsSBY >LCZXƼG_LBV_Y )وLg$5G{w/yo̷ZPfsUn^x޺|HM׷.-?{~^]T& ice-` T0p诈*{fǫ6ab:¹UXʦQX^0=J +I㙀jSe0O+vubZrs칕6!0La62Ļ#Xѫߔ>'5Y)OPӸQq=_Iz]e2&'# ᱨQͤ$Cb=0tkrF[+܍FI bOLc4H6(E*Ɉi/hso̾:lX^5G Rw֋O2g6 Sl!ĐdjHcK[097VsቨR?%BK͍/5aScaWi!#rk#Qe:ytz4u}d]m-ܡ2x~@3X/ؖ\+Mk~ӭ!*>1&Άk)-SHo?ª5&s>8g`ݫ^lU*=>u彤@A3bYIο}iyMk{X4>uNjy48~`˨. G)|NK9JW*.Ҙ}52`4Pn2k/A冫.{GLS/7/d'pqx,X4? `$r]jZlKsG$x4gaݕ(SS_ox !xAWu*$K͞젻?[>duPO*O[G%BQ a࣢y眕cv`W8Ιb |4^%Uliir nmQ|n$WXW%L,/z?b@`41%I䞕,M'{55-ˌ'KٍfCdhh`kHiòIJȆ3HquX J%$"$=?0\qj|"Gnj tB^M*u]:դH}t@/ bJG<%kca!xq3r>_~,lB'xk.inj`C 4:.HlJסIQd/_5Le#tK!$B|eCi,Tq<Ӹq-B.gH, PNՕQ~L44qZy꽴YT Y $.[@)A?[]h г~ү~I,:RS5&&=`t jR}ai^ӌ.qכs1` 8;qR"woX( 0cWNX8|niT~ϟ>.x>.mσLV߮) qLnysy)KIao[5[7L.e ynx̞ ݔGX7'6"klD y<4 0 $J ZN>>;n#c?E/+^,7Q{qF$ڒ95`j T9} [/IAVkHLW'(hq;a(e uВ ~Sg!V$}' -РDtr }opۨd h]j5mJJ0[iujWj>DYzC@y̿O_ᜩ$9./~-ꅬ=Z68S&I1MS/b R2OJa<} Jѣ]wU*Big^{|Uȅ]Q*@jI`U/cȵ6>?q.c8we8ylR{`,p\'Co8~HYb3n4١=l;'+ IQ_ BQEj=ݷal4 fxѶZꔙNDI|EMiBK)Q[Ύ:?:9a[GDW3G(#v:>Om+s{kA.}I}_š \Y*kr09쭔_ǍHP&7p u2&Y8@EԴpЏz1DJ 2ÔFW ifcw8fV96R&c=Q9Ei7ԛзX%٥ Ҋsg&5+?ĜK?>5UNEV aѦVK|H+?'5 uwuzے[Uy{ọ^iFezL}K^{BOm4Alk_<\藋4,ij73obz e=hжKЯU`[? *ʋ cN!NNfY089뤼5ZI5ʊѠŸ~^fB[˃SLZ[VP5fQ/=I8g';Qy'ZSiU]z|'4t⚃'! ]#Mk~NXV6)Ko+S@9`PkRsY;.t޴L_u~ 2ӧ5vp;b\)v=/, 4A0v@DݦğBL%z^N8d@ߦCegp1I<)giP="Ni++^l7~G:^XDZ&5 EySkW&C͠yÆDWcv2 mo2&{Y 曢gEBG\\=vR\hjorHl!oxw߻/qBS]=ю!ŬƍTVa t5p7HOo~}UlY6SPE=.SV' 2>AWQQ;ܮ8bSsȈ!4TMռ&[5R>VbgB83{ gcdVʬk>] |_YL,ZUQ@H-5N!;BZ&*LX>w奡L_`Z'aD2W1bWHSn.95cBog< K+k\+td<}0l,05ܥK^jdw 6U#g6)- K l#'`,|Ugs;>lOjKhpD+~Sk>V_[ u9G 5alZ\Y qtNLTf-H*̊ǵ; iw0a>HyVz7u,*!r I8O:iY%ΪvLyۚwn,h ļo_XēsIvwpeG1Q[L||YَL):h^Dme ~Fw^L{6z;{=8^άhNdF)yNT:@P2O!)'a7ƾ+khԽ߷ę6HNoS^KBOզDb Jll_Ɖ#q_IbBcK oE}Wr ֗ձGbo\KT(zi  Q[%O%Nպ}^Q]GpVAvb=9"Cos<}5BMJ5 b)" XgО߹P}6 }C@jvJad X"NЛ^ww9y]ym:Ux]T!q䬞j5{RA\n+]sX5d4k uKB~GjkY_0/:REk)rk)srxw&qaE[7%?,?jf$%1>" 6=~y#J՛uCP .;j[(6"#y3㷍1=6U,L 6l]mu7S#"F9]"'z!džVD;3nU"!;r.v_XTvYĹVUVeYV?ɛ{o~qu 4_Pmhp5ʻj}6I&q^N>s}id6{8H̢>J3g"fjۦ6P$ɗBV.K;/E.ɱҧ w_Lf : aG+V%yd~ il`J͈9҆ &)tbj˒HCQ''- *eTXܟ>:7+!>ιܾ % )$X[vmiu >N!68]% O:$.fq'V 'f_v sjo/*endstream endobj 46 0 obj << /Type /Font /Subtype /Type1 /Encoding 253 0 R /FirstChar 12 /LastChar 122 /Widths 254 0 R /BaseFont /LOQAOM+CMTI10 /FontDescriptor 44 0 R >> endobj 44 0 obj << /Ascent 694 /CapHeight 683 /Descent -194 /FontName /LOQAOM+CMTI10 /ItalicAngle -14.04 /StemV 68 /XHeight 431 /FontBBox [-163 -250 1146 969] /Flags 4 /CharSet (/fi/zero/one/two/four/five/nine/A/C/E/F/G/I/L/M/R/S/a/b/c/d/e/f/g/h/i/k/l/n/o/p/r/s/t/u/v/z) /FontFile 45 0 R >> endobj 254 0 obj [562 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 511 511 511 0 511 511 0 0 0 511 0 0 0 0 0 0 0 743 0 716 0 678 653 774 0 386 0 0 627 897 0 0 0 0 729 562 0 0 0 0 0 0 0 0 0 0 0 0 0 511 460 460 511 460 307 460 511 307 0 460 256 0 562 511 511 0 422 409 332 537 460 0 0 0 409 ] endobj 253 0 obj << /Type /Encoding /Differences [ 0 /.notdef 12/fi 13/.notdef 48/zero/one/two 51/.notdef 52/four/five 54/.notdef 57/nine 58/.notdef 65/A 66/.notdef 67/C 68/.notdef 69/E/F/G 72/.notdef 73/I 74/.notdef 76/L/M 78/.notdef 82/R/S 84/.notdef 97/a/b/c/d/e/f/g/h/i 106/.notdef 107/k/l 109/.notdef 110/n/o/p 113/.notdef 114/r/s/t/u/v 119/.notdef 122/z 123/.notdef] >> endobj 42 0 obj << /Length1 1745 /Length2 12503 /Length3 532 /Length 13492 /Filter /FlateDecode >> stream xeXCqR w;+\;ww+Vܥ{q 9}=}n'O>f|g$ URe67J930DUX," 3 ?_<<Q{3ZOa[  ol 05ڛZ=66f8TN@+Ќ`fe 0ZX!2#If3rI4ـ`-o.66 ƶQװvupqf@jMhfbߣ6Vv6@MVNV@3%+gSK_vw_eTS2sVpO,;@^#?+` { w8^,+;3;hg  ςל_#+ ?bZ?fvf1hg46۸81p,=,vLYfLLN6N,\&O  uv3l O]@ lt/\'bi/,o!\lcg'8C`o?.J? \$H!p%O!p>?ΧGQCf!pL?.ZhWӟ3C`O?[\_^!X_gE[`MB(3_VeU9`U!X/g`U!X_VUuzB*__W""^ ~cnN/ |mͭw$4E\Y7 Ni )/.hUD \)uݨzz{@L?˱e6I$ջ{xDUڸ7t 6 KksH8Zd*ۻ>,2E9OcI M 4L\2wQ |ɃAf~~1\)oNL)i$P0f1'29|p9U T}{mFw;gde H}4/9j۬qQCwA!szLdċrB6{A ׁF 䦱gil~P ̆we4?!̝bub>vflי .nUB:Ot+eoaЃM pivR~lvͥDB.}ӏ ͗E2?X! otZG̳E:2La>HߝıX`[}x.Q M9't_7?Pfa^V38ֵ^.*ϒه r7%fQGwvKmc`0SJqC{LKDQUH.D6/+xx( 31@FvU њy7@ہ˵hڥ?ƚ#UfD~,#^|Vnww")ƳP>XtA|#"f>BnsFT->{B_R(!4,ٰq /pNW1%F04᳈+K Ҥ$B嵴yߓUrxBI.1<"o緥v(h`MHc`Ё (uslٰuǔ S+"f@1334nGOM!ms\%(P:$aj7Mb.y tOq.t^Za3y;Ks ~M=W~&AP domznzw,$NΊ/?:Cv6Cv3nh~ cY=@lFeiR5qCVVg)RޛyrH0<^ 9yS&dIk$u~#AQpze~IU8э@yLcdAmf@4(erGTeJC\tv tX4MNOJcwtQ({]+tK‰C),VccitlJx'S<|jF1˛\ӋZrB) .gLw!6+(N=B0kk5o"io;3HleBo]}a\4-=L)w:m3ש_)~p+ދy򍺍V~?YC]3σ<Ƣxԕ5Ao:%.?"  [eW"),=_5!}];+78ŕ\!#eOYҹGr a)B4 D1!̘~FX#Kv[j 9<]|혊T2}/+Ui})܏6: ?.{V)N9dk1m9a4ᑛc$oJO^g~~gkhTAu5ײs8d "̍D4< 0F rAT^CƱ+Dٶ ]mT6sP+6}'?|]eC+5UJj?b.Zz3ʱ%=etC/l񽰪>Q;t>88˜FgVfCw ~}H5Q}1,Y!)uƮgg⯇z̴% >J>}?E7>&(_h mNv{^`Юvw) _8U32*x_&r9Y]N\V٧D<ڄ=4$PSqw;%`X @cIҤ,NQ>Ji]~m5z'B6 k<&%q./%3&rL1׭''Z/ޛSR85oQPtԴ4EbBgl߻ԑg*{٪>)(d4>LὌDgHFͳC}Χ2+=ebyPH^zI8?Ԭw&ca Mk' 1Ŝ6*%5{լ*NJe+Rʉz\@2 1~=UjI7Q;3ވ=hmksWe}ytA# !Xq?yi,E|[rЦbI_{?RqcPqSh( 3W O"Cm7-9y:>*bccZ>En\mD!+Tq!?@6*h)Zm/"ܢ.. >1_|6jtw4O9 j1u.wU~sJzz<_o cZ O.5 wB cݟf(*5#|źHMveqTE۩'}[Q܍L%@ ;aYvCwK"t-Ay=۲4Vt>kurkpWo;г{2=u 3Vk/T GȪ͑^Wd>X~=FLWm/$NȺ}%|g^:sTy(9ä=U|_2˘ vqbe,󖃀˷SD m %uيJ FA&2Xb85dDJ4C;h;6VDJo)/q:,JjDrH5UT?XLz#sfh3R>Ua 9JoWmvwDb)z94.*\XJ8Ŧb [ӂ%+bzW9-agz>B0'x$ (X"FH :lJ֐ƘRf2;Y[u^u1d!^|='~[?\,{dwM(6oulYA ;*Z~7'Å@Tv13 I{P wVwa?mʛM)㟩ec/fwvǃoxb$p&uOO:.OpbQk%FgŪ G8ex4urȋC o?` 웍ߟIxX)i%'hS4B,4C{:E)K귽 =;k͌ήErK~6[hTe%"DdEb6VYzm9U7-*5HȢYC1eͤf }bHu)\%&]q$C4qAtĜg%BG)r*(096/>fx2Rο`YDFd8>] +ٞ2Z˭p]|zoR\v|TVBŗrEZ_[H=mtg0PhgPKoDTjF9Gp$[ff#wdk#dZVqC w JB2e|~1Ln0bv߰,K7岑 ׬1z0z7~k$Y[DGaMr8 &.KT ``ՔBewmE33\b_0qh!"sq4F aKGie[-aSs|N _=Mh7TkR0{Hm`ې'X²q8%~ ]}"~!ӞmSWGFy>u˪h /Ryu.H`aF379ץ`>K=2(Q&8dĪ/W)};,LfE~t# 5;F$5饧$֘ n፠bӯ|4; d%;l(5$K2&hLj,OP#6uh4B7`|U\j (a%nڛD,cg\ :⵪ctS%AIct=W{HO]Tv<ea=zu1Hf|Sn!=oNtz8L ]4"\V״B:=_gvI'?蘆ӃRJ#vI={r6O L Xn3rYK4nJZ2R* C*$:^ c"E.\'XEXľl}O^~U's7b ߶}޿o6 ;hKylmAhfwʻeeR)] tc ަM%ۿQRwF \hrmM-31KBX6v5s: U4";T,5zv'9Th1pnv+EVEb itNOJ#2@'ϰEyR1FB*AUp(bme 2e33u-| F 11ޘyx*WBHa1ђEpj/A>_L@P-߄8FVJٲ$e=o*mHnjhp@(+? I/|XhFr44Ci2m`1Fjj{~\=hinQ慇fY9>Nwwsh C٥Z'9g*' v~k(uô0$O½tZyX^qRhRlE~C:#~$m%eПr#!E3^sYۧ-X-ZLy:2̝^q1쭻72xV÷.v *QJnK=J*Qƣq)Zw)2,4Bx%¡s Jos*rQoVrEx-]jJLy+%(r Qy hFy}R0 .xN̒D_}Yv"߾ߵ܏nW93)~#Lz3CӚ) IF˛gS!Y $_+u :8Z(|"(See=f0\I.v蚧dk!ċFQj-fz%3* ETƒqn;FW,Z\k{+Y#SBeHA "%}6VP3Pp>b#3U8VnƟh8b,veCC_ߛ{xPd/ҹX#kVa ƻ]PN,E=ô @@d+T މ+)gyr\UFR*kuVkL!}d)yť/Tl;[읨OWJ3w6MQ% JRu_*$U` :}~>޷.'_r&nBXg|dE<CpI G mI!vxLJB~ 8gC1posHUI{0@1K &*l<4I{̸%S)0E{4n6ƺ.k]hUAV8!,jPȚ*kf$CEY6I%|o= ,گzP*[aE`=hxZw])cVO;f?;)z͢v/tPuTL}KE)7rKb=̕Mtk~O;KM 9Pt&/|{&t cUf{ knsOQy2C~?k}ò\(pKNN~߃J{6c%({>ny`h9' K.˦x1>UY [pnRb[D+kʊ;cbwM554>WEs>Fq61JHE$8 Q/C;B QU$AB8۳_m0%DCZq\1$6 ڏ]!TL0H0e ^-SƆ}ڲoh#Is HHw>?~ (΁}]zF΍kPbwBj[];HBao Io)훞1_+։7v~xp>=Jty ,>BYٰٚuc- 0rΔ93w_L&Rg8r^mxDqrˉiPڨr阰fb%Ղ4 ϷhZ_ȯjn0GQVk9'hp)]'c˳lL /L0o$a Tnl+|]6uq |sh Cp!!Ng-Y.?>AM|wz [ꎷR+`+3=ڊ^}y#w|loZUXoylQI̓R [H)wDh}9!kZkpWV٘zR[虐˅烋,.V/h0 ]V)AzRa;/&˟tTrwʛrN{ԯ7nE%)کfJ++4'o9[:alm G';xuS O|F"ϳxXMeмٍ9\yFׄZWynT)(Ʉl[-ZE\(s^L K)9ă/N ꊓ>e$Ldn. VTb>~#ޏ .bj&՗3Z;ՂY[ @s\ŴWE\sFY{~̈́Ǒ-!S;Dw Ej t$mǎ(ͷ)rف,)o,(7fvn(嚭 I ,]؋b-ysR)y痔w\ ig[Ω g -'yj= mOr|iw8bN/=bCVh&PpklK1*F3F%%]3l#x;~[Wҩ Vå|<>0 o>^7LB RWwіv_yzK NN54 .z5ѱgnU7BYYZBxo[;^J7Q"STS"h:^r C% +(x]&3>[QlnA 3]w#(,a+{.119 cgQj}HNzsf}+$qeǷhfI#+ęX̿|o[?՜GM947JJZ">dּXT[V_}`IĒ@B&t#K>4 -863*FƓ>'oۏPD'Jگ@╺1Q@uF3l㬆.LwfE61rޥ(GGN`!jrngn^wsY+^2Qw8ɶPHYb=DdPP 1nJnY~b/ 7 7P531QnKg޹ʗ s«,Y!{}!+Is;H3 +^AqLjB0L,0~:뱂1H4cPLk!!u%cf:=v 6~͒f`"I pHgBI;Ndp;U픭G+.BR4><*ؚX{TcX5JxtGݥ,J">To E m1vB"G[#_h b \܊IkQM.r˄u] .׼#?ӎ&gW6y欔%3?(uzDqjV[TEu;_( [x>4˿?{#~xnQxfvXgS_(e}s[5?2rO];ԣ'Nk{,dů7/Ur֡x]'Knp fuE`87Q$]kjz#2` ,νYH Q5aCs9B+*C4&_,-0$+`s Xێб/M4jbh>*%5 ?kG⎊lV6ei ɿmxl{?ǞL},ZB}wcʪҾkвl$`(l[rAG4Cvy4H@6*BM޵}D i>=O48) + (v9FSm%%V pnkӯ6v4C4Ry Sbiܴ߾Pjs Q- rFO*iB엪˕kQj XظlC3 N"@*Wq;BL(,VVYA|k ,c/I)0 fz- r/)EX=\wZ:͉*SRS~dSvR!Cl'OYOLyOT? /VI`(NIGJ@9o޺BFjpoxq ɬDD(#( ujk,CQSo%|9VYJLwYH4Q]♩̭Z&_o:&z*DAoo0xr dP!ˈ+D%z R.& 6aݒX8~eٽ*dt/^bg{wX?g|ӮY]Nyq't Յ#}Ub^ðݡ#Qi ̱Cm(aWHY7aZ J#W &-)㉔w`'mC#*M-͇vYVT*1( =ٱtI5{ڨ艫Y!,_ۋM7KM^Slyx uPㅂPJ`@R- GRy`VX;8yGs7ˆZe4m=+?l9ʖ\ƒ@ɏ}~5"p ;r+R>N A'l@Pi}L{o#1ⷌ(~qjSY8CЈ|MP\=m\ECZnVŅt삮hAlQeD!qׅo؞-^c Gn-݊Y8\-2! ) Id%34rՏam|͢u t^f\'>S+Fzw(XSZMD+ q<éZ-6ņTuEt2:{#%c@" lok 4Z'endstream endobj 43 0 obj << /Type /Font /Subtype /Type1 /Encoding 255 0 R /FirstChar 11 /LastChar 122 /Widths 256 0 R /BaseFont /UKUULS+CMR10 /FontDescriptor 41 0 R >> endobj 41 0 obj << /Ascent 694 /CapHeight 683 /Descent -194 /FontName /UKUULS+CMR10 /ItalicAngle 0 /StemV 69 /XHeight 431 /FontBBox [-251 -250 1009 969] /Flags 4 /CharSet (/ff/fi/ffi/quoteright/parenleft/parenright/plus/comma/hyphen/period/slash/zero/one/two/three/four/five/six/seven/eight/nine/colon/A/B/D/E/F/G/H/I/K/L/N/O/S/T/U/W/Y/a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r/s/t/u/v/w/x/y/z) /FontFile 42 0 R >> endobj 256 0 obj [583 556 0 833 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 278 389 389 0 778 278 333 278 500 500 500 500 500 500 500 500 500 500 500 278 0 0 0 0 0 0 750 708 0 764 681 653 785 750 361 0 778 625 0 750 778 0 0 0 556 722 750 0 1028 0 750 0 0 0 0 0 0 0 500 556 444 556 444 306 500 556 278 306 528 278 833 556 500 556 528 392 394 389 556 528 722 528 528 444 ] endobj 255 0 obj << /Type /Encoding /Differences [ 0 /.notdef 11/ff/fi 13/.notdef 14/ffi 15/.notdef 39/quoteright/parenleft/parenright 42/.notdef 43/plus/comma/hyphen/period/slash/zero/one/two/three/four/five/six/seven/eight/nine/colon 59/.notdef 65/A/B 67/.notdef 68/D/E/F/G/H/I 74/.notdef 75/K/L 77/.notdef 78/N/O 80/.notdef 83/S/T/U 86/.notdef 87/W 88/.notdef 89/Y 90/.notdef 97/a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r/s/t/u/v/w/x/y/z 123/.notdef] >> endobj 39 0 obj << /Length1 1145 /Length2 5142 /Length3 532 /Length 5875 /Filter /FlateDecode >> stream xe\ nAZjNfa;iTP:AB@iPJi$μ_={<׽u]΢' A@$ ה ~ ;+C"QPIHBE0;@ w@J:A]a5ꄩak #maP?@ uC!D El0_TvH?ܡnS.In"{ P;"-$F qaߋ+p-k[;^@:9QPW&uE{QEYa{8GBt`([5 +E@m )>-X^+~3;0O)a1￾MLaXZ{a&C"@=POc~`t%:%H/P °+ A; g&1QoiML 3ֿI `0l&?c8"ybti!@@r1'G]u1]_%'ôOs= @LmѮPo 3P'Ԗhf i+Z^쯘?Zw[ξ!^c8S6`@b54lo'[T^K|պzw#0CkiyKǣmlIƯz{^p)`7~W cY_EcAkE'_F V9D*5ۙ)^ .O_jV(rMqxN41}z>a=(J}f*%rkb3Z[CeJiV]ܷpevE35^|aLX߼gG0EsPֵUMh'dpj)qi!_@Ϥ60XRq"q;|n\x.>ݶ-[~ EL߮#eQyhH=P!|4Sª̙@ 1w 4SR /V>l[㵡LR#0COGh%MʒH݆O8*;eq}sRGIuPKMxl9mB&JsmKf7pl Ռj؏ޫXUOXRߋeB"ո,1C|hRִ)/}`k^6M:GKTT\όՐM 2[]<#!펠X1b Z}yIS1O6u %_?i&^Ow#&"/89φ(_L{B}/ GARhC]Áa='fW&>5U= (6+2 Er gr"wϽmc=,ȑl,v2!ԯcweJIIfQy.0*~Y@HTAӐ@b+g0qxIYs˥ 3x+-ϧ_7QfnO>$~(u#GɍXxt/:h՞MvOP1)rwʨI5X'=gP{܋dCbQZZ5y*=gY. w;d%?q6x VjM*b7nСBcIevu9ZBZK[e̻~ns5BԀc{I9Fġ4+爻cyQ59n M2e+WӜʒ&*޾ctӢ鷬j5< MQL+jڼ8%]P4OHm^ޮ7w[Y t zh\d(ߙf;*nQ Vjg#Vlҙv5ͣ8'? 7>Ej'5]Lbdܜw5KDN\v}{6z^9V}YI|(PIo_??PGv?<>s)HzRZq\}c+| i& P|FM>=WO^`P{ 1uTsJ۟+i,oM=V/ݻ b Z^c7Je:/. PT 2d M!|HJx ^+*.D=:;n#B'Cߑ70Gmb3iB jYCa3I-BQ~KϹ)Lo;? Buoe^J:N ($ËDڜ38ב sK៽opKwiˮ=UFFR~ѹ"޷pPE5B8]OCNMfɋ^l`hZmLW~QT?LC\57sYf2߫!5 w xɫ5W>WW`Fշ=t]&Y*ؖ;<y PqENAD7xꖟs|G;Z#n QzsVٯh#!1iS6)gCq~syF݀ͼ4)i؆}3յ)׏d$u[I{۴@A*}JFRX[ٵ_Ce8#G_K*oɥ%6M>tuGd57eGT)7:<994"x-o{uﱙ8P},۶ {{)NG2L;5l>if4hGc}=y`~J,܁Nݸ_'gb(;Q2<.9= 3QԄUҎ$Xl^>}R;ט&'1#M‘{M=K>TLy/t6F ECȇuu4*%)J|k^ GdRwX<>giR sjˈ7}a ?|p+ d̂Fendstream endobj 40 0 obj << /Type /Font /Subtype /Type1 /Encoding 257 0 R /FirstChar 49 /LastChar 121 /Widths 258 0 R /BaseFont /JEJIXT+CMBX12 /FontDescriptor 38 0 R >> endobj 38 0 obj << /Ascent 694 /CapHeight 686 /Descent -194 /FontName /JEJIXT+CMBX12 /ItalicAngle 0 /StemV 109 /XHeight 444 /FontBBox [-53 -251 1139 750] /Flags 4 /CharSet (/one/two/three/four/five/C/L/O/W/a/b/c/e/g/h/i/k/l/n/o/p/r/s/t/u/v/w/y) /FontFile 39 0 R >> endobj 258 0 obj [562 562 562 562 562 0 0 0 0 0 0 0 0 0 0 0 0 0 812 0 0 0 0 0 0 0 0 676 0 0 845 0 0 0 0 0 0 0 1162 0 0 0 0 0 0 0 0 0 547 625 500 0 513 0 562 625 312 0 594 312 0 625 562 625 0 459 444 437 625 594 812 0 594 ] endobj 257 0 obj << /Type /Encoding /Differences [ 0 /.notdef 49/one/two/three/four/five 54/.notdef 67/C 68/.notdef 76/L 77/.notdef 79/O 80/.notdef 87/W 88/.notdef 97/a/b/c 100/.notdef 101/e 102/.notdef 103/g/h/i 106/.notdef 107/k/l 109/.notdef 110/n/o/p 113/.notdef 114/r/s/t/u/v/w 120/.notdef 121/y 122/.notdef] >> endobj 36 0 obj << /Length1 963 /Length2 3486 /Length3 532 /Length 4142 /Filter /FlateDecode >> stream xy<{Bl,{ىlQ,cf03f1,%1Z ;TDy՛Yl?MjJ}z"WC%~Όl )sE:[Bm R1WoWJ(Zr'㋩ q&nyԝ} ó˒{!-JW/0Ȩ gErw5_(J$cGΥÕčL 2UfOٵ9o6At lR^+f ^Ȝ굡>ְX> tsfN6x٬Hay44=؝iY2%] [ _bGX=A";Z<ͻFY@3c K/~,"w?K4A;9xES3+ +/+79#!9Uj3FpZvL%% G_:oo7N A"El_"4TxK+9'KA)ytF8ŭvJ{fGqU6:넖/T [(ez,#YXwyLYKٛId"U=9x.Rוϕx \>j%oJ (yhn©om17q n/,YBSW''RY[JWy+eK7=*_~%q ϣ'ڝ? ~QqcWK{~ BoZ[=Hiݙoo>H JbwY/Vדqɛoz2X`t82( -侮l68;ar`MLNSJd`b.švɾո) Kv#9#_)ΝYh0.rg+[cJajet(fty5f޻. R⑿#kg.:=m~bpkY V{y[,m粍E\9}xaD4߭qdM4TrU{A5^I|bU1`ecn“H}yP4ϳ_nx]WMjEC::·Xb.K ҀSLpŽH}Wޞ fhRw8|Vz~4tΓ= ϹwWzv9f$kF,w$s\V/6&yw51gꍺNܹAʱHsY3HrvPL%4/uحs=VRއͰok>v#>*"ozFvhQ W#mW5hq#f<{2B)aƮWQ݁GJ^Nqg/}"&EG( Ë]i+Z\l[&[EyϥW uʋzRы׆Z*#<1ɷY&jAR.VGu7Pxy~l` !K@Ѻimeج_|~k<Ǝv]kMz]7Guw` \jVosY*/@Vu_쨃/Q-D {c toN#WuM- у}O@G.1frxUVо2||XRrRPJ !(滻<~3rt`ar 6&|-LpOmIrQٟd˞X"6]c;!Vle!eL%U~ puIx8.t"_0L+2{#2kV> /}A7bcƒ1D_b>~F+ jO0<Ԣs׵0hZpL$Z&]' 74GQRʭ4U#bE;mݏo dͳw@\A˩JuLpJ}^7=_ї̭,?bqLOQlr%)AՄ<^L3ޜz{g<=;,Y 2p9:qFW  $e씥ƕF|'nHO+ |3FRxc4I}da ,QnE3CˣwL3 Ҙ#%1'ZpjZŸ(_T #@y "iendstream endobj 37 0 obj << /Type /Font /Subtype /Type1 /Encoding 259 0 R /FirstChar 11 /LastChar 121 /Widths 260 0 R /BaseFont /PPEBBF+CMR12 /FontDescriptor 35 0 R >> endobj 35 0 obj << /Ascent 694 /CapHeight 683 /Descent -194 /FontName /PPEBBF+CMR12 /ItalicAngle 0 /StemV 65 /XHeight 431 /FontBBox [-34 -251 988 750] /Flags 4 /CharSet (/ff/comma/zero/two/six/D/G/J/b/c/e/m/n/r/t/y) /FontFile 36 0 R >> endobj 260 0 obj [571 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 272 0 0 0 490 0 490 0 0 0 490 0 0 0 0 0 0 0 0 0 0 0 0 0 748 0 0 768 0 0 503 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 544 435 0 435 0 0 0 0 0 0 0 816 544 0 0 0 381 0 381 0 0 0 0 517 ] endobj 259 0 obj << /Type /Encoding /Differences [ 0 /.notdef 11/ff 12/.notdef 44/comma 45/.notdef 48/zero 49/.notdef 50/two 51/.notdef 54/six 55/.notdef 68/D 69/.notdef 71/G 72/.notdef 74/J 75/.notdef 98/b/c 100/.notdef 101/e 102/.notdef 109/m/n 111/.notdef 114/r 115/.notdef 116/t 117/.notdef 121/y 122/.notdef] >> endobj 33 0 obj << /Length1 883 /Length2 2651 /Length3 532 /Length 3267 /Filter /FlateDecode >> stream xy<ǭ87EG?4ƌ e{:*a4fc'Ze)FddWR(UZB!RN{v? &AJLПiHИWfOB mh0Na1EJHf\dzj2}~@,QLm=~WV(U$UQ*ؐsRA22g'Ab^C?[Sk]iՃ&dVRq[B{f8g}Nlѣ138 f>$`Sr#rnm*c]SrV/˞~J塽oì(5^&&6%=N%vԏ? #{>ܹWwADK9bJrjAo:Pʾ<(.E| eL=ؓ}ndfi豊d͖8kE7FNK1c :RhNkXبGQ{nO*9׳0 YƓO[-Qk%FyfRK ^`1g,E[Ko%q|ȍ`RWMS3R7ᄨ bdH''0u)TJ7ЃFAh)fKQ-#r;ӹ}}kQxVζkM ns}/A^9RuZcy-xQYGJ F!Ն^:_ܪ\c-~O%xWS,Zd1 ˟v^M=0΄ 0x'[+# <30=o/4jÒ'*7CPgRWyz aP=nt6%L.nIc6d\ IRwM6Y`YJ|ĆWR_ܔNANq9yY&#Ԙ;7~:z#T6ie]\`a*lmJhMꃡN˻7r"jzgfjf Szne g=\Zn{AHϡ"*cPZ Wp;l7TĉrtZs'PY󭼆qė~VEyG̾14 )<(z/z 0>IfPxίk!l#Ղ|`1 G}` 5ۍ984% &՚NQf s*Ɋ[ Jw+OynrHɆ72xȀ޹FL^犞[;(=͕kakk1fhσ=~IÁ;q곺gg&dž/3ߎ #H\鑼+y©=q<^.-7RKF-U7JQ*NtԬLMyqS s[F+drϙ*~ Xe "ܨHXѯRxhmA뼿Ɉ  (80b,E\am`isSK_bWeaјK; ř I[ǞQͳ7pN-XszS*˪_[1vRbKβsV4׏tRo]29ih;W܍}6>K:u^7GCCgB/[$wB(9J(ϺUh]11pWq TZջnk;,Wc%|KxPȔn߹,l }ߏ좯g_^ c6UggmWk;%N^9 1^}k};dPg C$qyQc.N+.aʽ;ők[E,0tcˁQ[擼Bd:y yعwׅsXq`+7Gg;%4D$t TZћĺ1EÚ?whh _VgjIӬ 8Lū4%40E.Uͱ90EC*wV#\^E:~, $2$yw3/#BZm){,]RwfG4@C "]{'iӒ$다S8( 3ShckȾݣAE\J r=!8b 92xպBI^eTϞmaΦݖ@&r$O>}"ʝ7HG4~( E{.#=g/ʼ&eySO:1O7ye4Bc&D@6H-a'L_7.0JffsɿxqAӄm-mޫdiXd_{m Xgn8=6i$2Nia> endobj 32 0 obj << /Ascent 694 /CapHeight 683 /Descent -195 /FontName /LFPGQS+CMR17 /ItalicAngle 0 /StemV 53 /XHeight 430 /FontBBox [-33 -250 945 749] /Flags 4 /CharSet (/H/T/a/h/l/o/p/t/u/w/y) /FontFile 33 0 R >> endobj 262 0 obj [693 0 0 0 0 0 0 0 0 0 0 0 668 0 0 0 0 0 0 0 0 0 0 0 0 459 0 0 0 0 0 0 511 0 0 0 250 0 0 459 511 0 0 0 354 511 0 668 0 485 ] endobj 261 0 obj << /Type /Encoding /Differences [ 0 /.notdef 72/H 73/.notdef 84/T 85/.notdef 97/a 98/.notdef 104/h 105/.notdef 108/l 109/.notdef 111/o/p 113/.notdef 116/t/u 118/.notdef 119/w 120/.notdef 121/y 122/.notdef] >> endobj 54 0 obj << /Type /Pages /Count 6 /Parent 263 0 R /Kids [26 0 R 57 0 R 65 0 R 69 0 R 73 0 R 77 0 R] >> endobj 84 0 obj << /Type /Pages /Count 6 /Parent 263 0 R /Kids [81 0 R 86 0 R 90 0 R 94 0 R 98 0 R 102 0 R] >> endobj 109 0 obj << /Type /Pages /Count 6 /Parent 263 0 R /Kids [106 0 R 111 0 R 115 0 R 119 0 R 123 0 R 127 0 R] >> endobj 135 0 obj << /Type /Pages /Count 6 /Parent 263 0 R /Kids [132 0 R 137 0 R 150 0 R 159 0 R 163 0 R 167 0 R] >> endobj 174 0 obj << /Type /Pages /Count 6 /Parent 263 0 R /Kids [171 0 R 176 0 R 180 0 R 184 0 R 188 0 R 192 0 R] >> endobj 199 0 obj << /Type /Pages /Count 6 /Parent 263 0 R /Kids [196 0 R 201 0 R 205 0 R 210 0 R 214 0 R 224 0 R] >> endobj 237 0 obj << /Type /Pages /Count 1 /Parent 264 0 R /Kids [234 0 R] >> endobj 263 0 obj << /Type /Pages /Count 36 /Parent 265 0 R /Kids [54 0 R 84 0 R 109 0 R 135 0 R 174 0 R 199 0 R] >> endobj 264 0 obj << /Type /Pages /Count 1 /Parent 265 0 R /Kids [237 0 R] >> endobj 265 0 obj << /Type /Pages /Count 37 /Kids [263 0 R 264 0 R] >> endobj 266 0 obj << /Type /Outlines /First 7 0 R /Last 23 0 R /Count 5 >> endobj 23 0 obj << /Title 24 0 R /A 21 0 R /Parent 266 0 R /Prev 19 0 R >> endobj 19 0 obj << /Title 20 0 R /A 17 0 R /Parent 266 0 R /Prev 15 0 R /Next 23 0 R >> endobj 15 0 obj << /Title 16 0 R /A 13 0 R /Parent 266 0 R /Prev 11 0 R /Next 19 0 R >> endobj 11 0 obj << /Title 12 0 R /A 9 0 R /Parent 266 0 R /Prev 7 0 R /Next 15 0 R >> endobj 7 0 obj << /Title 8 0 R /A 5 0 R /Parent 266 0 R /Next 11 0 R >> endobj 267 0 obj << /Names [(Doc-Start) 31 0 R (page.1) 30 0 R (page.10) 96 0 R (page.11) 100 0 R (page.12) 104 0 R (page.13) 108 0 R (page.14) 113 0 R (page.15) 117 0 R (page.16) 121 0 R (page.17) 125 0 R (page.18) 129 0 R (page.19) 134 0 R (page.2) 59 0 R (page.20) 139 0 R (page.21) 152 0 R (page.22) 161 0 R (page.23) 165 0 R (page.24) 169 0 R (page.25) 173 0 R (page.26) 178 0 R (page.27) 182 0 R (page.28) 186 0 R (page.29) 190 0 R (page.3) 67 0 R (page.30) 194 0 R (page.31) 198 0 R (page.32) 203 0 R (page.33) 207 0 R (page.34) 212 0 R (page.35) 216 0 R (page.36) 226 0 R (page.37) 236 0 R (page.4) 71 0 R (page.5) 75 0 R (page.6) 79 0 R (page.7) 83 0 R (page.8) 88 0 R (page.9) 92 0 R (section.1) 6 0 R (section.2) 10 0 R (section.3) 14 0 R (section.4) 18 0 R (section.5) 22 0 R] /Limits [(Doc-Start) (section.5)] >> endobj 268 0 obj << /Kids [267 0 R] >> endobj 269 0 obj << /Dests 268 0 R >> endobj 270 0 obj << /Type /Catalog /Pages 265 0 R /Outlines 266 0 R /Names 269 0 R /PageMode /UseOutlines /OpenAction 25 0 R >> endobj 271 0 obj << /Author()/Title()/Subject()/Creator(LaTeX with hyperref package)/Producer(pdfeTeX-1.21a)/Keywords() /CreationDate (D:20061226132459-08'00') /PTEX.Fullbanner (This is pdfeTeX, Version 3.141592-1.21a-2.2 (Web2C 7.5.4) kpathsea version 3.5.4) >> endobj xref 0 272 0000000001 65535 f 0000000002 00000 f 0000000003 00000 f 0000000004 00000 f 0000000000 00000 f 0000000009 00000 n 0000012181 00000 n 0000294947 00000 n 0000000054 00000 n 0000000080 00000 n 0000012241 00000 n 0000294861 00000 n 0000000125 00000 n 0000000171 00000 n 0000028309 00000 n 0000294773 00000 n 0000000217 00000 n 0000000256 00000 n 0000147191 00000 n 0000294685 00000 n 0000000302 00000 n 0000000344 00000 n 0000220985 00000 n 0000294610 00000 n 0000000390 00000 n 0000000420 00000 n 0000002095 00000 n 0000002243 00000 n 0000012303 00000 n 0000000470 00000 n 0000012058 00000 n 0000012120 00000 n 0000292925 00000 n 0000289380 00000 n 0000292766 00000 n 0000288553 00000 n 0000284133 00000 n 0000288394 00000 n 0000283328 00000 n 0000277173 00000 n 0000283168 00000 n 0000275939 00000 n 0000262167 00000 n 0000275780 00000 n 0000261184 00000 n 0000251275 00000 n 0000261024 00000 n 0000011272 00000 n 0000250044 00000 n 0000236801 00000 n 0000249884 00000 n 0000011460 00000 n 0000011648 00000 n 0000011853 00000 n 0000293507 00000 n 0000011169 00000 n 0000013931 00000 n 0000013761 00000 n 0000012475 00000 n 0000013869 00000 n 0000235473 00000 n 0000224061 00000 n 0000235311 00000 n 0000223690 00000 n 0000014699 00000 n 0000014529 00000 n 0000014048 00000 n 0000014637 00000 n 0000015549 00000 n 0000015379 00000 n 0000014792 00000 n 0000015487 00000 n 0000016285 00000 n 0000016115 00000 n 0000015642 00000 n 0000016223 00000 n 0000017029 00000 n 0000016859 00000 n 0000016378 00000 n 0000016967 00000 n 0000017802 00000 n 0000017632 00000 n 0000017122 00000 n 0000017740 00000 n 0000293617 00000 n 0000018547 00000 n 0000018377 00000 n 0000017895 00000 n 0000018485 00000 n 0000019401 00000 n 0000019231 00000 n 0000018640 00000 n 0000019339 00000 n 0000020259 00000 n 0000020089 00000 n 0000019494 00000 n 0000020197 00000 n 0000021152 00000 n 0000020981 00000 n 0000020352 00000 n 0000021089 00000 n 0000022095 00000 n 0000021920 00000 n 0000021245 00000 n 0000022031 00000 n 0000023036 00000 n 0000022860 00000 n 0000022189 00000 n 0000022972 00000 n 0000293728 00000 n 0000023734 00000 n 0000023558 00000 n 0000023118 00000 n 0000023670 00000 n 0000024414 00000 n 0000024238 00000 n 0000023828 00000 n 0000024350 00000 n 0000025060 00000 n 0000024884 00000 n 0000024496 00000 n 0000024996 00000 n 0000025818 00000 n 0000025642 00000 n 0000025142 00000 n 0000025754 00000 n 0000026577 00000 n 0000026401 00000 n 0000025912 00000 n 0000026513 00000 n 0000029974 00000 n 0000028372 00000 n 0000028133 00000 n 0000026671 00000 n 0000028245 00000 n 0000293845 00000 n 0000056375 00000 n 0000029862 00000 n 0000028502 00000 n 0000056311 00000 n 0000223170 00000 n 0000221170 00000 n 0000223009 00000 n 0000055716 00000 n 0000055860 00000 n 0000055945 00000 n 0000056045 00000 n 0000056068 00000 n 0000058250 00000 n 0000093587 00000 n 0000058138 00000 n 0000056522 00000 n 0000093523 00000 n 0000092928 00000 n 0000093072 00000 n 0000093157 00000 n 0000093257 00000 n 0000093280 00000 n 0000095999 00000 n 0000095823 00000 n 0000093721 00000 n 0000095935 00000 n 0000096810 00000 n 0000096634 00000 n 0000096118 00000 n 0000096746 00000 n 0000097743 00000 n 0000097567 00000 n 0000096892 00000 n 0000097679 00000 n 0000098442 00000 n 0000098266 00000 n 0000097825 00000 n 0000098378 00000 n 0000293962 00000 n 0000099118 00000 n 0000098942 00000 n 0000098536 00000 n 0000099054 00000 n 0000099788 00000 n 0000099612 00000 n 0000099200 00000 n 0000099724 00000 n 0000100481 00000 n 0000100305 00000 n 0000099870 00000 n 0000100417 00000 n 0000101141 00000 n 0000100965 00000 n 0000100563 00000 n 0000101077 00000 n 0000101928 00000 n 0000101752 00000 n 0000101223 00000 n 0000101864 00000 n 0000102617 00000 n 0000102441 00000 n 0000102022 00000 n 0000102553 00000 n 0000294079 00000 n 0000103421 00000 n 0000103245 00000 n 0000102699 00000 n 0000103357 00000 n 0000104355 00000 n 0000104179 00000 n 0000103515 00000 n 0000104291 00000 n 0000107409 00000 n 0000105469 00000 n 0000105293 00000 n 0000104449 00000 n 0000105405 00000 n 0000147254 00000 n 0000107297 00000 n 0000105575 00000 n 0000147127 00000 n 0000146532 00000 n 0000146676 00000 n 0000146761 00000 n 0000146861 00000 n 0000146884 00000 n 0000148620 00000 n 0000184339 00000 n 0000148508 00000 n 0000147413 00000 n 0000184275 00000 n 0000183680 00000 n 0000183824 00000 n 0000183909 00000 n 0000184009 00000 n 0000184032 00000 n 0000185572 00000 n 0000221048 00000 n 0000185460 00000 n 0000184461 00000 n 0000220921 00000 n 0000294196 00000 n 0000220326 00000 n 0000220470 00000 n 0000220555 00000 n 0000220655 00000 n 0000220678 00000 n 0000223401 00000 n 0000223377 00000 n 0000223488 00000 n 0000223938 00000 n 0000223964 00000 n 0000224025 00000 n 0000236238 00000 n 0000235914 00000 n 0000250822 00000 n 0000250478 00000 n 0000261791 00000 n 0000261475 00000 n 0000276723 00000 n 0000276348 00000 n 0000283816 00000 n 0000283593 00000 n 0000289063 00000 n 0000288789 00000 n 0000293281 00000 n 0000293139 00000 n 0000294273 00000 n 0000294389 00000 n 0000294466 00000 n 0000294536 00000 n 0000295019 00000 n 0000295845 00000 n 0000295884 00000 n 0000295922 00000 n 0000296051 00000 n trailer << /Size 272 /Root 270 0 R /Info 271 0 R /ID [ ] >> startxref 296314 %%EOF