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298.53 287.84 298.53 c 279.82 298.53 273.25 305.10 273.25 313.12 c S 211.14 264.56 m 211.14 272.58 217.70 279.14 225.72 279.14 c 233.74 279.14 240.31 272.58 240.31 264.56 c 240.31 256.54 233.74 249.97 225.72 249.97 c 217.70 249.97 211.14 256.54 211.14 264.56 c S 313.76 313.12 m 313.76 321.14 320.33 327.70 328.35 327.70 c 336.37 327.70 342.93 321.14 342.93 313.12 c 342.93 305.10 336.37 298.53 328.35 298.53 c 320.33 298.53 313.76 305.10 313.76 313.12 c S 180.89 361.67 m 180.89 369.70 187.45 376.26 195.47 376.26 c 203.50 376.26 210.06 369.70 210.06 361.67 c 210.06 353.65 203.50 347.09 195.47 347.09 c 187.45 347.09 180.89 353.65 180.89 361.67 c S 89.07 216.00 m 89.07 224.02 95.63 230.58 103.65 230.58 c 111.67 230.58 118.24 224.02 118.24 216.00 c 118.24 207.98 111.67 201.42 103.65 201.42 c 95.63 201.42 89.07 207.98 89.07 216.00 c S 293.24 264.56 m 293.24 272.58 299.80 279.14 307.82 279.14 c 315.84 279.14 322.41 272.58 322.41 264.56 c 322.41 256.54 315.84 249.97 307.82 249.97 c 299.80 249.97 293.24 256.54 293.24 264.56 c S 89.07 264.56 m 89.07 272.58 95.63 279.14 103.65 279.14 c 111.67 279.14 118.24 272.58 118.24 264.56 c 118.24 256.54 111.67 249.97 103.65 249.97 c 95.63 249.97 89.07 256.54 89.07 264.56 c S 313.76 361.67 m 313.76 369.70 320.33 376.26 328.35 376.26 c 336.37 376.26 342.93 369.70 342.93 361.67 c 342.93 353.65 336.37 347.09 328.35 347.09 c 320.33 347.09 313.76 353.65 313.76 361.67 c S 129.58 167.44 m 129.58 175.46 136.14 182.03 144.16 182.03 c 152.18 182.03 158.75 175.46 158.75 167.44 c 158.75 159.42 152.18 152.86 144.16 152.86 c 136.14 152.86 129.58 159.42 129.58 167.44 c S BT /sRGB cs 0.000 0.000 0.000 scn /F2 1 Tf 9.00 0.00 -0.00 9.00 100.95 358.53 Tm (EP300) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 136.46 358.44 Tm (CREBBP) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 123.05 18.54 Tm (NFKBIA) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 168.06 18.54 Tm (RELA) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 201.82 18.54 Tm (CREBBP) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 51.39 261.33 Tm (RELA) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 130.65 261.41 Tm (EP300) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 172.92 261.33 Tm (RELA) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 5.84 261.33 Tm (NFKBIA) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 316.59 164.21 Tm (RELA) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 353.92 164.21 Tm [(HD) 40 (A) 30 (C3)] TJ ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 393.65 164.21 Tm (NFKBIA) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 270.20 165.21 Tm (p50_0-0) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 167.03 165.21 Tm (p50_0-0) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 208.96 165.14 Tm (ubiquitin) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 182.70 68.09 Tm (p50_0-0) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 270.20 359.44 Tm (p50_0-0) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 97.80 407.85 Tm (I-kappa-B-alpha/RELA/p50) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 83.14 165.06 Tm (p300/CBP) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 253.18 213.62 Tm (I-kappa-B-alpha/RELA/p50/ubiquitin) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 101.89 310.73 Tm (p300/CBP/RELA/p50) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 319.60 407.00 Tm (TSA) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 199.21 213.70 Tm (NF-kappa-B) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 237.65 19.53 Tm [(degr) 10 (adation)] TJ ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 173.32 116.58 Tm (pid_i_100584) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 76.63 116.58 Tm (pid_i_100583) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 260.82 310.82 Tm (pid_i_100582) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 174.31 262.26 Tm [(pid_i_100581_activ) 25 (ator_1)] TJ ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 301.33 310.82 Tm (pid_i_100581) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 168.46 359.37 Tm (pid_i_100580) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 76.63 213.70 Tm (pid_i_100578) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 280.80 262.26 Tm (pid_i_100579) Tj ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 52.23 262.26 Tm [(pid_i_100579_activ) 25 (ator_1)] TJ ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 276.93 359.37 Tm [(pid_i_100580_activ) 25 (ator_1)] TJ ET BT /F2 1 Tf 9.00 0.00 -0.00 9.00 117.14 165.14 Tm (pid_i_100577) Tj ET 188.45 61.15 m 185.56 58.65 l 182.43 56.02 l 179.11 53.29 l 175.65 50.49 l 172.11 47.67 l 168.54 44.84 l 164.99 42.04 l 161.51 39.31 l 158.15 36.68 l 154.96 34.18 l S 158.15 36.68 m 154.96 34.18 l S 157.27 39.92 m 154.96 34.18 l 161.09 35.06 l S 194.39 56.30 m 193.73 54.81 l 193.04 53.27 l 192.33 51.68 l 191.61 50.06 l 190.88 48.41 l 190.16 46.74 l 189.43 45.07 l 188.73 43.40 l 188.04 41.74 l 187.37 40.11 l S 188.04 41.74 m 187.37 40.11 l S 186.52 46.24 m 187.37 40.11 l 192.26 43.91 l S 205.74 56.30 m 206.39 54.81 l 207.03 53.27 l 207.68 51.68 l 208.33 50.06 l 208.98 48.41 l 209.63 46.74 l 210.27 45.07 l 210.92 43.40 l 211.57 41.74 l 212.22 40.11 l S 211.57 41.74 m 212.22 40.11 l S 207.37 43.95 m 212.22 40.11 l 213.12 46.24 l S 216.00 57.38 m 218.82 55.21 l 221.73 52.94 l 224.73 50.60 l 227.78 48.20 l 230.85 45.78 l 233.93 43.35 l 236.98 40.96 l 239.97 38.61 l 242.89 36.34 l 245.71 34.18 l S 242.89 36.34 m 245.71 34.18 l S 239.57 34.99 m 245.71 34.18 l 243.34 39.90 l S 218.82 55.21 m 216.00 57.38 l S 222.14 56.56 m 216.00 57.38 l 218.36 51.66 l S 287.84 346.57 m 287.84 345.27 l 287.84 343.97 l 287.84 342.67 l 287.84 341.35 l 287.84 340.03 l 287.84 338.68 l 287.84 337.32 l 287.84 335.93 l 287.84 334.52 l 287.84 333.08 l S 287.84 334.52 m 287.84 333.08 l S 284.74 338.44 m 287.84 333.08 l 290.93 338.44 l S 300.26 346.03 m 301.73 344.23 l 303.23 342.42 l 304.75 340.58 l 306.28 338.75 l 307.82 336.92 l 309.36 335.11 l 310.89 333.33 l 312.41 331.58 l 313.91 329.87 l 315.38 328.22 l S 313.91 329.87 m 315.38 328.22 l S 309.51 330.16 m 315.38 328.22 l 314.12 334.28 l S 301.73 344.23 m 300.26 346.03 l S 306.05 343.85 m 300.26 346.03 l 301.27 339.92 l S 145.24 398.90 m 143.58 396.90 l 141.83 394.79 l 140.02 392.59 l 138.16 390.34 l 136.26 388.04 l 134.35 385.73 l 132.44 383.43 l 130.55 381.15 l 128.69 378.93 l 126.88 376.78 l S 128.69 378.93 m 126.88 376.78 l S 127.97 382.87 m 126.88 376.78 l 132.70 378.88 l S 154.96 395.13 m 154.96 393.83 l 154.96 392.53 l 154.96 391.23 l 154.96 389.91 l 154.96 388.58 l 154.96 387.24 l 154.96 385.88 l 154.96 384.49 l 154.96 383.08 l 154.96 381.64 l S 154.96 383.08 m 154.96 381.64 l S 151.87 387.00 m 154.96 381.64 l 158.06 387.00 l S 164.15 398.90 m 165.81 396.90 l 167.56 394.79 l 169.37 392.59 l 171.23 390.34 l 173.13 388.04 l 175.04 385.73 l 176.95 383.43 l 178.84 381.15 l 180.70 378.93 l 182.51 376.78 l S 180.70 378.93 m 182.51 376.78 l S 176.69 378.88 m 182.51 376.78 l 181.42 382.87 l S 114.99 158.27 m 115.97 157.77 l 116.94 157.24 l 117.91 156.70 l 118.88 156.14 l 119.86 155.57 l 120.83 155.01 l 121.80 154.45 l 122.77 153.90 l 123.74 153.38 l 124.72 152.87 l S 124.72 152.87 m 130.34 149.67 l 136.16 146.55 l 142.11 143.51 l 148.10 140.58 l 154.09 137.77 l 159.99 135.08 l 165.74 132.54 l 171.28 130.15 l 176.53 127.93 l 181.43 125.90 l S 176.53 127.93 m 181.43 125.90 l S 175.29 125.10 m 181.43 125.90 l 177.67 130.81 l S 103.65 146.94 m 103.65 146.13 l 103.65 145.32 l 103.65 144.51 l 103.65 143.70 l 103.65 142.89 l 103.65 142.08 l 103.65 141.27 l 103.65 140.47 l 103.65 139.66 l 103.65 138.85 l S 103.65 139.66 m 103.65 138.85 l S 100.56 144.21 m 103.65 138.85 l 106.75 144.21 l S 103.65 146.13 m 103.65 146.94 l S 106.75 141.58 m 103.65 146.94 l 100.56 141.58 l S 328.35 200.89 m 328.35 199.60 l 328.35 198.30 l 328.35 196.99 l 328.35 195.68 l 328.35 194.35 l 328.35 193.01 l 328.35 191.64 l 328.35 190.26 l 328.35 188.85 l 328.35 187.40 l S 328.35 188.85 m 328.35 187.40 l S 325.25 192.76 m 328.35 187.40 l 331.44 192.76 l S 337.53 204.67 m 339.20 202.67 l 340.94 200.56 l 342.76 198.36 l 344.62 196.11 l 346.51 193.81 l 348.42 191.50 l 350.33 189.20 l 352.22 186.92 l 354.08 184.70 l 355.89 182.55 l S 354.08 184.70 m 355.89 182.55 l S 350.07 184.65 m 355.89 182.55 l 354.81 188.64 l S 341.31 208.99 m 345.08 206.79 l 349.21 204.42 l 353.64 201.90 l 358.32 199.26 l 363.19 196.51 l 368.18 193.68 l 373.25 190.79 l 378.33 187.87 l 383.37 184.94 l 388.30 182.01 l S 388.30 182.01 m 388.79 181.69 l 389.28 181.36 l 389.76 181.04 l 390.25 180.71 l 390.73 180.39 l 391.22 180.07 l 391.71 179.74 l 392.19 179.42 l 392.68 179.10 l 393.16 178.77 l S 392.68 179.10 m 393.16 178.77 l S 386.99 179.17 m 393.16 178.77 l 390.42 184.32 l S 318.63 204.67 m 316.96 202.67 l 315.21 200.56 l 313.40 198.36 l 311.54 196.11 l 309.65 193.81 l 307.74 191.50 l 305.83 189.20 l 303.93 186.92 l 302.07 184.70 l 300.26 182.55 l S 302.07 184.70 m 300.26 182.55 l S 301.35 188.64 m 300.26 182.55 l 306.08 184.65 l S 130.66 306.10 m 126.89 303.90 l 122.77 301.54 l 118.35 299.02 l 113.69 296.37 l 108.85 293.63 l 103.90 290.80 l 98.90 287.91 l 93.91 284.99 l 88.99 282.05 l 84.21 279.13 l S 84.21 279.13 m 83.72 278.80 l 83.23 278.48 l 82.75 278.15 l 82.26 277.83 l 81.78 277.51 l 81.29 277.18 l 80.80 276.86 l 80.32 276.54 l 79.83 276.21 l 79.35 275.89 l S 79.83 276.21 m 79.35 275.89 l S 82.09 281.44 m 79.35 275.89 l 85.52 276.28 l S 144.16 298.01 m 144.16 296.71 l 144.16 295.42 l 144.16 294.11 l 144.16 292.80 l 144.16 291.47 l 144.16 290.12 l 144.16 288.76 l 144.16 287.37 l 144.16 285.96 l 144.16 284.52 l S 144.16 285.96 m 144.16 284.52 l S 141.07 289.88 m 144.16 284.52 l 147.26 289.88 l S 153.34 301.79 m 155.01 299.78 l 156.76 297.67 l 158.57 295.48 l 160.43 293.22 l 162.32 290.93 l 164.23 288.62 l 166.14 286.31 l 168.04 284.04 l 169.90 281.81 l 171.71 279.67 l S 169.90 281.81 m 171.71 279.67 l S 165.89 281.77 m 171.71 279.67 l 170.62 285.76 l S 129.58 309.34 m 123.10 307.56 l 115.77 305.47 l 107.73 303.09 l 99.11 300.41 l 90.08 297.47 l 80.77 294.27 l 71.33 290.82 l 61.91 287.14 l 52.65 283.23 l 43.70 279.13 l S 43.70 279.13 m 43.06 278.80 l 42.46 278.48 l 41.88 278.15 l 41.33 277.83 l 40.79 277.51 l 40.27 277.18 l 39.77 276.86 l 39.27 276.54 l 38.78 276.21 l 38.30 275.89 l S 38.78 276.21 m 38.30 275.89 l S 41.04 281.43 m 38.30 275.89 l 44.47 276.28 l S 157.13 306.10 m 160.89 303.90 l 165.02 301.54 l 169.45 299.02 l 174.13 296.37 l 179.00 293.63 l 184.00 290.80 l 189.07 287.91 l 194.15 284.99 l 199.18 282.05 l 204.12 279.13 l S 204.12 279.13 m 204.60 278.80 l 205.09 278.48 l 205.58 278.15 l 206.06 277.83 l 206.55 277.51 l 207.03 277.18 l 207.52 276.86 l 208.01 276.54 l 208.49 276.21 l 208.98 275.89 l S 208.49 276.21 m 208.98 275.89 l S 202.80 276.28 m 208.98 275.89 l 206.23 281.44 l S 134.44 301.79 m 132.77 299.78 l 131.03 297.67 l 129.21 295.48 l 127.35 293.22 l 125.46 290.93 l 123.55 288.62 l 121.64 286.31 l 119.75 284.04 l 117.89 281.81 l 116.08 279.67 l S 117.89 281.81 m 116.08 279.67 l S 117.16 285.76 m 116.08 279.67 l 121.90 281.77 l S 328.35 395.13 m 328.35 393.83 l 328.35 392.53 l 328.35 391.23 l 328.35 389.91 l 328.35 388.58 l 328.35 387.24 l 328.35 385.88 l 328.35 384.49 l 328.35 383.08 l 328.35 381.64 l S 328.35 383.08 m 328.35 381.64 l S 325.25 387.00 m 328.35 381.64 l 331.44 387.00 l S 216.00 204.67 m 214.33 202.67 l 212.59 200.56 l 210.77 198.36 l 208.91 196.11 l 207.02 193.81 l 205.11 191.50 l 203.20 189.20 l 201.31 186.92 l 199.45 184.70 l 197.64 182.55 l S 199.45 184.70 m 197.64 182.55 l S 198.73 188.64 m 197.64 182.55 l 203.46 184.65 l S 225.72 200.89 m 225.72 199.60 l 225.72 198.30 l 225.72 196.99 l 225.72 195.68 l 225.72 194.35 l 225.72 193.01 l 225.72 191.64 l 225.72 190.26 l 225.72 188.85 l 225.72 187.40 l S 225.72 188.85 m 225.72 187.40 l S 222.63 192.76 m 225.72 187.40 l 228.82 192.76 l S 234.36 204.13 m 236.99 199.87 l 239.58 195.23 l 242.04 190.27 l 244.23 185.08 l 246.05 179.72 l 247.35 174.26 l 248.04 168.77 l 247.98 163.33 l 247.07 158.01 l 245.17 152.87 l S 245.17 152.87 m 243.24 149.56 l 241.06 146.40 l 238.65 143.42 l 236.05 140.61 l 233.28 137.97 l 230.39 135.51 l 227.40 133.23 l 224.34 131.14 l 221.25 129.23 l 218.16 127.52 l S 221.25 129.23 m 218.16 127.52 l S 221.34 132.82 m 218.16 127.52 l 224.35 127.41 l S 234.36 227.33 m 235.53 229.32 l 236.73 231.40 l 237.96 233.55 l 239.18 235.77 l 240.37 238.05 l 241.52 240.38 l 242.60 242.75 l 243.58 245.15 l 244.44 247.56 l 245.17 249.99 l S 245.17 249.99 m 246.04 253.47 l 246.72 256.54 l 247.21 259.31 l 247.50 261.88 l 247.60 264.36 l 247.50 266.85 l 247.21 269.47 l 246.72 272.31 l 246.04 275.50 l 245.17 279.13 l S 245.17 279.13 m 242.62 286.72 l 239.58 294.26 l 236.14 301.69 l 232.39 308.93 l 228.42 315.95 l 224.32 322.67 l 220.18 329.05 l 216.10 335.01 l 212.15 340.51 l 208.44 345.49 l S 212.15 340.51 m 208.44 345.49 l S 214.12 343.04 m 208.44 345.49 l 209.16 339.34 l S 207.90 206.29 m 204.06 204.27 l 200.04 202.11 l 195.86 199.82 l 191.56 197.43 l 187.17 194.96 l 182.74 192.42 l 178.29 189.84 l 173.87 187.23 l 169.50 184.61 l 165.23 182.01 l S 165.23 182.01 m 164.74 181.69 l 164.26 181.36 l 163.77 181.04 l 163.28 180.71 l 162.80 180.39 l 162.31 180.07 l 161.82 179.74 l 161.34 179.42 l 160.85 179.10 l 160.37 178.77 l S 160.85 179.10 m 160.37 178.77 l S 163.11 184.32 m 160.37 178.77 l 166.54 179.17 l S 164.74 181.69 m 165.23 182.01 l S 162.48 176.46 m 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158.75 326.60 l S 160.37 332.58 m 158.75 326.60 l 164.73 328.18 l S 103.65 200.89 m 103.65 199.60 l 103.65 198.30 l 103.65 196.99 l 103.65 195.68 l 103.65 194.35 l 103.65 193.01 l 103.65 191.64 l 103.65 190.26 l 103.65 188.85 l 103.65 187.40 l S 103.65 188.85 m 103.65 187.40 l S 100.56 192.76 m 103.65 187.40 l 106.75 192.76 l S 313.22 250.53 m 313.89 249.04 l 314.58 247.50 l 315.29 245.91 l 316.01 244.29 l 316.74 242.64 l 317.46 240.97 l 318.18 239.30 l 318.89 237.63 l 319.58 235.98 l 320.25 234.34 l S 319.58 235.98 m 320.25 234.34 l S 315.36 238.15 m 320.25 234.34 l 321.10 240.47 l S 294.86 257.00 m 290.42 254.29 l 285.58 251.37 l 280.43 248.29 l 275.05 245.09 l 269.54 241.83 l 263.98 238.55 l 258.46 235.31 l 253.07 232.14 l 247.89 229.11 l 243.01 226.25 l S 247.89 229.11 m 243.01 226.25 l S 246.07 231.63 m 243.01 226.25 l 249.20 226.29 l S 103.65 249.45 m 103.65 248.16 l 103.65 246.86 l 103.65 245.55 l 103.65 244.24 l 103.65 242.91 l 103.65 241.57 l 103.65 240.20 l 103.65 238.82 l 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