版本变化0.99.1(2019-07-14)+版本提交给Bioconductor变化0.99.2(2019-08-18)+修改格式符合Bioconductor编码风格。+添加单元测试版本1.0.1的变化(2020-01-28)+修改一些错误片段和芒。改变版本1.1.0(2020-02-27)+修改一些错误小插曲和芒。1.1.1版的变化(2020-03-15)+添加PAS2GEF转换GTF不是参考。+添加REF4PAS生成引用区域3 'utr和introic不是在同一时间。+添加APAVolcano和APABox情节APAdiff结果。+添加调整假定值选项APAdiff +允许用户设置参数minMQS过滤器最小数读取映射质量分数。+添加内置hg38和mm10不是引用。+添加内置不是所有通过包括守恒和non-conserved参考。+更新小插曲和芒。 + PAS reference regions are now moved to a separate repo. Changes in version 1.1.2 (2020-03-18) + Add the download_testbam to download the testing data bam files. + Add extra section 'Complete Analysis Example' in vignettes + Revise some typos in vignettes and mans. Changes in version 1.1.3 (2020-04-27) + Optimize code to reduce the testing time. Changes in version 1.3.1 (2020-07-19) + Fixed the interval issues in hg38_REF.RData and mm10_REF.RData. + Updated the CITATION. Changes in version 1.3.2 (2020-07-20) + Updated the CITATION. Changes in version 1.3.3 (2020-07-20) + Fixed hg38_REF.RData. Changes in version 1.5.1 (2020-12-07) + Updated Imports and authors. Changes in version 1.5.3 (2021-01-05) + Updated the link of PolyA_DB. Changes in version 1.5.4 (2021-01-10) + Fixed the bug in PASEXP_3UTR. Changes in version 1.5.5 (2021-01-31) + Added ThreeMostPairBam to support paired-end bam. Changes in version 1.7.1 (2021-07-09) + Fixed the missing SS column issues in PAS2GEF. Changes in version 1.7.2 (2021-07-31) + Fixed the issues of using 3'most bam file (generate using ThreeMostPairBam) in PASEXP_IPA. Changes in version 1.7.3 (2021-08-01) + Fixed the typo in vignettes. Changes in version 1.9.1 (2021-11-28) + Added `MultiTest` parameter for APAdiff. + Improved the performance and fixed issues in PAS2GEF. + Update documents and authorships. Changes in version 1.9.2 (2022-01-02) + Added supporting of multi-condition design in `APAdiff`. Changes in version 1.9.3 (2022-02-27) + Fixed the issues caused by the lastest ensembl GRCm39 GTF. + Fixed typos in vignettes Changes in version 1.9.4 (2022-02-28) + Fixed typos in vignettes