%PDF-1.4 % 1 0 obj << /S /GoTo /D (section.1) >> endobj 4 0 obj (1 Introduction ) endobj 5 0 obj << /S /GoTo /D (section.2) >> endobj 8 0 obj (2 Example workflow for GSEA) endobj 9 0 obj << /S /GoTo /D (subsection.2.1) >> endobj 12 0 obj (2.1 Preparing our gene sets and our dataset for analysis) endobj 13 0 obj << /S /GoTo /D (subsection.2.2) >> endobj 16 0 obj (2.2 Running npGSEA) endobj 17 0 obj << /S /GoTo /D (subsection.2.3) >> endobj 20 0 obj (2.3 Running npGSEA with the beta and chi-sq approximations) endobj 21 0 obj << /S /GoTo /D (subsection.2.4) >> endobj 24 0 obj (2.4 Adding weights to the model) endobj 25 0 obj << /S /GoTo /D (subsection.2.5) >> endobj 28 0 obj (2.5 Adding covariates to model) endobj 29 0 obj << /S /GoTo /D (subsection.2.6) >> endobj 32 0 obj (2.6 Running npGSEA with multiple gene sets) endobj 33 0 obj << /S /GoTo /D (section.3) >> endobj 36 0 obj (3 Methods in brief) endobj 37 0 obj << /S /GoTo /D (subsection.3.1) >> endobj 40 0 obj (3.1 Disadvantages to a permutation approach) endobj 41 0 obj << /S /GoTo /D (subsection.3.2) >> endobj 44 0 obj (3.2 Test statistics) endobj 45 0 obj << /S /GoTo /D (subsection.3.3) >> endobj 48 0 obj (3.3 Moment based reference distributions) endobj 49 0 obj << /S /GoTo /D (section.4) >> endobj 52 0 obj (4 Session Info) endobj 53 0 obj << /S /GoTo /D (section.5) >> endobj 56 0 obj (5 References) endobj 57 0 obj << /S /GoTo /D [58 0 R /Fit] >> endobj 74 0 obj << /Length 1366 /Filter /FlateDecode >> stream xXKS#7W8Š#itd ك񌍳ani<BrZҧ% 6e#ww?)U ' .lƬ<)29d(^µT+Mk"|WE#OMkp;⦈#nfa :/c]ut0^Zf6(LHL/$!|Rpi,Q۾rA2ōڨTfǽ86К+4! /F;=O/@3Ye u=>Z.hAA+MX(|SDc ݠ]UkruϷr}i)YGZG*^BFiĈ]>eh֤'pCN-WUlT:COXv46r ^!{|*&stV8*i:?i$+i-4+=#MV UnH8Ѱ'Xnf)uv yo-I.X Bl.z4SH Ԑ*k(` %:,9)7kbaEoǍF(Qq} jAWHx>1'XodR-6d~ 8:XgR0! 6Mw65V QEHU:Zv얼,B%MZFu`Gul%deP ](dQjɔ@GD= k 'GErηeILʦxȂչy|?Э +7eux걢\ּpS+ઽ8 uvSvY?o7m4^}\gGϿO }u1zFEvC߄|>8eƷT?ËK$Ŧ'd!d_U}4ՖCPC>T#dOuAEU0bs7 \8{}xt4! endstream endobj 58 0 obj << /Type /Page /Contents 74 0 R /Resources 73 0 R /MediaBox [0 0 612 792] /Group << /S /Transparency /I true /CS /DeviceRGB>> /Parent 87 0 R /Annots [ 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R 72 0 R ] >> endobj 59 0 obj << /Type /Annot /Subtype /Link /Border[0 0 0]/H/I/C[.7 .7 .7] /Rect [55.697 412.179 146.892 422.468] /A << /S /GoTo /D (section.1) >> >> endobj 60 0 obj << /Type /Annot /Subtype /Link /Border[0 0 0]/H/I/C[.7 .7 .7] /Rect [55.697 383.71 229.334 396.318] /A << /S /GoTo /D (section.2) >> >> endobj 61 0 obj << /Type /Annot /Subtype /Link /Border[0 0 0]/H/I/C[.7 .7 .7] /Rect [73.253 369.264 355.037 381.759] /A << /S /GoTo /D (subsection.2.1) >> >> endobj 62 0 obj << /Type /Annot /Subtype /Link /Border[0 0 0]/H/I/C[.7 .7 .7] /Rect [73.253 354.818 187.177 367.313] /A << /S /GoTo /D (subsection.2.2) >> >> endobj 63 0 obj << /Type /Annot /Subtype /Link /Border[0 0 0]/H/I/C[.7 .7 .7] /Rect [73.253 340.372 387.185 352.867] /A << /S /GoTo /D (subsection.2.3) >> >> endobj 64 0 obj << /Type /Annot /Subtype /Link /Border[0 0 0]/H/I/C[.7 .7 .7] /Rect [73.253 325.927 243.067 338.421] /A << /S /GoTo /D (subsection.2.4) >> >> endobj 65 0 obj << /Type /Annot /Subtype /Link /Border[0 0 0]/H/I/C[.7 .7 .7] /Rect [73.253 311.481 235.499 323.976] /A << /S /GoTo /D (subsection.2.5) >> >> endobj 66 0 obj << /Type /Annot /Subtype /Link /Border[0 0 0]/H/I/C[.7 .7 .7] /Rect [73.253 297.035 303.248 309.53] /A << /S /GoTo /D (subsection.2.6) >> >> endobj 67 0 obj << /Type /Annot /Subtype /Link /Border[0 0 0]/H/I/C[.7 .7 .7] /Rect [55.697 273.204 165.721 283.494] /A << /S /GoTo /D (section.3) >> >> endobj 68 0 obj << /Type /Annot /Subtype /Link /Border[0 0 0]/H/I/C[.7 .7 .7] /Rect [73.253 256.439 306.213 268.934] /A << /S /GoTo /D (subsection.3.1) >> >> endobj 69 0 obj << /Type /Annot /Subtype /Link /Border[0 0 0]/H/I/C[.7 .7 .7] /Rect [73.253 244.313 169.376 254.488] /A << /S /GoTo /D (subsection.3.2) >> >> endobj 70 0 obj << /Type /Annot /Subtype /Link /Border[0 0 0]/H/I/C[.7 .7 .7] /Rect [73.253 229.867 284.802 240.042] /A << /S /GoTo /D (subsection.3.3) >> >> endobj 71 0 obj << /Type /Annot /Subtype /Link /Border[0 0 0]/H/I/C[.7 .7 .7] /Rect [55.697 203.717 140.675 214.006] /A << /S /GoTo /D (section.4) >> >> endobj 72 0 obj << /Type /Annot /Subtype /Link /Border[0 0 0]/H/I/C[.7 .7 .7] /Rect [55.697 177.567 134.112 187.856] /A << /S /GoTo /D (section.5) >> >> endobj 75 0 obj << /D [58 0 R /XYZ 55.693 758.996 null] >> endobj 76 0 obj << /D [58 0 R /XYZ 56.693 721.134 null] >> endobj 85 0 obj << /D [58 0 R /XYZ 56.693 464.479 null] >> endobj 73 0 obj << /Font << /F41 77 0 R /F45 78 0 R /F8 79 0 R /F14 80 0 R /F26 81 0 R /F47 82 0 R /F32 83 0 R /F49 84 0 R /F51 86 0 R >> /ProcSet [ /PDF /Text ] >> endobj 90 0 obj << /Length 2453 /Filter /FlateDecode >> stream xڵn_.-9Ic]P`93~\9sqzv\GR^E3[9L:6}ܪY&0y:_̸W0˜_չ7 xWxޅ뜗L.> ~`G/>O0Ib7|r eZE~?=0#R@E;xQg)wFWp#]6HaL*g/' 6j+/NgQ|;Kx ƹ!iau>%~!8L.Z)ĉH!"'U˚f=@/HR$2uˇJLh+N0P6 hEW&AQZ8Er3o2Rߝi'}X{&H%D.C?rЎ!T !_IF,I?3 Ҟ섉Lb&U1 ,7k<++. 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