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Tf 1.00 0.00 -0.00 1.00 40.75 274.13 Tm (SHC) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 67.61 325.03 Tm (FYN) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 67.24 280.38 Tm (GRB2) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 94.35 338.42 Tm (SOS) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 120.38 337.24 Tm (Ha-Ras) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 148.22 335.45 Tm (Raf) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 228.32 306.87 Tm (MEK) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 255.17 306.87 Tm (ERK) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 362.03 191.09 Tm (MYLK) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 389.10 132.75 Tm [(MY) 85 (O)] TJ ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 40.46 217.87 Tm [(A) 30 (CTN)] TJ ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 67.63 235.73 Tm (VCL) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 94.46 181.26 Tm (TLN) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 174.77 219.06 Tm (PXN) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 67.63 141.68 Tm (ZYX) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 94.11 136.91 Tm [(V) 80 (ASP)] TJ ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 93.79 294.07 Tm (SH3D5) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 94.40 249.42 Tm (TNS) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 120.81 150.90 Tm (CAPN) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 147.28 150.90 Tm (CAPNS) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 174.75 150.90 Tm (SRC) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 201.67 184.83 Tm [(F) 80 (AK)] TJ ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 227.73 184.83 Tm (BCAR1) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 201.57 117.27 Tm (CSK) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 255.14 184.83 Tm (CRK) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 281.28 225.31 Tm (DOCK1) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 281.66 136.32 Tm (GRF2) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 308.49 68.16 Tm (RAP1) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 362.45 68.17 Tm (JNK) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 201.49 254.19 Tm (GIT2) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 307.71 242.58 Tm (ARHGEF) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 335.66 191.09 Tm [(P) 120 (AK)] TJ ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 201.77 23.92 Tm (p85) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 228.29 23.92 Tm (p110) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 247.95 41.18 Tm (Phosphatidylinositol signaling system) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 282.07 68.16 Tm [(V) 80 (A) 70 (V)] TJ ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 281.36 23.81 Tm (PDPK1) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 308.82 23.81 Tm (AKT) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 308.76 149.71 Tm [(RA) 30 (C)] TJ ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 281.36 180.67 Tm (CDC42) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 201.49 70.24 Tm (RHO) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 228.32 68.17 Tm (PI5K) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 254.76 102.39 Tm [(R) 20 (OCK)] TJ ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 334.87 102.39 Tm [(MY) 85 (O-P)] TJ ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 386.44 63.40 Tm (cell maintenance) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 334.15 146.54 Tm (cell motility) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 415.34 132.75 Tm (F-actin) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 279.52 293.28 Tm [(cell prolif) 30 (er) 10 (ation)] TJ ET 17.39 307.53 m 19.16 314.60 l 21.22 322.93 l 23.50 332.21 l 25.92 342.13 l 28.41 352.36 l 30.90 362.60 l 33.31 372.54 l 35.59 381.87 l 37.65 390.26 l 39.42 397.42 l S 37.65 390.26 m 39.42 397.42 l S 40.37 394.14 m 39.42 397.42 l 37.06 394.96 l S 19.16 314.60 m 17.39 307.53 l S 16.45 310.81 m 17.39 307.53 l 19.76 309.98 l S 19.18 306.93 m 20.86 311.00 l 22.67 315.44 l 24.57 320.18 l 26.53 325.10 l 28.52 330.11 l 30.50 335.11 l 32.43 340.01 l 34.29 344.70 l 36.04 349.08 l 37.64 353.07 l S 36.04 349.08 m 37.64 353.07 l S 38.12 349.69 m 37.64 353.07 l 34.95 350.96 l S 20.86 311.00 m 19.18 306.93 l S 18.73 310.31 m 19.18 306.93 l 21.88 309.01 l S 23.64 303.95 m 24.55 304.77 l 25.49 305.59 l 26.45 306.42 l 27.43 307.26 l 28.41 308.08 l 29.39 308.91 l 30.36 309.71 l 31.32 310.50 l 32.26 311.26 l 33.17 311.99 l S 32.26 311.26 m 33.17 311.99 l S 31.94 308.81 m 33.17 311.99 l 29.80 311.47 l S 24.55 304.77 m 23.64 303.95 l S 24.71 307.20 m 23.64 303.95 l 26.98 304.65 l S 23.64 289.67 m 24.55 288.86 l 25.49 288.03 l 26.45 287.20 l 27.43 286.37 l 28.41 285.54 l 29.39 284.72 l 30.36 283.91 l 31.32 283.12 l 32.26 282.36 l 33.17 281.63 l S 32.26 282.36 m 33.17 281.63 l S 29.80 282.15 m 33.17 281.63 l 31.94 284.81 l S 24.55 288.86 m 23.64 289.67 l S 26.98 288.97 m 23.64 289.67 l 24.71 286.43 l S 18.58 286.10 m 20.30 281.28 l 22.20 275.87 l 24.23 270.00 l 26.36 263.84 l 28.52 257.52 l 30.67 251.21 l 32.77 245.04 l 34.76 239.18 l 36.60 233.76 l 38.23 228.95 l S 36.60 233.76 m 38.23 228.95 l S 35.67 231.20 m 38.23 228.95 l 38.90 232.29 l S 20.30 281.28 m 18.58 286.10 l S 21.18 283.89 m 18.58 286.10 l 17.97 282.74 l S 16.20 285.80 m 17.02 278.79 l 18.05 270.69 l 19.30 261.82 l 20.75 252.54 l 22.41 243.20 l 24.28 234.13 l 26.35 225.68 l 28.62 218.20 l 31.10 212.03 l 33.77 207.52 l S 33.77 207.52 m 37.85 202.91 l 42.49 198.89 l 47.57 195.41 l 52.96 192.43 l 58.52 189.92 l 64.12 187.82 l 69.64 186.10 l 74.95 184.72 l 79.91 183.64 l 84.39 182.81 l S 79.91 183.64 m 84.39 182.81 l S 81.17 181.67 m 84.39 182.81 l 81.79 185.03 l S 37.85 202.91 m 33.77 207.52 l S 37.00 206.44 m 33.77 207.52 l 34.45 204.17 l S 47.17 284.31 m 48.58 287.11 l 50.12 290.13 l 51.76 293.31 l 53.47 296.60 l 55.21 299.94 l 56.94 303.28 l 58.65 306.56 l 60.29 309.74 l 61.83 312.76 l 63.25 315.56 l S 61.83 312.76 m 63.25 315.56 l S 63.44 312.16 m 63.25 315.56 l 60.39 313.69 l S 48.58 287.11 m 47.17 284.31 l S 46.97 287.72 m 47.17 284.31 l 50.02 286.18 l S 52.82 277.17 m 53.35 277.26 l 53.86 277.38 l 54.37 277.50 l 54.86 277.63 l 55.35 277.76 l 55.85 277.90 l 56.34 278.03 l 56.84 278.15 l 57.36 278.26 l 57.89 278.36 l S 57.36 278.26 m 57.89 278.36 l S 55.29 276.14 m 57.89 278.36 l 54.67 279.50 l S 53.35 277.26 m 52.82 277.17 l S 55.42 279.38 m 52.82 277.17 l 56.04 276.03 l S 71.88 288.18 m 73.49 291.46 l 75.26 295.16 l 77.16 299.19 l 79.15 303.46 l 81.19 307.86 l 83.24 312.31 l 85.28 316.71 l 87.27 320.96 l 89.17 324.98 l 90.94 328.66 l S 89.17 324.98 m 90.94 328.66 l S 91.19 325.26 m 90.94 328.66 l 88.12 326.74 l S 103.44 338.48 m 104.17 338.47 l 104.91 338.45 l 105.66 338.42 l 106.43 338.38 l 107.20 338.33 l 107.99 338.29 l 108.78 338.25 l 109.58 338.22 l 110.38 338.19 l 111.19 338.18 l S 110.38 338.19 m 111.19 338.18 l S 108.21 336.51 m 111.19 338.18 l 108.25 339.92 l S 130.24 336.99 m 130.97 336.91 l 131.71 336.85 l 132.46 336.79 l 133.23 336.74 l 134.00 336.70 l 134.79 336.65 l 135.58 336.60 l 136.38 336.55 l 137.18 336.48 l 137.99 336.40 l S 137.18 336.48 m 137.99 336.40 l S 134.87 335.00 m 137.99 336.40 l 135.22 338.39 l S 156.74 333.12 m 161.52 331.43 l 167.13 329.43 l 173.39 327.20 l 180.11 324.80 l 187.08 322.30 l 194.11 319.77 l 201.01 317.29 l 207.59 314.92 l 213.64 312.74 l 218.98 310.80 l S 213.64 312.74 m 218.98 310.80 l S 215.62 310.20 m 218.98 310.80 l 216.78 313.41 l S 237.44 307.23 m 238.16 307.23 l 238.90 307.23 l 239.66 307.23 l 240.42 307.23 l 241.20 307.23 l 241.98 307.23 l 242.78 307.23 l 243.58 307.23 l 244.38 307.23 l 245.18 307.23 l S 244.38 307.23 m 245.18 307.23 l S 242.23 305.52 m 245.18 307.23 l 242.23 308.94 l S 264.24 308.42 m 266.58 308.58 l 269.11 308.67 l 271.79 308.68 l 274.57 308.58 l 277.41 308.35 l 280.27 307.95 l 283.11 307.37 l 285.88 306.57 l 288.53 305.54 l 291.04 304.25 l S 291.04 304.25 m 302.47 296.23 l 312.83 286.72 l 322.15 276.09 l 330.45 264.72 l 337.75 252.98 l 344.08 241.27 l 349.46 229.95 l 353.91 219.41 l 357.45 210.02 l 360.12 202.16 l S 357.45 210.02 m 360.12 202.16 l S 357.55 204.41 m 360.12 202.16 l 360.79 205.51 l S 263.34 303.66 m 264.26 303.19 l 265.20 302.70 l 266.16 302.19 l 267.15 301.66 l 268.15 301.13 l 269.15 300.59 l 270.17 300.07 l 271.18 299.55 l 272.18 299.06 l 273.17 298.60 l S 272.18 299.06 m 273.17 298.60 l S 269.77 298.30 m 273.17 298.60 l 271.22 301.39 l S 366.67 184.00 m 368.28 180.64 l 370.05 176.88 l 371.95 172.79 l 373.94 168.49 l 375.98 164.06 l 378.03 159.59 l 380.07 155.18 l 382.06 150.92 l 383.96 146.91 l 385.73 143.23 l S 383.96 146.91 m 385.73 143.23 l S 382.91 145.15 m 385.73 143.23 l 385.98 146.63 l S 401.21 133.11 m 401.67 133.11 l 402.14 133.11 l 402.62 133.11 l 403.10 133.11 l 403.59 133.11 l 404.08 133.11 l 404.57 133.11 l 405.05 133.11 l 405.52 133.11 l 405.98 133.11 l S 405.52 133.11 m 405.98 133.11 l S 403.02 131.40 m 405.98 133.11 l 403.02 134.81 l S 401.67 133.11 m 401.21 133.11 l S 404.17 134.81 m 401.21 133.11 l 404.17 131.40 l S 51.04 224.48 m 51.85 225.02 l 52.68 225.55 l 53.51 226.09 l 54.36 226.63 l 55.21 227.16 l 56.05 227.70 l 56.90 228.23 l 57.74 228.77 l 58.56 229.30 l 59.37 229.84 l S 58.56 229.30 m 59.37 229.84 l S 57.85 226.79 m 59.37 229.84 l 55.97 229.64 l S 51.85 225.02 m 51.04 224.48 l S 52.56 227.53 m 51.04 224.48 l 54.44 224.69 l S 50.74 211.98 m 53.93 209.82 l 57.37 207.47 l 61.01 204.99 l 64.77 202.42 l 68.61 199.82 l 72.44 197.22 l 76.20 194.67 l 79.84 192.24 l 83.28 189.95 l 86.47 187.87 l S 83.28 189.95 m 86.47 187.87 l S 83.06 188.06 m 86.47 187.87 l 84.93 190.92 l S 53.93 209.82 m 50.74 211.98 l S 54.14 211.73 m 50.74 211.98 l 52.23 208.91 l S 45.38 207.81 m 47.10 203.11 l 49.00 197.86 l 51.03 192.19 l 53.15 186.25 l 55.32 180.17 l 57.47 174.10 l 59.57 168.19 l 61.56 162.56 l 63.40 157.37 l 65.03 152.75 l S 63.40 157.37 m 65.03 152.75 l S 62.44 154.97 m 65.03 152.75 l 65.65 156.10 l S 47.10 203.11 m 45.38 207.81 l S 48.00 205.62 m 45.38 207.81 l 44.79 204.45 l S 73.37 226.27 m 74.87 223.18 l 76.51 219.85 l 78.24 216.33 l 80.05 212.68 l 81.89 208.97 l 83.75 205.25 l 85.58 201.57 l 87.36 198.01 l 89.06 194.61 l 90.64 191.44 l S 89.06 194.61 m 90.64 191.44 l S 87.79 193.32 m 90.64 191.44 l 90.84 194.85 l S 74.87 223.18 m 73.37 226.27 l S 76.20 224.36 m 73.37 226.27 l 73.13 222.87 l S 79.62 234.31 m 86.37 233.30 l 94.28 232.11 l 103.06 230.78 l 112.43 229.35 l 122.09 227.87 l 131.76 226.38 l 141.16 224.92 l 149.98 223.54 l 157.95 222.29 l 164.78 221.21 l S 157.95 222.29 m 164.78 221.21 l S 161.60 219.99 m 164.78 221.21 l 162.13 223.36 l S 86.37 233.30 m 79.62 234.31 l S 82.80 235.56 m 79.62 234.31 l 82.30 232.18 l S 73.07 246.21 m 74.66 249.66 l 76.36 253.37 l 78.14 257.27 l 79.98 261.29 l 81.86 265.37 l 83.73 269.44 l 85.57 273.44 l 87.36 277.29 l 89.05 280.94 l 90.64 284.31 l S 89.05 280.94 m 90.64 284.31 l S 90.93 280.91 m 90.64 284.31 l 87.84 282.36 l S 74.66 249.66 m 73.07 246.21 l S 72.75 249.61 m 73.07 246.21 l 75.86 248.19 l S 78.43 241.15 m 79.15 241.51 l 79.86 241.87 l 80.58 242.22 l 81.29 242.58 l 82.00 242.94 l 82.72 243.29 l 83.43 243.65 l 84.15 244.01 l 84.86 244.37 l 85.58 244.72 l S 84.86 244.37 m 85.58 244.72 l S 83.70 241.88 m 85.58 244.72 l 82.17 244.93 l S 79.15 241.51 m 78.43 241.15 l S 80.31 244.00 m 78.43 241.15 l 81.84 240.95 l S 102.85 172.99 m 104.03 171.79 l 105.23 170.51 l 106.45 169.18 l 107.68 167.80 l 108.92 166.40 l 110.14 165.00 l 111.34 163.60 l 112.52 162.22 l 113.66 160.88 l 114.76 159.60 l S 113.66 160.88 m 114.76 159.60 l S 111.54 160.73 m 114.76 159.60 l 114.14 162.95 l S 104.03 171.79 m 102.85 172.99 l S 106.14 172.07 m 102.85 172.99 l 103.70 169.68 l S 106.42 181.92 m 113.24 182.20 l 121.20 182.51 l 129.99 182.84 l 139.36 183.18 l 149.00 183.52 l 158.65 183.85 l 168.01 184.16 l 176.81 184.44 l 184.76 184.69 l 191.58 184.90 l S 184.76 184.69 m 191.58 184.90 l S 188.68 183.10 m 191.58 184.90 l 188.58 186.51 l S 113.24 182.20 m 106.42 181.92 l S 109.30 183.75 m 106.42 181.92 l 109.45 180.34 l S 182.65 214.96 m 185.65 213.02 l 189.04 210.82 l 192.73 208.43 l 196.65 205.89 l 200.70 203.28 l 204.80 200.64 l 208.85 198.05 l 212.77 195.57 l 216.47 193.24 l 219.87 191.15 l S 216.47 193.24 m 219.87 191.15 l S 216.46 191.25 m 219.87 191.15 l 218.25 194.15 l S 180.86 225.97 m 182.16 227.74 l 183.56 229.62 l 185.02 231.59 l 186.53 233.63 l 188.08 235.72 l 189.65 237.82 l 191.22 239.92 l 192.77 241.98 l 194.29 243.99 l 195.75 245.91 l S 194.29 243.99 m 195.75 245.91 l S 195.32 242.53 m 195.75 245.91 l 192.61 244.59 l S 182.65 210.79 m 183.92 209.23 l 185.21 207.60 l 186.53 205.92 l 187.86 204.20 l 189.20 202.46 l 190.54 200.72 l 191.87 199.00 l 193.19 197.31 l 194.48 195.68 l 195.75 194.12 l S 194.48 195.68 m 195.75 194.12 l S 192.56 195.34 m 195.75 194.12 l 195.21 197.49 l S 183.92 209.23 m 182.65 210.79 l S 185.84 209.57 m 182.65 210.79 l 183.19 207.42 l S 79.62 139.95 m 80.08 139.86 l 80.55 139.77 l 81.03 139.69 l 81.51 139.61 l 82.00 139.54 l 82.50 139.48 l 82.98 139.43 l 83.46 139.39 l 83.93 139.36 l 84.39 139.36 l S 83.93 139.36 m 84.39 139.36 l S 81.40 137.71 m 84.39 139.36 l 81.46 141.12 l S 80.08 139.86 m 79.62 139.95 l S 82.85 141.06 m 79.62 139.95 l 82.20 137.71 l S 133.22 151.26 m 133.68 151.26 l 134.15 151.26 l 134.63 151.26 l 135.11 151.26 l 135.60 151.26 l 136.09 151.26 l 136.58 151.26 l 137.06 151.26 l 137.53 151.26 l 137.99 151.26 l S 137.53 151.26 m 137.99 151.26 l S 135.03 149.56 m 137.99 151.26 l 135.03 152.97 l S 133.68 151.26 m 133.22 151.26 l S 136.18 152.97 m 133.22 151.26 l 136.18 149.56 l S 157.04 151.26 m 157.77 151.26 l 158.50 151.26 l 159.26 151.26 l 160.02 151.26 l 160.80 151.26 l 161.59 151.26 l 162.38 151.26 l 163.18 151.26 l 163.98 151.26 l 164.78 151.26 l S 163.98 151.26 m 164.78 151.26 l S 161.83 149.56 m 164.78 151.26 l 161.83 152.97 l S 180.86 157.51 m 182.16 159.19 l 183.56 160.98 l 185.02 162.86 l 186.53 164.82 l 188.08 166.81 l 189.65 168.83 l 191.22 170.83 l 192.77 172.81 l 194.29 174.73 l 195.75 176.56 l S 194.29 174.73 m 195.75 176.56 l S 195.25 173.19 m 195.75 176.56 l 192.58 175.31 l S 185.33 157.21 m 188.42 159.11 l 191.75 161.19 l 195.27 163.41 l 198.90 165.72 l 202.60 168.08 l 206.30 170.44 l 209.93 172.75 l 213.45 174.97 l 216.78 177.05 l 219.87 178.94 l S 216.78 177.05 m 219.87 178.94 l S 218.24 175.94 m 219.87 178.94 l 216.46 178.85 l S 188.42 159.11 m 185.33 157.21 l S 186.96 160.21 m 185.33 157.21 l 188.74 157.30 l S 182.65 142.63 m 183.92 141.08 l 185.21 139.47 l 186.52 137.82 l 187.84 136.14 l 189.16 134.44 l 190.48 132.75 l 191.77 131.07 l 193.04 129.42 l 194.27 127.81 l 195.45 126.26 l S 194.27 127.81 m 195.45 126.26 l S 192.30 127.57 m 195.45 126.26 l 195.01 129.64 l S 183.92 141.08 m 182.65 142.63 l S 185.84 141.42 m 182.65 142.63 l 183.20 139.26 l S 204.39 193.23 m 205.96 200.52 l 207.94 209.60 l 210.23 220.05 l 212.74 231.45 l 215.37 243.38 l 218.02 255.42 l 220.61 267.15 l 223.03 278.13 l 225.20 287.96 l 227.02 296.22 l S 225.20 287.96 m 227.02 296.22 l S 228.05 292.96 m 227.02 296.22 l 224.72 293.70 l S 210.64 185.19 m 211.36 185.19 l 212.10 185.19 l 212.86 185.19 l 213.62 185.19 l 214.40 185.19 l 215.19 185.19 l 215.98 185.19 l 216.78 185.19 l 217.58 185.19 l 218.38 185.19 l S 217.58 185.19 m 218.38 185.19 l S 215.43 183.49 m 218.38 185.19 l 215.43 186.90 l S 203.79 177.16 m 205.09 167.84 l 206.76 155.94 l 208.71 142.21 l 210.83 127.39 l 213.02 112.23 l 215.18 97.50 l 217.19 83.94 l 218.96 72.30 l 220.39 63.34 l 221.36 57.80 l S 221.36 57.80 m 221.82 55.53 l 222.32 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210.05 l 265.05 209.35 l 265.77 208.61 l 266.42 207.86 l 266.98 207.08 l 267.46 206.28 l 267.86 205.46 l 268.17 204.63 l 268.39 203.79 l 268.53 202.95 l 268.57 202.10 l 268.53 201.25 l 268.39 200.40 l 268.17 199.56 l 267.86 198.73 l 267.46 197.92 l 266.98 197.12 l 266.42 196.34 l 265.77 195.58 l 265.05 194.85 l 264.25 194.15 l 263.38 193.47 l 262.44 192.84 l 261.43 192.24 l 260.36 191.67 l 259.24 191.15 l 258.06 190.68 l 256.84 190.24 l 255.57 189.86 l 254.27 189.52 l 252.93 189.23 l 251.56 188.99 l 250.18 188.81 l 248.77 188.68 l 247.36 188.60 l 245.93 188.57 l 245.93 188.57 l S BT 0.000 0.000 0.000 rg /F2 1 Tf 4.00 0.00 -0.00 4.00 13.12 360.99 Tm (ITGB) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 35.75 302.87 Tm (ITGA) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 37.42 341.70 Tm (ILK) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 36.45 380.28 Tm [(CA) 70 (V)] TJ ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 81.98 409.08 Tm (SHC) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 105.35 370.51 Tm (FYN) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 103.90 409.08 Tm (GRB2) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 130.02 398.81 Tm (SOS) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 152.37 378.05 Tm (Ha-Ras) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 179.68 367.51 Tm (Raf) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 202.11 364.74 Tm (MEK) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 328.10 277.57 Tm (ERK) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 349.66 144.55 Tm (MYLK) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 373.61 121.00 Tm [(MY) 85 (O)] TJ ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 35.04 259.78 Tm [(A) 30 (CTN)] TJ ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 59.17 220.95 Tm (VCL) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 82.43 259.78 Tm (TLN) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 82.09 220.95 Tm (PXN) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 13.89 240.24 Tm (ZYX) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 35.25 220.95 Tm [(V) 80 (ASP)] TJ ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 79.76 143.29 Tm (SH3D5) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 82.20 182.12 Tm (TNS) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 103.79 300.61 Tm (CAPN) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 127.36 300.61 Tm (CAPNS) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 155.43 300.61 Tm (SRC) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 179.07 261.79 Tm [(F) 80 (AK)] TJ ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 199.77 276.31 Tm (BCAR1) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 178.68 300.61 Tm (CSK) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 241.71 292.85 Tm (CRK) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 278.79 292.85 Tm (DOCK1) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 280.34 331.68 Tm (GRF2) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 304.35 298.61 Tm (RAP1) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 351.33 184.17 Tm (JNK) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 104.90 142.54 Tm (GIT2) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 125.91 121.50 Tm (ARHGEF) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 328.45 144.55 Tm [(P) 120 (AK)] TJ ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 179.46 180.31 Tm (p85) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 201.99 232.17 Tm (p110) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 233.32 207.22 Tm (Phosphatidyl-) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 239.71 202.85 Tm (inositol) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 238.04 198.47 Tm (signaling) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 239.60 194.10 Tm (system) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 281.98 142.54 Tm [(V) 80 (A) 70 (V)] TJ ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 279.12 220.20 Tm (PDPK1) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 305.68 220.20 Tm (AKT) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 305.41 143.79 Tm [(RA) 30 (C)] TJ ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 279.12 181.37 Tm (CDC42) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 178.35 139.54 Tm (RHO) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 202.11 189.93 Tm (PI5K) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 200.70 139.54 Tm [(R) 20 (OCK)] TJ ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 239.05 136.03 Tm [(MY) 85 (O-P)] TJ ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 404.42 187.82 Tm (cell) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 395.97 183.44 Tm (maintenance) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 404.42 58.30 Tm (cell) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 401.20 53.93 Tm (motility) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 400.81 121.03 Tm (F-actin) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 404.42 278.50 Tm (cell) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 397.06 274.13 Tm [(prolif) 30 (er) 10 (ation)] TJ ET 25.08 355.66 m 26.29 352.67 l 27.63 348.91 l 29.06 344.55 l 30.55 339.76 l 32.06 334.71 l 33.55 329.56 l 35.00 324.48 l 36.36 319.63 l 37.59 315.19 l 38.66 311.32 l S 37.59 315.19 m 38.66 311.32 l S 37.29 312.67 m 38.66 311.32 l 39.14 313.18 l S 26.29 352.67 m 25.08 355.66 l S 26.59 354.48 m 25.08 355.66 l 24.81 353.76 l S 25.58 356.16 m 26.41 355.42 l 27.24 354.69 l 28.06 353.97 l 28.87 353.27 l 29.67 352.59 l 30.45 351.92 l 31.22 351.27 l 31.97 350.63 l 32.69 350.01 l 33.38 349.40 l S 32.69 350.01 m 33.38 349.40 l S 31.50 349.77 m 33.38 349.40 l 32.76 351.22 l S 26.41 355.42 m 25.58 356.16 l S 27.46 355.76 m 25.58 356.16 l 26.18 354.33 l S 25.08 368.69 m 25.85 369.37 l 26.64 370.06 l 27.45 370.76 l 28.27 371.46 l 29.10 372.16 l 29.93 372.85 l 30.76 373.53 l 31.57 374.19 l 32.36 374.83 l 33.13 375.45 l S 32.36 374.83 m 33.13 375.45 l S 32.43 373.66 m 33.13 375.45 l 31.23 375.16 l S 25.85 369.37 m 25.08 368.69 l S 25.68 370.51 m 25.08 368.69 l 26.96 369.07 l S 18.54 369.44 m 19.07 373.99 l 19.75 379.23 l 20.60 384.93 l 21.62 390.85 l 22.81 396.77 l 24.19 402.46 l 25.75 407.69 l 27.51 412.22 l 29.46 415.83 l 31.62 418.29 l S 31.62 418.29 m 35.75 420.85 l 40.24 422.47 l 44.99 423.26 l 49.89 423.34 l 54.86 422.83 l 59.78 421.84 l 64.57 420.50 l 69.13 418.92 l 73.35 417.22 l 77.15 415.53 l S 73.35 417.22 m 77.15 415.53 l S 75.24 415.33 m 77.15 415.53 l 76.02 417.09 l S 35.75 420.85 m 31.62 418.29 l S 32.53 419.98 m 31.62 418.29 l 33.54 418.35 l S 25.33 355.66 m 28.68 347.74 l 30.62 340.54 l 31.46 333.85 l 31.49 327.48 l 31.02 321.21 l 30.35 314.86 l 29.77 308.21 l 29.59 301.08 l 30.10 293.24 l 31.62 284.51 l S 31.62 284.51 m 32.03 282.78 l 32.49 281.04 l 33.00 279.30 l 33.55 277.58 l 34.13 275.87 l 34.75 274.20 l 35.39 272.56 l 36.05 270.97 l 36.73 269.44 l 37.40 267.98 l S 36.73 269.44 m 37.40 267.98 l S 35.83 269.09 m 37.40 267.98 l 37.58 269.89 l S 32.03 282.78 m 31.62 284.51 l S 32.93 283.11 m 31.62 284.51 l 31.06 282.67 l S 19.54 369.44 m 20.13 371.38 l 20.85 373.41 l 21.69 375.51 l 22.67 377.62 l 23.79 379.71 l 25.05 381.74 l 26.46 383.67 l 28.02 385.46 l 29.74 387.08 l 31.62 388.48 l S 31.62 388.48 m 33.60 389.58 l 35.48 390.47 l 37.28 391.14 l 39.01 391.58 l 40.71 391.76 l 42.38 391.69 l 44.04 391.33 l 45.73 390.69 l 47.45 389.74 l 49.23 388.48 l S 49.23 388.48 m 59.78 378.14 l 66.12 367.43 l 69.19 356.34 l 69.93 344.87 l 69.29 333.02 l 68.21 320.78 l 67.63 308.16 l 68.51 295.16 l 71.79 281.76 l 78.41 267.98 l S 71.79 281.76 m 78.41 267.98 l S 76.82 269.07 m 78.41 267.98 l 78.55 269.90 l S 59.78 378.14 m 49.23 388.48 l S 51.09 388.00 m 49.23 388.48 l 49.74 386.63 l S 90.23 403.76 m 91.51 401.54 l 92.93 399.13 l 94.46 396.58 l 96.05 393.93 l 97.68 391.23 l 99.32 388.53 l 100.94 385.88 l 102.50 383.33 l 103.97 380.92 l 105.32 378.71 l S 103.97 380.92 m 105.32 378.71 l S 103.63 379.63 m 105.32 378.71 l 105.27 380.63 l S 91.51 401.54 m 90.23 403.76 l S 91.89 402.80 m 90.23 403.76 l 90.23 401.84 l S 95.51 410.52 m 95.96 410.52 l 96.42 410.52 l 96.87 410.52 l 97.32 410.52 l 97.77 410.52 l 98.23 410.52 l 98.68 410.52 l 99.13 410.52 l 99.59 410.52 l 100.04 410.52 l S 99.59 410.52 m 100.04 410.52 l S 98.37 409.56 m 100.04 410.52 l 98.37 411.48 l S 95.96 410.52 m 95.51 410.52 l S 97.18 411.48 m 95.51 410.52 l 97.18 409.56 l S 116.14 407.77 m 116.98 407.39 l 117.85 407.01 l 118.74 406.64 l 119.65 406.26 l 120.57 405.89 l 121.50 405.51 l 122.43 405.13 l 123.36 404.76 l 124.28 404.38 l 125.19 404.01 l S 124.28 404.38 m 125.19 404.01 l S 123.29 403.75 m 125.19 404.01 l 124.02 405.53 l S 139.78 395.74 m 140.87 394.82 l 142.03 393.86 l 143.24 392.87 l 144.48 391.85 l 145.76 390.82 l 147.05 389.79 l 148.34 388.75 l 149.62 387.72 l 150.88 386.71 l 152.11 385.72 l S 150.88 386.71 m 152.11 385.72 l S 150.21 386.02 m 152.11 385.72 l 151.42 387.51 l S 166.95 376.20 m 167.57 375.89 l 168.21 375.57 l 168.88 375.25 l 169.56 374.91 l 170.25 374.57 l 170.95 374.24 l 171.66 373.90 l 172.36 373.57 l 173.05 373.25 l 173.74 372.94 l S 173.05 373.25 m 173.74 372.94 l S 171.83 372.75 m 173.74 372.94 l 172.62 374.50 l S 189.59 368.18 m 190.34 368.11 l 191.10 368.03 l 191.85 367.95 l 192.61 367.87 l 193.36 367.78 l 194.12 367.68 l 194.87 367.57 l 195.63 367.46 l 196.38 367.33 l 197.13 367.18 l S 196.38 367.33 m 197.13 367.18 l S 195.32 366.55 m 197.13 367.18 l 195.68 368.44 l S 213.23 365.68 m 218.65 365.10 l 225.25 364.22 l 232.81 362.99 l 241.10 361.36 l 249.90 359.26 l 258.98 356.64 l 268.13 353.45 l 277.12 349.63 l 285.73 345.12 l 293.73 339.88 l S 293.73 339.88 m 299.32 335.30 l 304.47 330.11 l 309.19 324.46 l 313.47 318.52 l 317.31 312.45 l 320.71 306.40 l 323.68 300.55 l 326.21 295.05 l 328.30 290.07 l 329.95 285.77 l S 328.30 290.07 m 329.95 285.77 l S 328.46 286.98 m 329.95 285.77 l 330.25 287.67 l S 332.97 274.49 m 333.70 269.34 l 334.66 262.59 l 335.83 254.49 l 337.19 245.25 l 338.72 235.10 l 340.39 224.28 l 342.19 213.01 l 344.08 201.52 l 346.04 190.04 l 348.06 178.80 l S 348.06 178.80 m 348.60 176.13 l 349.17 173.40 l 349.75 170.64 l 350.33 167.88 l 350.92 165.15 l 351.50 162.48 l 352.07 159.90 l 352.61 157.44 l 353.12 155.13 l 353.59 153.00 l S 353.12 155.13 m 353.59 153.00 l S 352.29 154.41 m 353.59 153.00 l 354.17 154.83 l S 339.00 279.00 m 342.90 278.92 l 347.42 278.83 l 352.43 278.72 l 357.82 278.61 l 363.47 278.50 l 369.25 278.39 l 375.05 278.28 l 380.74 278.18 l 386.21 278.08 l 391.33 278.00 l S 386.21 278.08 m 391.33 278.00 l S 389.65 277.07 m 391.33 278.00 l 389.68 278.99 l S 359.63 141.47 m 360.72 140.37 l 361.88 139.18 l 363.09 137.92 l 364.33 136.62 l 365.61 135.27 l 366.89 133.92 l 368.19 132.56 l 369.47 131.23 l 370.73 129.93 l 371.96 128.70 l S 370.73 129.93 m 371.96 128.70 l S 370.10 129.20 m 371.96 128.70 l 371.47 130.56 l S 387.30 122.43 m 388.30 122.43 l 389.34 122.43 l 390.41 122.43 l 391.49 122.43 l 392.58 122.43 l 393.68 122.43 l 394.76 122.43 l 395.83 122.43 l 396.86 122.43 l 397.87 122.43 l S 396.86 122.43 m 397.87 122.43 l S 396.20 121.47 m 397.87 122.43 l 396.20 123.40 l S 388.30 122.43 m 387.30 122.43 l S 388.96 123.40 m 387.30 122.43 l 388.96 121.47 l S 44.45 254.45 m 45.73 252.23 l 47.12 249.80 l 48.61 247.22 l 50.16 244.54 l 51.74 241.80 l 53.32 239.07 l 54.87 236.38 l 56.36 233.80 l 57.76 231.38 l 59.04 229.15 l S 57.76 231.38 m 59.04 229.15 l S 57.37 230.12 m 59.04 229.15 l 59.04 231.07 l S 45.73 252.23 m 44.45 254.45 l S 46.11 253.49 m 44.45 254.45 l 44.44 252.53 l S 49.73 261.22 m 52.23 261.22 l 54.87 261.22 l 57.63 261.22 l 60.45 261.22 l 63.31 261.22 l 66.17 261.22 l 69.00 261.22 l 71.75 261.22 l 74.40 261.22 l 76.90 261.22 l S 74.40 261.22 m 76.90 261.22 l S 75.23 260.26 m 76.90 261.22 l 75.23 262.18 l S 52.23 261.22 m 49.73 261.22 l S 51.39 262.18 m 49.73 261.22 l 51.39 260.26 l S 33.13 254.95 m 32.36 254.27 l 31.57 253.58 l 30.76 252.87 l 29.93 252.16 l 29.10 251.45 l 28.27 250.73 l 27.45 250.02 l 26.64 249.32 l 25.85 248.62 l 25.08 247.94 l S 25.85 248.62 m 25.08 247.94 l S 25.68 249.76 m 25.08 247.94 l 26.96 248.33 l S 32.36 254.27 m 33.13 254.95 l S 32.52 253.13 m 33.13 254.95 l 31.25 254.57 l S 67.09 229.15 m 68.37 231.38 l 69.79 233.80 l 71.31 236.38 l 72.91 239.07 l 74.54 241.80 l 76.18 244.54 l 77.79 247.22 l 79.35 249.80 l 80.83 252.23 l 82.18 254.45 l S 80.83 252.23 m 82.18 254.45 l S 82.13 252.53 m 82.18 254.45 l 80.49 253.53 l S 68.37 231.38 m 67.09 229.15 l S 67.09 231.07 m 67.09 229.15 l 68.75 230.11 l S 72.37 222.39 m 72.82 222.39 l 73.27 222.39 l 73.73 222.39 l 74.18 222.39 l 74.63 222.39 l 75.09 222.39 l 75.54 222.39 l 75.99 222.39 l 76.44 222.39 l 76.90 222.39 l S 76.44 222.39 m 76.90 222.39 l S 75.23 221.43 m 76.90 222.39 l 75.23 223.35 l S 72.82 222.39 m 72.37 222.39 l S 74.03 223.35 m 72.37 222.39 l 74.03 221.43 l S 64.82 215.37 m 65.73 211.75 l 66.77 207.55 l 67.94 202.87 l 69.24 197.79 l 70.64 192.39 l 72.14 186.77 l 73.73 181.01 l 75.39 175.20 l 77.12 169.42 l 78.91 163.77 l S 78.91 163.77 m 79.37 162.55 l 79.84 161.32 l 80.31 160.07 l 80.79 158.81 l 81.27 157.57 l 81.73 156.34 l 82.19 155.13 l 82.63 153.96 l 83.05 152.82 l 83.44 151.74 l S 83.05 152.82 m 83.44 151.74 l S 81.97 152.98 m 83.44 151.74 l 83.77 153.64 l S 79.37 162.55 m 78.91 163.77 l S 80.40 162.55 m 78.91 163.77 l 78.60 161.87 l S 67.09 215.62 m 68.37 213.40 l 69.79 210.97 l 71.31 208.39 l 72.91 205.71 l 74.54 202.97 l 76.18 200.24 l 77.79 197.56 l 79.35 194.97 l 80.83 192.55 l 82.18 190.32 l S 80.83 192.55 m 82.18 190.32 l S 80.49 191.24 m 82.18 190.32 l 82.13 192.24 l S 68.37 213.40 m 67.09 215.62 l S 68.75 214.66 m 67.09 215.62 l 67.09 213.70 l S 94.76 266.48 m 94.82 266.48 l 94.88 266.50 l 94.92 266.53 l 94.95 266.57 l 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0.00 -0.00 3.00 369.33 109.37 Tm [(MY) 85 (O)] TJ ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 18.78 0 0 18.78 39.97 245.72 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 43.36 251.16 Tm [(A) 30 (CTN)] TJ ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 16.90 0 0 16.90 61.73 208.90 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 65.50 213.69 Tm (VCL) Tj ET 0.000 1.000 0.000 rg BT /F1 1 Tf 2 Tr 16.90 0 0 16.90 83.20 247.94 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 87.06 252.73 Tm (TLN) Tj ET 0.000 0.000 1.000 rg BT /F1 1 Tf 2 Tr 16.90 0 0 16.90 83.20 208.90 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 86.81 213.69 Tm (PXN) Tj ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 16.90 0 0 16.90 19.69 225.28 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 23.47 230.07 Tm (ZYX) Tj ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 18.16 0 0 18.16 40.21 204.20 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 43.52 209.43 Tm [(V) 80 (ASP)] TJ ET BT /F1 1 Tf 1 Tr 20.03 0 0 20.03 81.96 127.27 Tm (l) Tj 0 Tr ET BT /F2 1 Tf 3.00 0.00 -0.00 3.00 85.06 133.15 Tm (SH3D5) Tj ET BT /F1 1 Tf 1 Tr 16.90 0 0 16.90 83.20 170.09 Tm (l) Tj 0 Tr ET BT /F2 1 Tf 3.00 0.00 -0.00 3.00 86.89 174.88 Tm (TNS) Tj ET 0.000 0.000 1.000 rg BT /F1 1 Tf 2 Tr 18.78 0 0 18.78 104.60 280.94 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 107.87 286.38 Tm (CAPN) Tj ET 0.000 0.000 1.000 rg BT /F1 1 Tf 2 Tr 21.91 0 0 21.91 127.32 281.42 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 130.83 287.95 Tm (CAPNS) Tj ET 0.000 0.000 1.000 rg BT /F1 1 Tf 2 Tr 16.90 0 0 16.90 153.71 283.16 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 157.24 287.95 Tm (SRC) Tj ET 0.000 0.000 1.000 rg BT /F1 1 Tf 2 Tr 16.90 0 0 16.90 175.18 244.12 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 179.08 248.91 Tm [(F) 80 (AK)] TJ ET BT /F1 1 Tf 1 Tr 21.29 0 0 21.29 195.37 259.43 Tm (l) Tj 0 Tr ET BT /F2 1 Tf 3.00 0.00 -0.00 3.00 198.79 265.74 Tm (BCAR1) Tj ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 16.90 0 0 16.90 175.18 283.16 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 178.79 287.95 Tm (CSK) Tj ET 0.000 1.000 0.000 rg BT /F1 1 Tf 2 Tr 16.90 0 0 16.90 238.46 277.10 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 241.99 281.89 Tm (CRK) Tj ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 21.91 0 0 21.91 278.06 275.36 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 281.57 281.89 Tm (DOCK1) Tj ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 18.16 0 0 18.16 279.55 321.09 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 282.74 326.31 Tm (GRF2) Tj ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 18.16 0 0 18.16 302.15 285.42 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 305.42 290.64 Tm (RAP1) Tj ET 0.000 0.000 1.000 rg BT /F1 1 Tf 2 Tr 16.90 0 0 16.90 344.68 156.40 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 348.54 161.22 Tm (JNK) Tj ET 0.000 1.000 0.000 rg BT /F1 1 Tf 2 Tr 16.90 0 0 16.90 105.35 116.92 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 108.70 121.71 Tm (GIT2) Tj ET 0.000 0.000 1.000 rg BT /F1 1 Tf 2 Tr 25.04 0 0 25.04 126.08 74.16 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 129.74 81.77 Tm (ARHGEF) Tj ET 0.000 0.000 1.000 rg BT /F1 1 Tf 2 Tr 16.90 0 0 16.90 323.44 111.08 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 327.31 115.87 Tm [(P) 120 (AK)] TJ ET 0.000 1.000 0.000 rg BT /F1 1 Tf 2 Tr 16.90 0 0 16.90 175.18 178.16 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 179.37 183.29 Tm (p85) Tj ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 16.90 0 0 16.90 197.10 180.41 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 200.46 185.53 Tm (p110) Tj ET 219.62 174.83 m 219.62 188.88 231.11 200.37 245.15 200.37 c 259.20 200.37 270.69 188.88 270.69 174.83 c 270.69 160.79 259.20 149.29 245.15 149.29 c 231.11 149.29 219.62 160.79 219.62 174.83 c S BT /F2 1 Tf 3.00 0.00 -0.00 3.00 220.40 174.09 Tm (Phosphatidylinositol signaling system) Tj ET 0.000 1.000 0.000 rg BT /F1 1 Tf 2 Tr 16.90 0 0 16.90 280.04 101.89 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 283.96 106.68 Tm [(V) 80 (A) 70 (V)] TJ ET 0.000 1.000 0.000 rg BT /F1 1 Tf 2 Tr 20.66 0 0 20.66 278.56 188.30 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 281.82 194.40 Tm (PDPK1) Tj ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 16.90 0 0 16.90 302.64 189.61 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 306.42 194.40 Tm (AKT) Tj ET 0.000 1.000 0.000 rg BT /F1 1 Tf 2 Tr 16.90 0 0 16.90 302.64 105.03 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 306.22 109.82 Tm [(RA) 30 (C)] TJ ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 20.66 0 0 20.66 278.56 142.76 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 281.82 148.85 Tm (CDC42) Tj ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 16.90 0 0 16.90 175.18 112.66 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 178.54 117.44 Tm (RHO) Tj ET BT /F1 1 Tf 1 Tr 16.90 0 0 16.90 197.10 136.88 Tm (l) Tj 0 Tr ET BT /F2 1 Tf 3.00 0.00 -0.00 3.00 200.54 141.70 Tm (PI5K) Tj ET 0.000 1.000 0.000 rg BT /F1 1 Tf 2 Tr 19.41 0 0 19.41 196.11 86.88 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 199.49 92.54 Tm [(R) 20 (OCK)] TJ ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 21.29 0 0 21.29 236.73 78.16 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 239.99 84.46 Tm [(MY) 85 (O-P)] TJ ET 386.86 166.76 m 386.86 173.59 392.45 179.19 399.29 179.19 c 406.12 179.19 411.72 173.59 411.72 166.76 c 411.72 159.92 406.12 154.33 399.29 154.33 c 392.45 154.33 386.86 159.92 386.86 166.76 c S BT /F2 1 Tf 3.00 0.00 -0.00 3.00 388.03 165.70 Tm (cell maintenance) Tj ET 387.08 54.58 m 387.08 61.29 392.57 66.79 399.29 66.79 c 406.00 66.79 411.49 61.29 411.49 54.58 c 411.49 47.87 406.00 42.38 399.29 42.38 c 392.57 42.38 387.08 47.87 387.08 54.58 c S BT /F2 1 Tf 3.00 0.00 -0.00 3.00 391.95 53.83 Tm (cell motility) Tj ET BT /F1 1 Tf 1 Tr 19.41 0 0 19.41 391.60 103.71 Tm (l) Tj 0 Tr ET BT /F2 1 Tf 3.00 0.00 -0.00 3.00 394.33 109.39 Tm (F-actin) Tj ET 387.08 235.41 m 387.08 242.12 392.57 247.61 399.29 247.61 c 406.00 247.61 411.49 242.12 411.49 235.41 c 411.49 228.69 406.00 223.20 399.29 223.20 c 392.57 223.20 387.08 228.69 387.08 235.41 c S BT /F2 1 Tf 3.00 0.00 -0.00 3.00 388.84 234.62 Tm [(cell prolif) 30 (er) 10 (ation)] TJ ET 32.03 349.60 m 32.10 349.47 l 32.15 349.36 l 32.19 349.25 l 32.23 349.15 l 32.26 349.07 l 32.30 348.99 l 32.33 348.91 l 32.37 348.84 l 32.43 348.77 l 32.49 348.70 l S 32.49 348.70 m 33.01 347.37 l 33.87 344.73 l 34.99 341.03 l 36.32 336.50 l 37.80 331.37 l 39.35 325.88 l 40.93 320.26 l 42.46 314.74 l 43.89 309.56 l 45.14 304.95 l S 32.10 349.47 m 32.03 349.60 l S 35.24 347.41 m 32.03 349.60 l 31.74 345.73 l S 43.89 309.56 m 45.14 304.95 l S 42.38 307.69 m 45.14 304.95 l 46.13 308.71 l S 32.49 350.05 m 33.31 349.23 l 34.16 348.41 l 35.03 347.58 l 35.91 346.75 l 36.81 345.93 l 37.71 345.11 l 38.61 344.30 l 39.52 343.50 l 40.41 342.72 l 41.30 341.97 l S 33.31 349.23 m 32.49 350.05 l S 36.25 349.07 m 32.49 350.05 l 33.52 346.30 l S 40.41 342.72 m 41.30 341.97 l S 37.48 342.67 m 41.30 341.97 l 39.99 345.63 l S 32.49 361.27 m 33.31 362.08 l 34.16 362.90 l 35.03 363.73 l 35.91 364.56 l 36.81 365.39 l 37.71 366.21 l 38.61 367.02 l 39.52 367.81 l 40.41 368.59 l 41.30 369.34 l S 33.31 362.08 m 32.49 361.27 l S 33.52 365.01 m 32.49 361.27 l 36.25 362.24 l S 40.41 368.59 m 41.30 369.34 l S 39.99 365.68 m 41.30 369.34 l 37.48 368.65 l S 27.06 363.96 m 27.59 368.31 l 28.24 373.18 l 29.02 378.37 l 29.93 383.70 l 30.99 388.97 l 32.20 394.00 l 33.59 398.60 l 35.14 402.58 l 36.88 405.75 l 38.81 407.93 l S 38.81 407.93 m 42.49 410.46 l 45.96 412.19 l 49.29 413.22 l 52.56 413.62 l 55.82 413.48 l 59.15 412.90 l 62.62 411.97 l 66.30 410.77 l 70.24 409.40 l 74.52 407.93 l S 74.52 407.93 m 75.53 407.57 l 76.53 407.16 l 77.51 406.70 l 78.47 406.21 l 79.41 405.69 l 80.33 405.14 l 81.23 404.56 l 82.11 403.97 l 82.96 403.37 l 83.79 402.77 l S 27.59 368.31 m 27.06 363.96 l S 25.54 367.53 m 27.06 363.96 l 29.40 367.06 l S 82.96 403.37 m 83.79 402.77 l S 79.93 403.19 m 83.79 402.77 l 82.22 406.32 l S 32.03 349.37 m 32.10 349.31 l 32.15 349.24 l 32.19 349.17 l 32.23 349.11 l 32.26 349.04 l 32.30 348.97 l 32.33 348.90 l 32.37 348.84 l 32.43 348.77 l 32.49 348.70 l S 32.49 348.70 m 35.61 340.33 l 37.44 332.83 l 38.25 325.97 l 38.33 319.51 l 37.94 313.23 l 37.37 306.88 l 36.89 300.24 l 36.79 293.08 l 37.34 285.15 l 38.81 276.24 l S 38.81 276.24 m 39.18 274.61 l 39.59 272.97 l 40.05 271.32 l 40.53 269.68 l 41.05 268.05 l 41.58 266.45 l 42.13 264.89 l 42.68 263.37 l 43.24 261.92 l 43.79 260.53 l S 32.10 349.31 m 32.03 349.37 l S 35.74 348.20 m 32.03 349.37 l 32.87 345.58 l S 43.24 261.92 m 43.79 260.53 l S 40.74 262.95 m 43.79 260.53 l 44.35 264.38 l S 27.74 363.96 m 28.20 365.96 l 28.78 368.05 l 29.49 370.19 l 30.34 372.33 l 31.33 374.45 l 32.48 376.49 l 33.79 378.43 l 35.28 380.23 l 36.95 381.85 l 38.81 383.25 l S 38.81 383.25 m 40.67 384.36 l 42.44 385.25 l 44.15 385.92 l 45.81 386.35 l 47.43 386.53 l 49.03 386.45 l 50.63 386.09 l 52.24 385.45 l 53.87 384.51 l 55.54 383.25 l S 55.54 383.25 m 66.21 372.69 l 72.57 361.83 l 75.56 350.66 l 76.15 339.13 l 75.29 327.22 l 73.93 314.89 l 73.03 302.11 l 73.55 288.85 l 76.44 275.08 l 82.66 260.76 l S 82.66 260.76 m 82.73 260.62 l 82.82 260.49 l 82.91 260.35 l 83.01 260.22 l 83.11 260.08 l 83.21 259.95 l 83.31 259.82 l 83.40 259.68 l 83.49 259.55 l 83.56 259.41 l S 28.20 365.96 m 27.74 363.96 l S 26.60 367.67 m 27.74 363.96 l 30.39 366.80 l S 83.49 259.55 m 83.56 259.41 l S 80.24 261.42 m 83.56 259.41 l 83.64 263.30 l S 93.96 389.31 m 95.18 387.05 l 96.52 384.63 l 97.95 382.07 l 99.44 379.43 l 100.97 376.75 l 102.49 374.06 l 103.98 371.42 l 105.41 368.86 l 106.75 366.44 l 107.97 364.18 l S 95.18 387.05 m 93.96 389.31 l S 97.27 387.28 m 93.96 389.31 l 93.86 385.43 l S 106.75 366.44 m 107.97 364.18 l S 104.66 366.21 m 107.97 364.18 l 108.08 368.07 l S 98.25 396.71 m 98.73 396.71 l 99.23 396.71 l 99.73 396.71 l 100.23 396.71 l 100.74 396.71 l 101.25 396.71 l 101.75 396.71 l 102.25 396.71 l 102.74 396.71 l 103.23 396.71 l S 98.73 396.71 m 98.25 396.71 l S 101.62 398.65 m 98.25 396.71 l 101.62 394.77 l S 102.74 396.71 m 103.23 396.71 l S 99.86 394.77 m 103.23 396.71 l 99.86 398.65 l S 117.92 394.02 m 118.88 393.55 l 119.89 393.08 l 120.92 392.60 l 121.97 392.12 l 123.03 391.64 l 124.10 391.15 l 125.17 390.65 l 126.23 390.14 l 127.28 389.62 l 128.31 389.08 l S 127.28 389.62 m 128.31 389.08 l S 124.43 388.90 m 128.31 389.08 l 126.21 392.35 l S 141.19 382.13 m 142.17 381.50 l 143.21 380.84 l 144.30 380.16 l 145.42 379.44 l 146.56 378.71 l 147.72 377.96 l 148.88 377.21 l 150.03 376.45 l 151.16 375.70 l 152.27 374.95 l S 151.16 375.70 m 152.27 374.95 l S 148.39 375.23 m 152.27 374.95 l 150.57 378.44 l S 167.18 367.32 m 167.86 367.06 l 168.54 366.81 l 169.21 366.56 l 169.88 366.32 l 170.55 366.09 l 171.20 365.85 l 171.85 365.61 l 172.49 365.37 l 173.12 365.12 l 173.74 364.85 l S 173.12 365.12 m 173.74 364.85 l S 169.88 364.39 m 173.74 364.85 l 171.40 367.96 l S 187.98 361.04 m 188.67 360.91 l 189.38 360.77 l 190.11 360.64 l 190.86 360.52 l 191.62 360.40 l 192.39 360.28 l 193.15 360.18 l 193.92 360.08 l 194.68 359.99 l 195.43 359.92 l S 194.68 359.99 m 195.43 359.92 l S 191.90 358.31 m 195.43 359.92 l 192.28 362.18 l S 209.90 358.35 m 215.40 358.26 l 222.23 357.93 l 230.14 357.28 l 238.88 356.20 l 248.21 354.62 l 257.85 352.44 l 267.57 349.57 l 277.11 345.91 l 286.22 341.39 l 294.65 335.91 l S 294.65 335.91 m 298.68 332.71 l 301.93 329.64 l 304.53 326.63 l 306.62 323.58 l 308.32 320.43 l 309.78 317.10 l 311.13 313.49 l 312.51 309.53 l 314.05 305.14 l 315.89 300.24 l S 315.89 300.24 m 317.91 295.08 l 319.75 289.75 l 321.42 284.32 l 322.93 278.90 l 324.28 273.55 l 325.48 268.36 l 326.52 263.41 l 327.41 258.80 l 328.16 254.59 l 328.77 250.89 l S 328.16 254.59 m 328.77 250.89 l S 326.31 253.89 m 328.77 250.89 l 330.14 254.52 l S 331.03 236.53 m 331.81 231.62 l 332.77 225.51 l 333.89 218.36 l 335.14 210.36 l 336.52 201.67 l 337.98 192.48 l 339.52 182.96 l 341.12 173.29 l 342.74 163.64 l 344.37 154.19 l S 344.37 154.19 m 344.86 151.26 l 345.39 148.28 l 345.93 145.27 l 346.49 142.27 l 347.05 139.30 l 347.61 136.39 l 348.15 133.57 l 348.66 130.87 l 349.13 128.31 l 349.57 125.92 l S 349.13 128.31 m 349.57 125.92 l S 347.06 128.89 m 349.57 125.92 l 350.88 129.58 l S 336.23 241.91 m 339.82 241.54 l 344.00 241.10 l 348.65 240.61 l 353.66 240.08 l 358.92 239.53 l 364.30 238.97 l 369.70 238.42 l 375.00 237.90 l 380.08 237.41 l 384.82 236.98 l S 380.08 237.41 m 384.82 236.98 l S 381.30 235.35 m 384.82 236.98 l 381.65 239.22 l S 358.15 114.93 m 358.77 114.73 l 359.40 114.53 l 360.03 114.33 l 360.68 114.12 l 361.32 113.92 l 361.96 113.72 l 362.60 113.52 l 363.24 113.32 l 363.87 113.11 l 364.48 112.91 l S 363.87 113.11 m 364.48 112.91 l S 360.68 112.11 m 364.48 112.91 l 361.89 115.80 l S 380.98 110.44 m 381.86 110.44 l 382.75 110.44 l 383.63 110.44 l 384.52 110.44 l 385.42 110.44 l 386.32 110.44 l 387.23 110.44 l 388.15 110.44 l 389.08 110.44 l 390.02 110.44 l S 381.86 110.44 m 380.98 110.44 l S 384.35 112.39 m 380.98 110.44 l 384.35 108.50 l S 389.08 110.44 m 390.02 110.44 l S 386.66 108.50 m 390.02 110.44 l 386.66 112.39 l S 51.92 244.38 m 53.05 242.29 l 54.26 240.09 l 55.52 237.80 l 56.82 235.46 l 58.14 233.11 l 59.46 230.76 l 60.76 228.47 l 62.02 226.25 l 63.22 224.14 l 64.35 222.17 l S 53.05 242.29 m 51.92 244.38 l S 55.23 242.34 m 51.92 244.38 l 51.81 240.50 l S 63.22 224.14 m 64.35 222.17 l S 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