## ----包括= false ------------------------------------------------------------------------------------------------------------- require(knitr) opts_chunk$set(concordance=TRUE,tidy=TRUE) ## ----config,echo=FALSE-------------------------------------------------------------------------------------------------------选项选项（warn = -1）## ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------＃if（！sireseenamespace（“ biocmanager”，悄悄= true））{＃install.packages（“ biocmanager”）＃}＃biocmanager :: install（“ microbiobiomedasim”）## ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------。，sigma = 1，num_timepoints = 2，t_interval = c（1，2），rho = 0.8，corr_str =“ ar1”，func_form =“ lineAr”，beta = c（1，2），sissove_pct = 0，sissing_per_subject = 0, dis_plot=TRUE) head(triv_ex$df) triv_ex$Sigma[seq_len(2), seq_len(2)] ## ----hockey_stick, fig.align='center', fig.height=4, fig.width= 6，tidy = false ---- true_mean <-mean_trend（TimePoints = 1：10，form =“ l_up”，beta = 0。=“ ar1”，func_form =“ l_up”，beta = 0.5，ip = 5，sissing_pct = 0，sissect_per_subject = 0，dis_plot = true，asynch_time = true）## --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- gen <-en_norm_microbiome（功能= 6，diff_abun_features = 3，n_control =30，n_treat = 20，control_mean = 2，sigma = 2，num_timepoints = 4，t_interval = c（0，3），rho = 0.9，corr_str =“ compound”，func_form =“ m”，beta = c（4，3，3），ip = c（2，3.3，6），丢失_pct = 0.2，sissect_per_subject = 2，miss_val = 0）head（bug_gen $ bug_feat）bug_gen $ y [，1：5] names（bug_gen）## -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------session_info---------------------------------------------- sessionInfo()