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BT /F2 1 Tf 1.00 0.00 -0.00 1.00 40.75 274.13 Tm (SHC) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 67.61 325.03 Tm (FYN) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 67.24 280.38 Tm (GRB2) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 94.35 338.42 Tm (SOS) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 120.38 337.24 Tm (Ha-Ras) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 148.22 335.45 Tm (Raf) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 228.32 306.87 Tm (MEK) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 255.17 306.87 Tm (ERK) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 362.03 191.09 Tm (MYLK) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 389.10 132.75 Tm [(MY) 85 (O)] TJ ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 40.46 217.87 Tm [(A) 30 (CTN)] TJ ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 67.63 235.73 Tm (VCL) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 94.46 181.26 Tm (TLN) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 174.77 219.06 Tm (PXN) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 67.63 141.68 Tm (ZYX) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 94.11 136.91 Tm [(V) 80 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335.66 191.09 Tm [(P) 120 (AK)] TJ ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 201.77 23.92 Tm (p85) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 228.29 23.92 Tm (p110) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 247.95 41.18 Tm (Phosphatidylinositol signaling system) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 282.07 68.16 Tm [(V) 80 (A) 70 (V)] TJ ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 281.36 23.81 Tm (PDPK1) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 308.82 23.81 Tm (AKT) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 308.76 149.71 Tm [(RA) 30 (C)] TJ ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 281.36 180.67 Tm (CDC42) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 201.49 70.24 Tm (RHO) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 228.32 68.17 Tm (PI5K) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 254.76 102.39 Tm [(R) 20 (OCK)] TJ ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 334.87 102.39 Tm [(MY) 85 (O-P)] TJ ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 386.44 63.40 Tm (cell maintenance) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 334.15 146.54 Tm (cell motility) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 415.34 132.75 Tm (F-actin) Tj ET BT /F2 1 Tf 1.00 0.00 -0.00 1.00 279.52 293.28 Tm [(cell prolif) 30 (er) 10 (ation)] TJ ET 17.39 307.53 m 19.16 314.60 l 21.22 322.93 l 23.50 332.21 l 25.92 342.13 l 28.41 352.36 l 30.90 362.60 l 33.31 372.54 l 35.59 381.87 l 37.65 390.26 l 39.42 397.42 l S 37.65 390.26 m 39.42 397.42 l S 40.37 394.14 m 39.42 397.42 l 37.06 394.96 l S 19.16 314.60 m 17.39 307.53 l S 16.45 310.81 m 17.39 307.53 l 19.76 309.98 l S 19.18 306.93 m 20.86 311.00 l 22.67 315.44 l 24.57 320.18 l 26.53 325.10 l 28.52 330.11 l 30.50 335.11 l 32.43 340.01 l 34.29 344.70 l 36.04 349.08 l 37.64 353.07 l S 36.04 349.08 m 37.64 353.07 l S 38.12 349.69 m 37.64 353.07 l 34.95 350.96 l S 20.86 311.00 m 19.18 306.93 l S 18.73 310.31 m 19.18 306.93 l 21.88 309.01 l S 23.64 303.95 m 24.55 304.77 l 25.49 305.59 l 26.45 306.42 l 27.43 307.26 l 28.41 308.08 l 29.39 308.91 l 30.36 309.71 l 31.32 310.50 l 32.26 311.26 l 33.17 311.99 l S 32.26 311.26 m 33.17 311.99 l S 31.94 308.81 m 33.17 311.99 l 29.80 311.47 l S 24.55 304.77 m 23.64 303.95 l S 24.71 307.20 m 23.64 303.95 l 26.98 304.65 l S 23.64 289.67 m 24.55 288.86 l 25.49 288.03 l 26.45 287.20 l 27.43 286.37 l 28.41 285.54 l 29.39 284.72 l 30.36 283.91 l 31.32 283.12 l 32.26 282.36 l 33.17 281.63 l S 32.26 282.36 m 33.17 281.63 l S 29.80 282.15 m 33.17 281.63 l 31.94 284.81 l S 24.55 288.86 m 23.64 289.67 l S 26.98 288.97 m 23.64 289.67 l 24.71 286.43 l S 18.58 286.10 m 20.30 281.28 l 22.20 275.87 l 24.23 270.00 l 26.36 263.84 l 28.52 257.52 l 30.67 251.21 l 32.77 245.04 l 34.76 239.18 l 36.60 233.76 l 38.23 228.95 l S 36.60 233.76 m 38.23 228.95 l S 35.67 231.20 m 38.23 228.95 l 38.90 232.29 l S 20.30 281.28 m 18.58 286.10 l S 21.18 283.89 m 18.58 286.10 l 17.97 282.74 l S 16.20 285.80 m 17.02 278.79 l 18.05 270.69 l 19.30 261.82 l 20.75 252.54 l 22.41 243.20 l 24.28 234.13 l 26.35 225.68 l 28.62 218.20 l 31.10 212.03 l 33.77 207.52 l S 33.77 207.52 m 37.85 202.91 l 42.49 198.89 l 47.57 195.41 l 52.96 192.43 l 58.52 189.92 l 64.12 187.82 l 69.64 186.10 l 74.95 184.72 l 79.91 183.64 l 84.39 182.81 l S 79.91 183.64 m 84.39 182.81 l S 81.17 181.67 m 84.39 182.81 l 81.79 185.03 l S 37.85 202.91 m 33.77 207.52 l S 37.00 206.44 m 33.77 207.52 l 34.45 204.17 l S 47.17 284.31 m 48.58 287.11 l 50.12 290.13 l 51.76 293.31 l 53.47 296.60 l 55.21 299.94 l 56.94 303.28 l 58.65 306.56 l 60.29 309.74 l 61.83 312.76 l 63.25 315.56 l S 61.83 312.76 m 63.25 315.56 l S 63.44 312.16 m 63.25 315.56 l 60.39 313.69 l S 48.58 287.11 m 47.17 284.31 l S 46.97 287.72 m 47.17 284.31 l 50.02 286.18 l S 52.82 277.17 m 53.35 277.26 l 53.86 277.38 l 54.37 277.50 l 54.86 277.63 l 55.35 277.76 l 55.85 277.90 l 56.34 278.03 l 56.84 278.15 l 57.36 278.26 l 57.89 278.36 l S 57.36 278.26 m 57.89 278.36 l S 55.29 276.14 m 57.89 278.36 l 54.67 279.50 l S 53.35 277.26 m 52.82 277.17 l S 55.42 279.38 m 52.82 277.17 l 56.04 276.03 l S 71.88 288.18 m 73.49 291.46 l 75.26 295.16 l 77.16 299.19 l 79.15 303.46 l 81.19 307.86 l 83.24 312.31 l 85.28 316.71 l 87.27 320.96 l 89.17 324.98 l 90.94 328.66 l S 89.17 324.98 m 90.94 328.66 l S 91.19 325.26 m 90.94 328.66 l 88.12 326.74 l S 103.44 338.48 m 104.17 338.47 l 104.91 338.45 l 105.66 338.42 l 106.43 338.38 l 107.20 338.33 l 107.99 338.29 l 108.78 338.25 l 109.58 338.22 l 110.38 338.19 l 111.19 338.18 l S 110.38 338.19 m 111.19 338.18 l S 108.21 336.51 m 111.19 338.18 l 108.25 339.92 l S 130.24 336.99 m 130.97 336.91 l 131.71 336.85 l 132.46 336.79 l 133.23 336.74 l 134.00 336.70 l 134.79 336.65 l 135.58 336.60 l 136.38 336.55 l 137.18 336.48 l 137.99 336.40 l S 137.18 336.48 m 137.99 336.40 l S 134.87 335.00 m 137.99 336.40 l 135.22 338.39 l S 156.74 333.12 m 161.52 331.43 l 167.13 329.43 l 173.39 327.20 l 180.11 324.80 l 187.08 322.30 l 194.11 319.77 l 201.01 317.29 l 207.59 314.92 l 213.64 312.74 l 218.98 310.80 l S 213.64 312.74 m 218.98 310.80 l S 215.62 310.20 m 218.98 310.80 l 216.78 313.41 l S 237.44 307.23 m 238.16 307.23 l 238.90 307.23 l 239.66 307.23 l 240.42 307.23 l 241.20 307.23 l 241.98 307.23 l 242.78 307.23 l 243.58 307.23 l 244.38 307.23 l 245.18 307.23 l S 244.38 307.23 m 245.18 307.23 l S 242.23 305.52 m 245.18 307.23 l 242.23 308.94 l S 264.24 308.42 m 266.58 308.58 l 269.11 308.67 l 271.79 308.68 l 274.57 308.58 l 277.41 308.35 l 280.27 307.95 l 283.11 307.37 l 285.88 306.57 l 288.53 305.54 l 291.04 304.25 l S 291.04 304.25 m 302.47 296.23 l 312.83 286.72 l 322.15 276.09 l 330.45 264.72 l 337.75 252.98 l 344.08 241.27 l 349.46 229.95 l 353.91 219.41 l 357.45 210.02 l 360.12 202.16 l S 357.45 210.02 m 360.12 202.16 l S 357.55 204.41 m 360.12 202.16 l 360.79 205.51 l S 263.34 303.66 m 264.26 303.19 l 265.20 302.70 l 266.16 302.19 l 267.15 301.66 l 268.15 301.13 l 269.15 300.59 l 270.17 300.07 l 271.18 299.55 l 272.18 299.06 l 273.17 298.60 l S 272.18 299.06 m 273.17 298.60 l S 269.77 298.30 m 273.17 298.60 l 271.22 301.39 l S 366.67 184.00 m 368.28 180.64 l 370.05 176.88 l 371.95 172.79 l 373.94 168.49 l 375.98 164.06 l 378.03 159.59 l 380.07 155.18 l 382.06 150.92 l 383.96 146.91 l 385.73 143.23 l S 383.96 146.91 m 385.73 143.23 l S 382.91 145.15 m 385.73 143.23 l 385.98 146.63 l S 401.21 133.11 m 401.67 133.11 l 402.14 133.11 l 402.62 133.11 l 403.10 133.11 l 403.59 133.11 l 404.08 133.11 l 404.57 133.11 l 405.05 133.11 l 405.52 133.11 l 405.98 133.11 l S 405.52 133.11 m 405.98 133.11 l S 403.02 131.40 m 405.98 133.11 l 403.02 134.81 l S 401.67 133.11 m 401.21 133.11 l S 404.17 134.81 m 401.21 133.11 l 404.17 131.40 l S 51.04 224.48 m 51.85 225.02 l 52.68 225.55 l 53.51 226.09 l 54.36 226.63 l 55.21 227.16 l 56.05 227.70 l 56.90 228.23 l 57.74 228.77 l 58.56 229.30 l 59.37 229.84 l S 58.56 229.30 m 59.37 229.84 l S 57.85 226.79 m 59.37 229.84 l 55.97 229.64 l S 51.85 225.02 m 51.04 224.48 l S 52.56 227.53 m 51.04 224.48 l 54.44 224.69 l S 50.74 211.98 m 53.93 209.82 l 57.37 207.47 l 61.01 204.99 l 64.77 202.42 l 68.61 199.82 l 72.44 197.22 l 76.20 194.67 l 79.84 192.24 l 83.28 189.95 l 86.47 187.87 l S 83.28 189.95 m 86.47 187.87 l S 83.06 188.06 m 86.47 187.87 l 84.93 190.92 l S 53.93 209.82 m 50.74 211.98 l S 54.14 211.73 m 50.74 211.98 l 52.23 208.91 l S 45.38 207.81 m 47.10 203.11 l 49.00 197.86 l 51.03 192.19 l 53.15 186.25 l 55.32 180.17 l 57.47 174.10 l 59.57 168.19 l 61.56 162.56 l 63.40 157.37 l 65.03 152.75 l S 63.40 157.37 m 65.03 152.75 l S 62.44 154.97 m 65.03 152.75 l 65.65 156.10 l S 47.10 203.11 m 45.38 207.81 l S 48.00 205.62 m 45.38 207.81 l 44.79 204.45 l S 73.37 226.27 m 74.87 223.18 l 76.51 219.85 l 78.24 216.33 l 80.05 212.68 l 81.89 208.97 l 83.75 205.25 l 85.58 201.57 l 87.36 198.01 l 89.06 194.61 l 90.64 191.44 l S 89.06 194.61 m 90.64 191.44 l S 87.79 193.32 m 90.64 191.44 l 90.84 194.85 l S 74.87 223.18 m 73.37 226.27 l S 76.20 224.36 m 73.37 226.27 l 73.13 222.87 l S 79.62 234.31 m 86.37 233.30 l 94.28 232.11 l 103.06 230.78 l 112.43 229.35 l 122.09 227.87 l 131.76 226.38 l 141.16 224.92 l 149.98 223.54 l 157.95 222.29 l 164.78 221.21 l S 157.95 222.29 m 164.78 221.21 l S 161.60 219.99 m 164.78 221.21 l 162.13 223.36 l S 86.37 233.30 m 79.62 234.31 l S 82.80 235.56 m 79.62 234.31 l 82.30 232.18 l S 73.07 246.21 m 74.66 249.66 l 76.36 253.37 l 78.14 257.27 l 79.98 261.29 l 81.86 265.37 l 83.73 269.44 l 85.57 273.44 l 87.36 277.29 l 89.05 280.94 l 90.64 284.31 l S 89.05 280.94 m 90.64 284.31 l S 90.93 280.91 m 90.64 284.31 l 87.84 282.36 l S 74.66 249.66 m 73.07 246.21 l S 72.75 249.61 m 73.07 246.21 l 75.86 248.19 l S 78.43 241.15 m 79.15 241.51 l 79.86 241.87 l 80.58 242.22 l 81.29 242.58 l 82.00 242.94 l 82.72 243.29 l 83.43 243.65 l 84.15 244.01 l 84.86 244.37 l 85.58 244.72 l S 84.86 244.37 m 85.58 244.72 l S 83.70 241.88 m 85.58 244.72 l 82.17 244.93 l S 79.15 241.51 m 78.43 241.15 l S 80.31 244.00 m 78.43 241.15 l 81.84 240.95 l S 102.85 172.99 m 104.03 171.79 l 105.23 170.51 l 106.45 169.18 l 107.68 167.80 l 108.92 166.40 l 110.14 165.00 l 111.34 163.60 l 112.52 162.22 l 113.66 160.88 l 114.76 159.60 l S 113.66 160.88 m 114.76 159.60 l S 111.54 160.73 m 114.76 159.60 l 114.14 162.95 l S 104.03 171.79 m 102.85 172.99 l S 106.14 172.07 m 102.85 172.99 l 103.70 169.68 l S 106.42 181.92 m 113.24 182.20 l 121.20 182.51 l 129.99 182.84 l 139.36 183.18 l 149.00 183.52 l 158.65 183.85 l 168.01 184.16 l 176.81 184.44 l 184.76 184.69 l 191.58 184.90 l S 184.76 184.69 m 191.58 184.90 l S 188.68 183.10 m 191.58 184.90 l 188.58 186.51 l S 113.24 182.20 m 106.42 181.92 l S 109.30 183.75 m 106.42 181.92 l 109.45 180.34 l S 182.65 214.96 m 185.65 213.02 l 189.04 210.82 l 192.73 208.43 l 196.65 205.89 l 200.70 203.28 l 204.80 200.64 l 208.85 198.05 l 212.77 195.57 l 216.47 193.24 l 219.87 191.15 l S 216.47 193.24 m 219.87 191.15 l S 216.46 191.25 m 219.87 191.15 l 218.25 194.15 l S 180.86 225.97 m 182.16 227.74 l 183.56 229.62 l 185.02 231.59 l 186.53 233.63 l 188.08 235.72 l 189.65 237.82 l 191.22 239.92 l 192.77 241.98 l 194.29 243.99 l 195.75 245.91 l S 194.29 243.99 m 195.75 245.91 l S 195.32 242.53 m 195.75 245.91 l 192.61 244.59 l S 182.65 210.79 m 183.92 209.23 l 185.21 207.60 l 186.53 205.92 l 187.86 204.20 l 189.20 202.46 l 190.54 200.72 l 191.87 199.00 l 193.19 197.31 l 194.48 195.68 l 195.75 194.12 l S 194.48 195.68 m 195.75 194.12 l S 192.56 195.34 m 195.75 194.12 l 195.21 197.49 l S 183.92 209.23 m 182.65 210.79 l S 185.84 209.57 m 182.65 210.79 l 183.19 207.42 l S 79.62 139.95 m 80.08 139.86 l 80.55 139.77 l 81.03 139.69 l 81.51 139.61 l 82.00 139.54 l 82.50 139.48 l 82.98 139.43 l 83.46 139.39 l 83.93 139.36 l 84.39 139.36 l S 83.93 139.36 m 84.39 139.36 l S 81.40 137.71 m 84.39 139.36 l 81.46 141.12 l S 80.08 139.86 m 79.62 139.95 l S 82.85 141.06 m 79.62 139.95 l 82.20 137.71 l S 133.22 151.26 m 133.68 151.26 l 134.15 151.26 l 134.63 151.26 l 135.11 151.26 l 135.60 151.26 l 136.09 151.26 l 136.58 151.26 l 137.06 151.26 l 137.53 151.26 l 137.99 151.26 l S 137.53 151.26 m 137.99 151.26 l S 135.03 149.56 m 137.99 151.26 l 135.03 152.97 l S 133.68 151.26 m 133.22 151.26 l S 136.18 152.97 m 133.22 151.26 l 136.18 149.56 l S 157.04 151.26 m 157.77 151.26 l 158.50 151.26 l 159.26 151.26 l 160.02 151.26 l 160.80 151.26 l 161.59 151.26 l 162.38 151.26 l 163.18 151.26 l 163.98 151.26 l 164.78 151.26 l S 163.98 151.26 m 164.78 151.26 l S 161.83 149.56 m 164.78 151.26 l 161.83 152.97 l S 180.86 157.51 m 182.16 159.19 l 183.56 160.98 l 185.02 162.86 l 186.53 164.82 l 188.08 166.81 l 189.65 168.83 l 191.22 170.83 l 192.77 172.81 l 194.29 174.73 l 195.75 176.56 l S 194.29 174.73 m 195.75 176.56 l S 195.25 173.19 m 195.75 176.56 l 192.58 175.31 l S 185.33 157.21 m 188.42 159.11 l 191.75 161.19 l 195.27 163.41 l 198.90 165.72 l 202.60 168.08 l 206.30 170.44 l 209.93 172.75 l 213.45 174.97 l 216.78 177.05 l 219.87 178.94 l S 216.78 177.05 m 219.87 178.94 l S 218.24 175.94 m 219.87 178.94 l 216.46 178.85 l S 188.42 159.11 m 185.33 157.21 l S 186.96 160.21 m 185.33 157.21 l 188.74 157.30 l S 182.65 142.63 m 183.92 141.08 l 185.21 139.47 l 186.52 137.82 l 187.84 136.14 l 189.16 134.44 l 190.48 132.75 l 191.77 131.07 l 193.04 129.42 l 194.27 127.81 l 195.45 126.26 l S 194.27 127.81 m 195.45 126.26 l S 192.30 127.57 m 195.45 126.26 l 195.01 129.64 l S 183.92 141.08 m 182.65 142.63 l S 185.84 141.42 m 182.65 142.63 l 183.20 139.26 l S 204.39 193.23 m 205.96 200.52 l 207.94 209.60 l 210.23 220.05 l 212.74 231.45 l 215.37 243.38 l 218.02 255.42 l 220.61 267.15 l 223.03 278.13 l 225.20 287.96 l 227.02 296.22 l S 225.20 287.96 m 227.02 296.22 l S 228.05 292.96 m 227.02 296.22 l 224.72 293.70 l S 210.64 185.19 m 211.36 185.19 l 212.10 185.19 l 212.86 185.19 l 213.62 185.19 l 214.40 185.19 l 215.19 185.19 l 215.98 185.19 l 216.78 185.19 l 217.58 185.19 l 218.38 185.19 l S 217.58 185.19 m 218.38 185.19 l S 215.43 183.49 m 218.38 185.19 l 215.43 186.90 l S 203.79 177.16 m 205.09 167.84 l 206.76 155.94 l 208.71 142.21 l 210.83 127.39 l 213.02 112.23 l 215.18 97.50 l 217.19 83.94 l 218.96 72.30 l 220.39 63.34 l 221.36 57.80 l S 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210.01 l 267.33 209.31 l 268.04 208.59 l 268.68 207.84 l 269.23 207.07 l 269.71 206.29 l 270.10 205.48 l 270.40 204.66 l 270.62 203.83 l 270.76 203.00 l 270.80 202.16 l 270.76 201.32 l 270.62 200.49 l 270.40 199.66 l 270.10 198.84 l 269.71 198.04 l 269.23 197.25 l 268.68 196.48 l 268.04 195.73 l 267.33 195.01 l 266.54 194.32 l 265.68 193.66 l 264.75 193.03 l 263.76 192.44 l 262.71 191.88 l 261.60 191.37 l 260.44 190.90 l 259.23 190.47 l 257.99 190.09 l 256.70 189.76 l 255.38 189.47 l 254.03 189.24 l 252.66 189.06 l 251.28 188.92 l 249.88 188.85 l 248.48 188.82 l 248.48 188.82 l S BT 0.000 0.000 0.000 rg /F2 1 Tf 4.00 0.00 -0.00 4.00 12.96 361.34 Tm (ITGB) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 35.53 303.03 Tm (ITGA) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 37.19 341.82 Tm (ILK) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 36.22 380.37 Tm [(CA) 70 (V)] TJ ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 82.09 409.28 Tm (SHC) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 106.12 370.73 Tm (FYN) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 104.67 409.28 Tm (GRB2) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 131.19 399.15 Tm (SOS) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 154.42 378.42 Tm (Ha-Ras) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 182.14 367.78 Tm (Raf) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 204.72 364.80 Tm (MEK) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 329.92 277.82 Tm (ERK) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 350.90 144.63 Tm (MYLK) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 374.28 120.91 Tm [(MY) 85 (O)] TJ ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 34.81 259.78 Tm [(A) 30 (CTN)] TJ ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 58.87 220.99 Tm (VCL) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 82.54 259.78 Tm (TLN) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 82.20 220.99 Tm (PXN) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 13.74 240.51 Tm (ZYX) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 35.02 220.99 Tm [(V) 80 (ASP)] TJ ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 79.87 143.15 Tm (SH3D5) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 82.32 182.19 Tm (TNS) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 104.56 300.80 Tm (CAPN) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 128.52 300.80 Tm (CAPNS) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 157.47 300.80 Tm (SRC) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 181.52 262.01 Tm [(F) 80 (AK)] TJ ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 202.39 276.34 Tm (BCAR1) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 181.14 300.80 Tm (CSK) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 244.26 292.89 Tm (CRK) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 281.02 292.89 Tm (DOCK1) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 282.58 331.69 Tm (GRF2) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 306.49 298.58 Tm (RAP1) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 352.57 184.21 Tm (JNK) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 105.67 142.66 Tm (GIT2) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 127.08 121.65 Tm (ARHGEF) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 330.27 144.63 Tm [(P) 120 (AK)] TJ ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 181.92 180.41 Tm (p85) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 204.61 232.31 Tm (p110) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 235.87 207.64 Tm (Phosphatidyl-) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 242.26 203.03 Tm (inositol) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 240.59 198.42 Tm (signaling) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 242.15 193.82 Tm (system) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 284.21 142.66 Tm [(V) 80 (A) 70 (V)] TJ ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 281.35 220.25 Tm (PDPK1) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 307.82 220.25 Tm (AKT) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 307.55 143.89 Tm [(RA) 30 (C)] TJ ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 281.35 181.45 Tm (CDC42) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 180.81 139.69 Tm (RHO) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 204.72 190.14 Tm (PI5K) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 203.32 139.69 Tm [(R) 20 (OCK)] TJ ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 241.60 135.99 Tm [(MY) 85 (O-P)] TJ ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 404.67 187.96 Tm (cell) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 396.22 183.35 Tm (maintenance) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 404.67 58.48 Tm (cell) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 401.45 53.87 Tm (motility) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 401.06 120.94 Tm (F-actin) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 404.67 278.64 Tm (cell) Tj ET BT /F2 1 Tf 4.00 0.00 -0.00 4.00 397.31 274.04 Tm [(prolif) 30 (er) 10 (ation)] TJ ET 24.57 356.11 m 25.65 353.26 l 26.92 349.58 l 28.33 345.25 l 29.84 340.43 l 31.39 335.32 l 32.95 330.08 l 34.45 324.89 l 35.86 319.92 l 37.13 315.36 l 38.21 311.38 l S 37.13 315.36 m 38.21 311.38 l S 36.87 312.72 m 38.21 311.38 l 38.70 313.21 l S 25.65 353.26 m 24.57 356.11 l S 26.04 354.91 m 24.57 356.11 l 24.27 354.24 l S 25.32 356.60 m 26.21 355.86 l 27.10 355.12 l 27.97 354.38 l 28.84 353.65 l 29.69 352.92 l 30.51 352.21 l 31.31 351.50 l 32.08 350.80 l 32.81 350.11 l 33.50 349.43 l S 32.81 350.11 m 33.50 349.43 l S 31.66 349.90 m 33.50 349.43 l 32.99 351.26 l S 26.21 355.86 m 25.32 356.60 l S 27.18 356.28 m 25.32 356.60 l 25.97 354.82 l S 25.07 368.96 m 25.76 369.63 l 26.49 370.31 l 27.24 371.00 l 28.02 371.70 l 28.82 372.38 l 29.62 373.07 l 30.42 373.73 l 31.22 374.39 l 32.00 375.02 l 32.76 375.63 l S 32.00 375.02 m 32.76 375.63 l S 32.07 373.86 m 32.76 375.63 l 30.88 375.34 l S 25.76 369.63 m 25.07 368.96 l S 25.58 370.78 m 25.07 368.96 l 26.90 369.42 l S 18.37 369.70 m 18.89 374.20 l 19.55 379.41 l 20.36 385.08 l 21.34 390.99 l 22.50 396.91 l 23.84 402.59 l 25.37 407.81 l 27.12 412.34 l 29.08 415.94 l 31.27 418.38 l S 31.27 418.38 m 35.50 420.97 l 40.09 422.60 l 44.93 423.39 l 49.93 423.45 l 54.98 422.92 l 59.98 421.90 l 64.82 420.52 l 69.40 418.90 l 73.63 417.15 l 77.39 415.41 l S 73.63 417.15 m 77.39 415.41 l S 75.50 415.24 m 77.39 415.41 l 76.30 416.96 l S 35.50 420.97 m 31.27 418.38 l S 32.17 420.04 m 31.27 418.38 l 33.16 418.42 l S 24.82 356.11 m 26.54 350.43 l 27.75 343.67 l 28.56 336.12 l 29.05 328.05 l 29.35 319.75 l 29.53 311.50 l 29.72 303.59 l 30.00 296.30 l 30.48 289.90 l 31.27 284.69 l S 31.27 284.69 m 31.74 282.97 l 32.27 281.21 l 32.83 279.45 l 33.43 277.68 l 34.06 275.92 l 34.70 274.20 l 35.34 272.52 l 35.98 270.90 l 36.61 269.35 l 37.22 267.89 l S 36.61 269.35 m 37.22 267.89 l S 35.71 269.04 m 37.22 267.89 l 37.46 269.77 l S 31.74 282.97 m 31.27 284.69 l S 32.62 283.36 m 31.27 284.69 l 30.79 282.86 l S 19.37 369.70 m 19.95 371.61 l 20.65 373.62 l 21.48 375.68 l 22.45 377.77 l 23.55 379.83 l 24.79 381.83 l 26.18 383.73 l 27.72 385.50 l 29.42 387.10 l 31.27 388.48 l S 31.27 388.48 m 33.29 389.56 l 35.19 390.45 l 37.01 391.11 l 38.75 391.54 l 40.44 391.72 l 42.10 391.64 l 43.76 391.29 l 45.42 390.66 l 47.12 389.72 l 48.87 388.48 l S 48.87 388.48 m 59.43 378.11 l 65.70 367.34 l 68.66 356.17 l 69.28 344.60 l 68.52 332.63 l 67.37 320.28 l 66.78 307.55 l 67.73 294.45 l 71.19 280.98 l 78.13 267.15 l S 71.19 280.98 m 78.13 267.15 l S 76.55 268.19 m 78.13 267.15 l 78.24 269.04 l S 59.43 378.11 m 48.87 388.48 l S 50.71 388.00 m 48.87 388.48 l 49.38 386.65 l S 90.53 404.04 m 91.88 401.78 l 93.37 399.33 l 94.97 396.75 l 96.64 394.07 l 98.34 391.35 l 100.05 388.64 l 101.72 385.98 l 103.31 383.43 l 104.80 381.03 l 106.15 378.84 l S 104.80 381.03 m 106.15 378.84 l S 104.49 379.74 m 106.15 378.84 l 106.10 380.73 l S 91.88 401.78 m 90.53 404.04 l S 92.18 403.12 m 90.53 404.04 l 90.56 402.15 l S 95.49 410.72 m 96.01 410.72 l 96.53 410.72 l 97.05 410.72 l 97.57 410.72 l 98.09 410.72 l 98.61 410.72 l 99.14 410.72 l 99.66 410.72 l 100.18 410.72 l 100.70 410.72 l S 100.18 410.72 m 100.70 410.72 l S 99.06 409.77 m 100.70 410.72 l 99.06 411.66 l S 96.01 410.72 m 95.49 410.72 l S 97.13 411.66 m 95.49 410.72 l 97.13 409.77 l S 117.06 408.00 m 117.96 407.63 l 118.88 407.26 l 119.80 406.89 l 120.74 406.51 l 121.68 406.14 l 122.63 405.77 l 123.59 405.40 l 124.55 405.03 l 125.52 404.66 l 126.49 404.29 l S 125.52 404.66 m 126.49 404.29 l S 124.61 403.99 m 126.49 404.29 l 125.29 405.76 l S 141.12 396.14 m 142.27 395.22 l 143.48 394.25 l 144.74 393.24 l 146.05 392.20 l 147.38 391.13 l 148.72 390.05 l 150.07 388.96 l 151.41 387.88 l 152.72 386.81 l 154.01 385.76 l S 152.72 386.81 m 154.01 385.76 l S 152.14 386.06 m 154.01 385.76 l 153.34 387.53 l S 169.63 376.37 m 170.24 376.06 l 170.87 375.75 l 171.53 375.43 l 172.20 375.10 l 172.89 374.76 l 173.58 374.43 l 174.27 374.10 l 174.96 373.77 l 175.65 373.46 l 176.33 373.16 l S 175.65 373.46 m 176.33 373.16 l S 174.44 372.96 m 176.33 373.16 l 175.22 374.69 l S 191.95 368.46 m 192.70 368.32 l 193.46 368.19 l 194.24 368.07 l 195.03 367.96 l 195.82 367.84 l 196.63 367.73 l 197.43 367.62 l 198.25 367.50 l 199.06 367.37 l 199.88 367.23 l S 199.06 367.37 m 199.88 367.23 l S 198.10 366.57 m 199.88 367.23 l 198.43 368.44 l S 215.75 365.74 m 221.11 365.17 l 227.65 364.30 l 235.17 363.08 l 243.42 361.45 l 252.20 359.35 l 261.28 356.72 l 270.43 353.51 l 279.43 349.66 l 288.06 345.11 l 296.09 339.80 l S 296.09 339.80 m 301.66 335.21 l 306.78 330.02 l 311.44 324.38 l 315.66 318.45 l 319.43 312.40 l 322.76 306.39 l 325.66 300.57 l 328.13 295.11 l 330.18 290.18 l 331.80 285.93 l S 330.18 290.18 m 331.80 285.93 l S 330.33 287.12 m 331.80 285.93 l 332.10 287.80 l S 334.77 274.81 m 335.49 269.70 l 336.44 262.96 l 337.60 254.85 l 338.94 245.58 l 340.45 235.40 l 342.09 224.53 l 343.86 213.22 l 345.72 201.69 l 347.66 190.19 l 349.65 178.93 l S 349.65 178.93 m 350.19 176.23 l 350.74 173.46 l 351.31 170.67 l 351.88 167.88 l 352.44 165.13 l 352.99 162.44 l 353.52 159.85 l 354.01 157.40 l 354.46 155.10 l 354.86 152.99 l S 354.46 155.10 m 354.86 152.99 l S 353.62 154.42 m 354.86 152.99 l 355.48 154.78 l S 340.73 279.01 m 344.56 278.93 l 348.99 278.84 l 353.90 278.73 l 359.17 278.63 l 364.68 278.52 l 370.33 278.41 l 375.98 278.30 l 381.52 278.20 l 386.83 278.10 l 391.81 278.02 l S 386.83 278.10 m 391.81 278.02 l S 390.15 277.10 m 391.81 278.02 l 390.18 279.00 l S 360.56 141.62 m 361.64 140.47 l 362.78 139.24 l 363.97 137.96 l 365.20 136.64 l 366.45 135.29 l 367.72 133.94 l 368.99 132.59 l 370.26 131.27 l 371.50 129.99 l 372.71 128.77 l S 371.50 129.99 m 372.71 128.77 l S 370.88 129.27 m 372.71 128.77 l 372.23 130.61 l S 387.84 122.35 m 388.75 122.35 l 389.70 122.35 l 390.68 122.35 l 391.69 122.35 l 392.70 122.35 l 393.73 122.35 l 394.75 122.35 l 395.77 122.35 l 396.78 122.35 l 397.76 122.35 l S 396.78 122.35 m 397.76 122.35 l S 396.12 121.40 m 397.76 122.35 l 396.12 123.30 l S 388.75 122.35 m 387.84 122.35 l S 389.48 123.30 m 387.84 122.35 l 389.48 121.40 l S 43.91 254.55 m 45.25 252.29 l 46.70 249.84 l 48.24 247.24 l 49.83 244.56 l 51.45 241.82 l 53.06 239.09 l 54.63 236.40 l 56.13 233.81 l 57.53 231.36 l 58.79 229.10 l S 57.53 231.36 m 58.79 229.10 l S 57.16 230.06 m 58.79 229.10 l 58.82 230.99 l S 45.25 252.29 m 43.91 254.55 l S 45.56 253.62 m 43.91 254.55 l 43.93 252.65 l S 49.62 261.22 m 52.10 261.22 l 54.74 261.22 l 57.52 261.22 l 60.38 261.22 l 63.29 261.22 l 66.20 261.22 l 69.09 261.22 l 71.90 261.22 l 74.60 261.22 l 77.14 261.22 l S 74.60 261.22 m 77.14 261.22 l S 75.50 260.27 m 77.14 261.22 l 75.50 262.17 l S 52.10 261.22 m 49.62 261.22 l S 51.26 262.17 m 49.62 261.22 l 51.26 260.27 l S 33.00 255.04 m 32.18 254.37 l 31.34 253.68 l 30.50 252.99 l 29.66 252.29 l 28.82 251.58 l 27.99 250.88 l 27.17 250.18 l 26.36 249.48 l 25.58 248.80 l 24.82 248.12 l S 25.58 248.80 m 24.82 248.12 l S 25.42 249.92 m 24.82 248.12 l 26.68 248.51 l S 32.18 254.37 m 33.00 255.04 l S 32.33 253.27 m 33.00 255.04 l 31.13 254.74 l S 66.73 229.10 m 68.07 231.36 l 69.57 233.81 l 71.16 236.40 l 72.83 239.09 l 74.54 241.82 l 76.24 244.56 l 77.91 247.24 l 79.51 249.84 l 81.00 252.29 l 82.35 254.55 l S 81.00 252.29 m 82.35 254.55 l S 82.32 252.65 m 82.35 254.55 l 80.69 253.62 l S 68.07 231.36 m 66.73 229.10 l S 66.75 230.99 m 66.73 229.10 l 68.38 230.02 l S 71.93 222.42 m 72.45 222.42 l 72.98 222.42 l 73.50 222.42 l 74.02 222.42 l 74.54 222.42 l 75.06 222.42 l 75.58 222.42 l 76.10 222.42 l 76.62 222.42 l 77.14 222.42 l S 76.62 222.42 m 77.14 222.42 l S 75.50 221.48 m 77.14 222.42 l 75.50 223.37 l S 72.45 222.42 m 71.93 222.42 l S 73.57 223.37 m 71.93 222.42 l 73.57 221.48 l S 64.25 215.51 m 65.14 211.92 l 66.19 207.74 l 67.38 203.06 l 68.69 197.97 l 70.11 192.56 l 71.62 186.92 l 73.22 181.13 l 74.89 175.31 l 76.61 169.52 l 78.38 163.86 l S 78.38 163.86 m 78.84 162.59 l 79.33 161.29 l 79.83 159.99 l 80.34 158.68 l 80.86 157.38 l 81.38 156.09 l 81.89 154.82 l 82.40 153.59 l 82.88 152.40 l 83.34 151.26 l S 82.88 152.40 m 83.34 151.26 l S 81.85 152.43 m 83.34 151.26 l 83.60 153.14 l S 78.84 162.59 m 78.38 163.86 l S 79.83 162.64 m 78.38 163.86 l 78.05 162.00 l S 66.73 215.75 m 68.07 213.49 l 69.57 211.04 l 71.16 208.45 l 72.83 205.76 l 74.54 203.03 l 76.24 200.29 l 77.91 197.60 l 79.51 195.01 l 81.00 192.56 l 82.35 190.30 l S 81.00 192.56 m 82.35 190.30 l S 80.69 191.23 m 82.35 190.30 l 82.32 192.20 l S 68.07 213.49 m 66.73 215.75 l S 68.38 214.83 m 66.73 215.75 l 66.75 213.86 l S 94.99 266.66 m 94.99 266.66 l 94.99 266.66 l 94.99 266.66 l 94.99 266.66 l 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3.00 0.00 -0.00 3.00 367.87 108.08 Tm [(MY) 85 (O)] TJ ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 18.08 0 0 18.08 39.54 248.90 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 42.66 254.09 Tm [(A) 30 (CTN)] TJ ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 16.28 0 0 16.28 60.49 212.96 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 64.02 217.53 Tm (VCL) Tj ET 0.000 1.000 0.000 rg BT /F1 1 Tf 2 Tr 16.28 0 0 16.28 81.82 251.05 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 85.43 255.62 Tm (TLN) Tj ET 0.000 0.000 1.000 rg BT /F1 1 Tf 2 Tr 16.28 0 0 16.28 81.82 212.96 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 85.18 217.53 Tm (PXN) Tj ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 16.28 0 0 16.28 19.80 228.85 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 23.32 233.42 Tm (ZYX) Tj ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 18.08 0 0 18.08 39.54 207.55 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 42.82 212.75 Tm [(V) 80 (ASP)] TJ ET BT /F1 1 Tf 1 Tr 21.10 0 0 21.10 79.91 130.99 Tm (l) Tj 0 Tr ET BT /F2 1 Tf 3.00 0.00 -0.00 3.00 83.43 137.24 Tm (SH3D5) Tj ET BT /F1 1 Tf 1 Tr 16.28 0 0 16.28 81.82 174.88 Tm (l) Tj 0 Tr ET BT /F2 1 Tf 3.00 0.00 -0.00 3.00 85.26 179.45 Tm (TNS) Tj ET 0.000 0.000 1.000 rg BT /F1 1 Tf 2 Tr 18.69 0 0 18.69 103.06 283.94 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 106.29 289.35 Tm (CAPN) Tj ET 0.000 0.000 1.000 rg BT /F1 1 Tf 2 Tr 22.30 0 0 22.30 125.35 284.43 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 129.01 291.09 Tm (CAPNS) Tj ET 0.000 0.000 1.000 rg BT /F1 1 Tf 2 Tr 16.28 0 0 16.28 152.32 286.52 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 155.60 291.09 Tm (SRC) Tj ET 0.000 0.000 1.000 rg BT /F1 1 Tf 2 Tr 16.28 0 0 16.28 173.65 248.43 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 177.30 253.01 Tm [(F) 80 (AK)] TJ ET BT /F1 1 Tf 1 Tr 21.70 0 0 21.70 193.04 276.15 Tm (l) Tj 0 Tr ET BT /F2 1 Tf 3.00 0.00 -0.00 3.00 196.64 282.60 Tm (BCAR1) Tj ET 0.000 0.000 1.000 rg BT /F1 1 Tf 2 Tr 16.28 0 0 16.28 173.65 286.52 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 177.01 291.09 Tm (CSK) Tj ET 0.000 0.000 1.000 rg BT /F1 1 Tf 2 Tr 16.28 0 0 16.28 238.28 288.04 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 241.56 292.61 Tm (CRK) Tj ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 22.30 0 0 22.30 279.20 285.95 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 282.86 292.61 Tm (DOCK1) Tj ET 0.000 1.000 0.000 rg BT /F1 1 Tf 2 Tr 18.08 0 0 18.08 280.87 332.46 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 284.03 337.66 Tm (GRF2) Tj ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 18.08 0 0 18.08 303.28 274.79 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 306.53 279.99 Tm (RAP1) Tj ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 16.28 0 0 16.28 344.47 161.17 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 348.09 165.77 Tm (JNK) Tj ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 16.28 0 0 16.28 104.01 147.46 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 107.12 152.03 Tm (GIT2) Tj ET 0.000 0.000 1.000 rg BT /F1 1 Tf 2 Tr 25.32 0 0 25.32 124.15 108.20 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 127.93 115.91 Tm (ARHGEF) Tj ET 0.000 1.000 0.000 rg BT /F1 1 Tf 2 Tr 16.28 0 0 16.28 324.24 113.08 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 327.86 117.65 Tm [(P) 120 (AK)] TJ ET 0.000 0.000 1.000 rg BT /F1 1 Tf 2 Tr 16.28 0 0 16.28 173.65 182.72 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 177.59 187.62 Tm (p85) Tj ET 0.000 0.000 1.000 rg BT /F1 1 Tf 2 Tr 16.28 0 0 16.28 195.19 215.58 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 198.30 220.48 Tm (p110) Tj ET 217.31 180.53 m 217.31 195.61 229.64 207.95 244.72 207.95 c 259.81 207.95 272.14 195.61 272.14 180.53 c 272.14 165.45 259.81 153.11 244.72 153.11 c 229.64 153.11 217.31 165.45 217.31 180.53 c S BT /F2 1 Tf 3.00 0.00 -0.00 3.00 219.97 179.78 Tm (Phosphatidylinositol signaling system) Tj ET 0.000 1.000 0.000 rg BT /F1 1 Tf 2 Tr 16.28 0 0 16.28 281.58 107.20 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 285.25 111.77 Tm [(V) 80 (A) 70 (V)] TJ ET 0.000 1.000 0.000 rg BT /F1 1 Tf 2 Tr 21.10 0 0 21.10 279.67 194.32 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 283.11 200.56 Tm (PDPK1) Tj ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 16.28 0 0 16.28 304.00 195.99 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 307.53 200.56 Tm (AKT) Tj ET 0.000 1.000 0.000 rg BT /F1 1 Tf 2 Tr 16.28 0 0 16.28 304.00 109.82 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 307.32 114.39 Tm [(RA) 30 (C)] TJ ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 21.10 0 0 21.10 279.67 147.75 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 283.11 153.99 Tm (CDC42) Tj ET 0.000 1.000 0.000 rg BT /F1 1 Tf 2 Tr 16.28 0 0 16.28 173.65 122.00 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 176.76 126.57 Tm (RHO) Tj ET BT /F1 1 Tf 1 Tr 16.28 0 0 16.28 195.19 166.39 Tm (l) Tj 0 Tr ET BT /F2 1 Tf 3.00 0.00 -0.00 3.00 198.39 170.99 Tm (PI5K) Tj ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 19.29 0 0 19.29 194.00 98.32 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 197.33 103.94 Tm [(R) 20 (OCK)] TJ ET 1.000 0.000 0.000 rg BT /F1 1 Tf 2 Tr 20.50 0 0 20.50 236.61 79.41 Tm (l) Tj 0 Tr ET BT 0.000 0.000 0.000 rg /F2 1 Tf 3.00 0.00 -0.00 3.00 239.56 85.44 Tm [(MY) 85 (O-P)] TJ ET 384.87 169.00 m 384.87 176.42 390.94 182.49 398.36 182.49 c 405.78 182.49 411.85 176.42 411.85 169.00 c 411.85 161.58 405.78 155.50 398.36 155.50 c 390.94 155.50 384.87 161.58 384.87 169.00 c S BT /F2 1 Tf 3.00 0.00 -0.00 3.00 387.11 167.94 Tm (cell maintenance) Tj ET 386.61 53.66 m 386.61 60.12 391.90 65.41 398.36 65.41 c 404.82 65.41 410.11 60.12 410.11 53.66 c 410.11 47.20 404.82 41.91 398.36 41.91 c 391.90 41.91 386.61 47.20 386.61 53.66 c S BT /F2 1 Tf 3.00 0.00 -0.00 3.00 391.03 52.90 Tm (cell motility) Tj ET BT /F1 1 Tf 1 Tr 19.89 0 0 19.89 390.48 102.25 Tm (l) Tj 0 Tr ET BT /F2 1 Tf 3.00 0.00 -0.00 3.00 393.40 108.10 Tm (F-actin) Tj ET 385.52 242.33 m 385.52 249.39 391.30 255.17 398.36 255.17 c 405.42 255.17 411.20 249.39 411.20 242.33 c 411.20 235.27 405.42 229.49 398.36 229.49 c 391.30 229.49 385.52 235.27 385.52 242.33 c S BT /F2 1 Tf 3.00 0.00 -0.00 3.00 387.92 241.55 Tm [(cell prolif) 30 (er) 10 (ation)] TJ ET 31.90 349.40 m 31.96 349.27 l 32.01 349.16 l 32.05 349.06 l 32.08 348.96 l 32.12 348.88 l 32.15 348.80 l 32.19 348.73 l 32.23 348.66 l 32.28 348.59 l 32.33 348.53 l S 32.33 348.53 m 32.83 347.24 l 33.64 344.72 l 34.71 341.18 l 35.97 336.84 l 37.37 331.93 l 38.85 326.67 l 40.37 321.27 l 41.85 315.97 l 43.26 310.98 l 44.52 306.53 l S 31.96 349.27 m 31.90 349.40 l S 34.98 347.28 m 31.90 349.40 l 31.60 345.67 l S 43.26 310.98 m 44.52 306.53 l S 41.84 309.13 m 44.52 306.53 l 45.44 310.15 l S 32.55 349.83 m 33.29 349.11 l 34.06 348.37 l 34.85 347.63 l 35.67 346.88 l 36.50 346.13 l 37.33 345.38 l 38.17 344.63 l 38.99 343.89 l 39.81 343.16 l 40.60 342.43 l S 33.29 349.11 m 32.55 349.83 l S 36.17 348.89 m 32.55 349.83 l 33.55 346.23 l S 39.81 343.16 m 40.60 342.43 l S 36.95 343.23 m 40.60 342.43 l 39.47 346.00 l S 32.12 361.37 m 32.92 362.15 l 33.75 362.95 l 34.61 363.76 l 35.48 364.58 l 36.36 365.39 l 37.24 366.21 l 38.11 367.02 l 38.97 367.83 l 39.80 368.63 l 40.60 369.42 l S 32.92 362.15 m 32.12 361.37 l S 33.11 364.97 m 32.12 361.37 l 35.74 362.31 l S 39.80 368.63 m 40.60 369.42 l S 39.61 365.81 m 40.60 369.42 l 36.98 368.48 l S 26.89 363.76 m 27.41 368.06 l 28.05 372.88 l 28.82 378.03 l 29.73 383.31 l 30.78 388.54 l 31.99 393.53 l 33.35 398.09 l 34.87 402.02 l 36.56 405.15 l 38.43 407.28 l S 38.43 407.28 m 41.95 409.71 l 45.26 411.33 l 48.43 412.24 l 51.53 412.55 l 54.64 412.34 l 57.83 411.73 l 61.16 410.82 l 64.72 409.70 l 68.58 408.49 l 72.81 407.28 l S 72.81 407.28 m 73.73 407.06 l 74.66 406.79 l 75.59 406.48 l 76.52 406.14 l 77.44 405.76 l 78.34 405.35 l 79.23 404.93 l 80.09 404.49 l 80.93 404.04 l 81.73 403.58 l S 27.41 368.06 m 26.89 363.76 l S 25.42 367.20 m 26.89 363.76 l 29.14 366.75 l S 80.93 404.04 m 81.73 403.58 l S 77.99 403.56 m 81.73 403.58 l 79.84 406.81 l S 31.90 349.40 m 31.96 349.33 l 32.01 349.24 l 32.05 349.15 l 32.08 349.06 l 32.12 348.96 l 32.15 348.86 l 32.19 348.77 l 32.23 348.68 l 32.28 348.60 l 32.33 348.53 l S 32.33 348.53 m 35.34 340.41 l 37.10 333.15 l 37.89 326.52 l 37.96 320.29 l 37.58 314.22 l 37.04 308.10 l 36.58 301.69 l 36.48 294.77 l 37.01 287.10 l 38.43 278.45 l S 38.43 278.45 m 38.78 276.88 l 39.18 275.28 l 39.61 273.68 l 40.08 272.09 l 40.58 270.51 l 41.09 268.96 l 41.62 267.44 l 42.15 265.98 l 42.69 264.57 l 43.22 263.22 l S 31.96 349.33 m 31.90 349.40 l S 35.41 348.10 m 31.90 349.40 l 32.53 345.71 l S 42.69 264.57 m 43.22 263.22 l S 40.29 265.55 m 43.22 263.22 l 43.77 266.92 l S 27.55 363.76 m 27.99 365.77 l 28.55 367.86 l 29.24 369.99 l 30.06 372.13 l 31.03 374.23 l 32.15 376.26 l 33.45 378.18 l 34.91 379.96 l 36.57 381.54 l 38.43 382.91 l S 38.43 382.91 m 40.21 383.98 l 41.92 384.85 l 43.57 385.50 l 45.16 385.92 l 46.72 386.09 l 48.27 386.01 l 49.81 385.66 l 51.35 385.04 l 52.92 384.13 l 54.53 382.91 l S 54.53 382.91 m 64.83 372.58 l 70.91 361.96 l 73.70 351.02 l 74.16 339.73 l 73.22 328.07 l 71.83 316.02 l 70.93 303.56 l 71.47 290.66 l 74.40 277.29 l 80.64 263.44 l S 80.64 263.44 m 80.72 263.25 l 80.80 263.07 l 80.90 262.90 l 81.01 262.73 l 81.13 262.57 l 81.27 262.41 l 81.42 262.24 l 81.58 262.07 l 81.76 261.89 l 81.95 261.70 l S 27.99 365.77 m 27.55 363.76 l S 26.42 367.33 m 27.55 363.76 l 30.07 366.52 l S 81.76 261.89 m 81.95 261.70 l S 78.34 262.67 m 81.95 261.70 l 80.99 265.31 l S 92.18 391.61 m 93.48 389.34 l 94.88 386.87 l 96.36 384.26 l 97.89 381.54 l 99.44 378.77 l 100.98 376.01 l 102.49 373.29 l 103.94 370.67 l 105.30 368.21 l 106.54 365.94 l S 93.48 389.34 m 92.18 391.61 l S 95.41 389.73 m 92.18 391.61 l 92.17 387.87 l S 105.30 368.21 m 106.54 365.94 l S 103.35 367.88 m 106.54 365.94 l 106.63 369.67 l S 96.31 398.79 m 96.84 398.79 l 97.36 398.79 l 97.88 398.79 l 98.40 398.79 l 98.92 398.79 l 99.45 398.79 l 99.97 398.79 l 100.49 398.79 l 101.01 398.79 l 101.54 398.79 l S 96.84 398.79 m 96.31 398.79 l S 99.55 400.67 m 96.31 398.79 l 99.55 396.92 l S 101.01 398.79 m 101.54 398.79 l S 98.30 396.92 m 101.54 398.79 l 98.30 400.67 l S 116.99 397.05 m 117.85 396.79 l 118.75 396.53 l 119.68 396.27 l 120.62 396.01 l 121.58 395.75 l 122.55 395.49 l 123.51 395.23 l 124.47 394.96 l 125.42 394.70 l 126.34 394.44 l S 125.42 394.70 m 126.34 394.44 l S 122.72 393.52 m 126.34 394.44 l 123.73 397.12 l S 139.40 389.87 m 140.34 389.41 l 141.32 388.93 l 142.34 388.45 l 143.39 387.95 l 144.46 387.45 l 145.54 386.94 l 146.63 386.43 l 147.71 385.91 l 148.79 385.39 l 149.85 384.87 l S 148.79 385.39 m 149.85 384.87 l S 146.11 384.63 m 149.85 384.87 l 147.77 387.98 l S 166.17 378.34 m 166.76 378.15 l 167.36 377.97 l 167.98 377.80 l 168.59 377.63 l 169.21 377.47 l 169.83 377.31 l 170.45 377.14 l 171.06 376.97 l 171.67 376.79 l 172.26 376.60 l S 171.67 376.79 m 172.26 376.60 l S 168.60 375.80 m 172.26 376.60 l 169.74 379.37 l S 185.75 373.12 m 186.54 372.97 l 187.34 372.81 l 188.15 372.62 l 188.96 372.43 l 189.78 372.22 l 190.59 372.00 l 191.41 371.79 l 192.21 371.57 l 193.01 371.36 l 193.80 371.16 l S 193.01 371.36 m 193.80 371.16 l S 190.20 370.15 m 193.80 371.16 l 191.13 373.77 l S 207.51 369.63 m 213.25 369.85 l 220.48 369.87 l 228.91 369.58 l 238.22 368.83 l 248.13 367.49 l 258.32 365.42 l 268.52 362.49 l 278.41 358.58 l 287.70 353.53 l 296.08 347.22 l S 296.08 347.22 m 300.48 342.00 l 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